BioPAX pathway converted from "UCH proteinases" in the Reactome database.UCH proteinasesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTADRM1 binds 26S proteasomeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ADRM1rpn-13Q09289Reactome DB_ID: 10621509cytosolGENE ONTOLOGYGO:0005829UniProt:Q09289rpn-13Caenorhabditis elegansNCBI Taxonomy6239UniProtQ092892EQUAL407EQUALReactome Database ID Release 7510621509Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621509ReactomeR-CEL-56659391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665939.1Reactomehttp://www.reactome.org26S proteasomeReactome DB_ID: 10570893pas-6PSMA1O44156Reactome DB_ID: 10570706UniProt:O44156pas-6UniProtO441561EQUAL263EQUALReactome Database ID Release 7510570706Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570706ReactomeR-CEL-687241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68724.11Ghost homologue of PSMD10Reactome DB_ID: 10570814Reactome Database ID Release 7510570814Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570814ReactomeR-CEL-687881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68788.11pbs-5PSMB5Q9XUV0Reactome DB_ID: 10570766UniProt:Q9XUV0pbs-5UniProtQ9XUV060EQUAL263EQUALReactome Database ID Release 7510570766Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570766ReactomeR-CEL-687531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68753.11rpt-3PSMC4P46502Reactome DB_ID: 10570797UniProt:P46502rpt-3UniProtP465021EQUAL418EQUALReactome Database ID Release 7510570797Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570797ReactomeR-CEL-687771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68777.11rpn-8PSMD7O61792Reactome DB_ID: 10570859UniProt:O61792rpn-8UniProtO617921EQUAL324EQUALReactome Database ID Release 7510570859Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570859ReactomeR-CEL-688061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68806.11PSME4Q17971Reactome DB_ID: 10570885UniProt:Q17971UniProtQ179711EQUAL1843EQUALReactome Database ID Release 7510570885Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570885ReactomeR-CEL-9476061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-947606.11pbs-2PSMB7O62102Reactome DB_ID: 10570773UniProt:O62102pbs-2UniProtO6210244EQUAL277EQUALReactome Database ID Release 7510570773Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570773ReactomeR-CEL-687591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68759.11PSME3Q95PZ7Reactome DB_ID: 10570878UniProt:Q95PZ7UniProtQ95PZ72EQUAL254EQUALReactome Database ID Release 7510570878Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570878ReactomeR-CEL-688161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68816.11PSMD11rpn-6.1Q20938Reactome DB_ID: 10570819UniProt:Q20938rpn-6.1UniProtQ209382EQUAL422EQUALReactome Database ID Release 7510570819Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570819ReactomeR-CEL-687901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68790.11pas-7PSMA3Q09583Reactome DB_ID: 10570716UniProt:Q09583pas-7UniProtQ095832EQUAL255EQUALReactome Database ID Release 7510570716Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570716ReactomeR-CEL-687281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68728.11PSMD8rpn-12Q23449Reactome DB_ID: 10570864UniProt:Q23449rpn-12UniProtQ234491EQUAL350EQUALReactome Database ID Release 7510570864Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570864ReactomeR-CEL-688081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68808.11PSMD4rpn-10O61742Reactome DB_ID: 10570844UniProt:O61742rpn-10UniProtO617421EQUAL377EQUALReactome Database ID Release 7510570844Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570844ReactomeR-CEL-688001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68800.11pas-3PSMA4Q9N599Reactome DB_ID: 10570721UniProt:Q9N599pas-3UniProtQ9N5991EQUAL261EQUALReactome Database ID Release 7510570721Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570721ReactomeR-CEL-687301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68730.11pbs-7PSMB4P90868Reactome DB_ID: 10570761UniProt:P90868pbs-7UniProtP9086846EQUAL264EQUALReactome Database ID Release 7510570761Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570761ReactomeR-CEL-687501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68750.11pbs-1PSMB6Q966I8Reactome DB_ID: 10570771UniProt:Q966I8pbs-1UniProtQ966I835EQUAL239EQUALReactome