BioPAX pathway converted from "PIP3 activates AKT signaling" in the Reactome database. PI3K/AKT Signaling PIP3 activates AKT signaling This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.1.153 PI3K phosphorylates PIP2 to PIP3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 cytosol GENE ONTOLOGY GO:0005829 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 Reactome http://www.reactome.org COMPOUND C00002 additional information MI MI:0361 PIP2 PI(4,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Phosphatidylinositol-4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate Reactome DB_ID: 179856 plasma membrane GENE ONTOLOGY GO:0005886 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [ChEBI:58456] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) 2,3-bis(alkanoyloxy)propyl (1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonatooxy)cyclohexyl phosphate ChEBI CHEBI:58456 Reactome Database ID Release 82 179856 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179856 Reactome R-ALL-179856 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179856.4 COMPOUND C04637 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 PIP3 PI(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate Phosphatidylinositol-3,4,5-trisphosphate Reactome DB_ID: 179838 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836] 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) 2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) ChEBI CHEBI:57836 Reactome Database ID Release 82 179838 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179838 Reactome R-ALL-179838 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179838.4 COMPOUND C05981 ACTIVATION Converted from EntitySet in Reactome Activator:PI3K Reactome DB_ID: 10705410 PDGF:Phospho-PDGF receptor dimer:PI3K Reactome DB_ID: 10674799 PDGF:Phospho-PDGF receptor dimer Reactome DB_ID: 10674751 Converted from EntitySet in Reactome Phospho- PDGF receptor dimer Reactome DB_ID: 10674730 Phospho-alpha receptor homodimer Reactome DB_ID: 10674666 Converted from EntitySet in Reactome Homologues of p-11Y-PDGFRA Reactome DB_ID: 10674664 P13368 phospho-p-11Y-PDGFRA Reactome DB_ID: 10674626 UniProt:P13368 Drosophila melanogaster NCBI Taxonomy 7227 UniProt P13368 1018 EQUAL O4'-phospho-L-tyrosine MOD MOD:00048 572 EQUAL 574 EQUAL 720 EQUAL 731 EQUAL 742 EQUAL 754 EQUAL 762 EQUAL 768 EQUAL 988 EQUAL 849 EQUAL 24 EQUAL 1089 EQUAL Reactome Database ID Release 82 10674626 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674626 Reactome R-DME-186806 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186806.1 Q8IQ00 phospho-p-11Y-PDGFRA Reactome DB_ID: 10674638 UniProt:Q8IQ00 UniProt Q8IQ00 1018 EQUAL 572 EQUAL 574 EQUAL 720 EQUAL 731 EQUAL 742 EQUAL 754 EQUAL 762 EQUAL 768 EQUAL 988 EQUAL 849 EQUAL 24 EQUAL 1089 EQUAL Reactome Database ID Release 82 10674638 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674638 Reactome R-DME-186806-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186806-2.1 Q9VBW3 phospho-p-11Y-PDGFRA Reactome DB_ID: 10674650 UniProt:Q9VBW3 UniProt Q9VBW3 1018 EQUAL 572 EQUAL 574 EQUAL 720 EQUAL 731 EQUAL 742 EQUAL 754 EQUAL 762 EQUAL 768 EQUAL 988 EQUAL 849 EQUAL 24 EQUAL 1089 EQUAL Reactome Database ID Release 82 10674650 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674650 Reactome R-DME-186806-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186806-3.1 Q9VZA8 phospho-p-11Y-PDGFRA Reactome DB_ID: 10674662 UniProt:Q9VZA8 UniProt Q9VZA8 1018 EQUAL 572 EQUAL 574 EQUAL 720 EQUAL 731 EQUAL 742 EQUAL 754 EQUAL 762 EQUAL 768 EQUAL 988 EQUAL 849 EQUAL 24 EQUAL 1089 EQUAL Reactome Database ID Release 82 10674662 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674662 Reactome R-DME-186806-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186806-4.1 Reactome Database ID Release 82 10674664 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674664 Reactome R-DME-186806-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186806-5.1 2 Reactome Database ID Release 82 10674666 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674666 Reactome R-DME-186816 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186816.1 Phospho-alpha-Phospho-beta receptor heterodimer Reactome DB_ID: 10674726 1 Converted from EntitySet in Reactome Homologues of p-12Y-PDGFRB Reactome DB_ID: 10674724 P13368 phospho-p-12Y-PDGFRB Reactome DB_ID: 10674680 1009 EQUAL 1021 EQUAL 579 EQUAL 581 EQUAL 716 EQUAL 740 EQUAL 751 EQUAL 763 EQUAL 771 EQUAL 775 EQUAL 778 EQUAL 857 EQUAL 33 EQUAL 1106 EQUAL Reactome Database ID Release 82 10674680 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674680 Reactome R-DME-186803 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186803.1 