BioPAX pathway converted from "Ca permeable AMPA receptor ligand binding" in the Reactome database. LEFT-TO-RIGHT Ca permeable AMPA receptor ligand binding This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> L-Glu L-Glutamate L-glutamate(1-) L-glutamic acid L-Glutaminic acid Reactome DB_ID: 210382 extracellular region GENE ONTOLOGY GO:0005576 L-glutamate(1-) [ChEBI:29985] L-glutamate(1-) L-glutamic acid, ion(1-) [NH3+][C@@H](CCC([O-])=O)C([O-])=O WHUUTDBJXJRKMK-VKHMYHEASA-M C5H8NO4 146.12136 (2S)-2-ammoniopentanedioate hydrogen L-glutamate L-glutamate L-glutamic acid monoanion InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 ChEBI CHEBI:29985 Reactome Database ID Release 82 210382 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=210382 Reactome R-ALL-210382 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-210382.4 Reactome http://www.reactome.org COMPOUND C00025 additional information MI MI:0361 Converted from EntitySet in Reactome Ca permeable AMPA receptors Reactome DB_ID: 10683557 AMPA receptors containing GluR1 (heteromers) Reactome DB_ID: 10683553 plasma membrane GENE ONTOLOGY GO:0005886 GRIA1 GluRIB M9PHV5 Reactome DB_ID: 10683540 UniProt:M9PHV5 GluRIB Drosophila melanogaster NCBI Taxonomy 7227 UniProt M9PHV5 19 EQUAL 906 EQUAL Reactome Database ID Release 82 10683540 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683540 Reactome R-DME-3004495 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004495.1 2 Converted from EntitySet in Reactome GRIA3,GRIA4 GluR3/GluR4 Reactome DB_ID: 10683520 Converted from EntitySet in Reactome Homologues of GRIA3 Reactome DB_ID: 10683502 Ir25a GRIA3 E9NA96 Reactome DB_ID: 10683473 UniProt:E9NA96 Ir25a UniProt E9NA96 29 EQUAL 894 EQUAL Reactome Database ID Release 82 10683473 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683473 Reactome R-DME-3004508 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508.1 GRIA3 GluRIB M9PHV5 Reactome DB_ID: 10683475 29 EQUAL 894 EQUAL Reactome Database ID Release 82 10683475 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683475 Reactome R-DME-3004508-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508-2.1 GRIA3 GluRIA Q03445 Reactome DB_ID: 10683480 UniProt:Q03445 GluRIA UniProt Q03445 29 EQUAL 894 EQUAL Reactome Database ID Release 82 10683480 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683480 Reactome R-DME-3004508-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508-3.1 Ir93a GRIA3 Q9VDH6 Reactome DB_ID: 10683485 UniProt:Q9VDH6 Ir93a UniProt Q9VDH6 29 EQUAL 894 EQUAL Reactome Database ID Release 82 10683485 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683485 Reactome R-DME-3004508-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508-4.1 Ir64a GRIA3 Q9VRL4 Reactome DB_ID: 10683490 UniProt:Q9VRL4 Ir64a UniProt Q9VRL4 29 EQUAL 894 EQUAL Reactome Database ID Release 82 10683490 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683490 Reactome R-DME-3004508-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508-5.1 Ir76b GRIA3 Q9VW78 Reactome DB_ID: 10683495 UniProt:Q9VW78 Ir76b UniProt Q9VW78 29 EQUAL 894 EQUAL Reactome Database ID Release 82 10683495 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683495 Reactome R-DME-3004508-6 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508-6.1 Ir8a GRIA3 Q9W365 Reactome DB_ID: 10683500 UniProt:Q9W365 Ir8a UniProt Q9W365 29 EQUAL 894 EQUAL Reactome Database ID Release 82 10683500 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683500 Reactome R-DME-3004508-7 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508-7.1 Reactome Database ID Release 82 10683502 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683502 Reactome R-DME-3004508-8 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3004508-8.1 Converted from EntitySet in Reactome Homologues of GRIA4 Reactome DB_ID: 10683518 Ir25a GRIA4 E9NA96 Reactome DB_ID: 10683504 21 EQUAL 902 EQUAL Reactome Database ID Release 82 10683504 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683504 Reactome R-DME-392229 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229.1 GRIA4 GluRIB M9PHV5 Reactome DB_ID: 10683506 21 EQUAL 902 EQUAL Reactome Database ID Release 82 10683506 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683506 Reactome R-DME-392229-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229-2.1 GRIA4 GluRIA Q03445 Reactome DB_ID: 10683508 21 EQUAL 902 EQUAL Reactome Database ID Release 82 10683508 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683508 Reactome R-DME-392229-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229-3.1 Ir93a GRIA4 Q9VDH6 Reactome DB_ID: 10683510 21 EQUAL 902 EQUAL Reactome Database ID Release 82 10683510 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683510 Reactome R-DME-392229-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229-4.1 Ir64a GRIA4 Q9VRL4 Reactome DB_ID: 10683512 21 EQUAL 902 EQUAL Reactome Database ID Release 82 10683512 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683512 Reactome R-DME-392229-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229-5.1 Ir76b GRIA4 Q9VW78 Reactome DB_ID: 10683514 21 EQUAL 902 EQUAL Reactome Database ID Release 82 10683514 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683514 Reactome R-DME-392229-6 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229-6.1 Ir8a GRIA4 Q9W365 Reactome DB_ID: 10683516 21 EQUAL 902 EQUAL Reactome Database ID Release 82 10683516 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683516 Reactome R-DME-392229-7 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229-7.1 Reactome Database ID Release 82 10683518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683518 Reactome R-DME-392229-8 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392229-8.1 Reactome Database ID Release 82 10683520 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683520 Reactome R-DME-399698 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-399698.1 2 Reactome Database ID Release 82 10683553 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683553 Reactome R-DME-399696 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-399696.1 GluR1 receptors Reactome DB_ID: 10683555 4 Reactome Database ID Release 82 10683555 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683555 Reactome R-DME-399700 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-399700.1 Reactome Database ID Release 82 10683557 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683557 Reactome R-DME-399714 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-399714.1 Ca permeable AMPA receptor ligand complex Reactome DB_ID: 10683559 1 1 Reactome Database ID Release 82 10683559 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683559 Reactome R-DME-420976 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-420976.1 Reactome Database ID Release 82 10684330 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10684330 Reactome R-DME-420977 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-420977.1 AMPA receptors bind glutamate, released in the synaptic cleft by the presynaptic cell, in the ligand binding region in the N terminal domain. 14567697 Pubmed 2003 Channel-opening kinetics of GluR2Q(flip) AMPA receptor: a laser-pulse photolysis study Li, G Pei, W Niu, L Biochemistry 42:12358-66 19144831 Pubmed 2009 Agonist occupancy is essential for forward trafficking of AMPA receptors Coleman, SK Möykkynen, T Jouppila, A Koskelainen, S Rivera, C Korpi, ER Keinänen, K J Neurosci 29:303-12 inferred from electronic annotation EVIDENCE CODE ECO:0000203