BioPAX pathway converted from "G alpha (12/13) signalling events" in the Reactome database. G alpha (12/13) signalling events This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Ligand:GPCR complexes that activate G12/13 Reactome DB_ID: 10608544 TBXA2R:TXA2 Reactome DB_ID: 10599890 plasma membrane GENE ONTOLOGY GO:0005886 TBXA2R TBXA2R A0A1D5P7R6 Reactome DB_ID: 10599888 UniProt:A0A1D5P7R6 TBXA2R Gallus gallus NCBI Taxonomy 9031 UniProt A0A1D5P7R6 1 EQUAL 343 EQUAL Reactome Database ID Release 83 10599888 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10599888 Reactome R-GGA-391837 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-391837.1 Reactome http://www.reactome.org 1 TXA2 (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate thromboxane A2 (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid Reactome DB_ID: 391932 extracellular region GENE ONTOLOGY GO:0005576 thromboxane A2 [ChEBI:15627] thromboxane A2 ChEBI CHEBI:15627 Reactome Database ID Release 83 391932 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=391932 Reactome R-ALL-391932 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-391932.3 COMPOUND C02198 additional information MI MI:0361 1 Reactome Database ID Release 83 10599890 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10599890 Reactome R-GGA-391925 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-391925.1 ADRA1A,B,D:ADR,NAd Reactome DB_ID: 10599794 Converted from EntitySet in Reactome ADRA1A,B,D Alpha-1 adrenoceptor Reactome DB_ID: 10599792 ADRA1A ADRA1A F1NP52 Reactome DB_ID: 10599782 UniProt:F1NP52 ADRA1A UniProt F1NP52 1 EQUAL 466 EQUAL Reactome Database ID Release 83 10599782 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10599782 Reactome R-GGA-390669 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-390669.1 ADRA1B ADRA1B F1NIZ5 Reactome DB_ID: 10599786 UniProt:F1NIZ5 ADRA1B UniProt F1NIZ5 1 EQUAL 520 EQUAL Reactome Database ID Release 83 10599786 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10599786 Reactome R-GGA-390661 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-390661.1 ADRA1D ADRA1D A0A1D5PRZ3 Reactome DB_ID: 10599790 UniProt:A0A1D5PRZ3 ADRA1D UniProt A0A1D5PRZ3 1 EQUAL 572 EQUAL Reactome Database ID Release 83 10599790 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10599790 Reactome R-GGA-390680 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-390680.1 Reactome Database ID Release 83 10599792 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10599792 Reactome R-GGA-390684 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-390684.1 1 Converted from EntitySet in Reactome ADR, NAd Catecholamine adrenaline or noradrenaline Reactome DB_ID: 390627 ADR (R)-adrenaline(1+) Adrenaline (R)-adrenaline Epinephrine Reactome DB_ID: 549254 (R)-adrenaline(1+) [ChEBI:71406] (R)-adrenaline(1+) (R)-adrenaline L-epinephrine(1+) L-epinephrine cation (R)-adrenaline cation (2R)-2-(3,4-dihydroxyphenyl)-2-hydroxy-N-methylethanaminium ChEBI CHEBI:71406 Reactome Database ID Release 83 549254 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=549254 Reactome R-ALL-549254 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-549254.4 COMPOUND C00788 NAd (R)-noradrenaline(1+) Noradrenaline (R)-noradrenaline Norepinephrine Reactome DB_ID: 374935 (R)-noradrenaline(1+) [ChEBI:72587] (R)-noradrenaline(1+) (R)-noradrenalinium cation (R)-noradrenalinium(1+) (R)-noradrenaline cation (R)-noradrenaline (2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium ChEBI CHEBI:72587 Reactome Database ID Release 83 374935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=374935 Reactome R-ALL-374935 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-374935.4 COMPOUND C00547 Reactome Database ID Release 83 390627 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=390627 Reactome R-ALL-390627 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-390627.3 1 Reactome Database ID Release 83 10599794 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10599794 Reactome R-GGA-390633 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-390633.1 Reactome Database ID Release 83 10608544 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608544 Reactome R-GGA-751003 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-751003.1 Converted from EntitySet in Reactome G-protein G12/G13 (inactive) Reactome DB_ID: 10585153 Heterotrimeric G-protein G12 (inactive) Reactome DB_ID: 10585147 G-protein alpha (12):GDP Reactome DB_ID: 10585145 GDP Guanosine 5'-diphosphate Guanosine diphosphate Reactome DB_ID: 114549 GDP [ChEBI:17552] GDP Guanosine 5'-diphosphate Guanosine diphosphate ChEBI CHEBI:17552 Reactome Database ID Release 83 114549 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114549 Reactome R-ALL-114549 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114549.2 COMPOUND C00035 1 GNA12 A0A3Q2U2K8 Reactome DB_ID: 10585143 UniProt:A0A3Q2U2K8 UniProt A0A3Q2U2K8 1 EQUAL 381 EQUAL Reactome Database ID Release 83 10585143 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585143 Reactome R-GGA-55355 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-55355.1 1 Reactome Database ID Release 83 10585145 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585145 Reactome R-GGA-114550 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-114550.1 1 G-protein beta-gamma complex Reactome DB_ID: 10584699 Converted from EntitySet in Reactome G-protein gamma subunit Reactome DB_ID: 10584679 GNG2 GNG2 Q5ZJ03 Reactome DB_ID: 10584649 UniProt:Q5ZJ03 GNG2 UniProt Q5ZJ03 2 EQUAL 68 EQUAL Reactome Database ID Release 83 10584649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584649 Reactome R-GGA-164380 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-164380.1 GNG4 GNG4 A0A1L1RJ14 Reactome DB_ID: 10584653 UniProt:A0A1L1RJ14 GNG4 UniProt