Q8IQ00 phospho-p-12Y-PDGFRB Reactome DB_ID: 10674694 1009 EQUAL 1021 EQUAL 579 EQUAL 581 EQUAL 716 EQUAL 740 EQUAL 751 EQUAL 763 EQUAL 771 EQUAL 775 EQUAL 778 EQUAL 857 EQUAL 33 EQUAL 1106 EQUAL Reactome Database ID Release 82 10674694 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674694 Reactome R-DME-186803-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186803-2.1 Q9VBW3 phospho-p-12Y-PDGFRB Reactome DB_ID: 10674708 1009 EQUAL 1021 EQUAL 579 EQUAL 581 EQUAL 716 EQUAL 740 EQUAL 751 EQUAL 763 EQUAL 771 EQUAL 775 EQUAL 778 EQUAL 857 EQUAL 33 EQUAL 1106 EQUAL Reactome Database ID Release 82 10674708 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674708 Reactome R-DME-186803-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186803-3.1 Q9VZA8 phospho-p-12Y-PDGFRB Reactome DB_ID: 10674722 1009 EQUAL 1021 EQUAL 579 EQUAL 581 EQUAL 716 EQUAL 740 EQUAL 751 EQUAL 763 EQUAL 771 EQUAL 775 EQUAL 778 EQUAL 857 EQUAL 33 EQUAL 1106 EQUAL Reactome Database ID Release 82 10674722 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674722 Reactome R-DME-186803-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186803-4.1 Reactome Database ID Release 82 10674724 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674724 Reactome R-DME-186803-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186803-5.1 1 Reactome Database ID Release 82 10674726 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674726 Reactome R-DME-186769 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186769.1 Phospho-beta receptor homodimer Reactome DB_ID: 10674728 2 Reactome Database ID Release 82 10674728 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674728 Reactome R-DME-186805 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186805.1 Reactome Database ID Release 82 10674730 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674730 Reactome R-DME-186821 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186821.1 1 Converted from EntitySet in Reactome Active PDGF dimers (AA, AB, BB) Reactome DB_ID: 10674749 active PDGF-AA dimer Reactome DB_ID: 10674739 extracellular region GENE ONTOLOGY GO:0005576 Pvf1 PDGFA-1 Q9VWP6 Reactome DB_ID: 10674735 UniProt:Q9VWP6 Pvf1 UniProt Q9VWP6 87 EQUAL 211 EQUAL Reactome Database ID Release 82 10674735 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674735 Reactome R-DME-184199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-184199.1 2 Reactome Database ID Release 82 10674739 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674739 Reactome R-DME-380761 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-380761.1 active PDGF-BB dimer Reactome DB_ID: 10674745 Pvf1 PDGFB (82-190) Q9VWP6 Reactome DB_ID: 10674741 82 EQUAL 190 EQUAL Reactome Database ID Release 82 10674741 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674741 Reactome R-DME-184201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-184201.1 2 Reactome Database ID Release 82 10674745 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674745 Reactome R-DME-184206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-184206.1 PDGF A/B heterodimer Reactome DB_ID: 10674747 1 Pvf1 PDGFA-2 Q9VWP6 Reactome DB_ID: 10674737 87 EQUAL 196 EQUAL Reactome Database ID Release 82 10674737 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674737 Reactome R-DME-380739 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-380739.1 1 Reactome Database ID Release 82 10674747 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674747 Reactome R-DME-380759 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-380759.1 Reactome Database ID Release 82 10674749 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674749 Reactome R-DME-380760 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-380760.1 1 Reactome Database ID Release 82 10674751 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674751 Reactome R-DME-186811 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186811.1 1 PI3K Reactome DB_ID: 10668059 PIK3CB Pi3K92E P91634 Reactome DB_ID: 10668057 UniProt:P91634 Pi3K92E Pi3K92E CG4141 Dmel_CG4141 SIMILARITY Contains 1 PI3K/PI4K domain. UniProt P91634 1 EQUAL 1070 EQUAL Reactome Database ID Release 82 10668057 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10668057 Reactome R-DME-74788 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74788.1 1 PIK3R1 Pi3K21B Q7KTZ2 Reactome DB_ID: 10668051 UniProt:Q7KTZ2 Pi3K21B UniProt Q7KTZ2 1 EQUAL 724 EQUAL Reactome Database ID Release 82 10668051 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10668051 Reactome R-DME-74789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74789.1 1 Reactome Database ID Release 82 10668059 