BioPAX pathway converted from "Enzyme-bound ATP is released" in the Reactome database. LEFT-TO-RIGHT Enzyme-bound ATP is released This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> H+ hydron Reactome DB_ID: 163953 mitochondrial intermembrane space GENE ONTOLOGY GO:0005758 hydron [ChEBI:15378] hydron ChEBI CHEBI:15378 Reactome Database ID Release 83 163953 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=163953 Reactome R-ALL-163953 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-163953.3 Reactome http://www.reactome.org COMPOUND C00080 additional information MI MI:0361 3 ATPase:ATP Reactome DB_ID: 10680328 mitochondrial inner membrane GENE ONTOLOGY GO:0005743 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113593 mitochondrial matrix GENE ONTOLOGY GO:0005759 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 83 113593 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113593 Reactome R-ALL-113593 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113593.4 COMPOUND C00002 1 F1Fo ATP synthase Reactome DB_ID: 10680324 ATP5O ATPsynO Q24439 Reactome DB_ID: 10680315 UniProt:Q24439 ATPsynO Drosophila melanogaster NCBI Taxonomy 7227 UniProt Q24439 24 EQUAL 213 EQUAL Reactome Database ID Release 83 10680315 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680315 Reactome R-DME-164533 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164533.1 1 ATPase CF(0) Reactome DB_ID: 10680310 ATP5H ATPsynD Q24251 Reactome DB_ID: 10680272 UniProt:Q24251 ATPsynD UniProt Q24251 2 EQUAL 161 EQUAL Reactome Database ID Release 83 10680272 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680272 Reactome R-DME-50522 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-50522.1 1 ATP5J2 ATPsynF Q9W141 Reactome DB_ID: 10680282 UniProt:Q9W141 ATPsynF UniProt Q9W141 2 EQUAL 94 EQUAL Reactome Database ID Release 83 10680282 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680282 Reactome R-DME-50516 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-50516.1 1 ATP5G1 ATPsynC Q6NN09 Reactome DB_ID: 10680299 UniProt:Q6NN09 ATPsynC UniProt Q6NN09 62 EQUAL 136 EQUAL Reactome Database ID Release 83 10680299 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680299 Reactome R-DME-164535 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164535.1 1 Ghost homologue of MT-ATP8 Reactome DB_ID: 10680289 Reactome Database ID Release 83 10680289 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680289 Reactome R-DME-50500 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-50500.1 1 ATP5J ATPsynCF6 Q24407 Reactome DB_ID: 10680294 UniProt:Q24407 ATPsynCF6 UniProt Q24407 33 EQUAL 108 EQUAL Reactome Database ID Release 83 10680294 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680294 Reactome R-DME-164532 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164532.1 1 ATP5G2 ATPsynC Q6NN09 Reactome DB_ID: 10680306 mitochondrial outer membrane GENE ONTOLOGY GO:0005741 67 EQUAL 141 EQUAL Reactome Database ID Release 83 10680306 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680306 Reactome R-DME-5215956 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5215956.1 1 P00850 mt:ATPase6 MT-ATP6 Reactome DB_ID: 10680267 UniProt:P00850 mt:ATPase6 UniProt P00850 1 EQUAL 226 EQUAL Reactome Database ID Release 83 10680267 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680267 Reactome R-DME-50498 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-50498.1 1 ATP5F1 ATPsynB Q94516 Reactome DB_ID: 10680304 UniProt:Q94516 ATPsynB UniProt Q94516 43 EQUAL 256 EQUAL Reactome Database ID Release 83 10680304 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680304 Reactome R-DME-164537 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164537.1 1 ATP5L ATPsynG Q9VKM3 Reactome DB_ID: 10680287 UniProt:Q9VKM3 ATPsynG UniProt Q9VKM3 2 EQUAL 103 EQUAL Reactome Database ID Release 83 10680287 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680287 Reactome R-DME-50518 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-50518.1 1 ATP5I ATPsynE O77134 Reactome DB_ID: 10680277 UniProt:O77134 ATPsynE UniProt O77134 2 EQUAL 69 EQUAL Reactome Database ID Release 83 10680277 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680277 Reactome R-DME-50514 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-50514.1 1 ATP5G3 ATPsynC Q6NN09 Reactome DB_ID: 10680308 68 EQUAL 142 EQUAL Reactome Database ID Release 83 10680308 