BioPAX pathway converted from "Formation of Incision Complex in GG-NER" in the Reactome database.Formation of Incision Complex in GG-NERThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTTFIIH binds GG-NER site to form a verification complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TFIIHReactome DB_ID: 10495590nucleoplasmGENE ONTOLOGYGO:0005654Tfb4GTF2H3Q9VPX4Reactome DB_ID: 10495568UniProt:Q9VPX4Tfb4Drosophila melanogasterNCBI Taxonomy7227UniProtQ9VPX41EQUAL308EQUALReactome Database ID Release 7510495568Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495568ReactomeR-DME-659161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65916.1Reactomehttp://www.reactome.org1hayERCC3Q02870Reactome DB_ID: 10495563UniProt:Q02870hayUniProtQ028701EQUAL782EQUALReactome Database ID Release 7510495563Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495563ReactomeR-DME-674391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-67439.11mrnGTF2H4Q9VUR1Reactome DB_ID: 10495578UniProt:Q9VUR1mrnUniProtQ9VUR11EQUAL462EQUALReactome Database ID Release 7510495578Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495578ReactomeR-DME-659181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65918.11XpdERCC2Q7KVP9Reactome DB_ID: 10495558UniProt:Q7KVP9XpdUniProtQ7KVP91EQUAL760EQUALReactome Database ID Release 7510495558Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495558ReactomeR-DME-674431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-67443.11Ssl1GTF2H2Q9VNP8Reactome DB_ID: 10495573UniProt:Q9VNP8Ssl1UniProtQ9VNP81EQUAL395EQUALReactome Database ID Release 7510495573Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495573ReactomeR-DME-659141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65914.11Tfb5GTF2H5B7Z018Reactome DB_ID: 10495588UniProt:B7Z018Tfb5UniProtB7Z0181EQUAL71EQUALReactome Database ID Release 7510495588Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495588ReactomeR-DME-56884461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5688446.11CAKReactome DB_ID: 10495553Cdk7CDK7Q24216Reactome DB_ID: 10495541UniProt:Q24216Cdk7UniProtQ242161EQUAL346EQUALReactome Database ID Release 7510495541Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495541ReactomeR-DME-692181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-69218.11Mat1MNAT1Q7KPG8Reactome DB_ID: 10495551UniProt:Q7KPG8Mat1UniProtQ7KPG81EQUAL309EQUALReactome Database ID Release 7510495551Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495551ReactomeR-DME-590121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-59012.11CycHCCNHO76513Reactome DB_ID: 10495546UniProt:O76513CycHUniProtO765131EQUAL323EQUALReactome Database ID Release 7510495546Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495546ReactomeR-DME-692201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-69220.11Reactome Database ID Release 7510495553Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495553ReactomeR-DME-692211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-69221.11Tfb1GTF2H1Q960E8Reactome DB_ID: 10495583UniProt:Q960E8Tfb1UniProtQ960E81EQUAL548EQUALReactome Database ID Release 7510495583Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495583ReactomeR-DME-659121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65912.11Reactome Database ID Release 7510495590Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10495590ReactomeR-DME-1096341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-109634.1Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2Reactome DB_ID: 10546090PAR-PARP1,PAR-PARP2 dimersReactome DB_ID: 10543247ParpPAR-PARP1P35875Reactome DB_ID: 10543245UniProt:P35875ParpUniProtP35875L-glutamyl-5-poly(ADP-ribose)MODMOD:003002EQUAL1014EQUALReactome Database ID Release 7510543245Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10543245ReactomeR-DME-56517131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5651713.12Reactome Database ID Release 7510543247Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10543247ReactomeR-DME-56517091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5651709.11Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDBReactome DB_ID: 10546088Distorted dsDNAReactome DB_ID: 5688114Reactome Database ID Release 755688114Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5688114ReactomeR-ALL-56881142Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5688114.2ChEBI61120additional informationMIMI:03611Ub:XPC:RAD23:CETN2Reactome DB_ID: 10546086Converted from EntitySet in ReactomeHomologues