A0A1L1RJ14 1 EQUAL 72 EQUAL Reactome Database ID Release 83 10584653 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584653 Reactome R-GGA-164350 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-164350.1 GNG5 GNG5 R4GKD1 Reactome DB_ID: 10584657 UniProt:R4GKD1 GNG5 UniProt R4GKD1 2 EQUAL 65 EQUAL Reactome Database ID Release 83 10584657 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584657 Reactome R-GGA-164383 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-164383.1 GNG7 A0A3Q2UHW3 Reactome DB_ID: 10584661 UniProt:A0A3Q2UHW3 UniProt A0A3Q2UHW3 2 EQUAL 65 EQUAL Reactome Database ID Release 83 10584661 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584661 Reactome R-GGA-164325 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-164325.1 GNGT2 GNGT2 A0A1D5PLZ8 Reactome DB_ID: 10584665 UniProt:A0A1D5PLZ8 GNGT2 UniProt A0A1D5PLZ8 1 EQUAL 66 EQUAL Reactome Database ID Release 83 10584665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584665 Reactome R-GGA-167440 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-167440.1 GNG10 GNG10 E1C795 Reactome DB_ID: 10584669 UniProt:E1C795 GNG10 UniProt E1C795 1 EQUAL 65 EQUAL Reactome Database ID Release 83 10584669 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584669 Reactome R-GGA-164344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-164344.1 GNG12 GNG12 R4GFT9 Reactome DB_ID: 10584673 UniProt:R4GFT9 GNG12 UniProt R4GFT9 2 EQUAL 69 EQUAL Reactome Database ID Release 83 10584673 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584673 Reactome R-GGA-164367 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-164367.1 GNG13 GNG13 E1C1U6 Reactome DB_ID: 10584677 UniProt:E1C1U6 GNG13 UniProt E1C1U6 1 EQUAL 64 EQUAL Reactome Database ID Release 83 10584677 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584677 Reactome R-GGA-164346 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-164346.1 Reactome Database ID Release 83 10584679 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584679 Reactome R-GGA-167442 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-167442.1 1 Converted from EntitySet in Reactome GNB G-protein beta subunit Reactome DB_ID: 10584697 GNB1 GNB1 F1NLV4 Reactome DB_ID: 10584683 cytosol GENE ONTOLOGY GO:0005829 UniProt:F1NLV4 GNB1 UniProt F1NLV4 2 EQUAL 340 EQUAL Reactome Database ID Release 83 10584683 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584683 Reactome R-GGA-6814412 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-6814412.1 P3H3 GNB3 A0A1D5P7Z5 Reactome DB_ID: 10584687 UniProt:A0A1D5P7Z5 P3H3 UniProt A0A1D5P7Z5 1 EQUAL 340 EQUAL Reactome Database ID Release 83 10584687 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584687 Reactome R-GGA-6814414 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-6814414.1 GNB4 GNB4 E1BW98 Reactome DB_ID: 10584691 UniProt:E1BW98 GNB4 UniProt E1BW98 2 EQUAL 340 EQUAL Reactome Database ID Release 83 10584691 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584691 Reactome R-GGA-6814417 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-6814417.1 GNB5 GNB5 A0A1D5P714 Reactome DB_ID: 10584695 UniProt:A0A1D5P714 GNB5 UniProt A0A1D5P714 1 EQUAL 395 EQUAL Reactome Database ID Release 83 10584695 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584695 Reactome R-GGA-6814416 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-6814416.1 Reactome Database ID Release 83 10584697 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584697 Reactome R-GGA-6814413 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-6814413.1 1 Reactome Database ID Release 83 10584699 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10584699 Reactome R-GGA-167434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-167434.1 1 Reactome Database ID Release 83 10585147 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585147 Reactome R-GGA-114551 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-114551.1 Heterotrimeric G-protein G13 (inactive) Reactome DB_ID: 10585151 G-protein alpha (13):GDP Reactome DB_ID: 10585149 1 GNA13 GNA13 A0A1D5PQE8 Reactome DB_ID: 10585127 UniProt:A0A1D5PQE8 GNA13 UniProt A0A1D5PQE8 1 EQUAL 377 EQUAL Reactome Database ID Release 83 10585127 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585127 Reactome R-GGA-167451 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-167451.1 1 Reactome Database ID Release 83 10585149 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585149 Reactome R-GGA-398057 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398057.1 1 1 Reactome Database ID Release 83 10585151 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585151 Reactome R-GGA-398072 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398072.1 Reactome Database ID Release 83 10585153 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585153 Reactome R-GGA-398082 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398082.1 Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). Reactome DB_ID: 10608554 1 1 Reactome Database ID Release 83 10608554 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608554 Reactome R-GGA-750994 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-750994.1 Reactome Database ID Release 83 10608556 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608556 Reactome R-GGA-751027 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-751027.1 About 25 receptors are reported to couple to the G12/13 G protein subtype (Riobo & Manning, 2005).Direct assay methods have not identified a receptor that only couples with G12. At least one receptor (5-HT4) only couples with G13, but most other receptors are reported to couple with both G12 and G13. 