BioPAX pathway converted from "KDM6B demethylates H3K27me3 on p16INK4A promoter" in the Reactome database.LEFT-TO-RIGHT1.14.11.68KDM6B demethylates H3K27me3 on p16INK4A promoterThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>2OG2-Oxoglutarate2-oxoglutaric acidalpha-ketoglutarateReactome DB_ID: 113671nucleoplasmGENE ONTOLOGYGO:00056542-oxoglutarate(2-) [ChEBI:16810]2-oxoglutarate(2-)2-ketoglutaratealpha-ketoglutarate2-oxopentanedioic acid, ion(2-)2-oxoglutarateChEBICHEBI:16810Reactome Database ID Release 75113671Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113671ReactomeR-ALL-1136714Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113671.4Reactomehttp://www.reactome.orgCOMPOUNDC00026additional informationMIMI:03613CDKN2A Gene:H3K27Me3-NucleosomeReactome DB_ID: 10673052Ghost homologue of CDKN2A geneReactome DB_ID: 10673037Reactome Database ID Release 7510673037Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673037ReactomeR-DDI-32000171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3200017.11Nucleosome with H3K27me3Reactome DB_ID: 10673050Converted from EntitySet in ReactomeHistone H2AReactome DB_ID: 10649184Converted from EntitySet in ReactomeHomologues of H2AFB1Reactome DB_ID: 10649135H2Av3H2AFB1Q54HV7Reactome DB_ID: 10649118UniProt:Q54HV7H2Av3Dictyostelium discoideumNCBI Taxonomy44689UniProtQ54HV71EQUAL115EQUALReactome Database ID Release 7510649118Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649118ReactomeR-DDI-1818871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181887.1H2Av2H2AFB1Q54HV9Reactome DB_ID: 10649123UniProt:Q54HV9H2Av2UniProtQ54HV91EQUAL115EQUALReactome Database ID Release 7510649123Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649123ReactomeR-DDI-181887-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181887-2.1H2Av1H2AFB1Q54HW2Reactome DB_ID: 10649128UniProt:Q54HW2H2Av1UniProtQ54HW21EQUAL115EQUALReactome Database ID Release 7510649128Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649128ReactomeR-DDI-181887-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181887-3.1H2AXH2AFB1Q54WG6Reactome DB_ID: 10649133UniProt:Q54WG6H2AXUniProtQ54WG61EQUAL115EQUALReactome Database ID Release 7510649133Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649133ReactomeR-DDI-181887-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181887-4.1Reactome Database ID Release 7510649135Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649135ReactomeR-DDI-181887-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181887-5.1Converted from EntitySet in ReactomeHomologues of HIST1H2ABReactome DB_ID: 10649145H2Av3HIST1H2ABQ54HV7Reactome DB_ID: 106491372EQUAL130EQUALReactome Database ID Release 7510649137Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649137ReactomeR-DDI-1818881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181888.1H2Av2HIST1H2ABQ54HV9Reactome DB_ID: 106491392EQUAL130EQUALReactome Database ID Release 7510649139Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649139ReactomeR-DDI-181888-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181888-2.1H2Av1HIST1H2ABQ54HW2Reactome DB_ID: 106491412EQUAL130EQUALReactome Database ID Release 7510649141Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649141ReactomeR-DDI-181888-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181888-3.1H2AXHIST1H2ABQ54WG6Reactome DB_ID: 106491432EQUAL130EQUALReactome Database ID Release 7510649143Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649143ReactomeR-DDI-181888-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181888-4.1Reactome Database ID Release 7510649145Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649145ReactomeR-DDI-181888-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181888-5.1Converted from EntitySet in ReactomeHomologues of HIST1H2AJReactome DB_ID: 10649155H2Av3HIST1H2AJQ54HV7Reactome DB_ID: 106491472EQUAL128EQUALReactome Database ID Release 7510649147Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649147ReactomeR-DDI-1818901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181890.1H2Av2HIST1H2AJQ54HV9Reactome DB_ID: 106491492EQUAL128EQUALReactome Database ID Release 7510649149Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649149ReactomeR-DDI-181890-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181890-2.1H2Av1HIST1H2AJQ54HW2Reactome DB_ID: 106491512EQUAL128EQUALReactome Database ID Release 7510649151Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649151ReactomeR-DDI-181890-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181890-3.1H2AXHIST1H2AJQ54WG6Reactome DB_ID: 106491532EQUAL128EQUALReactome Database ID Release 7510649153Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649153ReactomeR-DDI-181890-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181890-4.1Reactome Database ID Release 7510649155Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649155ReactomeR-DDI-181890-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181890-5.1Converted from EntitySet in ReactomeHomologues of HIST2H2ACReactome DB_ID: 10649165H2Av3HIST2H2ACQ54HV7Reactome DB_ID: 106491572EQUAL129EQUALReactome Database ID Release 7510649157Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649157ReactomeR-DDI-1818921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181892.1H2Av2HIST2H2ACQ54HV9Reactome DB_ID: 106491592EQUAL129EQUALReactome