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10668059 Reactome R-DME-74693 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74693.1 1 Reactome Database ID Release 82 10674799 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674799 Reactome R-DME-186789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-186789.1 Phospho-IRS1/2:PI3K(p85:p110) Reactome DB_ID: 10676616 Q9XTN2 phospho-chico p-Y-IRS1 Reactome DB_ID: 10676612 UniProt:Q9XTN2 chico chico IRS CG5686 FUNCTION Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.SUBUNIT Bindings to phosphatidylinositol 3-kinase and SHP2.DEVELOPMENTAL STAGE Expressed during G1, S and G2 phase of the cell cycle.DISRUPTION PHENOTYPE Female sterile. Extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes.MISCELLANEOUS 'Chico' means 'small boy' in Spanish. UniProt Q9XTN2 1 EQUAL 1242 EQUAL Reactome Database ID Release 82 10676612 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676612 Reactome R-DME-198366 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198366.1 1 1 Reactome Database ID Release 82 10676616 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676616 Reactome R-DME-198344 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198344.1 NRG1/2:p-ERBB3:p-ERBB2:PI3K Reactome DB_ID: 10698124 Ghost homologue of PIK3CA Reactome DB_ID: 10698104 Reactome Database ID Release 82 10698104 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698104 Reactome R-DME-74787 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74787.1 1 NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 Reactome DB_ID: 10698122 PIK3R1 Pi3K21B Q7KTZ2 Reactome DB_ID: 10698120 1 EQUAL 724 EQUAL Reactome Database ID Release 82 10698120 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698120 Reactome R-DME-198365 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198365.1 1 Converted from EntitySet in Reactome Phosphorylated ERBB2:ERBB3 heterodimers Reactome DB_ID: 10697930 NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 Reactome DB_ID: 10697923 P04412 phospho-p-Y-ERBB2 Reactome DB_ID: 10697921 UniProt:P04412 UniProt P04412 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10697921 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697921 Reactome R-DME-1678589 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1678589.1 1 NRG1/2:p-10Y-ERBB3 Reactome DB_ID: 10697918 P04412 phospho-p-10Y-ERBB3-1 Reactome DB_ID: 10697916 1328 EQUAL 1054 EQUAL 1197 EQUAL 1199 EQUAL 1222 EQUAL 1224 EQUAL 1260 EQUAL 1262 EQUAL 1276 EQUAL 1289 EQUAL 20 EQUAL 1342 EQUAL Reactome Database ID Release 82 10697916 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697916 Reactome R-DME-1248742 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1248742.1 1 vn NRG2 Q94918 Reactome DB_ID: 10697730 UniProt:Q94918 vn UniProt Q94918 112 EQUAL 404 EQUAL Reactome Database ID Release 82 10697730 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697730 Reactome R-DME-1227953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1227953.1 1 Reactome Database ID Release 82 10697918 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697918 Reactome R-DME-1248743 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1248743.1 1 Reactome Database ID Release 82 10697923 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697923 Reactome R-DME-1963583 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1963583.1 NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 Reactome DB_ID: 10697928 P04412 phospho-p-Y,Y877-ERBB2 Reactome DB_ID: 10697926 877 EQUAL 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10697926 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697926 Reactome R-DME-1810446 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1810446.1 1 1 Reactome Database ID Release 82 10697928 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697928 Reactome R-DME-1248749 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1248749.1 Reactome Database ID Release 82 10697930 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697930 Reactome R-DME-1963572 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1963572.1 1 Reactome Database ID Release 82 10698122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698122 Reactome R-DME-1250191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250191.1 1 Reactome Database ID Release 82 10698124 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698124 Reactome R-DME-1250508 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250508.1 NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K Reactome DB_ID: 10698645 PIK3CA:PIK3R1 Reactome DB_ID: 10698106 1 1 Reactome Database ID Release 82 10698106 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698106 