of CETN2Reactome DB_ID: 10538461CETN2Dmel\CG17493M9PGG8Reactome DB_ID: 10538454UniProt:M9PGG8Dmel\CG17493UniProtM9PGG81EQUAL172EQUALReactome Database ID Release 7510538454Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10538454ReactomeR-DME-45704901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-4570490.1CETN2CG15158Q8T415Reactome DB_ID: 10538459UniProt:Q8T415CG15158UniProtQ8T4151EQUAL172EQUALReactome Database ID Release 7510538459Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10538459ReactomeR-DME-4570490-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-4570490-2.1Reactome Database ID Release 7510538461Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10538461ReactomeR-DME-4570490-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-4570490-3.11Ub:XPCReactome DB_ID: 10546084XpcUb-XPCQ24595Reactome DB_ID: 10546082UniProt:Q24595XpcUniProtQ24595ubiquitinylated lysineMODMOD:011482EQUAL940EQUALReactome Database ID Release 7510546082Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546082ReactomeR-DME-67829441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6782944.11Converted from EntitySet in ReactomeUbUbiquitinUBIQ_HUMANReactome DB_ID: 10491837RpL40UBA52(1-76)P18101Reactome DB_ID: 10491817UniProt:P18101 RpL40RpL40Ubi-fUBI-F52CG2960SUBUNIT 60S ribosomal protein is part of the 60S ribosomal subunit.MISCELLANEOUS In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.UniProtP181011EQUAL76EQUALReactome Database ID Release 7510491817Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491817ReactomeR-DME-9398441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-939844.1UBI-P63E 1ubiquitin 1Reactome DB_ID: 1221576UniProt:P0CG69 Ubi-p63EUbi-p63EUbi-mCG11624FUNCTION Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).MISCELLANEOUS In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family.UniProtP0CG691EQUAL76EQUALReactome Database ID Release 751221576Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1221576ReactomeR-DME-12215761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1221576.1UBI-P63E 2ubiquitin 2Reactome DB_ID: 122158677EQUAL152EQUALReactome Database ID Release 751221586Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1221586ReactomeR-DME-12215861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1221586.1UBI-P63E 3ubiquitin 3Reactome DB_ID: 1221575153EQUAL228EQUALReactome Database ID Release 751221575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1221575ReactomeR-DME-12215751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1221575.1Q9W418Ubi-p5EUBC(1-76)Reactome DB_ID: 10491819UniProt:Q9W418Ubi-p5EUniProtQ9W4181EQUAL76EQUALReactome Database ID Release 7510491819Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491819ReactomeR-DME-9398711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-939871.1Reactome Database ID Release 7510491837Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491837ReactomeR-DME-685241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68524.11Reactome Database ID Release 7510546084Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546084ReactomeR-DME-67829511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6782951.11Converted from EntitySet in ReactomeRAD23Reactome DB_ID: 10546079Rad23RAD23BQ9V3W9Reactome DB_ID: 10545715UniProt:Q9V3W9Rad23UniProtQ9V3W91EQUAL409EQUALReactome Database ID Release 7510545715Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10545715ReactomeR-DME-625901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-62590.1Converted from EntitySet in ReactomeHomologues of RAD23AReactome DB_ID: 10545713Rad23RAD23AQ9V3W9Reactome DB_ID: 105457061EQUAL363EQUALReactome Database ID Release 7510545706Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10545706ReactomeR-DME-56880761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5688076.1RAD23ADmel\CG10694Q9VCD5Reactome DB_ID: 10545711UniProt:Q9VCD5Dmel\CG10694UniProtQ9VCD51EQUAL363EQUALReactome Database ID Release 7510545711Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10545711ReactomeR-DME-5688076-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5688076-2.1Reactome Database ID Release 7510545713Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10545713ReactomeR-DME-5688076-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5688076-3.1Reactome Database ID Release 7510546079Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546079ReactomeR-DME-56881301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5688130.11Reactome Database ID Release 