12433842 Pubmed 2002 Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy Maruyama, Y Nishida, M Sugimoto, Y Tanabe, S Turner, JH Kozasa, T Wada, T Nagao, T Kurose, H Circ Res 91:961-9 18374420 Pubmed 2008 Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology Nakahata, N Pharmacol Ther 118:18-35 15749160 Pubmed 2005 Receptors coupled to heterotrimeric G proteins of the G12 family Riobo, NA Manning, DR Trends Pharmacol Sci 26:146-54 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT Liganded G12/13-activating GPCR acts as a GEF for G12/13 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 83 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 COMPOUND C00044 GDP Guanosine 5'-diphosphate Guanosine diphosphate GDP(3-) Reactome DB_ID: 29420 GDP(3-) [ChEBI:58189] GDP(3-) 5'-O-[(phosphonatooxy)phosphinato]guanosine guanosine 5'-diphosphate(3-) GDP guanosine 5'-diphosphate trianion guanosine 5'-diphosphate GDP trianion ChEBI CHEBI:58189 Reactome Database ID Release 83 29420 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420 Reactome R-ALL-29420 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29420.3 COMPOUND C00035 Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). Reactome DB_ID: 10608546 1 Converted from EntitySet in Reactome G-protein G12/G13 (active) Reactome DB_ID: 10585163 Heterotrimeric G-protein G12 (active) Reactome DB_ID: 10585159 G-protein alpha (12):GTP Reactome DB_ID: 10585157 1 1 Reactome Database ID Release 83 10585157 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585157 Reactome R-GGA-114525 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-114525.1 1 1 Reactome Database ID Release 83 10585159 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585159 Reactome R-GGA-114547 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-114547.1 Heterotrimeric G-protein G13 (active) Reactome DB_ID: 10585161 G-protein alpha (13):GTP Reactome DB_ID: 10585129 1 1 Reactome Database ID Release 83 10585129 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585129 Reactome R-GGA-398056 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398056.1 1 1 Reactome Database ID Release 83 10585161 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585161 Reactome R-GGA-398074 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398074.1 Reactome Database ID Release 83 10585163 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585163 Reactome R-GGA-398080 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398080.1 1 Reactome Database ID Release 83 10608546 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608546 Reactome R-GGA-751015 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-751015.1 ACTIVATION GENE ONTOLOGY GO:0005085 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 83 10608557 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608557 Reactome Database ID Release 83 10608559 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608559 Reactome R-GGA-751029 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-751029.1 The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein. This event is negatively regulated by some Activators of G protein signaling (AGS) proteins, a class of proteins identified in yeast functional screens for proteins able to activate G protein signaling in the absence of a G protein–coupled receptor (GPCR) (Cismowski et al. 1999, Takesono et al. 1999). AGS proteins contain G protein regulatory (GPR) motifs (also referred to as the GoLoco motif) that bind and stabilize the Galpha subunit in its GDP-bound conformation (Mochizuki et al. 1996, Peterson et al. 2000, Cao et al. 2004, Blumer & Lanier 2014). Some RGS proteins similarly bind to Galpha preventing the exchange of GDP for GTP (Soundararajan et al. 2008). 3086311 Pubmed 1986 The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins Ferguson, KM Higashijima, T Smigel, MD Gilman, AG J Biol Chem 261:7393-9 11024022 Pubmed 2000 AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin Natochin, M Lester, B Peterson, Y K Bernard, M L Lanier, S M Artemyev, NO J. Biol. Chem. 275:40981-5 12860983 Pubmed 2003 Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor Wakasugi, Keisuke Nakano, Tomomi Morishima, Isao J. Biol. Chem. 278:36505-12 18434541 Pubmed 2008 Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits Soundararajan, Meera Willard, Francis S Kimple, Adam J Turnbull, Andrew P Ball, Linda J Schoch, Guillaume A Gileadi, Carina Fedorov, Oleg Y Dowler, Elizabeth F Higman, Victoria A Hutsell, Stephanie Q Sundström, M Doyle, DA Siderovski, David P Proc. Natl. Acad. Sci. U.S.A. 105:6457-62 3113327 Pubmed 1987 G proteins: transducers of receptor-generated signals Gilman, AG Annu Rev Biochem 56:615-49 9032437 Pubmed 1997 Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins Fields, TA Casey, PJ Biochem J 321:561-71 8973305 Pubmed 1996 Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2 Mochizuki, N Cho, G Wen, B Insel, P A Gene 181:39-43 10559191 Pubmed 1999 Receptor-independent activators of heterotrimeric G-protein signaling pathways Takesono, A Cismowski, M J Ribas, C Bernard, M Chung, P Hazard, S Duzic, E Lanier, S M J. Biol. Chem. 274:33202-5 10471929 Pubmed 1999 Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling Cismowski, M J Takesono, A Ma, C Lizano, J S Xie, X Fuernkranz, H Lanier, S M Duzic, E Nat. Biotechnol. 17:878-83 10969064 Pubmed 2000 Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3 Peterson, Y K Bernard, M L Ma, H Hazard, S Graber, S G Lanier, S M J. Biol. Chem. 275:33193-6 24302560 Pubmed 2014 Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad Blumer, Joe B Lanier, Stephen M Mol. Pharmacol. 