BioPAX pathway converted from "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" in the Reactome database.RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTRecognition and Binding of Core Promoter Elements by TFIIDThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TFIIDReactome DB_ID: 10701907nucleoplasmGENE ONTOLOGYGO:0005654taf12TAF12O13722Reactome DB_ID: 10701858UniProt:O13722taf12Schizosaccharomyces pombeNCBI Taxonomy4896UniProtO137221EQUAL161EQUALReactome Database ID Release 7510701858Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701858ReactomeR-SPO-655551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65555.1Reactomehttp://www.reactome.org1taf7TAF7O13701Reactome DB_ID: 10701901UniProt:O13701taf7UniProtO137011EQUAL349EQUALReactome Database ID Release 7510701901Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701901ReactomeR-SPO-2123471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-212347.11Converted from EntitySet in ReactomeHomologues of TAF13Reactome DB_ID: 10701853spt3TAF13O14311Reactome DB_ID: 10701846UniProt:O14311spt3UniProtO143111EQUAL124EQUALReactome Database ID Release 7510701846Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701846ReactomeR-SPO-655571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65557.1taf13TAF13O60076Reactome DB_ID: 10701851UniProt:O60076taf13UniProtO600761EQUAL124EQUALReactome Database ID Release 7510701851Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701851ReactomeR-SPO-65557-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65557-2.1Reactome Database ID Release 7510701853Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701853ReactomeR-SPO-65557-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65557-3.11Ghost homologue of TAF3Reactome DB_ID: 10701885Reactome Database ID Release 7510701885Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701885ReactomeR-SPO-2124461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-212446.11taf4TAF4BQ9P7S4Reactome DB_ID: 10701839UniProt:Q9P7S4taf4UniProtQ9P7S41EQUAL862EQUALReactome Database ID Release 7510701839Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701839ReactomeR-SPO-655591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65559.11Ghost homologue of TAF15Reactome DB_ID: 10701905Reactome Database ID Release 7510701905Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701905ReactomeR-SPO-90206801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-9020680.11Converted from EntitySet in ReactomeTAF1,TAF1LReactome DB_ID: 10701896TAF1Q09813Reactome DB_ID: 10701892UniProt:Q09813UniProtQ098131EQUAL1872EQUALReactome Database ID Release 7510701892Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701892ReactomeR-SPO-655391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65539.1TAF1LQ09813Reactome DB_ID: 107018941EQUAL1826EQUALReactome Database ID Release 7510701894Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701894ReactomeR-SPO-2124351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-212435.1Reactome Database ID Release 7510701896Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701896ReactomeR-SPO-54208801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5420880.11TBPtbp1P17871Reactome DB_ID: 10701637UniProt:P17871tbp1UniProtP178711EQUAL339EQUALReactome Database ID Release 7510701637Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701637ReactomeR-SPO-837181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-83718.11taf11TAF11Q9US54Reactome DB_ID: 10701863UniProt:Q9US54taf11UniProtQ9US541EQUAL211EQUALReactome Database ID Release 7510701863Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701863ReactomeR-SPO-655531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65553.11taf10TAF10O60171Reactome DB_ID: 10701868UniProt:O60171taf10UniProtO601711EQUAL218EQUALReactome Database ID Release 7510701868Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701868ReactomeR-SPO-655511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65551.11taf2TAF2P87121Reactome DB_ID: 10701883UniProt:P87121taf2UniProtP871211EQUAL1199EQUALReactome Database ID Release 7510701883Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701883ReactomeR-SPO-2124081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-212408.11taf5TAF5O13282Reactome DB_ID: 10701834UniProt:O13282taf5UniProtO132821EQUAL800EQUALReactome Database ID Release 7510701834Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701834ReactomeR-SPO-655431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65543.11taf9TAF9BQ09869Reactome DB_ID: 10701887UniProt:Q09869taf9UniProtQ098691EQUAL251EQUALReactome Database ID Release 7510701887Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701887ReactomeR-SPO-2124041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-212404.11taf4TAF4Q9P7S4Reactome DB_ID: 107018411EQUAL1085EQUALReactome Database ID Release 7510701841Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701841ReactomeR-SPO-655411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65541.11taf9TAF9Q09869Reactome DB_ID: 107018781EQUAL264EQUALReactome Database ID Release 7510701878Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701878ReactomeR-SPO-2124521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-212452.11taf6TAF6O74462Reactome DB_ID: 