Database ID Release 7510570771Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570771ReactomeR-CEL-687561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68756.11pbs-1PSMB9Q966I8Reactome DB_ID: 1057077721EQUAL219EQUALReactome Database ID Release 7510570777Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570777ReactomeR-CEL-687651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68765.11pbs-5PSMB11Q9XUV0Reactome DB_ID: 1057088950EQUAL300EQUALReactome Database ID Release 7510570889Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570889ReactomeR-CEL-9476071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-947607.11rpn-3PSMD3Q04908Reactome DB_ID: 10570839UniProt:Q04908rpn-3UniProtQ049081EQUAL534EQUALReactome Database ID Release 7510570839Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570839ReactomeR-CEL-687981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68798.11Ghost homologue of PSMF1Reactome DB_ID: 10570880Reactome Database ID Release 7510570880Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570880ReactomeR-CEL-688181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68818.11rpn-7PSMD6Q20585Reactome DB_ID: 10570854UniProt:Q20585rpn-7UniProtQ205851EQUAL389EQUALReactome Database ID Release 7510570854Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570854ReactomeR-CEL-688041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68804.11Ghost homologue of SHFM1Reactome DB_ID: 10570891Reactome Database ID Release 7510570891Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570891ReactomeR-CEL-88666741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8866674.11pas-5PSMA5Q95008Reactome DB_ID: 10570726UniProt:Q95008pas-5UniProtQ950081EQUAL241EQUALReactome Database ID Release 7510570726Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570726ReactomeR-CEL-687321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68732.11rpn-5PSMD12Q19324Reactome DB_ID: 10570824UniProt:Q19324rpn-5UniProtQ193242EQUAL456EQUALReactome Database ID Release 7510570824Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570824ReactomeR-CEL-687921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68792.11pbs-5PSMB8Q9XUV0Reactome DB_ID: 1057077573EQUAL276EQUALReactome Database ID Release 7510570775Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570775ReactomeR-CEL-687621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68762.11rpn-11PSMD14O76577Reactome DB_ID: 10570701UniProt:O76577rpn-11UniProtO765771EQUAL310EQUALReactome Database ID Release 7510570701Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570701ReactomeR-CEL-687221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68722.11pas-2PSMA2Q27488Reactome DB_ID: 10570711UniProt:Q27488pas-2UniProtQ274882EQUAL234EQUALReactome Database ID Release 7510570711Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570711ReactomeR-CEL-687261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68726.11pbs-6PSMB1P34286Reactome DB_ID: 10570741UniProt:P34286pbs-6UniProtP3428629EQUAL241EQUALReactome Database ID Release 7510570741Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570741ReactomeR-CEL-687381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68738.11rpt-4PSMC6O17071Reactome DB_ID: 10570807UniProt:O17071rpt-4UniProtO170711EQUAL389EQUALReactome Database ID Release 7510570807Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570807ReactomeR-CEL-687831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68783.11PSMD9psmd-9Q10920Reactome DB_ID: 10570869UniProt:Q10920psmd-9UniProtQ109201EQUAL223EQUALReactome Database ID Release 7510570869Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570869ReactomeR-CEL-688101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68810.11rpt-1PSMC2Q18787Reactome DB_ID: 10570787UniProt:Q18787rpt-1UniProtQ187872EQUAL433EQUALReactome Database ID Release 7510570787Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570787ReactomeR-CEL-687711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68771.11rpt-6PSMC5Q9XTT9Reactome DB_ID: 10570802UniProt:Q9XTT9rpt-6UniProtQ9XTT92EQUAL406EQUALReactome Database ID Release 7510570802Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570802ReactomeR-CEL-687801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68780.11rpn-9PSMD13Q22253Reactome DB_ID: 10570829UniProt:Q22253rpn-9UniProtQ222531EQUAL376EQUALReactome Database ID Release 