7510546086Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546086ReactomeR-DME-67829471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6782947.11PAR-UV-DDBReactome DB_ID: 10546077Cul4CUL4AQ5BI50Reactome DB_ID: 10543266UniProt:Q5BI50Cul4UniProtQ5BI501EQUAL759EQUALReactome Database ID Release 7510543266Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10543266ReactomeR-DME-9760061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-976006.11DDB1:PAR-DDB2Reactome DB_ID: 10546075Ghost homologue of PAR-DDB2Reactome DB_ID: 10546073Reactome Database ID Release 7510546073Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546073ReactomeR-DME-56966541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696654.11picDDB1Q9XYZ5Reactome DB_ID: 10543273UniProt:Q9XYZ5picUniProtQ9XYZ51EQUAL1140EQUALReactome Database ID Release 7510543273Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10543273ReactomeR-DME-534891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-53489.11Reactome Database ID Release 7510546075Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546075ReactomeR-DME-56966801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696680.11RBX1Roc1aQ9W5E1Reactome DB_ID: 10491857UniProt:Q9W5E1 Roc1aRoc1aCG16982FUNCTION Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex (PubMed:12062088). During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (Probable).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of SCF E3 ubiquitin-protein ligase complexes consisting of Skpa, Cul1, Roc1a and an F-box protein. In larvae neuroblast self renewal and asymmetric division, as well as ddaC dendrite and mushroom body axon pruning, the complex contains the F-box protein slmb (SCF-slmb) (PubMed:24068890, PubMed:24413555). Interacts directly with Cul1 and Slmb (PubMed:11500045). In caspase activation during sperm differentiation, the complex contains the F-box protein ntc (Probable).TISSUE SPECIFICITY Widely expressed. Expressed in embryonic, larval and adult tissues.DEVELOPMENTAL STAGE Expressed both maternally and zygotically.DOMAIN The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity).DISRUPTION PHENOTYPE Severe pruning defect in ddaC neurons (PubMed:24068890). Also shows defects in ddaD and ddaE neuron pruning and in ddaF apoptosis (PubMed:24068890). RNAi-mediated knockdown results in apical detachment of scolopidial cells in Johnston's organ (PubMed:27331610).SIMILARITY Belongs to the RING-box family.UniProtQ9W5E12EQUAL108EQUALReactome Database ID Release 7510491857Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491857ReactomeR-DME-12341421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1234142.11Reactome Database ID Release 7510546077Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546077ReactomeR-DME-56966491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696649.11Reactome Database ID Release 7510546088Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546088ReactomeR-DME-56966591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696659.11Reactome Database ID Release 7510546090Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546090ReactomeR-DME-56966811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696681.1Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2Reactome DB_ID: 1054609211Reactome Database ID Release 7510546092Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546092ReactomeR-DME-56898621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5689862.1Reactome Database ID Release 7510546725Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546725ReactomeR-DME-56910001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5691000.1GENE ONTOLOGYGO:0006294gene ontology term for cellular processMIMI:0359Transcription factor II H (TFIIH) complex is recruited to DNA damage sites after the damage is recognized by the XPC:RAD23:CETN2 complex and the UV-DDB complex (DDB1:DDB2) (Volker et al. 2001, Araujo and Wood 1999).