BioPAX pathway converted from "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter" in the Reactome database. LEFT-TO-RIGHT Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> SAM AdoMet S-adenosylmethionine S-adenosyl-L-methionine Reactome DB_ID: 77087 nucleoplasm GENE ONTOLOGY GO:0005654 S-adenosyl-L-methionine [ChEBI:15414] S-adenosyl-L-methionine ChEBI CHEBI:15414 Reactome Database ID Release 83 77087 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77087 Reactome R-ALL-77087 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-77087.3 Reactome http://www.reactome.org COMPOUND C00019 additional information MI MI:0361 2 H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B Reactome DB_ID: 10740228 Ghost homologue of GP1BA gene Reactome DB_ID: 10740219 Reactome Database ID Release 83 10740219 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740219 Reactome R-DME-8936595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936595.1 1 Nucleosome with H3K4me2 Reactome DB_ID: 10740147 Ghost homologue of HIST1H4 Reactome DB_ID: 10715458 Reactome Database ID Release 83 10715458 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10715458 Reactome R-DME-181902 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-181902.1 2 Converted from EntitySet in Reactome Histone H3 (H3K4me2) Histone H3 with dimethylated lysine-4 Reactome DB_ID: 10740145 Converted from EntitySet in Reactome Homologues of Me2K5-H3F3A Reactome DB_ID: 10740140 C0HL66 His3.3A Me2K5-H3F3A Reactome DB_ID: 10740135 UniProt:C0HL66 His3.3A Drosophila melanogaster NCBI Taxonomy 7227 UniProt C0HL66 5 EQUAL N6,N6-dimethyl-L-lysine MOD MOD:00084 2 EQUAL 136 EQUAL Reactome Database ID Release 83 10740135 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740135 Reactome R-DME-1214206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214206.1 C0HL67 His3.3B Me2K5-H3F3A Reactome DB_ID: 10740138 UniProt:C0HL67 His3.3B UniProt C0HL67 5 EQUAL 2 EQUAL 136 EQUAL Reactome Database ID Release 83 10740138 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740138 Reactome R-DME-1214206-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214206-2.1 Reactome Database ID Release 83 10740140 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740140 Reactome R-DME-1214206-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214206-3.1 P02299 His3:CG33845 Me2K5-HIST2H3A Reactome DB_ID: 10740143 UniProt:P02299 His3:CG33845 UniProt P02299 5 EQUAL 2 EQUAL 136 EQUAL Reactome Database ID Release 83 10740143 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740143 Reactome R-DME-1214225 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214225.1 Reactome Database ID Release 83 10740145 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740145 Reactome R-DME-1214192 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214192.1 2 Converted from EntitySet in Reactome Histone H2A Reactome DB_ID: 10715467 H2AFV His2Av P08985 Reactome DB_ID: 10715463 UniProt:P08985 His2Av UniProt P08985 1 EQUAL 128 EQUAL Reactome Database ID Release 83 10715463 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10715463 Reactome R-DME-8862427 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8862427.1 Reactome Database ID Release 83 10715467 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10715467 Reactome R-DME-181899 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-181899.1 2 Converted from EntitySet in Reactome Histone H2B Reactome DB_ID: 10715476 His2B HIST1H2BK P02283 Reactome DB_ID: 10715472 UniProt:P02283 His2B UniProt P02283 2 EQUAL 126 EQUAL Reactome Database ID Release 83 10715472 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10715472 Reactome R-DME-181898 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-181898.1 Reactome Database ID Release 83 10715476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10715476 Reactome R-DME-181911 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-181911.1 2 Reactome Database ID Release 83 10740147 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740147 Reactome R-DME-1214200 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214200.1 1 RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B Reactome DB_ID: 10740173 EP300 M9MS40 Reactome DB_ID: 10705715 UniProt:M9MS40 UniProt M9MS40 2 EQUAL 2414 EQUAL Reactome Database ID Release 83 10705715 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705715 Reactome R-DME-381325 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-381325.1 1 Gcn5 KAT2B Q9VTZ1 Reactome DB_ID: 10712244 UniProt:Q9VTZ1 Gcn5 UniProt Q9VTZ1 1 EQUAL 832 EQUAL Reactome Database ID Release 83 10712244 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10712244 Reactome R-DME-352430 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-352430.1 1 Core MLL complex Reactome DB_ID: 10740171 Rbbp5 RBBP5 Q9VPH8 Reactome DB_ID: 10716204 UniProt:Q9VPH8 Rbbp5 UniProt Q9VPH8 1 EQUAL 538 EQUAL Reactome Database ID Release 83 10716204 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10716204 Reactome R-DME-1629836 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1629836.1 1 ash2 ASH2L Q94545 Reactome DB_ID: 10716199 UniProt:Q94545 ash2 UniProt Q94545 1 EQUAL 628 EQUAL Reactome Database ID Release 83 10716199 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10716199 Reactome R-DME-1629834 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1629834.1 1 Ghost homologue of DPY30 Reactome DB_ID: 10740169 Reactome Database ID Release 83 10740169 