BioPAX pathway converted from "PTPN3 dephosphorylates EPS15" in the Reactome database.LEFT-TO-RIGHT3.1.3.48PTPN3 dephosphorylates EPS15This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>H2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7029356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293564Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.4Reactomehttp://www.reactome.orgEGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAMReactome DB_ID: 10647270plasma membraneGENE ONTOLOGYGO:0005886p-Eps15:HGS:STAMReactome DB_ID: 10647171Q9BIF4phospho-p-Y850 EPS15Reactome DB_ID: 10647169UniProt:Q9BIF4Caenorhabditis elegansNCBI Taxonomy6239UniProtQ9BIF4850EQUALO4'-phospho-L-tyrosineMODMOD:000481EQUAL896EQUALReactome Database ID Release 7010647169Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10647169ReactomeR-CEL-88670281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867028.11HGSQ17796Reactome DB_ID: 10590502UniProt:Q17796UniProtQ177961EQUAL777EQUALReactome Database ID Release 7010590502Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590502ReactomeR-CEL-1829541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182954.11Converted from EntitySet in ReactomeSTAMReactome DB_ID: 10590511STAMO01498Reactome DB_ID: 10590507UniProt:O01498UniProtO014982EQUAL540EQUALReactome Database ID Release 7010590507Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590507ReactomeR-CEL-1829251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182925.1STAM2O01498Reactome DB_ID: 105905091EQUAL525EQUALReactome Database ID Release 7010590509Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590509ReactomeR-CEL-1829651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182965.1Reactome Database ID Release 7010590511Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590511ReactomeR-CEL-1829291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182929.11Reactome Database ID Release 7010647171Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10647171ReactomeR-CEL-88670321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867032.11EPN1Q9BI71Reactome DB_ID: 10590492UniProt:Q9BI71UniProtQ9BI711EQUAL576EQUALReactome Database ID Release 7010590492Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590492ReactomeR-CEL-1829521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182952.11EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:EndophilinReactome DB_ID: 10590563Q19019phospho-p-Y371-CBLReactome DB_ID: 10590542UniProt:Q19019UniProtQ19019371EQUAL1EQUAL906EQUALReactome Database ID Release 7010590542Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590542ReactomeR-CEL-1829231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182923.12CIN85:endophilinReactome DB_ID: 10590538Converted from EntitySet in ReactomeSH3GLsendophilinsReactome DB_ID: 10590536SH3GL2 dimerReactome DB_ID: 10590526SH3GL2B1V8A0Reactome DB_ID: 10590524UniProt:B1V8A0UniProtB1V8A01EQUAL352EQUALReactome Database ID Release 7010590524Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590524ReactomeR-CEL-1829581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182958.12Reactome Database ID Release 7010590526Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590526ReactomeR-CEL-88677411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867741.1SH3GL1 dimerReactome DB_ID: 10590530SH3GL1B1V8A0Reactome DB_ID: 105905281EQUAL368EQUALReactome Database ID Release 7010590528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590528ReactomeR-CEL-88677321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867732.12Reactome Database ID Release 7010590530Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590530ReactomeR-CEL-88677431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867743.1SH3GL3 dimerReactome DB_ID: 10590534SH3GL3B1V8A0Reactome DB_ID: 105905321EQUAL347EQUALReactome Database ID Release 7010590532Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590532ReactomeR-CEL-88677341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867734.12Reactome Database ID Release 7010590534Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590534ReactomeR-CEL-88677391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867739.1Reactome Database ID Release 7010590536Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590536ReactomeR-CEL-88677461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867746.11SH3KBP1 tetramerReactome DB_ID: 10590522Q6A573SH3KBP1Reactome DB_ID: 10590520UniProt:Q6A573UniProtQ6A5731EQUAL665EQUALReactome Database ID Release 7010590520Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590520ReactomeR-CEL-1829571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182957.14Reactome Database ID Release 7010590522Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590522ReactomeR-CEL-88754751Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8875475.11Reactome