BioPAX pathway converted from "Activation of Rap1 by membrane-associated GEFs" in the Reactome database.LEFT-TO-RIGHTActivation of Rap1 by membrane-associated GEFsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>GTPGuanosine 5'-triphosphateReactome DB_ID: 29438cytosolGENE ONTOLOGYGO:0005829GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBICHEBI:15996Reactome Database ID Release 7529438Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438ReactomeR-ALL-294383Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.3Reactomehttp://www.reactome.orgCOMPOUNDC00044additional informationMIMI:0361RAP1:GDPReactome DB_ID: 10657179plasma membraneGENE ONTOLOGYGO:0005886Converted from EntitySet in ReactomeRAP1Reactome DB_ID: 10657175Converted from EntitySet in ReactomeHomologues of RAP1AReactome DB_ID: 10657173rapARAP1AP18613Reactome DB_ID: 10657165UniProt:P18613rapADictyostelium discoideumNCBI Taxonomy44689UniProtP186131EQUAL181EQUALReactome Database ID Release 7510657165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657165ReactomeR-DDI-3541181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354118.1RAP1AQ54BC3Reactome DB_ID: 10657167UniProt:Q54BC3UniProtQ54BC31EQUAL181EQUALReactome Database ID Release 7510657167Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657167ReactomeR-DDI-354118-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354118-2.1rapCRAP1AQ55BW0Reactome DB_ID: 10657169UniProt:Q55BW0rapCUniProtQ55BW01EQUAL181EQUALReactome Database ID Release 7510657169Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657169ReactomeR-DDI-354118-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354118-3.1rapBRAP1AQ86L51Reactome DB_ID: 10657171UniProt:Q86L51rapBUniProtQ86L511EQUAL181EQUALReactome Database ID Release 7510657171Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657171ReactomeR-DDI-354118-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354118-4.1Reactome Database ID Release 7510657173Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657173ReactomeR-DDI-354118-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354118-5.1Reactome Database ID Release 7510657175Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657175ReactomeR-DDI-3776001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-377600.11GDPGuanosine 5'-diphosphateGuanosine diphosphateReactome DB_ID: 29420GDP [ChEBI:17552]GDPGuanosine 5'-diphosphateGuanosine diphosphateChEBICHEBI:17552Reactome Database ID Release 7529420Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420ReactomeR-ALL-294202Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29420.2COMPOUNDC000351Reactome Database ID Release 7510657179Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657179ReactomeR-DDI-3540741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354074.1RAP1:GTPReactome DB_ID: 1065717711Reactome Database ID Release 7510657177Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657177ReactomeR-DDI-3541261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354126.1ACTIVATIONConverted from EntitySet in ReactomeRap1 cAMP-GEFsReactome DB_ID: 10658403Converted from EntitySet in ReactomeHomologues of RAPGEF3Reactome DB_ID: 10657803gefFRAPGEF3Q54C94Reactome DB_ID: 10657759UniProt:Q54C94gefFUniProtQ54C941EQUAL923EQUALReactome Database ID Release 7510657759Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657759ReactomeR-DDI-30086701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670.1Q54H95RAPGEF3Reactome DB_ID: 10657764UniProt:Q54H95UniProtQ54H951EQUAL923EQUALReactome Database ID Release 7510657764Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657764ReactomeR-DDI-3008670-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-2.1gefARAPGEF3Q54PQ4Reactome DB_ID: 10657769UniProt:Q54PQ4gefAUniProtQ54PQ41EQUAL923EQUALReactome Database ID Release 7510657769Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657769ReactomeR-DDI-3008670-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-3.1gbpDRAPGEF3Q54S40Reactome DB_ID: 10657774UniProt:Q54S40gbpDUniProtQ54S401EQUAL923EQUALReactome Database ID Release 7510657774Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657774ReactomeR-DDI-3008670-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-4.1gefPRAPGEF3Q54TK8Reactome DB_ID: 10657776UniProt:Q54TK8gefPUniProtQ54TK81EQUAL923EQUALReactome Database ID Release 7510657776Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657776ReactomeR-DDI-3008670-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-5.1gefVRAPGEF3Q55FD8Reactome DB_ID: 10657781UniProt:Q55FD8gefVUniProtQ55FD81EQUAL923EQUALReactome Database ID Release 7510657781Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657781ReactomeR-DDI-3008670-61Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-6.1gefJRAPGEF3Q8IS14Reactome DB_ID: 10657786UniProt:Q8IS14gefJUniProtQ8IS141EQUAL923EQUALReactome Database ID Release 7510657786Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657786ReactomeR-DDI-3008670-71Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-7.1gefIRAPGEF3Q8IS15Reactome DB_ID: 10657791UniProt:Q8IS15gefIUniProtQ8IS151EQUAL923EQUALReactome Database ID Release 7510657791Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657791ReactomeR-DDI-3008670-81Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-8.1gefHRAPGEF3Q8IS16Reactome DB_ID: 10657796UniProt:Q8IS16gefHUniProtQ8IS161EQUAL923EQUALReactome Database ID Release 7510657796Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657796ReactomeR-DDI-3008670-91Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-9.1gefRRAPGEF3Q8SSQ0Reactome DB_ID: 10657801UniProt:Q8SSQ0gefRUniProtQ8SSQ01EQUAL923EQUALReactome Database ID Release 7510657801Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657801ReactomeR-DDI-3008670-101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-10.1Reactome Database ID Release 7510657803Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657803ReactomeR-DDI-3008670-111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008670-11.1gefPRAPGEF4Q54TK8Reactome DB_ID: 106577261EQUAL1011EQUALReactome Database ID Release 7510657726Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657726ReactomeR-DDI-30086661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3008666.1Reactome Database ID Release 7510658403Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10658403ReactomeR-DDI-3924851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-392485.1GENE ONTOLOGYGO:0005085gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510662598Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10662598Reactome Database ID Release 7510662600Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10662600ReactomeR-DDI-9392651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-939265.1Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.12585966Pubmed2003Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase CGiuliano, SNesbitt, WSRooney, MJackson, SPBiochem J 372:163-7215469846Pubmed2004RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesionLafuente, EMvan Puijenbroek, AAKrause, MCarman, CVFreeman, GJBerezovskaya, AConstantine, ESpringer, TAGertler, FBBoussiotis, VADev Cell 7:585-9516757337Pubmed2006Rap1 regulation of RIAM and cell adhesionLafuente, EBoussiotis, VAMethods Enzymol 407:345-5815334074Pubmed2004CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationCrittenden, JRBergmeier, WZhang, YPiffath, CLLiang, YWagner, DDHousman, DEGraybiel, AMNat Med 10:982-616076873Pubmed2005Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsStork, PJDillon, TJBlood 106:2952-61inferred from electronic annotationEVIDENCE CODEECO:0000203