BioPAX pathway converted from "CFTR transits to the plasma membrane" in the Reactome database.LEFT-TO-RIGHTCFTR transits to the plasma membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeHomologues of misfolded CFTRReactome DB_ID: 10635091mrp-5misfolded CFTRG5EE72Reactome DB_ID: 10635085endoplasmic reticulum membraneGENE ONTOLOGYGO:0005789UniProt:G5EE72mrp-5Caenorhabditis elegansNCBI Taxonomy6239UniProtG5EE721EQUAL1480EQUALReactome Database ID Release 7510635085Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635085ReactomeR-CEL-88687301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8868730.1Reactomehttp://www.reactome.orgmrp-6misfolded CFTRQ19625Reactome DB_ID: 10635087UniProt:Q19625mrp-6UniProtQ196251EQUAL1480EQUALReactome Database ID Release 7510635087Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635087ReactomeR-CEL-8868730-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8868730-2.1cft-1misfolded CFTRQ95QV2Reactome DB_ID: 10635089UniProt:Q95QV2cft-1UniProtQ95QV21EQUAL1480EQUALReactome Database ID Release 7510635089Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635089ReactomeR-CEL-8868730-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8868730-3.1Reactome Database ID Release 7510635091Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635091ReactomeR-CEL-8868730-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8868730-4.1Converted from EntitySet in ReactomeHomologues of CFTRReactome DB_ID: 10590050CFTRmrp-5G5EE72Reactome DB_ID: 10590038plasma membraneGENE ONTOLOGYGO:00058861EQUAL1480EQUALReactome Database ID Release 7510590038Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590038ReactomeR-CEL-3831881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-383188.1CFTRmrp-6Q19625Reactome DB_ID: 105900431EQUAL1480EQUALReactome Database ID Release 7510590043Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590043ReactomeR-CEL-383188-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-383188-2.1CFTRcft-1Q95QV2Reactome DB_ID: 105900481EQUAL1480EQUALReactome Database ID Release 7510590048Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590048ReactomeR-CEL-383188-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-383188-3.1Reactome Database ID Release 7510590050Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590050ReactomeR-CEL-383188-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-383188-4.1Reactome Database ID Release 7510635142Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635142ReactomeR-CEL-88668511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8866851.1The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride ion channel that undergoes multiple folding processes and post-translational modifications during its biosynthesis. 60-80% of CFTR protein encoded by the wild-type (WT) gene is successfully modified and transits the secretory system to the plasma membrane. The remaining misfolded protein is targeted for degradation by the ER, lysosomes or autophagy (reviewed in Pranke and Sermet-Gaudelus, 2014)24685677Pubmed2014Biosynthesis of cystic fibrosis transmembrane conductance regulatorPranke, Iwona MSermet-Gaudelus, IsabelleInt. J. Biochem. Cell Biol. 52:26-38inferred from electronic annotationEVIDENCE CODEECO:0000203