85:388-96 19212140 Pubmed 2009 Regulation and physiological functions of G12/13-mediated signaling pathways Suzuki, N Hajicek, N Kozasa, T Neurosignals 17:55-70 15096500 Pubmed 2004 Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha Cao, Xiaoqing Cismowski, Mary J Sato, Motohiko Blumer, Joe B Lanier, Stephen M J. Biol. Chem. 279:27567-74 LEFT-TO-RIGHT The Ligand:GPCR:G12/13 complex dissociates This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Ligands of GPCRs that activate G12/13 Reactome DB_ID: 791498 Reactome Database ID Release 83 791498 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=791498 Reactome R-ALL-791498 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-791498.1 Converted from EntitySet in Reactome GPCRs that activate G12/13 Reactome DB_ID: 10608548 Reactome Database ID Release 83 10608548 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608548 Reactome R-GGA-791500 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-791500.1 Converted from EntitySet in Reactome G-protein alpha (12/13):GTP Reactome DB_ID: 10602549 Reactome Database ID Release 83 10602549 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10602549 Reactome R-GGA-418572 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-418572.1 2 Reactome Database ID Release 83 10608550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608550 Reactome R-GGA-751019 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-751019.1 The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (12/13) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008). 18577758 Pubmed 2008 Dissociation of heterotrimeric g proteins in cells Lambert, NA Sci Signal 1:re5 LEFT-TO-RIGHT GEFs activate RhoA,B,C This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> RhoA,B,C:GDP Reactome DB_ID: 10603011 1 Converted from EntitySet in Reactome RHOA/B/C Reactome DB_ID: 10603009 RHOA cRhoA O93467 Reactome DB_ID: 10585119 UniProt:O93467 cRhoA UniProt O93467 1 EQUAL 190 EQUAL Reactome Database ID Release 83 10585119 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10585119 Reactome R-GGA-194510 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-194510.1 RHOB cRhoB O93468 Reactome DB_ID: 10603003 UniProt:O93468 cRhoB UniProt O93468 1 EQUAL 193 EQUAL Reactome Database ID Release 83 10603003 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603003 Reactome R-GGA-194891 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-194891.1 RHOC Q9PSX7 Reactome DB_ID: 10603007 UniProt:Q9PSX7 UniProt Q9PSX7 1 EQUAL 190 EQUAL Reactome Database ID Release 83 10603007 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603007 Reactome R-GGA-194870 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-194870.1 Reactome Database ID Release 83 10603009 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603009 Reactome R-GGA-419160 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419160.1 1 Reactome Database ID Release 83 10603011 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603011 Reactome R-GGA-419164 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419164.1 RHOA/B/C:GTP Reactome DB_ID: 10603013 1 1 Reactome Database ID Release 83 10603013 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603013 Reactome R-GGA-419161 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419161.1 ACTIVATION Converted from EntitySet in Reactome GEFs Reactome DB_ID: 10596129 F1ND09 RASGRF2 RASGRF2 Reactome DB_ID: 10595995 UniProt:F1ND09 RASGRF2 UniProt F1ND09 1 EQUAL 1237 EQUAL Reactome Database ID Release 83 10595995 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595995 Reactome R-GGA-194944 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-194944.1 VAV2 VAV2 A0A1D5NVQ5 Reactome DB_ID: 10595999 UniProt:A0A1D5NVQ5 VAV2 UniProt A0A1D5NVQ5 1 EQUAL 878 EQUAL Reactome Database ID Release 83 10595999 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595999 Reactome R-GGA-195012 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195012.1 VAV3 VAV3 Q8UUX6 Reactome DB_ID: 10596003 UniProt:Q8UUX6 VAV3 UniProt Q8UUX6 1 EQUAL 847 EQUAL Reactome Database ID Release 83 10596003 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596003 Reactome R-GGA-430152 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-430152.1 TIAM1 TIAM1 A0A1D5P0C4 Reactome DB_ID: 10596007 UniProt:A0A1D5P0C4 TIAM1 UniProt A0A1D5P0C4 2 EQUAL 1591 EQUAL Reactome Database ID Release 83 10596007 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596007 Reactome R-GGA-195013 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195013.1 TIAM2 TIAM2 A0A1D5PML9 Reactome DB_ID: 10596011 UniProt:A0A1D5PML9 TIAM2 UniProt A0A1D5PML9 2 EQUAL 1701 EQUAL Reactome Database ID Release 83 10596011 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596011 Reactome R-GGA-561165 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-561165.1 TRIO TRIO A0A1D5NZW8 Reactome DB_ID: 10596015 UniProt:A0A1D5NZW8 TRIO UniProt A0A1D5NZW8 1 EQUAL 3097 EQUAL Reactome Database ID Release 83 10596015 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596015 Reactome R-GGA-2980605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2980605.1 MCF2L MCF2L R4GL74 Reactome DB_ID: 10596019 UniProt:R4GL74 MCF2L UniProt R4GL74 1 EQUAL 1137 EQUAL Reactome Database ID Release 83 10596019 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596019 Reactome R-GGA-195070 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195070.1 ECT2 ECT2 E1BWT7 Reactome DB_ID: 10596023 UniProt:E1BWT7 ECT2 UniProt E1BWT7 1 EQUAL 914 EQUAL Reactome Database ID Release 83 10596023 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596023 Reactome R-GGA-195036 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195036.1 PLEKHG5 PLEKHG5 A0A1D5PX49 Reactome DB_ID: 10596027 UniProt:A0A1D5PX49 PLEKHG5 UniProt A0A1D5PX49 1 EQUAL 1062 EQUAL Reactome Database ID Release 83 10596027 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596027 Reactome R-GGA-195060 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195060.1 SOS1 SOS1 A0A1D5PEZ2 Reactome DB_ID: 10582252 UniProt:A0A1D5PEZ2 SOS1 UniProt A0A1D5PEZ2 1 EQUAL 1333 EQUAL