7510570829Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570829ReactomeR-CEL-687941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68794.11PSME1Q95PZ7Reactome DB_ID: 105708741EQUAL249EQUALReactome Database ID Release 7510570874Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570874ReactomeR-CEL-688121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68812.11rpn-2PSMD1Q18115Reactome DB_ID: 10570812UniProt:Q18115rpn-2UniProtQ181151EQUAL953EQUALReactome Database ID Release 7510570812Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570812ReactomeR-CEL-687861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68786.11rpt-2PSMC1O16368Reactome DB_ID: 10570782UniProt:O16368rpt-2UniProtO163682EQUAL440EQUALReactome Database ID Release 7510570782Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570782ReactomeR-CEL-687681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68768.11PSMD5Q20058Reactome DB_ID: 10570849UniProt:Q20058UniProtQ200582EQUAL504EQUALReactome Database ID Release 7510570849Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570849ReactomeR-CEL-688021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68802.11pbs-2PSMB10O62102Reactome DB_ID: 1057074640EQUAL273EQUALReactome Database ID Release 7510570746Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570746ReactomeR-CEL-687411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68741.11pbs-3PSMB3Q23237Reactome DB_ID: 10570756UniProt:Q23237pbs-3UniProtQ232372EQUAL205EQUALReactome Database ID Release 7510570756Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570756ReactomeR-CEL-687471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68747.11pas-4PSMA8Q95005Reactome DB_ID: 10570887UniProt:Q95005pas-4UniProtQ950051EQUAL256EQUALReactome Database ID Release 7510570887Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570887ReactomeR-CEL-9476101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-947610.11pas-4PSMA7Q95005Reactome DB_ID: 105707361EQUAL248EQUALReactome Database ID Release 7510570736Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570736ReactomeR-CEL-687361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68736.11PSME2Q95PZ7Reactome DB_ID: 105708762EQUAL239EQUALReactome Database ID Release 7510570876Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570876ReactomeR-CEL-688141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68814.11pbs-4PSMB2P91477Reactome DB_ID: 10570751UniProt:P91477pbs-4UniProtP914771EQUAL201EQUALReactome Database ID Release 7510570751Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570751ReactomeR-CEL-687441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68744.11rpt-5PSMC3O76371Reactome DB_ID: 10570792UniProt:O76371rpt-5UniProtO763711EQUAL439EQUALReactome Database ID Release 7510570792Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570792ReactomeR-CEL-687741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68774.11rpn-1PSMD2Q9GZH5Reactome DB_ID: 10570834UniProt:Q9GZH5rpn-1UniProtQ9GZH51EQUAL908EQUALReactome Database ID Release 7510570834Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570834ReactomeR-CEL-687961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68796.11pas-1PSMA6O17586Reactome DB_ID: 10570731UniProt:O17586pas-1UniProtO175861EQUAL246EQUALReactome Database ID Release 7510570731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570731ReactomeR-CEL-687341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68734.11Reactome Database ID Release 7510570893Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570893ReactomeR-CEL-688191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68819.1ADRM1:26S proteasomeReactome DB_ID: 1062151111Reactome Database ID Release 7510621511Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621511ReactomeR-CEL-56658581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665858.1Reactome Database ID Release 7510621538Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621538ReactomeR-CEL-56658711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665871.1ADRM1 (also called Rpn13) interacts with the 26S proteasome base unit PRDM1 (Rpn2) via its amino-terminus and is found in the majority of 26S proteasomes. It is a receptor for Ubiquitin (Ub) that can bind K48-linked di-Ub (Schreiner et al. 2008, Husnjak et al. 2008) and de-ubiquitinating enzymes (DUBs) such as PSMD14 (Rpn11, POH1), USP14, and UCHL5 (UCH37) (Reyes-Turcu et al., 