Database ID Release 7510649159Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649159ReactomeR-DDI-181892-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181892-2.1H2Av1HIST2H2ACQ54HW2Reactome DB_ID: 106491612EQUAL129EQUALReactome Database ID Release 7510649161Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649161ReactomeR-DDI-181892-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181892-3.1H2AXHIST2H2ACQ54WG6Reactome DB_ID: 106491632EQUAL129EQUALReactome Database ID Release 7510649163Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649163ReactomeR-DDI-181892-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181892-4.1Reactome Database ID Release 7510649165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649165ReactomeR-DDI-181892-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181892-5.1H2AZH2AFVQ54LA5Reactome DB_ID: 10649170UniProt:Q54LA5H2AZUniProtQ54LA51EQUAL128EQUALReactome Database ID Release 7510649170Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649170ReactomeR-DDI-88624271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-8862427.1Converted from EntitySet in ReactomeHomologues of H2AFXReactome DB_ID: 10649180H2Av3H2AFXQ54HV7Reactome DB_ID: 106491722EQUAL143EQUALReactome Database ID Release 7510649172Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649172ReactomeR-DDI-561511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-56151.1H2Av2H2AFXQ54HV9Reactome DB_ID: 106491742EQUAL143EQUALReactome Database ID Release 7510649174Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649174ReactomeR-DDI-56151-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-56151-2.1H2Av1H2AFXQ54HW2Reactome DB_ID: 106491762EQUAL143EQUALReactome Database ID Release 7510649176Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649176ReactomeR-DDI-56151-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-56151-3.1H2AXH2AFXQ54WG6Reactome DB_ID: 106491782EQUAL143EQUALReactome Database ID Release 7510649178Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649178ReactomeR-DDI-56151-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-56151-4.1Reactome Database ID Release 7510649180Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649180ReactomeR-DDI-56151-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-56151-5.1Reactome Database ID Release 7510649184Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649184ReactomeR-DDI-1818991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181899.12H4bHIST1H4Q76NW2Reactome DB_ID: 10649113UniProt:Q76NW2H4bUniProtQ76NW22EQUAL103EQUALReactome Database ID Release 7510649113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649113ReactomeR-DDI-1819021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181902.12Converted from EntitySet in ReactomeHistone H3 (H3K27me3)Reactome DB_ID: 10673048H3aMe3K-28-HIST2H3AO15819Reactome DB_ID: 10673040UniProt:O15819H3aUniProtO1581928EQUALN6,N6,N6-trimethyl-L-lysineMODMOD:000832EQUAL136EQUALReactome Database ID Release 7510673040Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673040ReactomeR-DDI-2122531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-212253.1H3bMe3K-28-H3F3AQ55BN9Reactome DB_ID: 10673043UniProt:Q55BN9H3bUniProtQ55BN928EQUAL2EQUAL136EQUALReactome Database ID Release 7510673043Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673043ReactomeR-DDI-2122821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-212282.1H3v1Me3K-28-HIST1H3AQ54F38Reactome DB_ID: 10673046UniProt:Q54F38H3v1UniProtQ54F3828EQUAL2EQUAL136EQUALReactome Database ID Release 7510673046Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673046ReactomeR-DDI-2122201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-212220.1Reactome Database ID Release 7510673048Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673048ReactomeR-DDI-2122661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-212266.12Converted from EntitySet in ReactomeHistone H2BReactome DB_ID: 10649211Converted from EntitySet in ReactomeHomologues of HIST1H2BKReactome DB_ID: 10649201H2Bv1HIST1H2BKQ54BC2Reactome DB_ID: 10649189UniProt:Q54BC2H2Bv1UniProtQ54BC22EQUAL126EQUALReactome Database ID Release 7510649189Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649189ReactomeR-DDI-1818981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181898.1H2Bv3HIST1H2BKQ54LP8Reactome DB_ID: 10649194UniProt:Q54LP8H2Bv3UniProtQ54LP82EQUAL126EQUALReactome Database ID Release 7510649194Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649194ReactomeR-DDI-181898-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181898-2.1H2Bv2HIST1H2BKQ7KWR7Reactome DB_ID: 10649199UniProt:Q7KWR7H2Bv2UniProtQ7KWR72EQUAL126EQUALReactome Database ID Release 7510649199Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649199ReactomeR-DDI-181898-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181898-3.1Reactome Database ID Release 7510649201Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649201ReactomeR-DDI-181898-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181898-4.1Converted from EntitySet in ReactomeHomologues of HIST1H2BAReactome DB_ID: 10649209H2Bv1HIST1H2BAQ54BC2Reactome DB_ID: 106492032EQUAL127EQUALReactome Database ID Release 7510649203Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649203ReactomeR-DDI-1819161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181916.1H2Bv3HIST1H2BAQ54LP8Reactome