BioPAX pathway converted from "SMURF2 binds AXIN" in the Reactome database. LEFT-TO-RIGHT SMURF2 binds AXIN This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Smurf SMURF2 Q9V853 Reactome DB_ID: 10681616 cytosol GENE ONTOLOGY GO:0005829 UniProt:Q9V853 Smurf Drosophila melanogaster NCBI Taxonomy 7227 UniProt Q9V853 1 EQUAL 748 EQUAL Reactome Database ID Release 83 10681616 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10681616 Reactome R-DME-173537 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-173537.1 Reactome http://www.reactome.org Axn AXIN1 Q9V407 Reactome DB_ID: 10684353 UniProt:Q9V407 Axn Axn CG7926 FUNCTION Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).SUBUNIT Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.DEVELOPMENTAL STAGE Ubiquitously expressed throughout the development. UniProt Q9V407 1 EQUAL 862 EQUAL Reactome Database ID Release 83 10684353 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10684353 Reactome R-DME-195249 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-195249.1 AXIN:SMURF2 Reactome DB_ID: 10717790 1 1 Reactome Database ID Release 83 10717790 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10717790 Reactome R-DME-4641136 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-4641136.1 Reactome Database ID Release 83 10717802 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10717802 Reactome R-DME-4641134 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-4641134.1 SMURF2 is an E3 ubiquitin ligase for AXIN and promotes its ubiquitin-mediated degradation. Ectopic SMURF2 immunoprecipitates both exogenously expressed and endogenous AXIN. AXIN is polyubiquitinated by SMURF2 at lysine 505 both in vitro and in vivo (Kim and Jho, 2012). 20858899 Pubmed 2010 The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2) Kim, Sewoon Jho, Eek-hoon J. Biol. Chem. 285:36420-6 inferred from electronic annotation EVIDENCE CODE ECO:0000203