2009). Together, these DUBs disassemble poly-Ub chains and recycle ubiquitin during proteasomal degradation.18497817Pubmed2008Proteasome subunit Rpn13 is a novel ubiquitin receptorHusnjak, KoraljkaElsasser, SuzanneZhang, NaixiaChen, XiangRandles, LeahShi, YuanHofmann, KayWalters, Kylie JFinley, DanielDikic, IvanNature 453:481-818497827Pubmed2008Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionSchreiner, PatrickChen, XiangHusnjak, KoraljkaRandles, LeahZhang, NaixiaElsasser, SuzanneFinley, DanielDikic, IvanWalters, Kylie JGroll, MichaelNature 453:548-5219489724Pubmed2009Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymesReyes-Turcu, Francisca EVentii, Karen HWilkinson, Keith DAnnu. Rev. Biochem. 78:363-97inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTADRM1:26S proteaseome binds UCHL5This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ubh-4UCHL5Q09444Reactome DB_ID: 10621504UniProt:Q09444ubh-4UniProtQ094441EQUAL329EQUALReactome Database ID Release 7510621504Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621504ReactomeR-CEL-16297781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1629778.1ADRM1:26S proteasome:UCHL5Reactome DB_ID: 1062151311Reactome Database ID Release 7510621513Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621513ReactomeR-CEL-56658451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665845.1Reactome Database ID Release 7510621515Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621515ReactomeR-CEL-56658541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665854.1The C-terminal extension of UCHL5 (UCH37) binds to ADRM1, part of the proteasomal 19S regulatory subunit which is itself a subunit of the 26S proteasome. Binding of UCHL5 enhances its DUB activity (Qiu et al. 2006). UCHL5 forms oligomers in solution that have very low DUB activity. Binding with ADRM1 is 1:1, preventing oligomerization of UCHL5 while making the active site of UCHL5 accessible to Ubiquitin (Jiao et al. 2014). When associated with the proteasome, UCHL5 disassembles poly-Ub chains by hydrolyzing the distal ubiquitin from a chain. This dissassembly of the degradation signal from only the distal end of polyubiquitin chains may selectively rescue poorly ubiquitinated or slowly degraded Ub-protein conjugates from proteolysis (Lam et al. 1997). 16990800Pubmed2006A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomesHamazaki, JunIemura, SNatsume, TYashiroda, HidekiTanaka, KeijiMurata, ShigeoEMBO J. 25:4524-3617139257Pubmed2006hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37Qiu, XBOuyang, Song-YingLi, Chao-JunMiao, ShiyingWang, LinfangGoldberg, Alfred LEMBO J. 25:5742-539034192Pubmed1997Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeLam, Y AXu, WDeMartino, G NCohen, R ENature 385:737-4024752541Pubmed2014Mechanism of the Rpn13-induced activation of Uch37Jiao, LianyingOuyang, SongyingShaw, NeilSong, GaojieFeng, YingangNiu, FengfengQiu, WeichengZhu, HongtaoHung, Li-WeiZuo, XiaobingEleonora Shtykova, VZhu, PingDong, Yu-HuiXu, RuxiangLiu, Zhi-JieProtein Cell 5:616-30LEFT-TO-RIGHTUCHL1, UCHL3 cleave ubiquitin adductsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 29356water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001additional informationMIMI:0361UCHL1,UCHL3:Ub-LysReactome DB_ID: 10623937Converted from EntitySet in ReactomeUCHL1,UCHL3Reactome DB_ID: 10623908Converted from EntitySet in ReactomeHomologues of UCHL1Reactome DB_ID: 10623904ubh-2UCHL1Q8MNY0Reactome DB_ID: 10623892UniProt:Q8MNY0ubh-2UniProtQ8MNY01EQUAL220EQUALReactome Database ID Release 7510623892Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623892ReactomeR-CEL-56606791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5660679.1ubh-3UCHL1Q965V9Reactome DB_ID: 10623897UniProt:Q965V9ubh-3UniProtQ965V91EQUAL220EQUALReactome Database ID Release 7510623897Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623897ReactomeR-CEL-5660679-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5660679-2.1ubh-1UCHL1Q9UAV3Reactome DB_ID: 10623902UniProt:Q9UAV3ubh-1UniProtQ9UAV31EQUAL220EQUALReactome Database ID Release 7510623902Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623902ReactomeR-CEL-5660679-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5660679-3.1Reactome Database ID Release 7510623904Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623904ReactomeR-CEL-5660679-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5660679-4.1ubh-1UCHL3Q9UAV3Reactome