BioPAX pathway converted from "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane" in the Reactome database.LEFT-TO-RIGHT3.1.3PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>PI(3,5)P21-phosphatidyl-1D-myo-inositol 3,5-bisphosphateReactome DB_ID: 1806224plasma membraneGENE ONTOLOGYGO:00058861-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]1-phosphatidyl-1D-myo-inositol 3,5-bisphosphatePtsIns(3,5)P21,2-Diacyl-sn-glycero-3-phospho-(1&apos;-myo-inositol-3&apos;,5&apos;-bisphosphate)PtsIns-3,5-P2ChEBICHEBI:16851Reactome Database ID Release 751806224Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806224ReactomeR-ALL-18062243Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1806224.3Reactomehttp://www.reactome.orgH2OwaterReactome DB_ID: 29356cytosolGENE ONTOLOGYGO:0005829water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001additional informationMIMI:0361PiOrthophosphatehydrogenphosphatePhosphateInorganic PhosphateReactome DB_ID: 29372hydrogenphosphate [ChEBI:43474]hydrogenphosphatehydrogen phosphatephosphate[PO3(OH)](2-)INORGANIC PHOSPHATE GROUPHYDROGENPHOSPHATE IONHPO4(2-)[P(OH)O3](2-)ChEBICHEBI:43474Reactome Database ID Release 7529372Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372ReactomeR-ALL-293724Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4COMPOUNDC00009PI5P1-phosphatidyl-1D-myo-inositol 5-phosphateReactome DB_ID: 18062401-phosphatidyl-1D-myo-inositol 5-phosphate [ChEBI:16500]1-phosphatidyl-1D-myo-inositol 5-phosphatePI5PChEBICHEBI:16500Reactome Database ID Release 751806240Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806240ReactomeR-ALL-18062403Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1806240.3ACTIVATIONConverted from EntitySet in ReactomeSYNJ/MTM(1)MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2Reactome DB_ID: 10711735MTM1O13819Reactome DB_ID: 10711653UniProt:O13819Schizosaccharomyces pombeNCBI Taxonomy4896UniProtO138191EQUAL603EQUALReactome Database ID Release 7510711653Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711653ReactomeR-SPO-16046461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1604646.1MTMR1O13819Reactome DB_ID: 107117291EQUAL665EQUALReactome Database ID Release 7510711729Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711729ReactomeR-SPO-16046471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1604647.1MTMR3O13819Reactome DB_ID: 107117311EQUAL1198EQUALReactome Database ID Release 7510711731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711731ReactomeR-SPO-16046351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1604635.1MTMR6O13819Reactome DB_ID: 107117331EQUAL621EQUALReactome Database ID Release 7510711733Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711733ReactomeR-SPO-16046661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1604666.1syj1SYNJ1O43001Reactome DB_ID: 10711685UniProt:O43001syj1UniProtO430011EQUAL1573EQUALReactome Database ID Release 7510711685Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711685ReactomeR-SPO-16046341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1604634.1Converted from EntitySet in ReactomeHomologues of SYNJ2Reactome DB_ID: 10711694syj1SYNJ2O43001Reactome DB_ID: 107116871EQUAL1496EQUALReactome Database ID Release 7510711687Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711687ReactomeR-SPO-18061931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1806193.1syj2SYNJ2Q9USQ6Reactome DB_ID: 10711692UniProt:Q9USQ6syj2UniProtQ9USQ61EQUAL1496EQUALReactome Database ID Release 7510711692Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711692ReactomeR-SPO-1806193-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1806193-2.1Reactome Database ID Release 7510711694Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711694ReactomeR-SPO-1806193-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1806193-3.1Reactome Database ID Release 7510711735Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711735ReactomeR-SPO-18062231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1806223.1GENE ONTOLOGYGO:0052629gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510711796Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711796Reactome Database ID Release 7510711798Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711798ReactomeR-SPO-16762031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1676203.1At the plasma membrane, synaptojanin-1 aka Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1) (Guo et al. 1999), -2 (SYNJ2) and some myotubularins (MTMs) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P). The MTMs involved are: myotubularin (MTM1) (Cao et al. 2007, Tronchere et al. 2004, Schaletzky et al. 2003, Laporte et al. 2002) and myotubularin-related proteins 1 (MTMR1) (Tronchere et al. 2004), 3 (MTMR3) (Walker et al. 2001, Lorenzo et al. 2005), 6 (MTMR6) (Schaletzky et al. 2003, Choudhury et al. 2006), and 14 (MTMR14) (Tosch et al. 2006).14660569Pubmed2004Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cellsTronchère, HLaporte, JPendaries, CChaussade, CLiaubet, LPirola, LMandel, JLPayrastre, BJ Biol Chem 279:7304-1215840652Pubmed2005Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3Lorenzo, OUrbé, SClague, MJJ Cell Sci 118:2005-1212646134Pubmed2003Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatasesSchaletzky, JDove, SKShort, BLorenzo, OClague, MJBarr, Francis ACurr Biol 13:504-911676921Pubmed2001Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificityWalker, DMUrbé, SDove, SKTenza, DRaposo, GClague, MJCurr Biol 11:1600-517651088Pubmed2007Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomesCao, CLaporte, JBacker, JMWandinger-Ness, AStein, MPTraffic 8:1052-6717008356Pubmed2006A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathyTosch, VRohde, HMTronchère, HZanoteli, EMonroy, NKretz, CDondaine, NPayrastre, BMandel, JLLaporte, JHum Mol Genet 15:3098-10610224048Pubmed1999SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatasesGuo, SStolz, LELemrow, SMYork, JDJ Biol Chem 274:12990-512118066Pubmed2002The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane rufflesLaporte, JBlondeau, FGansmuller, ALutz, YVonesch, JLMandel, JLJ Cell Sci 115:3105-1716914545Pubmed2006Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domainChoudhury, PSrivastava, SLi, ZKo, KAlbaqumi, MNarayan, KCoetzee, WALemmon, MASkolnik, EYJ Biol Chem 281:31762-9inferred from electronic annotationEVIDENCE CODEECO:0000203