BioPAX pathway converted from "Sema3A PAK dependent Axon repulsion" in the Reactome database. Sema3A PAK dependent Axon repulsion This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT Activation of PAK by Rac1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome PAK1,2,3 dimer Reactome DB_ID: 10594171 PAK1 dimer Reactome DB_ID: 10594157 cytosol GENE ONTOLOGY GO:0005829 PAK1 E1C3P6 Reactome DB_ID: 10594155 UniProt:E1C3P6 Gallus gallus NCBI Taxonomy 9031 UniProt E1C3P6 1 EQUAL 545 EQUAL Reactome Database ID Release 82 10594155 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594155 Reactome R-GGA-162629 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-162629.1 Reactome http://www.reactome.org 2 Reactome Database ID Release 82 10594157 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594157 Reactome R-GGA-445002 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-445002.1 PAK2 dimer Reactome DB_ID: 10594163 PAK2 E1BS97 Reactome DB_ID: 10594161 UniProt:E1BS97 UniProt E1BS97 2 EQUAL 524 EQUAL Reactome Database ID Release 82 10594161 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594161 Reactome R-GGA-211604 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-211604.1 2 Reactome Database ID Release 82 10594163 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594163 Reactome R-GGA-2685645 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2685645.1 PAK3 dimer Reactome DB_ID: 10594169 PAK3 F1N8W8 Reactome DB_ID: 10594167 UniProt:F1N8W8 UniProt F1N8W8 1 EQUAL 559 EQUAL Reactome Database ID Release 82 10594167 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594167 Reactome R-GGA-428457 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-428457.1 2 Reactome Database ID Release 82 10594169 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594169 Reactome R-GGA-5669154 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5669154.1 Reactome Database ID Release 82 10594171 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594171 Reactome R-GGA-399856 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399856.1 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP Reactome DB_ID: 10594899 plasma membrane GENE ONTOLOGY GO:0005886 RAC1:GTP Reactome DB_ID: 10577354 GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 82 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 COMPOUND C00044 additional information MI MI:0361 1 RAC1 cRac1A Q6LC82 Reactome DB_ID: 10577352 UniProt:Q6LC82 cRac1A UniProt Q6LC82 1 EQUAL 189 EQUAL Reactome Database ID Release 82 10577352 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10577352 Reactome R-GGA-351141 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-351141.1 1 Reactome Database ID Release 82 10577354 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10577354 Reactome R-GGA-442641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442641.1 1 Sema3A:NRP-1:pPlexin-A:Fyn:Fes Reactome DB_ID: 10594897 FES A0A1D5PZX7 Reactome DB_ID: 10588531 UniProt:A0A1D5PZX7 UniProt A0A1D5PZX7 1 EQUAL 822 EQUAL Reactome Database ID Release 82 10588531 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10588531 Reactome R-GGA-396937 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-396937.1 1 Sema3A:NRP-1:pPlexin-A:fyn Reactome DB_ID: 10594895 Sema3A dimer Reactome DB_ID: 10594874 extracellular region GENE ONTOLOGY GO:0005576 SEMA3A SEMA3A R4GJE6 Reactome DB_ID: 10594872 UniProt:R4GJE6 SEMA3A UniProt R4GJE6 21 EQUAL 771 EQUAL Reactome Database ID Release 82 10594872 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594872 Reactome R-GGA-198235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-198235.1 2 Reactome Database ID Release 82 10594874 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594874 Reactome R-GGA-399861 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399861.1 1 NRP1:p-Plexin-A1-4:FYN Reactome DB_ID: 10594893 FYN A0A3Q2U639 Reactome DB_ID: 10588434 UniProt:A0A3Q2U639 UniProt A0A3Q2U639 2 EQUAL 537 EQUAL Reactome Database ID Release 82 10588434 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10588434 Reactome R-GGA-200917 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-200917.1 1 NRP1 A0A1L1RW02 Reactome DB_ID: 10585055 UniProt:A0A1L1RW02 UniProt A0A1L1RW02 22 EQUAL 923 EQUAL Reactome Database ID Release 82 10585055 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585055 Reactome R-GGA-3008773 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3008773.1 1 Converted from EntitySet in Reactome p-Plexin-A1-4 Reactome DB_ID: 10594891 p-Y-PLXNA1 phospho-PLXNA1 A0A3Q2U4H8 Reactome DB_ID: 10594879 UniProt:A0A3Q2U4H8 PLXNA1 UniProt A0A3Q2U4H8 O4'-phospho-L-tyrosine MOD MOD:00048 27 EQUAL 1896 EQUAL Reactome Database ID Release 82 10594879 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594879 Reactome R-GGA-419614 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419614.1 F1NYZ6 phospho-PLXNA2 p-Y-PLXNA2 Reactome DB_ID: 10594884 UniProt:F1NYZ6 PLXNA2 UniProt F1NYZ6 35 EQUAL 1894 EQUAL Reactome Database ID Release 82 10594884 