DB_ID: 106239061EQUAL230EQUALReactome Database ID Release 7510623906Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623906ReactomeR-CEL-56907731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690773.1Reactome Database ID Release 7510623908Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623908ReactomeR-CEL-56907681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690768.11ubq-1N6-glycyl-L-lysine-UBC(1-76)P0CG71Reactome DB_ID: 10623911UniProt:P0CG71ubq-1UniProtP0CG7176EQUALN6-glycyl-L-lysineMODMOD:001341EQUAL76EQUALReactome Database ID Release 7510623911Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623911ReactomeR-CEL-88690301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8869030.11Reactome Database ID Release 7510623937Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623937ReactomeR-CEL-67826331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782633.1UCHL1,UCHL3:UbReactome DB_ID: 106239391ubq-1UBC(1-76)P0CG71Reactome DB_ID: 105706801EQUAL76EQUALReactome Database ID Release 7510570680Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570680ReactomeR-CEL-9391881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-939188.11Reactome Database ID Release 7510623939Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623939ReactomeR-CEL-67825921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782592.1L-lysinephys-ent-participant14764L-lysinium(1+)phys-ent-participant79754phys-ent-participant96221phys-ent-participant79814phys-ent-participant14570Reactome DB_ID: 1131871cytoplasmGENE ONTOLOGYGO:0005737L-lysinium(1+) [ChEBI:32551]L-lysinium(1+)147.19558InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1L-lysine monocationL-lysineC6H15N2O2L-lysinium[NH3+]CCCC[C@H]([NH3+])C([O-])=O(2S)-2,6-diammoniohexanoateKDXKERNSBIXSRK-YFKPBYRVSA-OChEBICHEBI:32551Reactome Database ID Release 751131871Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1131871ReactomeR-ALL-11318715Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1131871.5ACTIVATIONactiveUnit: #PhysicalEntity4GENE ONTOLOGYGO:0004843gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510623940Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623940Reactome Database ID Release 7510623942Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623942ReactomeR-CEL-56903191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690319.1UCHL1 and UCHL3 can hydrolyze several short C-terminal ubiquitin adducts to generate ubiquitin monomers (Wilkinson et al. 1989, Wada et al. 1998, Larsen et al. 1998). This liberates small molecule nucleophiles that may have inadvertently reacted with Ub C-terminal thiolesters. Because these enzymes can cleave small peptides from the C-terminus of Ub, they could also function in recycling Ub from incomplete proteasomal or lysosomal protein degradation. UCHL3, but not UCHL1, is able to cleave the C-terminus of Neural precursor cell expressed developmentally downregulated protein 8 (NEDD8), a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases (Wada et al. 1998, Enchev et al. 2015). UCHL1 and 3 are specifically expressed in neurons, cells of the diffuse neuroendocrine system and their tumors. A polymorphism (S18Y) in UCHL1 is associated with a reduced risk for Parkinson's disease (Wang et al. 2002) and its overexpression is protective in models of Alzheimer's disease (Gong et al. 2006). UCHL1 has been shown to interact with alpha-synuclein, but as a ubiquitin ligase rather than as a ubiquitin hydrolase (Liu et al. 2002). It is K63-polyubiquitinated by Parkin in cooperation with the Ubc13/Uev1a E2 ubiquitin-conjugating enzyme complex, promoting UCH-L1 degradation by the autophagy-lysosome pathway (McKeon et al. 2015).25403879Pubmed2015Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome systemMcKeon, Jeanne ESha, DiLi, LianChin, Lih-ShenCell. Mol. Life Sci. 72:1811-2416923396Pubmed2006Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memoryGong, BingCao, ZixuanZheng, PingVitolo, Ottavio VLiu, ShuminStaniszewski, AgnieszkaMoolman, DonnaZhang, HongShelanski, MichaelArancio, OttavioCell 126:775-8825531226Pubmed2015Protein neddylation: beyond cullin-RING ligasesEnchev, Radoslav ISchulman, Brenda APeter, MatthiasNat. Rev. Mol. Cell Biol. 16:30-442530630Pubmed1989The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolaseWilkinson, K DLee, K MDeshpande, SDuerksen-Hughes, PBoss, J MPohl, JScience 246:670-39790970Pubmed1998Cleavage of the C-terminus of NEDD8 by UCH-L3Wada, HKito, KCaskey, L SYeh, E TKamitani, TBiochem. Biophys. Res. Commun. 