Reactome Database ID Release 83 10582252 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10582252 Reactome R-GGA-64847 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-64847.1 SOS2 SOS2 F1N8Q9 Reactome DB_ID: 10596031 UniProt:F1N8Q9 SOS2 UniProt F1N8Q9 1 EQUAL 1332 EQUAL Reactome Database ID Release 83 10596031 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596031 Reactome R-GGA-167221 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-167221.1 ABR ABR A0A1D5NWU3 Reactome DB_ID: 10596035 UniProt:A0A1D5NWU3 ABR UniProt A0A1D5NWU3 1 EQUAL 859 EQUAL Reactome Database ID Release 83 10596035 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596035 Reactome R-GGA-2975963 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2975963.1 AKAP13 AKAP13 F1NIT0 Reactome DB_ID: 10596039 UniProt:F1NIT0 AKAP13 UniProt F1NIT0 1 EQUAL 2813 EQUAL Reactome Database ID Release 83 10596039 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596039 Reactome R-GGA-2975983 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2975983.1 ARHGEF3 ARHGEF3 A0A3Q2U9N5 Reactome DB_ID: 10596043 UniProt:A0A3Q2U9N5 ARHGEF3 UniProt A0A3Q2U9N5 1 EQUAL 526 EQUAL Reactome Database ID Release 83 10596043 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596043 Reactome R-GGA-2976629 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2976629.1 E1C6J2 ARHGEF5 ARHGEF5 Reactome DB_ID: 10596047 UniProt:E1C6J2 ARHGEF5 UniProt E1C6J2 1 EQUAL 1597 EQUAL Reactome Database ID Release 83 10596047 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596047 Reactome R-GGA-8873909 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8873909.1 F1NEF5 ARHGEF6 ARHGEF6 Reactome DB_ID: 10596051 UniProt:F1NEF5 ARHGEF6 UniProt F1NEF5 1 EQUAL 776 EQUAL Reactome Database ID Release 83 10596051 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596051 Reactome R-GGA-195017 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195017.1 ARHGEF7 ARHGEF7 A0A3Q2TZR1 Reactome DB_ID: 10590875 UniProt:A0A3Q2TZR1 ARHGEF7 UniProt A0A3Q2TZR1 1 EQUAL 803 EQUAL Reactome Database ID Release 83 10590875 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10590875 Reactome R-GGA-430346 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-430346.1 ARHGEF9 ARHGEF9 A0A3Q2U0A5 Reactome DB_ID: 10596055 UniProt:A0A3Q2U0A5 ARHGEF9 UniProt A0A3Q2U0A5 1 EQUAL 516 EQUAL Reactome Database ID Release 83 10596055 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596055 Reactome R-GGA-195067 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195067.1 ARHGEF11 ARHGEF11 A0A1D5PNR3 Reactome DB_ID: 10596059 UniProt:A0A1D5PNR3 ARHGEF11 UniProt A0A1D5PNR3 1 EQUAL 1522 EQUAL Reactome Database ID Release 83 10596059 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596059 Reactome R-GGA-195102 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-195102.1 F1P1Y1 ARHGEF12 ARHGEF12 Reactome DB_ID: 10596063 UniProt:F1P1Y1 ARHGEF12 UniProt F1P1Y1 1 EQUAL 1544 EQUAL Reactome Database ID Release 83 10596063 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596063 Reactome R-GGA-416560 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-416560.1 E1BQT7 ARHGEF16 ARHGEF16 Reactome DB_ID: 10596067 UniProt:E1BQT7 ARHGEF16 UniProt E1BQT7 2 EQUAL 709 EQUAL Reactome Database ID Release 83 10596067 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596067 Reactome R-GGA-2976623 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-2976623.1 E1C588 ARHGEF17 ARHGEF17 Reactome DB_ID: 10596071 UniProt:E1C588 ARHGEF17 UniProt E1C588 1 EQUAL 2063 EQUAL Reactome Database ID Release 83 10596071 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596071 Reactome R-GGA-194925 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-194925.1 F1NBE4 ARHGEF26 ARHGEF26 Reactome DB_ID: 10596075 UniProt:F1NBE4 ARHGEF26 UniProt F1NBE4 1 EQUAL 871 EQUAL Reactome Database ID Release 83 10596075 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596075 Reactome R-GGA-8873912 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8873912.1 FGD3 FGD3 A0A1D5NVP9 Reactome DB_ID: 10596079 UniProt:A0A1D5NVP9 FGD3 UniProt A0A1D5NVP9 1 EQUAL 725 EQUAL Reactome Database ID Release 83 10596079 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596079 Reactome R-GGA-3000205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3000205.1 FGD4 FGD4 A0A3Q2TZP0 Reactome DB_ID: 10596083 UniProt:A0A3Q2TZP0 FGD4 UniProt A0A3Q2TZP0 1 EQUAL 766 EQUAL Reactome Database ID Release 83 10596083 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596083 Reactome R-GGA-3000215 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3000215.1 ITSN1 ITSN1 A0A1D5P467 Reactome DB_ID: 10596087 UniProt:A0A1D5P467 ITSN1 UniProt A0A1D5P467 1 EQUAL 1721 EQUAL Reactome Database ID Release 83 10596087 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596087 Reactome R-GGA-3006481 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3006481.1 KALRN A0A1D5PRH4 Reactome DB_ID: 10596091 UniProt:A0A1D5PRH4 UniProt A0A1D5PRH4 1 EQUAL 2985 EQUAL Reactome Database ID Release 83 10596091 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596091 Reactome R-GGA-3006505 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3006505.1 MCF2 MCF2 E1BWQ1 Reactome DB_ID: 10592653 UniProt:E1BWQ1 MCF2 UniProt E1BWQ1 1 EQUAL 925 EQUAL Reactome Database ID Release 83 10592653 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10592653 Reactome R-GGA-3006639 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3006639.1 NET1 NET1 Q5ZJM0 Reactome DB_ID: 10596095 UniProt:Q5ZJM0 NET1 UniProt Q5ZJM0 1 EQUAL 596 EQUAL Reactome Database ID Release 83 10596095 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596095 Reactome R-GGA-3006799 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3006799.1 NGEF NGEF A0A1D5NXP9 Reactome DB_ID: 10596099 UniProt:A0A1D5NXP9 NGEF