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740169 Reactome R-DME-5669104 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5669104.1 1 Converted from EntitySet in Reactome KMT2A-E, SETD1A,(SETD1B) Reactome DB_ID: 10740167 Set1 SETD1A Q5LJZ2 Reactome DB_ID: 10740154 UniProt:Q5LJZ2 Set1 UniProt Q5LJZ2 1 EQUAL 1707 EQUAL Reactome Database ID Release 83 10740154 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740154 Reactome R-DME-3239027 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3239027.1 KMT2A P20659 Reactome DB_ID: 10737806 UniProt:P20659 UniProt P20659 1 EQUAL 3969 EQUAL Reactome Database ID Release 83 10737806 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737806 Reactome R-DME-1183223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1183223.1 KMT2B P20659 Reactome DB_ID: 10740156 2 EQUAL 2715 EQUAL Reactome Database ID Release 83 10740156 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740156 Reactome R-DME-1183216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1183216.1 Lpt KMT2C Q9W1H0 Reactome DB_ID: 10740158 UniProt:Q9W1H0 Lpt UniProt Q9W1H0 1 EQUAL 4911 EQUAL Reactome Database ID Release 83 10740158 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740158 Reactome R-DME-1183224 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1183224.1 upSET KMT2E Q9VUB5 Reactome DB_ID: 10740163 UniProt:Q9VUB5 upSET UniProt Q9VUB5 1 EQUAL 1858 EQUAL Reactome Database ID Release 83 10740163 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740163 Reactome R-DME-1183225 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1183225.1 Reactome Database ID Release 83 10740167 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740167 Reactome R-DME-5244745 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5244745.1 1 wds WDR5 Q9V3J8 Reactome DB_ID: 10718887 UniProt:Q9V3J8 wds UniProt Q9V3J8 2 EQUAL 334 EQUAL Reactome Database ID Release 83 10718887 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10718887 Reactome R-DME-1629838 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1629838.1 1 Reactome Database ID Release 83 10740171 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740171 Reactome R-DME-5244738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5244738.1 1 Converted from EntitySet in Reactome RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 Reactome DB_ID: 10740076 RUNX1:CBFB Reactome DB_ID: 10737790 Bgb CBFB Q24040 Reactome DB_ID: 10737778 UniProt:Q24040 Bgb UniProt Q24040 1 EQUAL 182 EQUAL Reactome Database ID Release 83 10737778 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737778 Reactome R-DME-8865293 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8865293.1 1 Converted from EntitySet in Reactome Homologues of RUNX1 Reactome DB_ID: 10737788 RunxA RUNX1 M9PI08 Reactome DB_ID: 10737780 UniProt:M9PI08 RunxA UniProt M9PI08 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10737780 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737780 Reactome R-DME-8865295 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8865295.1 run RUNX1 P22814 Reactome DB_ID: 10737782 UniProt:P22814 run UniProt P22814 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10737782 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737782 Reactome R-DME-8865295-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8865295-2.1 RunxB RUNX1 Q9VRA9 Reactome DB_ID: 10737784 UniProt:Q9VRA9 RunxB UniProt Q9VRA9 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10737784 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737784 Reactome R-DME-8865295-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8865295-3.1 lz RUNX1 Q9W349 Reactome DB_ID: 10737786 UniProt:Q9W349 lz UniProt Q9W349 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10737786 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737786 Reactome R-DME-8865295-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8865295-4.1 Reactome Database ID Release 83 10737788 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737788 Reactome R-DME-8865295-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8865295-5.1 1 Reactome Database ID Release 83 10737790 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10737790 Reactome R-DME-8865330 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8865330.1 MeR206,MeR210-RUNX1:CBFB:PRMT1 Reactome DB_ID: 10740059 1 Converted from EntitySet in Reactome Homologues of MeR206,MeR210-RUNX1 Reactome DB_ID: 10740057 RunxA MeR206,MeR210-RUNX1 M9PI08 Reactome DB_ID: 10740043 206 EQUAL omega-N-methyl-L-arginine MOD MOD:00078 210 EQUAL 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10740043 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740043 Reactome R-DME-8934750 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8934750.1 run MeR206,MeR210-RUNX1 P22814 Reactome DB_ID: 10740047 206 EQUAL 210 EQUAL 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10740047 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740047 Reactome R-DME-8934750-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8934750-2.1 RunxB MeR206,MeR210-RUNX1 Q9VRA9 Reactome DB_ID: 10740051 206 EQUAL 210 EQUAL 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10740051 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740051 Reactome R-DME-8934750-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8934750-3.1 lz MeR206,MeR210-RUNX1 Q9W349 Reactome DB_ID: 10740055 206 EQUAL 210 EQUAL 1 EQUAL 453 EQUAL Reactome Database ID Release 83 10740055 