251:688-9212210873Pubmed2002ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onsetWang, JianZhao, Chun-YingSi, Yan-MeiLiu, Zhuo-LinChen, BiaoYu, LongMov. Disord. 17:767-719521656Pubmed1998Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolasesLarsen, C NKrantz, B AWilkinson, K DBiochemistry 37:3358-6812408865Pubmed2002The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibilityLiu, YichinFallon, LaraLashuel, Hilal ALiu, ZhihuaLansbury, Peter TCell 111:209-18LEFT-TO-RIGHTUCHL3, SENP8 cleave NEDD8This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>UCHL3,SENP8:NEDD8(1-88)Reactome DB_ID: 10623986Converted from EntitySet in ReactomeUCHL3,SENP8Reactome DB_ID: 10623979ulp-3SENP8Q86FN3Reactome DB_ID: 10623977UniProt:Q86FN3ulp-3UniProtQ86FN31EQUAL212EQUALReactome Database ID Release 7510623977Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623977ReactomeR-CEL-56907511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690751.1Reactome Database ID Release 7510623979Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623979ReactomeR-CEL-56907831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690783.11ned-8NEDD8(1-88)Q93725Reactome DB_ID: 10623984UniProt:Q93725ned-8UniProtQ937251EQUAL88EQUALReactome Database ID Release 7510623984Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623984ReactomeR-CEL-56907941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690794.11Reactome Database ID Release 7510623986Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623986ReactomeR-CEL-67826351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782635.1UCHL3,SENP8:NEDD8Reactome DB_ID: 106239901ned-8NEDD8Q93725Reactome DB_ID: 106239881EQUAL76EQUALReactome Database ID Release 7510623988Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623988ReactomeR-CEL-4169691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-416969.11Reactome Database ID Release 7510623990Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623990ReactomeR-CEL-67826431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782643.1ned-8NEDD8(77-88)Q93725Reactome DB_ID: 1062399277EQUAL88EQUALReactome Database ID Release 7510623992Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623992ReactomeR-CEL-67826541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782654.1ACTIVATIONactiveUnit: #Protein52GENE ONTOLOGYGO:0019784Reactome Database ID Release 7510623993Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623993Reactome Database ID Release 7510623995Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623995ReactomeR-CEL-56908081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690808.1UCHL3 and SENP8 (DEN1) remove the C-terminal extension of NEDD8 propeptides, exposing a C-terminal Gly residue. UCHL3 can also process ubiquitin (Wada et al. 1998). UCHL3 and SENP8 are probably functionally redundant in NEDD8 processing as deletion of either enzyme does not lead to neddylation defects (Chan et al. 2008, Kurihara et al. 2000).18782863Pubmed2008DEN1 deneddylates non-cullin proteins in vivoChan, YaruYoon, JeongsookWu, June-TaiKim, Hyung-JunPan, Kuan-TingYim, JeongbinChien, Cheng-TingJ. Cell. Sci. 121:3218-2310713173Pubmed2000Expression and functional analysis of Uch-L3 during mouse developmentKurihara, L JSemenova, ELevorse, J MTilghman, S MMol. Cell. Biol. 20:2498-504Reactome Database ID Release 7510643468Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10643468ReactomeR-CEL-56896031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5689603.1DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).19188440Pubmed2009Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1Misaghi, ShahramOttosen, SørenIzrael-Tomasevic, AnitaArnott, DavidLamkanfi, MohamedLee, JamesLiu, JinfengO'Rourke, KarenDixit, Vishva MWilson, Angus CMol. Cell. Biol. 29:2181-9219243136Pubmed2009Polyubiquitin binding and disassembly by deubiquitinating enzymesReyes-Turcu, Francisca EWilkinson, Keith DChem. Rev. 109:1495-50816325574Pubmed2005A genomic and functional inventory of deubiquitinating enzymesNijman, Sebastian M BLuna-Vargas, Mark P AVelds, ArnoBrummelkamp, Thijn RDirac, Annette M GSixma, Titia KBernards, RCell 123:773-86