<p>TFIIH consists of ten subunits organized into a ring-like structure (Schultz et al. 2000). The TFIIH core, also forming a ring-like structure, includes a DNA helicase ERCC3 (XPB), GTF2H1 (BTF2-p62), GTF2H2 (BTF2-p44), GTF2H3 (BTF2-p34) and GTF2H4 (BTF2-p52). GTF2H4 directly interacts with ERCC3 and anchors it to the TFIIH complex (Jawhari et al. 2002). Another DNA helicase, ERCC2 (XPD) is anchored to the TFIIH complex by binding to the GTF2H2 subunit (Coin et al. 1998). The CDK-activating kinase (CAK) complex, consisting of CCNH (cyclin H), CDK7 and MNAT1 (MAT1) is included in the TFIIH complex through an interaction with ERCC2 (Reardon et al. 1996, Rossignol et al. 1997). The tenth subunit, GTF2H5 (TTDA, TFB5, BTF2-p5) is important for the stability of the TFIIH complex (Giglia-Mari et al. 2004). The TFIIH complex binds the DNA damage site after XPC:RAD23:CETN2 complex recognizes the damage (Volker et al. 2001, Riedl et al. 2003), and the ERCC3 and GTF2H1 subunits of TFIIH directly interact with XPC (Yokoi et al. 2003).11511374Pubmed2001Sequential assembly of the nucleotide excision repair factors in vivo.Volker, MMoné, MJKarmakar, Pvan Hoffen, ASchul, WVermeulen, WHoeijmakers, Jan H Jvan Driel, Rvan Zeeland, AAMullenders, LHMol Cell 8:213-249130708Pubmed1997Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIHRossignol, MKolb-Cheynel, IEgly, JMEMBO J. 16:1628-3725154395Pubmed2014Sequential and ordered assembly of a large DNA repair complex on undamaged chromatinZiani, SalimNagy, ZitaAlekseev, SergeySoutoglou, EviEgly, Jean-MarcCoin, FredericJ. Cell Biol. 206:589-9815220921Pubmed2004A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group AGiglia-Mari, GiuseppinaCoin, FredericRanish, Jeffrey AHoogstraten, DeborahTheil, ArjanWijgers, NilsJaspers, Nicolaas G JRaams, AnjaArgentini, Manuelavan der Spek, P JBotta, ElenaStefanini, MiriaEgly, Jean-MarcAebersold, RuediHoeijmakers, Jan H JVermeulen, WimNat. Genet. 36:714-911007478Pubmed2000Molecular structure of human TFIIHSchultz, PFribourg, SPoterszman, AMallouh, VMoras, DEgly, JMCell 102:599-60712080057Pubmed2002p52 Mediates XPB function within the transcription/repair factor TFIIHJawhari, AnassLainé, Jean-PhilippeDubaele, SandyLamour, VPoterszman, ArnaudCoin, FredericMoras, DinoEgly, Jean-MarcJ. Biol. Chem. 277:31761-79771713Pubmed1998Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIHCoin, FMarinoni, J CRodolfo, CFribourg, SPedrini, A MEgly, JMNat. Genet. 20:184-88692841Pubmed1996Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIHReardon, J TGe, HGibbs, ESancar, AHurwitz, JPan, ZQProc. Natl. Acad. Sci. U.S.A. 93:6482-714517266Pubmed2003The comings and goings of nucleotide excision repair factors on damaged DNARiedl, ThiloHanaoka, FumioEgly, Jean-MarcEMBO J. 22:5293-30310734143Pubmed2000The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNAYokoi, MMasutani, CMaekawa, TSugasawa, KOhkuma, YHanaoka, FJ. Biol. Chem. 275:9870-510526214Pubmed1999Protein complexes in nucleotide excision repair.Araujo, SJWood, Richard DMutat Res 435:23-33inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTRecruitment of XPA and release of CAK This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>XPAXpacP28518Reactome DB_ID: 10546071UniProt:P28518XpacUniProtP285182EQUAL273EQUALReactome Database ID Release 7510546071Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546071ReactomeR-DME-674371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-67437.1Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2Reactome DB_ID: 1054609611TFIIH CoreReactome DB_ID: 105460941111111Reactome Database ID Release 7510546094Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546094ReactomeR-DME-56896241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5689624.11Reactome Database ID Release 7510546096Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546096ReactomeR-DME-56893001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5689300.1Reactome Database ID Release 7510546098Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546098ReactomeR-DME-56898611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5689861.1XPA binds the DNA damage site through interaction with the TFIIH complex subunit GTF2H5 (TTDA) (Ziani et al. 2014), and also interacts with the DDB2 subunit of the UV-DDB complex (Wakasugi et al. 2001, Wakasugi et al. 2009, Takedachi et al. 2010). PARylated PARP1 (or possibly PARP2) (King et al. 2012) facilitates XPA association with chromatin. Binding of XPA is accompanied by the release of the CAK subcomplex from the TFIIH complex (Coin et al. 2008).11278856Pubmed2001Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein AWakasugi, MShimizu, MMorioka, HLinn, SNikaido, OMatsunaga, TJ. Biol. Chem. 276:15434-4020368362Pubmed2010DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPATakedachi, AratoSaijo, MasafumiTanaka, KiyojiMol. Cell. Biol. 30:2708-2318614043Pubmed2008Nucleotide excision repair driven by the dissociation of CAK from TFIIHCoin, FredericOksenych, ValentynMocquet, VincentGroh, StefanieBlattner, ChristineEgly, Jean