BioPAX pathway converted from "DNA replication initiation" in the Reactome database.DNA replication initiationThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHT2.7.7.6The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the originThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>DNA polymerase alpha:primase:DNA polymerase alpha:origin complexReactome DB_ID: 10644544nucleoplasmGENE ONTOLOGYGO:0005654DNA polymerase epsilon:origin complexReactome DB_ID: 10644542DNA polymerase epsilonReactome DB_ID: 10644540polePOLEQ54RD4Reactome DB_ID: 10644523UniProt:Q54RD4poleDictyostelium discoideumNCBI Taxonomy44689UniProtQ54RD41EQUAL2286EQUALReactome Database ID Release 7510644523Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644523ReactomeR-DDI-684731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68473.1Reactomehttp://www.reactome.org1pole3POLE3Q75JQ9Reactome DB_ID: 10644533UniProt:Q75JQ9pole3UniProtQ75JQ92EQUAL147EQUALReactome Database ID Release 7510644533Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644533ReactomeR-DDI-88666851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-8866685.11pole2POLE2Q54Y85Reactome DB_ID: 10644528UniProt:Q54Y85pole2UniProtQ54Y851EQUAL527EQUALReactome Database ID Release 7510644528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644528ReactomeR-DDI-684821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68482.11POLE4Q7KWN0Reactome DB_ID: 10644538UniProt:Q7KWN0UniProtQ7KWN02EQUAL117EQUALReactome Database ID Release 7510644538Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644538ReactomeR-DDI-88666841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-8866684.11Reactome Database ID Release 7510644540Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644540ReactomeR-DDI-684831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68483.11ARSorigin of replicationoriginautonomously replicating sequenceReactome DB_ID: 68419Reactome Database ID Release 7568419Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68419ReactomeR-ALL-684192Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-68419.2ChEBI61120additional informationMIMI:03611Reactome Database ID Release 7510644542Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644542ReactomeR-DDI-684851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68485.11DNA polymerase alpha:primaseReactome DB_ID: 10644518pola1POLA1Q54SV8Reactome DB_ID: 10644499UniProt:Q54SV8pola1UniProtQ54SV81EQUAL1462EQUALReactome Database ID Release 7510644499Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644499ReactomeR-DDI-684871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68487.11polA2POLA2Q54S08Reactome DB_ID: 10644504UniProt:Q54S08polA2UniProtQ54S081EQUAL598EQUALReactome Database ID Release 7510644504Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644504ReactomeR-DDI-684931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68493.11PRIM1:PRIM2Reactome DB_ID: 10644516PRIM1Q54MM7Reactome DB_ID: 10644509UniProt:Q54MM7UniProtQ54MM71EQUAL420EQUALReactome Database ID Release 7510644509Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644509ReactomeR-DDI-684971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68497.11prim2PRIM2Q55BM5Reactome DB_ID: 10644514UniProt:Q55BM5prim2UniProtQ55BM51EQUAL509EQUALReactome Database ID Release 7510644514Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644514ReactomeR-DDI-684951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68495.11Reactome Database ID Release 7510644516Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644516ReactomeR-DDI-96688121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-9668812.11Reactome Database ID Release 7510644518Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644518ReactomeR-DDI-685071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68507.11Reactome Database ID Release 7510644544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644544ReactomeR-DDI-685101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68510.1Converted from EntitySet in ReactomeNTPReactome DB_ID: 30595ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 29358ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 7529358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358ReactomeR-ALL-293583Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3COMPOUNDC00002CTPcytidine 5'-triphosphateCytidine triphosphateReactome DB_ID: 29470CTP [ChEBI:17677]CTPcytidine 5'-triphosphateCytidine triphosphateChEBICHEBI:17677Reactome Database ID Release 7529470Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29470ReactomeR-ALL-294702Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29470.2COMPOUNDC00063GTPGuanosine 5'-triphosphateReactome DB_ID: 113571GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBICHEBI:15996Reactome Database ID Release 75113571Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113571ReactomeR-ALL-1135712Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113571.2COMPOUNDC00044UTPuridine 5'-triphosphateUridine triphosphateReactome DB_ID: 113562UTP [ChEBI:15713]UTPuridine 5'-triphosphateUridine triphosphateChEBICHEBI:15713Reactome Database ID Release 75113562Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113562ReactomeR-ALL-1135622Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113562.2COMPOUNDC00075Reactome