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680308 Reactome R-DME-5216110 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5216110.1 1 Reactome Database ID Release 83 10680310 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680310 Reactome R-DME-74185 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74185.1 1 ATPase CF(1) Reactome DB_ID: 10680262 ATP5B Q05825 Reactome DB_ID: 10680245 UniProt:Q05825 UniProt Q05825 48 EQUAL 529 EQUAL Reactome Database ID Release 83 10680245 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680245 Reactome R-DME-164576 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164576.1 3 ATP5C1 ATPsyngamma O01666 Reactome DB_ID: 10680250 UniProt:O01666 ATPsyngamma UniProt O01666 26 EQUAL 298 EQUAL Reactome Database ID Release 83 10680250 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680250 Reactome R-DME-164577 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164577.1 1 ATP5A1 P35381 Reactome DB_ID: 10680240 UniProt:P35381 UniProt P35381 44 EQUAL 553 EQUAL Reactome Database ID Release 83 10680240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680240 Reactome R-DME-164575 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164575.1 3 ATP5D ATPsyndelta Q9W2X6 Reactome DB_ID: 10680255 UniProt:Q9W2X6 ATPsyndelta UniProt Q9W2X6 23 EQUAL 168 EQUAL Reactome Database ID Release 83 10680255 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680255 Reactome R-DME-164574 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164574.1 1 sun ATP5E Q9VXN2 Reactome DB_ID: 10680260 UniProt:Q9VXN2 sun UniProt Q9VXN2 2 EQUAL 51 EQUAL Reactome Database ID Release 83 10680260 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680260 Reactome R-DME-50508 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-50508.1 1 Reactome Database ID Release 83 10680262 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680262 Reactome R-DME-74184 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74184.1 1 ATP5S tetramer Reactome DB_ID: 10680322 ATPW ATP5S A1ZAA9 Reactome DB_ID: 10680320 UniProt:A1ZAA9 ATPW UniProt A1ZAA9 41 EQUAL 215 EQUAL Reactome Database ID Release 83 10680320 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680320 Reactome R-DME-5215992 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5215992.1 4 Reactome Database ID Release 83 10680322 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680322 Reactome R-DME-5252095 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5252095.1 1 Reactome Database ID Release 83 10680324 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680324 Reactome R-DME-74186 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74186.1 1 Reactome Database ID Release 83 10680328 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680328 Reactome R-DME-164835 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164835.1 H+ hydron Reactome DB_ID: 113529 Reactome Database ID Release 83 113529 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529 Reactome R-ALL-113529 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113529.4 COMPOUND C00080 3 ACTIVATION activeUnit: #Complex2 GENE ONTOLOGY GO:0015078 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 83 10680332 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680332 Reactome Database ID Release 83 10680334 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680334 Reactome R-DME-164834 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-164834.1 GENE ONTOLOGY GO:0042776 gene ontology term for cellular process MI MI:0359 In the last step, the beta subunit is converted to the open form and ATP is released. Passage of protons through the Fo part causes a ring of approximately 10 subunits to rotate. This rotation in turn drives the rotation of the gamma subunits, which forms part of one of the stalks. The gamma subunit moves between the three beta subunits which are held in place by the second stalk which can be regarded as a stator. The polypeptide called OSCP connects the stator stalk to the assembly of alpha and beta subunits. It is this step that is coupled to proton translocation as energy is required to break the strong bond between ATP and the protein. 4517936 Pubmed 1973 A new concept for energy coupling in oxidative phosphorylation based on a Boyer, PD Cross, RL Momsen, W Proc Natl Acad Sci U S A 70:2837-9 inferred from electronic annotation EVIDENCE CODE ECO:0000203