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594884 Reactome R-GGA-419607 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419607.1 F1NZB0 phospho-p-Y-PLXNA4 Reactome DB_ID: 10594889 UniProt:F1NZB0 UniProt F1NZB0 24 EQUAL 1894 EQUAL Reactome Database ID Release 82 10594889 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594889 Reactome R-GGA-419608 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419608.1 Reactome Database ID Release 82 10594891 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594891 Reactome R-GGA-419620 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419620.1 1 Reactome Database ID Release 82 10594893 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594893 Reactome R-GGA-419625 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419625.1 1 Reactome Database ID Release 82 10594895 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594895 Reactome R-GGA-419622 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419622.1 1 Reactome Database ID Release 82 10594897 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594897 Reactome R-GGA-399859 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399859.1 1 Reactome Database ID Release 82 10594899 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594899 Reactome R-GGA-399872 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399872.1 Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK Reactome DB_ID: 10594901 Converted from EntitySet in Reactome PAK1,2,3 Reactome DB_ID: 10594173 Reactome Database ID Release 82 10594173 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594173 Reactome R-GGA-390765 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-390765.1 1 1 Reactome Database ID Release 82 10594901 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594901 Reactome R-GGA-399876 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399876.1 Reactome Database ID Release 82 10594903 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594903 Reactome R-GGA-399930 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399930.1 Plexin-bound Rac1 binds to and stimulates the kinase activity of PAK. PAK dimers are arranged in head-to-tail fashion, in which the catalytic domain binds the kinase inhibitory (KI) domain and is supported by associated PAK-interacting exchange factor (PIX) dimers. Upon Rac1 binding the kinase undergoes conformational change that allows autophosphorylation. Phosphorylation of serine residues disables the KI-domain-kinase interaction and thereby reduces the affinity of PIX. 15548136 Pubmed 2005 PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Zhao, ZS Manser, E Biochem J 386:201-14 11604131 Pubmed 2001 Plexin signaling via off-track and rho family GTPases Whitford, KL Ghosh, A Neuron 32:1-3 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT 2.7.11.1 Autophosphorylation of PAK This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 2 Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK Reactome DB_ID: 10594953 Converted from EntitySet in Reactome p-S,T-PAK1,2,3 Reactome DB_ID: 10594951 E1C3P6 phospho-p-S144,T423-PAK1 Reactome DB_ID: 10594941 144 EQUAL O-phospho-L-serine MOD MOD:00046 423 EQUAL O-phospho-L-threonine MOD MOD:00047 1 EQUAL 545 EQUAL Reactome Database ID Release 82 10594941 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594941 Reactome R-GGA-399819 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399819.1 E1BS97 phospho-p-S141,T402-PAK2 Reactome DB_ID: 10594945 141 EQUAL 402 EQUAL 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10594945 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594945 Reactome R-GGA-399824 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399824.1 F1N8W8 phospho-p-S154,T436-PAK3 Reactome DB_ID: 10594949 154 EQUAL 436 EQUAL 1 EQUAL 559 EQUAL Reactome Database ID Release 82 10594949 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594949 Reactome R-GGA-5357471 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-5357471.1 Reactome Database ID Release 82 10594951 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594951 Reactome R-GGA-399836 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399836.1 1 1 Reactome Database ID Release 82 10594953 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594953 Reactome R-GGA-399874 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399874.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 2 ACTIVATION activeUnit: #Protein13 GENE ONTOLOGY GO:0004674 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10594954 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594954 Reactome Database ID Release 82 10594956 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594956 Reactome R-GGA-399939 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399939.1 PAK is autophosphorylated at several sites but S-144 flanking the kinase inhibitor region and T-423 (S-141/T-402 in PAK-gamma) within the catalytic domain are the two conserved sites that regulate the catalytic activity. 