BioPAX pathway converted from "Activation of Rap1 by cytosolic GEFs" in the Reactome database.LEFT-TO-RIGHTActivation of Rap1 by cytosolic GEFsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>RAP1:GDPReactome DB_ID: 10735075plasma membraneGENE ONTOLOGYGO:0005886RSR1RAP1AP13856Reactome DB_ID: 10735071UniProt:P13856RSR1Saccharomyces cerevisiaeNCBI Taxonomy4932UniProtP138561EQUAL181EQUALReactome Database ID Release 7510735071Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735071ReactomeR-SCE-3541181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-354118.1Reactomehttp://www.reactome.org1GDPGuanosine 5'-diphosphateGuanosine diphosphateReactome DB_ID: 29420cytosolGENE ONTOLOGYGO:0005829GDP [ChEBI:17552]GDPGuanosine 5'-diphosphateGuanosine diphosphateChEBICHEBI:17552Reactome Database ID Release 7529420Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420ReactomeR-ALL-294202Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29420.2COMPOUNDC00035additional informationMIMI:03611Reactome Database ID Release 7510735075Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735075ReactomeR-SCE-3540741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-354074.1GTPGuanosine 5'-triphosphateReactome DB_ID: 29438GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBICHEBI:15996Reactome Database ID Release 7529438Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438ReactomeR-ALL-294383Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.3COMPOUNDC00044RAP1:GTPReactome DB_ID: 1073507311Reactome Database ID Release 7510735073Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735073ReactomeR-SCE-3541261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-354126.1ACTIVATIONCalDAG-GEFs:DAG:Ca2+Reactome DB_ID: 10735091Ca2+Calciumcalcium(2+)Reactome DB_ID: 74016calcium(2+) [ChEBI:29108]calcium(2+)ChEBICHEBI:29108Reactome Database ID Release 7574016Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74016ReactomeR-ALL-740163Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74016.3COMPOUNDC000761Converted from EntitySet in ReactomeCalDAG-GEFsReactome DB_ID: 10735089Converted from EntitySet in ReactomeHomologues of RASGRP2Reactome DB_ID: 10735081CDC25RASGRP2P04821Reactome DB_ID: 10735077UniProt:P04821CDC25UniProtP048211EQUAL609EQUALReactome Database ID Release 7510735077Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735077ReactomeR-SCE-30086711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-3008671.1BUD5RASGRP2P25300Reactome DB_ID: 10735079UniProt:P25300BUD5UniProtP253001EQUAL609EQUALReactome Database ID Release 7510735079Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735079ReactomeR-SCE-3008671-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-3008671-2.1Reactome Database ID Release 7510735081Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735081ReactomeR-SCE-3008671-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-3008671-3.1Converted from EntitySet in ReactomeHomologues of RASGRP1Reactome DB_ID: 10735087CDC25RASGRP1P04821Reactome DB_ID: 107350831EQUAL797EQUALReactome Database ID Release 7510735083Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735083ReactomeR-SCE-8702701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-870270.1BUD5RASGRP1P25300Reactome DB_ID: 107350851EQUAL797EQUALReactome Database ID Release 7510735085Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735085ReactomeR-SCE-870270-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-870270-2.1Reactome Database ID Release 7510735087Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735087ReactomeR-SCE-870270-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-870270-3.1Reactome Database ID Release 7510735089Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735089ReactomeR-SCE-3924881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-392488.11DAG1,2-Diacylglycerol1,2-diacyl-sn-glycerolReactome DB_ID: 1145191,2-diacyl-sn-glycerol [ChEBI:17815]1,2-diacyl-sn-glycerolChEBICHEBI:17815Reactome Database ID Release 75114519Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114519ReactomeR-ALL-1145194Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114519.41Reactome Database ID Release 7510735091Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735091ReactomeR-SCE-3928411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-392841.1GENE ONTOLOGYGO:0005085gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510735092Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735092Reactome Database ID Release 7510735094Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10735094ReactomeR-SCE-3541731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-354173.1Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.15469846Pubmed2004RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesionLafuente, EMvan Puijenbroek, AAKrause, MCarman, CVFreeman, GJBerezovskaya, AConstantine, ESpringer, TAGertler, FBBoussiotis, VADev Cell 7:585-9516757337Pubmed2006Rap1 regulation of RIAM and cell adhesionLafuente, EBoussiotis, VAMethods Enzymol 407:345-5815334074Pubmed2004CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationCrittenden, JRBergmeier, WZhang, YPiffath, CLLiang, YWagner, DDHousman, DEGraybiel, AMNat Med 10:982-616076873Pubmed2005Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsStork, PJDillon, TJBlood 106:2952-6112585966Pubmed2003Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase CGiuliano, SNesbitt, WSRooney, MJackson, SPBiochem J 372:163-72inferred from electronic annotationEVIDENCE CODEECO:0000203