MarcMol. Cell 31:9-2019056823Pubmed2009Physical and functional interaction between DDB and XPA in nucleotide excision repairWakasugi, MitsuoKasashima, HiromiFukase, YukoImura, MayumiImai, RikaYamada, SakiCleaver, James EMatsunaga, TsukasaNucleic Acids Res. 37:516-2523038248Pubmed2012Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repairKing, Brenee SCooper, Karen LLiu, Ke JianHudson, Laurie GJ. Biol. Chem. 287:39824-33LEFT-TO-RIGHTERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNAThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 29358ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 7529358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358ReactomeR-ALL-293583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3COMPOUNDC00002Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1LReactome DB_ID: 105467141Ghost homologue of CHD1LReactome DB_ID: 10546477Reactome Database ID Release 7510546477Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546477ReactomeR-DME-56889161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5688916.11Reactome Database ID Release 7510546714Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546714ReactomeR-DME-56966521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696652.1Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1LReactome DB_ID: 10546718Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDBReactome DB_ID: 10546716damaged DNA with open bubble structureReactome DB_ID: 109944Reactome Database ID Release 75109944Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109944ReactomeR-ALL-1099442Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109944.2ChEBI61120111Reactome Database ID Release 7510546716Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546716ReactomeR-DME-56892971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5689297.111111Reactome Database ID Release 7510546718Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546718ReactomeR-DME-56910181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5691018.1PiOrthophosphatehydrogenphosphatePhosphateInorganic PhosphateReactome DB_ID: 113550hydrogenphosphate [ChEBI:43474]hydrogenphosphatehydrogen phosphatephosphate[PO3(OH)](2-)INORGANIC PHOSPHATE GROUPHYDROGENPHOSPHATE IONHPO4(2-)[P(OH)O3](2-)ChEBICHEBI:43474Reactome Database ID Release 75113550Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113550ReactomeR-ALL-1135504Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113550.4COMPOUNDC00009ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 113582ADP(3-) [ChEBI:456216]ADP(3-)ADP5&apos;-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 75113582Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582ReactomeR-ALL-1135823Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3COMPOUNDC00008ACTIVATIONGENE ONTOLOGYGO:0004386gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510546719Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546719Reactome Database ID Release 7510546721Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546721ReactomeR-DME-56909961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5690996.1GENE ONTOLOGYGO:0000717Two DNA helicases XPB (ERCC3) and XPD (ERCC2), which are part of the TFIIH complex, unwind the distorted DNA duplex around the lesion to form an open bubble structure that exposes the damaged site. The helicase activity of the TFIIH complex is stimulated by the presence of XPA and the XPC:RAD23:CETN2 complex (Winkler et al. 2001). The 5'->3' directed helicase activity of ERCC2 (Kuper et al. 2012) is crucial for unwinding of the distorted dsDNA during nucleotide excision repair (NER) (Coin et al. 2007). The 3'->5' directed DNA helicase ERCC3 contributes to dsDNA unwinding during NER through ATP hydrolysis (Coin et al. 2007). In addition to DNA unwinding, ERCC2 and ERCC3 verify the presence of DNA damage (Oksenych et al. 2009, Mathieu et al. 2010, Mathieu et al. 2013). Verification of DNA damage also involves XPA (Camenisch et al. 2006). The binding site of XPC determines which DNA strand is selected by ERCC2 to verify the presence of lesions (Sugasawa et al. 2009).22081108Pubmed2012Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocationKuper, JochenWolski, Stefanie CMichels, GudrunKisker, CarolineEMBO J. 31:494-50219713942Pubmed2009Molecular insights into the recruitment of TFIIH to sites of DNA damageOksenych, ValentynBernardes de Jesus, BrunoZhovmer, AlexanderEgly, Jean-MarcCoin, FredericEMBO J. 28:2971-8011141066Pubmed2001Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPFWinkler, G