Database ID Release 7530595Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30595ReactomeR-ALL-305951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-30595.1COMPOUNDC00699RNA primer:origin duplex:DNA polymerase alpha:primase complexReactome DB_ID: 10644546RNA primerReactome DB_ID: 68422Reactome Database ID Release 7568422Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68422ReactomeR-ALL-684223Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-68422.3ChEBI33697111Reactome Database ID Release 7510644546Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644546ReactomeR-DDI-684231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68423.1ACTIVATIONactiveUnit: #Complex4GENE ONTOLOGYGO:0003899gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510644547Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644547Reactome Database ID Release 7510644549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10644549ReactomeR-DDI-689131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68913.1At the beginning of this reaction, 1 molecule of 'DNA polymerase alpha:primase:DNA polymerase alpha:origin complex', and 1 molecule of 'NTP' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon', and 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex' are present.<br><br> This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed RNA polymerase activity' of 'DNA polymerase alpha:primase'.<br>6693436Pubmed1984DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.Wang, TSHu, SZKorn, DJ Biol Chem 259:1854-65inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHT2.7.7.7The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the originThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>dATP2'-deoxyadenosine 5'-triphosphateDeoxyadenosine 5'-triphosphateDeoxyadenosine triphosphateReactome DB_ID: 29604dATP [ChEBI:16284]dATP2'-deoxyadenosine 5'-triphosphateDeoxyadenosine 5'-triphosphateDeoxyadenosine triphosphateChEBICHEBI:16284Reactome Database ID Release 7529604Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29604ReactomeR-ALL-296042Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29604.2COMPOUNDC00131dCTPdeoxycytidine 5'-triphosphateDeoxycytidine triphosphate2'-Deoxycytidine 5'-triphosphateReactome DB_ID: 30185dCTP [ChEBI:16311]dCTPdeoxycytidine 5'-triphosphateDeoxycytidine triphosphate2'-Deoxycytidine 5'-triphosphateChEBICHEBI:16311Reactome Database ID Release 7530185Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30185ReactomeR-ALL-301852Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-30185.2COMPOUNDC00458dGTP2'-deoxyguanosine 5'-triphosphateDeoxyguanosine 5'-triphosphateDeoxyguanosine triphosphateReactome DB_ID: 29892dGTP [ChEBI:16497]dGTP2'-deoxyguanosine 5'-triphosphateDeoxyguanosine 5'-triphosphateDeoxyguanosine triphosphateChEBICHEBI:16497Reactome Database ID Release 7529892Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29892ReactomeR-ALL-298922Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29892.2COMPOUNDC00286TTPdTTPDeoxythymidine triphosphateDeoxythymidine 5'-triphosphateReactome DB_ID: 30187dTTP [ChEBI:18077]dTTPDeoxythymidine triphosphateDeoxythymidine 5'-triphosphateTTPChEBICHEBI:18077Reactome Database ID Release 7530187Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30187ReactomeR-ALL-301872Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-30187.2COMPOUNDC00459RNA primer-DNA primer:origin duplexReactome DB_ID: 106451511DNA primerReactome DB_ID: 68424Reactome Database ID Release 7568424Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=68424ReactomeR-ALL-684242Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-68424.2ChEBI611201Reactome Database ID Release 7510645151Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10645151ReactomeR-DDI-684251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68425.1ACTIVATIONGENE ONTOLOGYGO:0003887Reactome Database ID Release 7510645152Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10645152Reactome Database ID Release 7510645154Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10645154ReactomeR-DDI-689501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68950.1At the beginning of this reaction, 1 molecule of 'dTTP', 1 molecule of 'dGTP', 1 molecule of 'dATP', 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex', and 1 molecule of 'dCTP' are present. At the end of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present.<br><br> This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed DNA polymerase activity' of 'DNA polymerase alpha:primase'.<br>6094569Pubmed1984Purification of a DNA polymerase-DNA primase complex from calf thymus glandsChang, L MRafter, EAugl, CBollum, F JJ. Biol. Chem. 259:14679-87Reactome Database ID Release 7510696653Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10696653ReactomeR-DDI-689521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-68952.1GENE ONTOLOGYGO:0006270gene ontology term for cellular processMIMI:0359DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA (Frick & Richardson 2002; Wang et al 1984).11395402Pubmed2002DNA primases.Frick, DNRichardson, CCAnnu Rev Biochem 70:39-80