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740055 Reactome R-DME-8934750-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8934750-4.1 Reactome Database ID Release 83 10740057 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740057 Reactome R-DME-8934750-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8934750-5.1 1 Art1 PRMT1 Q9VGW7 Reactome DB_ID: 10715248 UniProt:Q9VGW7 Art1 UniProt Q9VGW7 1 EQUAL 361 EQUAL Reactome Database ID Release 83 10715248 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10715248 Reactome R-DME-3215140 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3215140.1 1 Reactome Database ID Release 83 10740059 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740059 Reactome R-DME-8935724 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8935724.1 Reactome Database ID Release 83 10740076 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740076 Reactome R-DME-8935716 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8935716.1 1 GATA1:ZFPM1 Reactome DB_ID: 10740149 ZFPM1 Q9VPQ6 Reactome DB_ID: 10704943 UniProt:Q9VPQ6 UniProt Q9VPQ6 1 EQUAL 1006 EQUAL Reactome Database ID Release 83 10704943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704943 Reactome R-DME-996748 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-996748.1 1 grn GATA1 P91623 Reactome DB_ID: 10704952 UniProt:P91623 grn UniProt P91623 1 EQUAL 413 EQUAL Reactome Database ID Release 83 10704952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704952 Reactome R-DME-996772 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-996772.1 1 Reactome Database ID Release 83 10740149 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740149 Reactome R-DME-8936469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936469.1 1 Reactome Database ID Release 83 10740173 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740173 Reactome R-DME-8936477 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936477.1 1 Reactome Database ID Release 83 10740228 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740228 Reactome R-DME-8936615 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936615.1 H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B Reactome DB_ID: 10740230 1 Nucleosome with H3K4me3 Reactome DB_ID: 10740190 2 2 2 Converted from EntitySet in Reactome Histone H3 (H3K4me3) Histone H3 with trimethylated lysine-4 Reactome DB_ID: 10740188 Converted from EntitySet in Reactome Homologues of Me3K5-H3F3A Reactome DB_ID: 10740183 C0HL66 His3.3A Me3K5-H3F3A Reactome DB_ID: 10740178 5 EQUAL N6,N6,N6-trimethyl-L-lysine MOD MOD:00083 2 EQUAL 136 EQUAL Reactome Database ID Release 83 10740178 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740178 Reactome R-DME-1214216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214216.1 C0HL67 His3.3B Me3K5-H3F3A Reactome DB_ID: 10740181 5 EQUAL 2 EQUAL 136 EQUAL Reactome Database ID Release 83 10740181 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740181 Reactome R-DME-1214216-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214216-2.1 Reactome Database ID Release 83 10740183 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740183 Reactome R-DME-1214216-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214216-3.1 P02299 His3:CG33845 Me3K5-HIST2H3A Reactome DB_ID: 10740186 5 EQUAL 2 EQUAL 136 EQUAL Reactome Database ID Release 83 10740186 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740186 Reactome R-DME-1214223 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214223.1 Reactome Database ID Release 83 10740188 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740188 Reactome R-DME-1214232 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214232.1 2 Reactome Database ID Release 83 10740190 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740190 Reactome R-DME-1214169 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214169.1 1 1 Reactome Database ID Release 83 10740230 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740230 Reactome R-DME-8936620 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936620.1 SAH AdoHcy S-adenosylhomocysteine S-adenosyl-L-homocysteine Reactome DB_ID: 77502 S-adenosyl-L-homocysteine [ChEBI:16680] S-adenosyl-L-homocysteine ChEBI CHEBI:16680 Reactome Database ID Release 83 77502 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=77502 Reactome R-ALL-77502 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-77502.3 COMPOUND C00021 2 ACTIVATION activeUnit: #Complex4 GENE ONTOLOGY GO:0042800 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 83 10740231 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740231 Reactome Database ID Release 83 10740233 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740233 Reactome R-DME-8936621 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936621.1 The WDR5-containing histone methyltransferase MLL complex, recruited to the GP1BA promoter via RUNX1 (and possibly GATA1), methylates histone H3 on dimethylated lysine residue K4 (K5 when taking into account the initiator methionine), producing the H3K4me3 mark. The H3K4me3 mark is characteristic of nucleosome associated with transcriptionally active promoters of megakaryocyte-specific genes (Herglotz et al. 2013). 22777353 Pubmed 2013 Histone arginine methylation keeps RUNX1 target genes in an intermediate state Herglotz, J Kuvardina, O N Kolodziej, S Kumar, A Hussong, H Grez, M Lausen, J Oncogene 32:2565-75 inferred from electronic annotation EVIDENCE CODE ECO:0000203