UniProt A0A1D5NXP9 1 EQUAL 710 EQUAL Reactome Database ID Release 83 10596099 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596099 Reactome R-GGA-3006800 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3006800.1 OBSL1 OBSCN F1P369 Reactome DB_ID: 10596103 UniProt:F1P369 OBSL1 UniProt F1P369 1 EQUAL 7968 EQUAL Reactome Database ID Release 83 10596103 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596103 Reactome R-GGA-3008877 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3008877.1 PREX1 PREX1 A0A3Q2U7M9 Reactome DB_ID: 10596107 UniProt:A0A3Q2U7M9 PREX1 UniProt A0A3Q2U7M9 1 EQUAL 1659 EQUAL Reactome Database ID Release 83 10596107 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596107 Reactome R-GGA-8863083 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8863083.1 F1NNU8 ARHGEF10 ARHGEF10 Reactome DB_ID: 10596111 UniProt:F1NNU8 ARHGEF10 UniProt F1NNU8 1 EQUAL 1369 EQUAL Reactome Database ID Release 83 10596111 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596111 Reactome R-GGA-8873917 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8873917.1 ARHGEF10L ARHGEF10L A0A1D5PC33 Reactome DB_ID: 10596115 UniProt:A0A1D5PC33 ARHGEF10L UniProt A0A1D5PC33 1 EQUAL 1279 EQUAL Reactome Database ID Release 83 10596115 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596115 Reactome R-GGA-8873915 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8873915.1 F1NMA5 ARHGEF33 ARHGEF33 Reactome DB_ID: 10596119 UniProt:F1NMA5 ARHGEF33 UniProt F1NMA5 1 EQUAL 844 EQUAL Reactome Database ID Release 83 10596119 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596119 Reactome R-GGA-8873913 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8873913.1 ARHGEF38 ARHGEF38 A0A1D5PLE2 Reactome DB_ID: 10596123 UniProt:A0A1D5PLE2 ARHGEF38 UniProt A0A1D5PLE2 1 EQUAL 777 EQUAL Reactome Database ID Release 83 10596123 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596123 Reactome R-GGA-8873914 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8873914.1 F1NHV7 ARHGEF39 ARHGEF39 Reactome DB_ID: 10596127 UniProt:F1NHV7 ARHGEF39 UniProt F1NHV7 1 EQUAL 335 EQUAL Reactome Database ID Release 83 10596127 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596127 Reactome R-GGA-8873910 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8873910.1 Reactome Database ID Release 83 10596129 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596129 Reactome R-GGA-194849 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-194849.1 Reactome Database ID Release 83 10596130 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10596130 Reactome Database ID Release 83 10603421 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603421 Reactome R-GGA-419166 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419166.1 Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994). 8810315 Pubmed 1996 Identification of a novel guanine nucleotide exchange factor for the Rho GTPase Hart, MJ Sharma, S elMasry, N Qiu, RG McCabe, P Polakis, P Bollag, G J Biol Chem 271:25452-8 16212495 Pubmed 2005 Rho GTPases: biochemistry and biology Jaffe, AB Hall, A Annu Rev Cell Dev Biol 21:247-69 9308960 Pubmed 1997 Rho GTPases and signaling networks Van Aelst, L D'Souza-Schorey, C Genes Dev 11:2295-322 8276860 Pubmed 1994 Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product Hart, MJ Eva, A Zangrilli, D Aaronson, Stuart A Evans, T Cerione, RA Zheng, Y J Biol Chem 269:62-5 12101119 Pubmed 2002 Guanine nucleotide exchange factors for Rho GTPases: turning on the switch Schmidt, A Hall, A Genes Dev 16:1587-609 LEFT-TO-RIGHT ROCK activation by RHO This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome ROCK1,ROCK2 Reactome DB_ID: 10603412 ROCK1 A0A1D5PK41 Reactome DB_ID: 10594516 UniProt:A0A1D5PK41 UniProt A0A1D5PK41 2 EQUAL 1354 EQUAL Reactome Database ID Release 83 10594516 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594516 Reactome R-GGA-212509 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-212509.1 ROCK2 A0A3Q2TTH6 Reactome DB_ID: 10603410 UniProt:A0A3Q2TTH6 UniProt A0A3Q2TTH6 1 EQUAL 1388 EQUAL Reactome Database ID Release 83 10603410 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603410 Reactome R-GGA-419058 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419058.1 Reactome Database ID Release 83 10603412 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603412 Reactome R-GGA-419057 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419057.1 Activated ROCK:RhoA/B/C:GTP Reactome DB_ID: 10603414 1 1 Reactome Database ID Release 83 10603414 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603414 Reactome R-GGA-422483 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-422483.1 Reactome Database ID Release 83 10603418 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603418 Reactome R-GGA-419049 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-419049.1 ROCKs are primarily known as downstream effectors of RHO, but they can also be activated by arachidonic acid, which binds to the pleckstrin homology domain, releasing an autoinhibitory loop within ROCK and allowing catalytic activity (Araki et al. 2001). Proteolytic cleavage at the C-terminus by caspase-3 and granzyme B also activates ROCK1 and ROCK2, causing plasma membrane blebbing during apoptosis (Coleman et al. 2001, Sebbagh et al. 2005). Multiple targets of ROCK contribute to the stabilization of actin filaments and the generation of actin-myosin contractile force. 