Database ID Release 7010590538Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590538ReactomeR-CEL-88754801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8875480.11P24348phospho-p-6Y-EGFRReactome DB_ID: 10590360UniProt:P24348UniProtP24348992EQUAL1045EQUAL1068EQUAL1086EQUAL1148EQUAL1173EQUAL25EQUAL1210EQUALReactome Database ID Release 7010590360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590360ReactomeR-CEL-1798031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-179803.12EGFG5EFK8Reactome DB_ID: 10590258extracellular regionGENE ONTOLOGYGO:0005576UniProt:G5EFK8UniProtG5EFK8971EQUAL1023EQUALReactome Database ID Release 7010590258Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590258ReactomeR-CEL-1798631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-179863.12GRB2-1P29355Reactome DB_ID: 10584586UniProt:P29355UniProtP293551EQUAL217EQUALReactome Database ID Release 7010584586Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584586ReactomeR-CEL-746861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74686.12Reactome Database ID Release 7010590563Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590563ReactomeR-CEL-1829461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182946.11PIP2PI(4,5)P21-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePhosphatidylinositol-4,5-bisphosphate1-phosphatidyl-1D-myo-inositol 4,5- bisphosphateReactome DB_ID: 1798561-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePIP2ChEBICHEBI:18348Reactome Database ID Release 70179856Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179856ReactomeR-ALL-1798563Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179856.31Q9BIF4EPS15L1Reactome DB_ID: 105905152EQUAL864EQUALReactome Database ID Release 7010590515Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590515ReactomeR-CEL-1829371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182937.11Reactome Database ID Release 7010647270Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10647270ReactomeR-CEL-88670351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867035.1PiOrthophosphatephosphate(3-)PhosphateInorganic PhosphateReactome DB_ID: 29372phosphate(3-) [ChEBI:18367]phosphate(3-)ChEBICHEBI:18367Reactome Database ID Release 7029372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372ReactomeR-ALL-293723Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.3EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAMReactome DB_ID: 106472681EPS15:HGS:STAMReactome DB_ID: 105905131EPS15Q9BIF4Reactome DB_ID: 105904971EQUAL896EQUALReactome Database ID Release 7010590497Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590497ReactomeR-CEL-1829201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182920.111Reactome Database ID Release 7010590513Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590513ReactomeR-CEL-1829471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-182947.11111Reactome Database ID Release 7010647268Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10647268ReactomeR-CEL-88670341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867034.1ACTIVATIONPTPN3P28191Reactome DB_ID: 10647277UniProt:P28191UniProtP281911EQUAL913EQUALReactome Database ID Release 7010647277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10647277ReactomeR-CEL-54903171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5490317.1GENE ONTOLOGYGO:0004725gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7010647278Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10647278Reactome Database ID Release 7010647280Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10647280ReactomeR-CEL-88670471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8867047.1While the roles of EGFR and EPS15 phosphorylation and ubiquitination are not completely clear, recent evidence supports the idea that EGFR-mediated phosphorylation of EPS15 promotes the clustering of the activated receptor into clathrin-coated pits, while the dephosphorylated EPS15 targets EGFR for endocytosis through a caveolin-and lipid raft-dependent route (reviewed in van Bergen en Henegouwen, 2009). Consistent with this, overexpression of the phosphatase PTPN3, which dephosphorylates EPS15 in vitro and in vivo, promotes the internalization of EGFR into caveolin-enriched structures and targets it for lysosomal degradation (Li et al, 2015).25263444Pubmed2015Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradationLi, M-YLai, P-LChou, Y-TChi, A-PMi, Y-ZKhoo, K-HChang, G-DWu, C-WMeng, T-CChen, Guang-ChaoOncogene 34:3791-80319814798Pubmed2009Eps15: a multifunctional adaptor protein regulating intracellular traffickingvan Bergen En Henegouwen, Paul MpCell Commun. Signal 7:24inferred from electronic annotationEVIDENCE CODEECO:0000203