SSugasawa, KEker, A Pde Laat, W LHoeijmakers, Jan H JBiochemistry 40:160-519941824Pubmed2009Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanningSugasawa, KaoruAkagi, Jun-IchiNishi, RyotaroIwai, ShigenoriHanaoka, FumioMol. Cell 36:642-5317466626Pubmed2007Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repairCoin, FredericOksenych, ValentynEgly, Jean-MarcMol. Cell 26:245-5620876134Pubmed2010Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicaseMathieu, NadineKaczmarek, NinaNaegeli, HanspeterProc. Natl. Acad. Sci. U.S.A. 107:17545-5023352696Pubmed2013DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIHMathieu, NadineKaczmarek, NinaRüthemann, PeterLuch, AndreasNaegeli, HanspeterCurr. Biol. 23:204-1216491090Pubmed2006Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repairCamenisch, UlrikeDip, RamiroSchumacher, Sylvie BriandSchuler, BenjaminNaegeli, HanspeterNat. Struct. Mol. Biol. 13:278-84LEFT-TO-RIGHTSUMOylation of XPCThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeSUMO1,2,3:UBE2IReactome DB_ID: 10549426SUMO2:UBE2IReactome DB_ID: 10535738lwrSUMO2-C93-UBE2IQ7KNM2Reactome DB_ID: 10535733UniProt:Q7KNM2lwrUniProtQ7KNM293EQUALS-(glycyl)-L-cysteine (Cys-Gly)MODMOD:002111EQUAL158EQUALReactome Database ID Release 7510535733Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535733ReactomeR-DME-37306191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3730619.11smt3UBE2I-G93-SUMO2O97102Reactome DB_ID: 10535736UniProt:O97102smt3UniProtO9710293EQUAL1EQUAL93EQUALReactome Database ID Release 7510535736Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535736ReactomeR-DME-37306251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3730625.11Reactome Database ID Release 7510535738Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535738ReactomeR-DME-29937781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2993778.1SUMO3:UBE2IReactome DB_ID: 10535746lwrSUMO3-C93-UBE2IQ7KNM2Reactome DB_ID: 1053574193EQUAL1EQUAL158EQUALReactome Database ID Release 7510535741Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535741ReactomeR-DME-37306291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3730629.11smt3UBE2I-G92-SUMO3O97102Reactome DB_ID: 1053574492EQUAL1EQUAL92EQUALReactome Database ID Release 7510535744Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535744ReactomeR-DME-37306111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3730611.11Reactome Database ID Release 7510535746Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535746ReactomeR-DME-29937821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2993782.1Reactome Database ID Release 7510549426Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549426ReactomeR-DME-67904711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790471.1Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1LReactome DB_ID: 10549435Ub,SUMO:XPC:RAD23:CETN2Reactome DB_ID: 1054943311Ub,SUMO:XPCReactome DB_ID: 10549431smt3SUMO2O97102Reactome DB_ID: 105355761EQUAL93EQUALReactome Database ID Release 7510535576Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535576ReactomeR-DME-29842811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2984281.11XpcUb,SUMO-XPCQ24595Reactome DB_ID: 10549429sumoylated lysineMODMOD:011492EQUAL940EQUALReactome Database ID Release 7510549429Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549429ReactomeR-DME-67904601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790460.111Reactome Database ID Release 7510549431Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549431ReactomeR-DME-67904621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790462.11Reactome Database ID Release 7510549433Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549433ReactomeR-DME-67904611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790461.11111111Reactome Database ID Release 7510549435Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549435ReactomeR-DME-67904681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790468.1lwrUBE2IQ7KNM2Reactome DB_ID: 105356511EQUAL158EQUALReactome Database ID Release 7510535651Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10535651ReactomeR-DME-9124811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-912481.1ACTIVATIONConverted from EntitySet in ReactomePIAS1,3Reactome DB_ID: 10549437PIAS1Su(var)2-10A1Z7P5Reactome DB_ID: 10519472UniProt:A1Z7P5Su(var)2-10UniProtA1Z7P51EQUAL651EQUALReactome Database ID Release 