11294240 Pubmed 2001 Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase Araki, S Ito, M Kureishi, Y Feng, J Machida, H Isaka, N Amano, M Kaibuchi, K Hartshorne, D J Nakano, T Pflugers Arch. 441:596-603 8617235 Pubmed 1996 The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase Ishizaki, T Maekawa, M Fujisawa, K Okawa, K Iwamatsu, A Fujita, A Watanabe, Nobumoto Saito, Y Kakizuka, A Morii, N Narumiya, S EMBO J 15:1885-93 8816443 Pubmed 1996 The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton Leung, T Chen, X Q Manser, E Lim, L Mol. Cell. Biol. 16:5313-27 15699075 Pubmed 2005 Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner Sebbagh, Michael Hamelin, Jocelyne Bertoglio, Jacques Solary, Eric Breard, Jacqueline J. Exp. Med. 201:465-71 12778124 Pubmed 2003 Rocks: multifunctional kinases in cell behaviour Riento, K Ridley, AJ Nat Rev Mol Cell Biol 4:446-56 9920927 Pubmed 1999 Rho-associated kinase of chicken gizzard smooth muscle Feng, J Ito, M Kureishi, Y Ichikawa, K Amano, M Isaka, N Okawa, K Iwamatsu, A Kaibuchi, K Hartshorne, DJ Nakano, T J Biol Chem 274:3744-52 11283606 Pubmed 2001 Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I Coleman, M L Sahai, E A Yeo, M Bosch, M Dewar, A Olson, M F Nat. Cell Biol. 3:339-45 INHIBITION Reactome Database ID Release 83 10603419 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603419 ROCK1,ROCK2:ROCKi Reactome DB_ID: 10603416 1 Converted from EntitySet in Reactome ROCKi ROCK inhibitors Reactome DB_ID: 9686558 ripasudil Glanatec&reg; K-115 (ripasudil hydrochloride dihydrate) Reactome DB_ID: 9680440 ripasudil [Guide to Pharmacology:10423] ripasudil Glanatec&reg; K-115 (ripasudil hydrochloride dihydrate) Guide to Pharmacology 10423 Reactome Database ID Release 83 9680440 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9680440 Reactome R-ALL-9680440 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9680440.1 netarsudil Reactome DB_ID: 9686545 netarsudil [Guide to Pharmacology:9322] netarsudil AR11324 AR-11324 ester 60 [PMID: 27072905] Rhokiinsa&reg; Rhopressa&reg; Guide to Pharmacology 9322 Reactome Database ID Release 83 9686545 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9686545 Reactome R-ALL-9686545 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9686545.1 Reactome Database ID Release 83 9686558 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9686558 Reactome R-ALL-9686558 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9686558.1 1 Reactome Database ID Release 83 10603416 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603416 Reactome R-GGA-9680444 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9680444.1 LEFT-TO-RIGHT ROCK1,2 bind ROCKi This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome Database ID Release 83 10664542 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10664542 Reactome R-GGA-9680443 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9680443.1 Ripasudil (Glanatec), as its hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (ROCKi) used for the treatment of glaucoma and ocular hypertension in Japan (Garnock-Jones 2014). Netarsudil is a USA-approved ROCKi used to treat glaucoma and ocular hypertenstion (Sturdivant et al. 2016, Tanna & Johnson 2018). 25414122 Pubmed 2014 Ripasudil: first global approval Garnock-Jones, Karly P Drugs 74:2211-5 27072905 Pubmed 2016 Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma Sturdivant, Jill M Royalty, Susan M Lin, Cheng-Wen Moore, Lori A Yingling, Jeffrey D Laethem, Carmen L Sherman, Bryan Heintzelman, Geoffrey R Kopczynski, Casey C deLong, Mitchell A Bioorg. Med. Chem. Lett. 26:2475-2480 30007591 Pubmed 2018 Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension Tanna, Angelo P Johnson, Mark Ophthalmology 125:1741-1756 LEFT-TO-RIGHT LARG activation by G alpha 12/13 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> G-protein alpha (12/13):LARG Reactome DB_ID: 10602559 1 1 Reactome Database ID Release 83 10602559 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10602559 Reactome R-GGA-398145 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398145.1 Reactome Database ID Release 83 10602561 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10602561 Reactome R-GGA-398184 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398184.1 Leukemia-associated RhoGEF (LARG) serves as a G alpha responsive RhoGEF for G alpha 12, 13 and possibly G alpha q. G alpha 12 activity appears to depend on LARG tyrosine phosphorylation by Tec-family kinases (Suzuki et al. 2003) or FAK (Chikumi et al. 2002). The involvement of LARG may be specific to particular receptor signalling pathways; RNAi-mediated knockdown of LARG specifically inhibited thrombin signaling via PAR1 but not LPA receptors (Wang et al 2004). 11799111 Pubmed 2002 Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase Chikumi, H Fukuhara, S Gutkind, JS J Biol Chem 277:12463-73 15951850 Pubmed 2005 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Siderovski, DP Willard, FS Int J Biol Sci 1:51-66 15143072 Pubmed 2004 Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells Wang, Q Liu, M Kozasa, T Rothstein, JD Sternweis, PC Neubig, RR J Biol Chem 279:28831-4 12515866 Pubmed 2003 Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF Suzuki, N Nakamura, S Mano, H Kozasa, T Proc Natl Acad Sci U S A 100:733-8 12771155 Pubmed 2003 Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11 Vogt, S Grosse, R Schultz, G Offermanns, S J Biol Chem 278:28743-9 LEFT-TO-RIGHT LARG binds plexin B1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PLXNB3 PLXNB1 A0A3Q2TW45 Reactome DB_ID: 10598677 UniProt:A0A3Q2TW45 PLXNB3 UniProt A0A3Q2TW45 20 EQUAL 2135 EQUAL Reactome Database ID Release 83 10598677 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10598677 Reactome R-GGA-3008951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-3008951.1 G-protein alpha (12/13):LARG:Plexin B1 Reactome DB_ID: 10602563 1 1 Reactome Database ID Release 83 10602563 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10602563 Reactome R-GGA-398146 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398146.1 Reactome Database ID Release 83 10602565 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10602565 Reactome R-GGA-398185 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398185.1 LARG binds plexin-B1, a transmembrane receptor for the semaphorin Sema4D. Binding of Sema4D to plexin-B1 stimulates RhoA activation. 