BioPAX pathway converted from "Carbonic anhydrase dehydrates bicarbonate (mitochondria)" in the Reactome database.LEFT-TO-RIGHT4.2.1.1Carbonic anhydrase dehydrates bicarbonate (mitochondria)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>HCO3-BicarbonatehydrogencarbonateAcid carbonateReactome DB_ID: 29896mitochondrial matrixGENE ONTOLOGYGO:0005759hydrogencarbonate [ChEBI:17544]hydrogencarbonateChEBICHEBI:17544Reactome Database ID Release 7529896Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29896ReactomeR-ALL-298963Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29896.3Reactomehttp://www.reactome.orgCOMPOUNDC00288additional informationMIMI:0361H+hydronReactome DB_ID: 113529hydron [ChEBI:15378]hydronChEBICHEBI:15378Reactome Database ID Release 75113529Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529ReactomeR-ALL-1135294Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113529.4COMPOUNDC00080H2OwaterReactome DB_ID: 113521water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 75113521Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113521ReactomeR-ALL-1135213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113521.3COMPOUNDC00001CO2carbon dioxideReactome DB_ID: 29376carbon dioxide [ChEBI:16526]carbon dioxideChEBICHEBI:16526Reactome Database ID Release 7529376Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29376ReactomeR-ALL-293763Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29376.3COMPOUNDC00011ACTIVATIONConverted from EntitySet in ReactomeCA5A,B:ZincMitochondrial Carbonic AnhydraseReactome DB_ID: 10603787CA5A:ZincReactome DB_ID: 10603781Zn2+Zn++zinc(2+)Zinc ionZn(II)Reactome DB_ID: 880067zinc(2+) [ChEBI:29105]zinc(2+)ChEBICHEBI:29105Reactome Database ID Release 75880067Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880067ReactomeR-ALL-8800673Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-880067.3COMPOUNDC000381CA5Acah-6O02637Reactome DB_ID: 10603779UniProt:O02637cah-6Caenorhabditis elegansNCBI Taxonomy6239UniProtO0263739EQUAL305EQUALReactome Database ID Release 7510603779Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603779ReactomeR-CEL-12370281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1237028.11Reactome Database ID Release 7510603781Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603781ReactomeR-CEL-12373141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1237314.1CA5B:ZincReactome DB_ID: 10603785CA5Bcah-6O02637Reactome DB_ID: 1060378334EQUAL317EQUALReactome Database ID Release 7510603783Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603783ReactomeR-CEL-12370231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1237023.111Reactome Database ID Release 7510603785Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603785ReactomeR-CEL-12373191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1237319.1Reactome Database ID Release 7510603787Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603787ReactomeR-CEL-14750161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1475016.1GENE ONTOLOGYGO:0004089gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510603788Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603788Reactome Database ID Release 7510603790Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603790ReactomeR-CEL-14750281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1475028.1Carbonic anhydrase VA (CA5A, Nagao et al. 1993, Franchi et al. 2003, Nishimori et al. 2007) and carbonic anhydrase VB (CA5B, Fujikawa-Adachi et al. 1999, Nishimori et al. 2005, Nishimori et al. 2007) dehydrate bicarbonate in mitochondria to yield water and carbon dioxide (reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.16302824Pubmed2005Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitorsNishimori, IVullo, DInnocenti, AScozzafava, AMastrolorenzo, ASupuran, CTJ Med Chem 48:7860-69336012Pubmed1997Structure and mechanism of carbonic anhydraseLindskog, SPharmacol Ther 74:1-2014611844Pubmed2003Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anionsFranchi, MVullo, DGallori, EAntel, JWurl, MScozzafava, ASupuran, CTBioorg Med Chem Lett 13:2857-618356065Pubmed1993Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16Nagao, YPlatero, JSWaheed, ASly, William SProc Natl Acad Sci U S A 90:7623-710409679Pubmed1999Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome xFujikawa-Adachi, KNishimori, ITaguchi, TOnishi, SJ Biol Chem 274:21228-3317761422Pubmed2007Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very differentNishimori, IInnocenti, AVullo, DScozzafava, ASupuran, CTBioorg Med Chem 15:6742-7inferred from electronic annotationEVIDENCE CODEECO:0000203