7510519472Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10519472ReactomeR-DME-8773071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-877307.1Reactome Database ID Release 7510549437Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549437ReactomeR-DME-67904551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790455.1GENE ONTOLOGYGO:0019789Reactome Database ID Release 7510549438Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549438Reactome Database ID Release 7510549440Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10549440ReactomeR-DME-67904541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790454.1XPC undergoes SUMOylation following UV irradiation on several consensus SUMOylation sites (van Cuijk et al. 2015). SUMOylation of XPC probably succeeds the UV-DDB mediated ubiquitination of XPC, as the presence of both DDB2 and XPA is required for SUMOylation (Wang et al. 2005), but it has also been reported that SUMOylation of XPC was DDB2-independent (Akita et al. 2015). It is unclear whether XPC is modified by SUMO1 (Wang et al. 2005, Akita et al. 2015) or poly-SUMO2/3 (Poulsen et al. 2013). SUMO conjugases PIAS1 and PIAS3 both interact with XPC and may catalyze XPC SUMOylation (Akita et al. 2015).26042670Pubmed2015SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repairAkita, MasakiTak, Yon-SooShimura, TsutomuMatsumoto, SyotaOkuda-Shimizu, YukiShimizu, YuichiroNishi, RyotaroSaitoh, HisatoIwai, ShigenoriMori, ToshioIkura, TsuyoshiSakai, WataruHanaoka, FumioSugasawa, KaoruSci Rep 5:1098423751493Pubmed2013RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage responsePoulsen, Sara LHansen, Rebecca KWagner, Sebastian Avan Cuijk, Loesvan Belle, Gijsbert JStreicher, WernerWikström, MatsChoudhary, ChunaramHoutsmuller, Adriaan BMarteijn, Jurgen ABekker-Jensen, SimonMailand, NielsJ. Cell Biol. 201:797-80726151477Pubmed2015SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repairvan Cuijk, Loesvan Belle, Gijsbert JTurkyilmaz, YaseminPoulsen, Sara LJanssens, Roel CTheil, Arjan FSabatella, MariangelaLans, HannesMailand, NielsHoutsmuller, Adriaan BVermeulen, WimMarteijn, Jurgen ANat Commun 6:749916030353Pubmed2005DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiationWang, Qi-EnZhu, QianzhengWani, GulzarEl-Mahdy, Mohamed ALi, JinyouWani, Altaf ANucleic Acids Res. 33:4023-34LEFT-TO-RIGHTERCC1 binds ERCC4 (XPF)Formation of ERCC1:XPF heterodimeric complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>mei-9ERCC4Q24087Reactome DB_ID: 10498194UniProt:Q24087mei-9UniProtQ240871EQUAL916EQUALReactome Database ID Release 7510498194Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10498194ReactomeR-DME-674451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-67445.1Ercc1ERCC1Q7KMG7Reactome DB_ID: 10498189UniProt:Q7KMG7Ercc1UniProtQ7KMG71EQUAL297EQUALReactome Database ID Release 7510498189Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10498189ReactomeR-DME-544271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-54427.1ERCC1:ERCC4Reactome DB_ID: 1049819611Reactome Database ID Release 7510498196Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10498196ReactomeR-DME-1099431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-109943.1Reactome Database ID Release 7510498198Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10498198ReactomeR-DME-1099551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-109955.1ERCC1 binds ERCC4 (XPF) to form a heterodimeric ERCC1:ERCC4 (ERCC1:XPF) complex with a DNA endonuclease activity, where ERCC4 is the catalytic subunit. Suitable substrates for the ERCC1:ERCC4 endonuclease are single strand DNA (ssDNA) and ssDNA region of a duplex DNA with an open bubble structure (Park et al. 1995). 7559382Pubmed1995Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nucleasePark, C HBessho, TMatsunaga, TSancar, AJ. Biol. Chem. 270:22657-60LEFT-TO-RIGHTBinding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NERThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GG-NER pre-incision complex:Open bubble-dsDNAReactome DB_ID: 10546705Ghost homologue of ERCC5Reactome DB_ID: 10546475Reactome Database ID Release 7510546475Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546475ReactomeR-DME-674471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-67447.11RPA heterotrimerReactome DB_ID: 10492071RPA2RPA2Q9VIH1Reactome DB_ID: 10491734UniProt:Q9VIH1RPA2UniProtQ9VIH11EQUAL270EQUALReactome Database ID Release 7510491734Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491734ReactomeR-DME-684571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68457.11RPA3RPA3Q9VYW3Reactome