12123608 Pubmed 2002 Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology Swiercz, JM Kuner, R Behrens, J Offermanns, S Neuron 35:51-63 LEFT-TO-RIGHT 3.6.5.4 3.6.5.3 3.6.5.2 3.6.5.1 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome G-protein alpha (12/13):GDP Reactome DB_ID: 10603273 Reactome Database ID Release 83 10603273 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603273 Reactome R-GGA-418570 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-418570.1 ACTIVATION GENE ONTOLOGY GO:0003924 Reactome Database ID Release 83 10603274 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603274 Reactome Database ID Release 83 10603276 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10603276 Reactome R-GGA-418574 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-418574.1 When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994). 7937899 Pubmed 1994 Mechanism of GTP hydrolysis by G-protein alpha subunits Kleuss, C Raw, AS Lee, E Sprang, SR Gilman, AG Proc Natl Acad Sci U S A 91:9828-31 LEFT-TO-RIGHT Inactive G alpha (12/13) reassociates with G beta:gamma This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 Reactome Database ID Release 83 10608561 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10608561 Reactome R-GGA-751039 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-751039.1 The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (12/13):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein. 16923326 Pubmed 2006 Structural basis of function in heterotrimeric G proteins Oldham, WM Hamm, HE Q Rev Biophys 39:117-66 LEFT-TO-RIGHT G alpha (12) binds BTK This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> BTK A0A1D5NXK5 Reactome DB_ID: 10626696 UniProt:A0A1D5NXK5 UniProt A0A1D5NXK5 2 EQUAL 659 EQUAL Reactome Database ID Release 83 10626696 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10626696 Reactome R-GGA-197948 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-197948.1 G alpha (12):BTK Reactome DB_ID: 10659841 1 1 Reactome Database ID Release 83 10659841 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10659841 Reactome R-GGA-8964310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8964310.1 Reactome Database ID Release 83 10659847 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10659847 Reactome R-GGA-8964274 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8964274.1 G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind directly to the PH domain of the non-receptor Tyrosine-protein kinase BTK (BTK) in vitro and in vivo. This binding results in the activation of BTK. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling. 9796816 Pubmed 1998 The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain Jiang, Y Ma, W Wan, Y Kozasa, T Hattori, S Huang, X Y Nature 395:808-13 LEFT-TO-RIGHT BTK in G alpha (12)-BTK complex is activated This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome Database ID Release 83 10659843 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10659843 Reactome R-GGA-8964246 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8964246.1 G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind the non-receptor Tyrosine-protein kinase BTK. In this complex, GNA12 triggers BTK activation. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling. 11742120 Pubmed 2002 Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization Laederach, Alain Cradic, Kendall W Brazin, Kristine N Zamoon, Jamillah Fulton, D Bruce Huang, Xin-Yun Andreotti, Amy H Protein Sci. 11:36-45 LEFT-TO-RIGHT G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome Database ID Release 83 10659859 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10659859 Reactome R-GGA-8964333 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-8964333.1 G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind to the non-receptor Tyrosine-protein kinase BTK. This complex facilitates BTK activation. Subsequently, the active BTK dissociates from GNA12 to phosphorylate downstream effectors. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling. Reactome Database ID Release 83 10669081 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669081 Reactome R-GGA-416482 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-416482.1 The G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay technologies that measure intracellular calcium. The G12/13 family are best known for their involvement in the processes of cell proliferation and morphology, such as stress fiber and focal adhesion formation. Interactions with Rho guanine nucleotide exchange factors (RhoGEFs) are thought to mediate many of these processes. (Buhl et al.1995, Sugimoto et al. 2003). Activation of Rho or the regulation of events through Rho is often taken as evidence of G12/13 signaling. Receptors that are coupled with G12/13 invariably couple with one or more other G protein subtypes, usually Gq. 16102047 Pubmed 2005 Protease-activated receptors in hemostasis, thrombosis and vascular biology Coughlin, SR J Thromb Haemost 3:1800-14 12588974 Pubmed 2003 Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform Sugimoto, N Takuwa, N Okamoto, H Sakurada, S Takuwa, Y Mol Cell Biol 23:1534-45 18814923 Pubmed 2008 G(12)/G(13)-mediated signalling in mammalian physiology and disease Worzfeld, T Wettschureck, N Offermanns, S Trends Pharmacol Sci 29:582-9 7559569 Pubmed 1995 G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly Buhl, AM Johnson, NL Dhanasekaran, N Johnson, GL J Biol Chem 270:24631-4