DB_ID: 106492052EQUAL127EQUALReactome Database ID Release 7510649205Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649205ReactomeR-DDI-181916-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181916-2.1H2Bv2HIST1H2BAQ7KWR7Reactome DB_ID: 106492072EQUAL127EQUALReactome Database ID Release 7510649207Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649207ReactomeR-DDI-181916-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181916-3.1Reactome Database ID Release 7510649209Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649209ReactomeR-DDI-181916-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181916-4.1Reactome Database ID Release 7510649211Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649211ReactomeR-DDI-1819111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181911.12Reactome Database ID Release 7510673050Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673050ReactomeR-DDI-4337571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-433757.11Reactome Database ID Release 7510673052Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673052ReactomeR-DDI-32225701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222570.1CDKN2A Gene:NucleosomeReactome DB_ID: 106730541NucleosomeReactome DB_ID: 10656786222Converted from EntitySet in ReactomeHistone H3Reactome DB_ID: 10656784H3v1HIST3H3Q54F38Reactome DB_ID: 106534242EQUAL136EQUALReactome Database ID Release 7510653424Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10653424ReactomeR-DDI-1819141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-181914.1H3aHIST2H3AO15819Reactome DB_ID: 106567802EQUAL136EQUALReactome Database ID Release 7510656780Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10656780ReactomeR-DDI-2122811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-212281.1H3bH3F3AQ55BN9Reactome DB_ID: 106567822EQUAL136EQUALReactome Database ID Release 7510656782Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10656782ReactomeR-DDI-2122951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-212295.1Reactome Database ID Release 7510656784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10656784ReactomeR-DDI-2122931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-212293.12Reactome Database ID Release 7510656786Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10656786ReactomeR-DDI-4274021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-427402.11Reactome Database ID Release 7510673054Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673054ReactomeR-DDI-32225921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222592.1SUCCASuccinatesuccinic acidsuccinate(2-)Reactome DB_ID: 159939succinate(2-) [ChEBI:30031]succinate(2-)(-)OOC-CH2-CH2-COO(-)succinatebutanedioic acid, ion(2-)butanedioateChEBICHEBI:30031Reactome Database ID Release 75159939Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=159939ReactomeR-ALL-1599395Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-159939.5COMPOUNDC000423ACTIVATIONKDM6B:Fe2+Reactome DB_ID: 10673061Fe2+iron (ferrous)Fe(II)Reactome DB_ID: 111793iron(2+) [ChEBI:29033]iron(2+)FE (II) IONFe2+Fe(2+)iron ion(2+)Fe(II)Ferrous ionChEBICHEBI:29033Reactome Database ID Release 75111793Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111793ReactomeR-ALL-1117934Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111793.4COMPOUNDC000231trfAKDM6BO77033Reactome DB_ID: 10673059UniProt:O77033trfAUniProtO770331EQUAL1643EQUALReactome Database ID Release 7510673059Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673059ReactomeR-DDI-16298331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-1629833.11Reactome Database ID Release 7510673061Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673061ReactomeR-DDI-32225891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222589.1GENE ONTOLOGYGO:0071558gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510673062Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673062Reactome Database ID Release 7510673064Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673064ReactomeR-DDI-32225931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222593.1Histone demethylase KDM6B (JMJD3) demethylates H3K27Me3 marks i.e. removes methyl groups from lysine 28 of histone HIST1H3A on CDKN2A locus, thereby activating CDKN2A transcription. In human cells, H3K27Me3 marks are predominantly found around the first exon of p16INK4A, and KDM6B therefore activates p16INK4A transcription but not p14ARF transcription. In mouse cells, H3K27Me3 marks are found throughout the Cdkn2a locus and Kdm6b demethylase activity induces transcription of both p16Ink4a and p19Arf. KDM6B action promotes both the oncogene-induced and oxidative stress-induced senescence (Agger et al. 2009, Barradas et al. 2009).19451218Pubmed2009Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RASBarradas, MartaAnderton, EmmaAcosta, Juan CarlosLi, SideBanito, AnaRodriguez-Niedenführ, MarcMaertens, GoedeleBanck, MichaelaZhou, Ming-MingWalsh, Martin JPeters, GordonGil, JesúsGenes Dev. 23:1177-8219451217Pubmed2009The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescenceAgger, KarlCloos, Paul A CRudkjaer, LiseWilliams, KristineAndersen, GitteChristensen, JesperHelin, KristianGenes Dev. 23:1171-6inferred from electronic annotationEVIDENCE CODEECO:0000203