BioPAX pathway converted from "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2" in the Reactome database.LEFT-TO-RIGHT4.1.1.50S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>SAMAdoMetS-adenosylmethionineS-adenosyl-L-methionineReactome DB_ID: 71284cytosolGENE ONTOLOGYGO:0005829S-adenosyl-L-methionine [ChEBI:15414]S-adenosyl-L-methionineChEBICHEBI:15414Reactome Database ID Release 7571284Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71284ReactomeR-ALL-712844Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-71284.4Reactomehttp://www.reactome.orgCOMPOUNDC00019additional informationMIMI:0361SAMdc-AdoMetdecarboxyAdoMetS-adenosylmethioninamineDecarboxylated AdoMetReactome DB_ID: 353113S-adenosylmethioninamine [ChEBI:15625]S-adenosylmethioninamineS--adenosylmethioninamine(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium saltS-Adenosyl-3-methylthiopropylamine[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulfoniumChEBICHEBI:15625Reactome Database ID Release 75353113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=353113ReactomeR-ALL-3531135Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-353113.5CO2carbon dioxideReactome DB_ID: 113528carbon dioxide [ChEBI:16526]carbon dioxideChEBICHEBI:16526Reactome Database ID Release 75113528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113528ReactomeR-ALL-1135283Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113528.3COMPOUNDC00011ACTIVATIONSPE2AMD1(1-67)P21182Reactome DB_ID: 10734999UniProt:P21182SPE2Saccharomyces cerevisiaeNCBI Taxonomy4932UniProtP211821EQUAL67EQUALReactome Database ID Release 7510734999Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10734999ReactomeR-SCE-3512231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-351223.1GENE ONTOLOGYGO:0004014gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510735000Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735000Reactome Database ID Release 7510735002Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735002ReactomeR-SCE-3512221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-351222.1S-Adenosylmethionine decarboxylase belongs to a small class of amino acid decarboxylases that use a covalently bound pyruvate as a prosthetic group. It is an essential enzyme for polyamine biosynthesis and provides an important target for the design of anti-parasitic and cancer chemotherapeutic agents. It catalyzes the formation of the aminopropyl group donor in the biosynthesis of the polyamines spermidine and spermine. These pyruvoyl-dependent decarboxylases also form amines such as histamine, decarboxylated S-adenosylmethionine, phosphatidylethanolamine (a component of membrane phospholipids), and -alanine (a precursor of coenzyme A), which are all of critical importance in cellular physiology and provide important targets for drug design.10029540Pubmed1999Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylaseXiong, HStanley, BAPegg, AEBiochemistry 38:2462-7011583147Pubmed2001The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylaseTolbert, WDEkstrom, JLMathews, IISecrist JA, 3rdKapoor, PPegg, AEEalick, SEBiochemistry 40:9484-94inferred from electronic annotationEVIDENCE CODEECO:0000203