10701873UniProt:O74462taf6UniProtO744621EQUAL677EQUALReactome Database ID Release 7510701873Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701873ReactomeR-SPO-655451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65545.11Reactome Database ID Release 7510701907Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701907ReactomeR-SPO-1096261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109626.1DNA containing RNA Polymerase II promoterReactome DB_ID: 109627Reactome Database ID Release 75109627Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109627ReactomeR-ALL-1096272Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109627.2ChEBI61120additional informationMIMI:0361pol II promoter:TFIID complexReactome DB_ID: 1070217311Reactome Database ID Release 7510702173Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702173ReactomeR-SPO-1096281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109628.1Reactome Database ID Release 7510702938Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702938ReactomeR-SPO-1096361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109636.1Although TBP (TATA box binding factor) is necessary and sufficient for initiation of basal transcription, the other subunits of the general transcription factor TFIID, the TBP-associated factors, are required for response to transcriptional activators. TBP binds to the TATA box (a core promoter element), and bends the DNA 80 degrees toward the major groove. This conformation of TBP-TATA box provides the proper topology for the binding of the general transcription factor TFIIB.<p>Transcriptional activators function by affecting the kinetics of binding of TBP to the promoter DNA.8330735Pubmed1993TBP, a universal eukaryotic transcription factor?Hernandez, NouriaGenes Dev 7:1291-3088946909Pubmed1997The general transcription factors of RNA polymerase II.Orphanides, GLagrange, TReinberg, DannyGenes Dev 10:2657-83inferred from electronic annotationEVIDENCE CODEECO:0000203LEFT-TO-RIGHTBinding of TFIIA and TFIIB to the pol II promoter:TFIID complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TFIIAReactome DB_ID: 10701824toa2GTF2A2O74948Reactome DB_ID: 10701822UniProt:O74948toa2UniProtO749481EQUAL109EQUALReactome Database ID Release 7510701822Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701822ReactomeR-SPO-655331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65533.11toa1GTF2A1(275-376)Q9USU9Reactome DB_ID: 10701817UniProt:Q9USU9toa1UniProtQ9USU9275EQUAL376EQUALReactome Database ID Release 7510701817Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701817ReactomeR-SPO-1097681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109768.11toa1GTF2A1(1-274)Q9USU9Reactome DB_ID: 107018151EQUAL274EQUALReactome Database ID Release 7510701815Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701815ReactomeR-SPO-1097671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109767.11Reactome Database ID Release 7510701824Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701824ReactomeR-SPO-1096291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109629.1sua7GTF2BO13749Reactome DB_ID: 10701829UniProt:O13749sua7UniProtO137491EQUAL316EQUALReactome Database ID Release 7510701829Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701829ReactomeR-SPO-658881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65888.1pol II promoter:TFIID:TFIIA:TFIIB complexReactome DB_ID: 10702175111Reactome Database ID Release 7510702175Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702175ReactomeR-SPO-1096301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109630.1Reactome Database ID Release 7510702940Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702940ReactomeR-SPO-1096371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109637.1The general transcription factor TFIIB is a single polypeptide of approximately 35 kDa. There is a Zn-binding domain near the N terminus of TFIIB, and the C-terminal domain encompasses two imperfect repeats; between the N and C termini is a phylogenetically conserved region. The C terminus interacts with TBP and RNA Polymerase II, whereas the N terminus interacts with factor TFIIF and RNA polymerase II. TFIIB is a sequence-specific factor, and it interacts with the BRE element within the promoter.<p>TFIIB interacts with the Rpb1 subunit of RNA polymerase II to define transcription strat sites. Several activators directly bind TFIIB, and stimulate transcription. The N-terminus and the C-terminus can participate in intramolecular interactions, and this can be disrupted by specific activators by causing a conformational change in TFIIB.