DB_ID: 10491727UniProt:Q9VYW3RPA3UniProtQ9VYW31EQUAL121EQUALReactome Database ID Release 7510491727Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491727ReactomeR-DME-684591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68459.11Ghost homologue of RPA1Reactome DB_ID: 10491722Reactome Database ID Release 7510491722Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10491722ReactomeR-DME-684611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68461.11Reactome Database ID Release 7510492071Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10492071ReactomeR-DME-684621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-68462.11Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1LReactome DB_ID: 10546703111111Reactome Database ID Release 7510546703Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546703ReactomeR-DME-67905171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6790517.11Reactome Database ID Release 7510546705Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546705ReactomeR-DME-56910431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5691043.1GG-NER incision complex:Open bubble dsDNAReactome DB_ID: 1054670711Reactome Database ID Release 7510546707Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546707ReactomeR-DME-56910461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5691046.1Reactome Database ID Release 7510546712Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10546712ReactomeR-DME-56909911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5690991.1GENE ONTOLOGYGO:0006293ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to the DNA damage at global genome nucleotide excision repair (GG-NER) sites to form the incision complex. Binding of ERCC5 (XPG) to the NER site precedes the recruitment of ERCC1:ERCC4 (Riedl et al. 2003). ERCC1 directly interacts with XPA, and this interaction is necessary for the loading of ERCC1:ERCC4 to the open bubble structure in damaged dsDNA and the progression of GG-NER (Tsodikov et al. 2007, Orelli et al. 2010).17948053Pubmed2007Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPATsodikov, Oleg VIvanov, DmitriOrelli, BarbaraStaresincic, LidijaShoshani, IlanaOberman, RobertSchärer, Orlando DWagner, GerhardEllenberger, TomEMBO J. 26:4768-7619940136Pubmed2010The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathwaysOrelli, BarbaraMcClendon, T BrookeTsodikov, Oleg VEllenberger, TomNiedernhofer, Laura JSchärer, Orlando DJ. Biol. Chem. 285:3705-12Reactome Database ID Release 7510567621Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10567621ReactomeR-DME-56963951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696395.1After the XPC complex and the UV-DDB complex bind damaged DNA, a basal transcription factor TFIIH is recruited to the nucleotide excision repair (NER) site (Volker et al. 2001, Riedl et al. 2003). DNA helicases ERCC2 (XPD) and ERCC3 (XPB) are subunits of the TFIIH complex. ERCC2 unwinds the DNA around the damage in concert with the ATPase activity of ERCC3, creating an open bubble (Coin et al. 2007). Simultaneously, the presence of the damage is verified by XPA (Camenisch et al. 2006). The recruitment of XPA is partially regulated by PARP1 and/or PARP2 (King et al. 2012).<p>Two DNA endonucleases, ERCC5 (XPG) and the complex of ERCC1 and ERCC4 (XPF), are recruited to the open bubble structure to form the incision complex that will excise the damaged oligonucleotide from the affected DNA strand (Dunand-Sauthier et al. 2005, Zotter et al. 2006, Riedl et al. 2003, Tsodikov et al. 2007, Orelli et al. 2010). The RPA heterotrimer coats the undamaged DNA strand, thus protecting it from the endonucleolytic attack (De Laat et al. 1998).15590680Pubmed2005The spacer region of XPG mediates recruitment to nucleotide excision repair complexes and determines substrate specificityDunand-Sauthier, IsabelleHohl, MarcelThorel, FabrizioJaquier-Gubler, PascaleClarkson, Stuart GSchärer, Orlando DJ. Biol. Chem. 280:7030-79716411Pubmed1998DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repairde Laat, W LAppeldoorn, ESugasawa, KWeterings, EJaspers, N GHoeijmakers, Jan H JGenes Dev. 12:2598-60917000769Pubmed2006Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIHZotter, AngelikaLuijsterburg, Martijn SWarmerdam, Daniël OIbrahim, ShehuNigg, Alexvan Cappellen, Wiggert AHoeijmakers, Jan H Jvan Driel, RoelVermeulen, WimHoutsmuller, Adriaan BMol. Cell. Biol. 26:8868-79