11278486 Pubmed 2001 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity Chong, C Tan, L Lim, L Manser, E J Biol Chem 276:17347-53 10075701 Pubmed 1999 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation Gatti, A Huang, Z Tuazon, PT Traugh, JA J Biol Chem 274:8022-8 LEFT-TO-RIGHT 2.7.11.1 Phosphorylation of LIMK-1 by PAK This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LIMK1 Q8QFP8 Reactome DB_ID: 10595082 UniProt:Q8QFP8 UniProt Q8QFP8 1 EQUAL 647 EQUAL Reactome Database ID Release 82 10595082 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595082 Reactome R-GGA-397785 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-397785.1 Q8QFP8 phospho-p-T508-LIMK1 Reactome DB_ID: 10595085 508 EQUAL 1 EQUAL 647 EQUAL Reactome Database ID Release 82 10595085 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595085 Reactome R-GGA-399816 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399816.1 ACTIVATION activeUnit: #Protein14 Reactome Database ID Release 82 10595086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595086 Reactome Database ID Release 82 10595088 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595088 Reactome R-GGA-399952 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399952.1 LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton. 11276226 Pubmed 2001 Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse Aizawa, H Wakatsuki, S Ishii, A Moriyama, K Sasaki, Y Ohashi, Ken Sekine-Aizawa, Y Sehara-Fujisawa, A Mizuno, K Goshima, Y Yahara, I Nat Neurosci 4:367-73 10559936 Pubmed 1999 Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics Edwards, DC Sanders, LC Bokoch, GM Gill, GN Nat Cell Biol 1:253-9 LEFT-TO-RIGHT Dimerization of LIMK1 by Hsp90 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 Converted from EntitySet in Reactome HSP90AA1,HSP90AB1 Reactome DB_ID: 10595699 HSP90AA1 HSP90AA1 A0A1L1RND0 Reactome DB_ID: 10587061 UniProt:A0A1L1RND0 HSP90AA1 UniProt A0A1L1RND0 2 EQUAL 732 EQUAL Reactome Database ID Release 82 10587061 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10587061 Reactome R-GGA-192864 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-192864.1 F1NC33 HSP90AB1 HSP90AB1 Reactome DB_ID: 10595697 UniProt:F1NC33 HSP90AB1 UniProt F1NC33 2 EQUAL 724 EQUAL Reactome Database ID Release 82 10595697 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595697 Reactome R-GGA-419617 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419617.1 Reactome Database ID Release 82 10595699 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595699 Reactome R-GGA-419619 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419619.1 pLIMK dimer:HSP-90 Reactome DB_ID: 10595701 2 1 Reactome Database ID Release 82 10595701 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595701 Reactome R-GGA-419632 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419632.1 Reactome Database ID Release 82 10595711 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595711 Reactome R-GGA-419645 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419645.1 After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain. 16641196 Pubmed 2006 Hsp90 increases LIM kinase activity by promoting its homo-dimerization Li, R Soosairajah, J Harari, D Citri, A Price, J Ng, HL Morton, CJ Parker, MW Yarden, Y Bernard, O FASEB J 20:1218-20 17188549 Pubmed 2007 Lim kinases, regulators of actin dynamics Bernard, O Int J Biochem Cell Biol 39:1071-6 LEFT-TO-RIGHT 2.7.11.1 Transphosphorylation of pLIMK1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Active LIMK1 Reactome DB_ID: 10595706 Q8QFP8 phospho-p-S,T508-LIMK1 Reactome DB_ID: 10595704 1 EQUAL 647 EQUAL Reactome Database ID Release 82 10595704 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595704 Reactome R-GGA-419610 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419610.1 2 Reactome Database ID Release 82 10595706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595706 Reactome R-GGA-419630 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419630.1 ACTIVATION activeUnit: #Protein19 Reactome Database ID Release 82 10595707 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595707 Reactome Database ID Release 82 10595709 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595709 Reactome R-GGA-419644 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419644.1 Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability. 7848918 Pubmed 1994 Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons Bernard, O Ganiatsas, S Kannourakis, G Dringen, R Cell Growth Differ 5:1159-71 Reactome Database ID Release 82 10660706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10660706 Reactome R-GGA-399954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399954.1 Activated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin. 18374575 Pubmed 2008 Semaphorin signaling: progress made and promises ahead Zhou, Y Gunput, RA Pasterkamp, RJ Trends Biochem Sci 33:161-70 12593985 Pubmed 2003 Semaphorin junction: making tracks toward neural connectivity Pasterkamp, RJ Kolodkin, AL Curr Opin Neurobiol 13:79-89