<p> TFIIA also binds the preinitiation complex along with TFIIB. However, TFIIA is not required for accurate initiation, but rather functions as a coactivator of transcription.LEFT-TO-RIGHTRecruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>RNA Polymerase II (unphosphorylated):TFIIF complexReactome DB_ID: 10700579RNA Polymerase II holoenzyme complex (unphosphorylated)Reactome DB_ID: 10700577rpc10POLR2KP48011Reactome DB_ID: 10700538UniProt:P48011rpc10UniProtP480111EQUAL58EQUALReactome Database ID Release 7510700538Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700538ReactomeR-SPO-635371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63537.11rpb8POLR2HQ92399Reactome DB_ID: 10700533UniProt:Q92399rpb8UniProtQ923992EQUAL150EQUALReactome Database ID Release 7510700533Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700533ReactomeR-SPO-635231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63523.11rpb1POLR2AP36594Reactome DB_ID: 10700575UniProt:P36594rpb1UniProtP365941EQUAL1970EQUALReactome Database ID Release 7510700575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700575ReactomeR-SPO-635021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63502.11rpb5POLR2EQ09191Reactome DB_ID: 10700543UniProt:Q09191rpb5UniProtQ091911EQUAL210EQUALReactome Database ID Release 7510700543Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700543ReactomeR-SPO-837131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-83713.11rpb7POLR2GO14459Reactome DB_ID: 10700523UniProt:O14459rpb7UniProtO144591EQUAL172EQUALReactome Database ID Release 7510700523Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700523ReactomeR-SPO-635171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63517.11rpb2POLR2BQ02061Reactome DB_ID: 10700513UniProt:Q02061rpb2UniProtQ020611EQUAL1174EQUALReactome Database ID Release 7510700513Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700513ReactomeR-SPO-635041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63504.11rpb3POLR2CP37382Reactome DB_ID: 10700528UniProt:P37382rpb3UniProtP373822EQUAL275EQUALReactome Database ID Release 7510700528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700528ReactomeR-SPO-635061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63506.11rpb11POLR2JP87123Reactome DB_ID: 10700503UniProt:P87123rpb11UniProtP871231EQUAL117EQUALReactome Database ID Release 7510700503Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700503ReactomeR-SPO-635311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63531.11rpb9POLR2IO74635Reactome DB_ID: 10700508UniProt:O74635rpb9UniProtO746351EQUAL125EQUALReactome Database ID Release 7510700508Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700508ReactomeR-SPO-635251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63525.11rpb6POLR2FP36595Reactome DB_ID: 10700548UniProt:P36595rpb6UniProtP365952EQUAL127EQUALReactome Database ID Release 7510700548Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700548ReactomeR-SPO-837141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-83714.11rpb10POLR2LO13877Reactome DB_ID: 10700553UniProt:O13877rpb10UniProtO138771EQUAL67EQUALReactome Database ID Release 7510700553Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700553ReactomeR-SPO-837151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-83715.11rpb4POLR2DO74825Reactome DB_ID: 10700518UniProt:O74825rpb4UniProtO748251EQUAL142EQUALReactome Database ID Release 7510700518Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700518ReactomeR-SPO-635081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-63508.11Reactome Database ID Release 7510700577Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700577ReactomeR-SPO-1134011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-113401.11TFIIFReactome DB_ID: 10700567tfg2GTF2F2O94424Reactome DB_ID: 10700565UniProt:O94424tfg2UniProtO944242EQUAL249EQUALReactome Database ID Release 7510700565Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700565ReactomeR-SPO-655671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65567.11tfg1GTF2F1O94416Reactome DB_ID: 10700560UniProt:O94416tfg1UniProtO944162EQUAL517EQUALReactome Database ID Release 7510700560Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700560ReactomeR-SPO-655651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65565.11Reactome Database ID Release 7510700567Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700567ReactomeR-SPO-1096311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109631.11Reactome Database ID Release 7510700579Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700579ReactomeR-SPO-713071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-71307.1pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complexReactome DB_ID: 1070217711Reactome Database ID Release 7510702177Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702177ReactomeR-SPO-1096321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109632.1Reactome Database ID Release 7510702942Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702942ReactomeR-SPO-1096381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109638.1The general transcription factor TFIIF has a high affinity for the RNA Polymerase II holoenzyme. TFIIF stabilizes the preinitiation complex, and suppresses non-specific binding of RNA Pol II to DNA, and is thus critical for start site recognition.LEFT-TO-RIGHTBinding of TFIIE to the growing preinitiation complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TFIIEReactome DB_ID: 10701919tfa1GTF2E1Q9P3W1Reactome DB_ID: 10701912UniProt:Q9P3W1tfa1UniProtQ9P3W12EQUAL439EQUALReactome Database ID Release 7510701912Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701912ReactomeR-SPO-655611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65561.11tfa2GTF2E2P79011Reactome DB_ID: 10701917UniProt:P79011tfa2UniProtP790111EQUAL291EQUALReactome Database ID Release 7510701917Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701917ReactomeR-SPO-655631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65563.11Reactome Database ID Release 7510701919Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701919ReactomeR-SPO-1096331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109633.1pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complexReactome DB_ID: 1070217911Reactome Database ID Release 7510702179Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702179ReactomeR-SPO-758711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-75871.1Reactome Database ID Release 7510702181Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702181ReactomeR-SPO-750951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-75095.1Factor TFIIE enters the preinitiation complex after TFIIF recruits RNA Polymerase II. TFIIE is composed of two subunits of 56 kDA and 34 kDa. TFIIE facilitates the recruitment of factor TFIIH to the preinitiation complex, and it also stimulates the phosphorylation of the RNA Polymerase II CTD by TFIIH.LEFT-TO-RIGHTFormation of the closed pre-initiation complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TFIIHReactome DB_ID: 10701699tfb1GTF2H1O13745Reactome DB_ID: 10701692UniProt:O13745tfb1UniProtO137451EQUAL548EQUALReactome Database ID Release 7510701692Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701692ReactomeR-SPO-659121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65912.11rad15ERCC2P26659Reactome DB_ID: 10701667UniProt:P26659rad15UniProtP266591EQUAL760EQUALReactome Database ID Release 7510701667Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701667ReactomeR-SPO-674431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-67443.11tfb2GTF2H4P87303Reactome DB_ID: 10701687UniProt:P87303tfb2UniProtP873031EQUAL462EQUALReactome Database ID Release 7510701687Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701687ReactomeR-SPO-659181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65918.11CAKReactome DB_ID: 10701662crk1CDK7Q12126Reactome DB_ID: 10701650UniProt:Q12126crk1UniProtQ121261EQUAL346EQUALReactome Database ID Release 7510701650Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701650ReactomeR-SPO-692181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-69218.11pmh1MNAT1O94684Reactome DB_ID: 10701660UniProt:O94684pmh1UniProtO946841EQUAL309EQUALReactome Database ID Release 7510701660Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701660ReactomeR-SPO-590121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-59012.11mcs2CCNHP36613Reactome DB_ID: 10701655UniProt:P36613mcs2UniProtP366131EQUAL323EQUALReactome Database ID Release 7510701655Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701655ReactomeR-SPO-692201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-69220.11Reactome Database ID Release 7510701662Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701662ReactomeR-SPO-692211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-69221.11tfb5GTF2H5Q9HDW3Reactome DB_ID: 10701697UniProt:Q9HDW3tfb5UniProtQ9HDW31EQUAL71EQUALReactome Database ID Release 7510701697Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701697ReactomeR-SPO-56884461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-5688446.11ptr8ERCC3O13768Reactome DB_ID: 10701672UniProt:O13768ptr8UniProtO137681EQUAL782EQUALReactome Database ID Release 7510701672Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701672ReactomeR-SPO-674391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-67439.11ssl1GTF2H2O74995Reactome DB_ID: 10701682UniProt:O74995ssl1UniProtO749951EQUAL395EQUALReactome Database ID Release 7510701682Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701682ReactomeR-SPO-659141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65914.11tfb4GTF2H3O74366Reactome DB_ID: 10701677UniProt:O74366tfb4UniProtO743661EQUAL308EQUALReactome Database ID Release 7510701677Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701677ReactomeR-SPO-659161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-65916.11Reactome Database ID Release 7510701699Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701699ReactomeR-SPO-1096341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109634.1pol II closed pre-initiation complexReactome DB_ID: 10702544111Reactome Database ID Release 7510702544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702544ReactomeR-SPO-1096351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109635.1Reactome Database ID Release 7510702944Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702944ReactomeR-SPO-1096391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109639.1The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.Reactome Database ID Release 7510725474Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10725474ReactomeR-SPO-737791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-73779.1GENE ONTOLOGYGO:0006367gene ontology term for cellular processMIMI:0359Formation of the pre-initiation complex proceeds in five steps, recognition and binding of core promoter elements by TFIID, binding of TFIIA and TFIIB to the pol II promoter:TFIID complex, recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex, binding of TFIIE to the growing preinitiation complex, and formation of the closed pre-initiation complex (Orphanides et al. 1997).