Reactome R-DME-1806218 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806218.1 1 Converted from EntitySet in Reactome Phosphorylated ERBB2:ERBB4cyt1 heterodimers Reactome DB_ID: 10698093 NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 Reactome DB_ID: 10697961 NRGs/EGF-like ligands:p-ERBB4cyt1 Reactome DB_ID: 10697959 Converted from EntitySet in Reactome p-ERBB4cyt1 Reactome DB_ID: 10697957 P04412 phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform Reactome DB_ID: 10697950 1056 EQUAL 1188 EQUAL 1242 EQUAL 26 EQUAL 1308 EQUAL Reactome Database ID Release 82 10697950 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697950 Reactome R-DME-1250319 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250319.1 P04412 phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform Reactome DB_ID: 10697955 1046 EQUAL 1178 EQUAL 1232 EQUAL 26 EQUAL 1298 EQUAL Reactome Database ID Release 82 10697955 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697955 Reactome R-DME-1250313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250313.1 Reactome Database ID Release 82 10697957 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697957 Reactome R-DME-1250325 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250325.1 1 vn NRG1 Q94918 Reactome DB_ID: 10697728 20 EQUAL 241 EQUAL Reactome Database ID Release 82 10697728 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697728 Reactome R-DME-1227951 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1227951.1 1 Reactome Database ID Release 82 10697959 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697959 Reactome R-DME-1250305 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250305.1 1 P04412 phospho-p-6Y-ERBB2 Reactome DB_ID: 10697943 1023 EQUAL 1139 EQUAL 1196 EQUAL 1221 EQUAL 1248 EQUAL 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10697943 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697943 Reactome R-DME-1963569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1963569.1 1 Reactome Database ID Release 82 10697961 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697961 Reactome R-DME-1250316 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250316.1 NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 Reactome DB_ID: 10697969 P04412 phospho-p-7Y-ERBB2 Reactome DB_ID: 10697967 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10697967 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697967 Reactome R-DME-1248698 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1248698.1 1 1 Reactome Database ID Release 82 10697969 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10697969 Reactome R-DME-1963579 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1963579.1 Reactome Database ID Release 82 10698093 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698093 Reactome R-DME-1963568 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1963568.1 1 Reactome Database ID Release 82 10698645 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698645 Reactome R-DME-1306974 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1306974.1 PI3K:p-ERBB4cyt1 Reactome DB_ID: 10698108 Converted from EntitySet in Reactome p-ERBB4cyt1 homodimers Phosphorylated ERBB4cyt1 homodimers Reactome DB_ID: 10698086 p-ERBB4jmAcyt1 Reactome DB_ID: 10698080 NRGs/EGF-like ligands:P-ERBB4jmAcyt1 Reactome DB_ID: 10698078 1 1 Reactome Database ID Release 82 10698078 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698078 Reactome R-DME-1251957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1251957.1 2 Reactome Database ID Release 82 10698080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698080 Reactome R-DME-1251953 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1251953.1 p-ERBB4jmBcyt1 Reactome DB_ID: 10698084 NRGs/EGF-like ligands:P-ERBB4jmBcyt1 Reactome DB_ID: 10698082 1 1 Reactome Database ID Release 82 10698082 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698082 Reactome R-DME-1251958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1251958.1 2 Reactome Database ID Release 82 10698084 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698084 Reactome R-DME-1251954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1251954.1 Reactome Database ID Release 82 10698086 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698086 Reactome R-DME-1250351 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250351.1 1 1 Reactome Database ID Release 82 10698108 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10698108 Reactome R-DME-1250373 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1250373.1 CD19 Signalosome Reactome DB_ID: 10704562 PIK3CD:PIK3R1 Reactome DB_ID: 10704229 1 PIK3CD Pi3K92E P91634 Reactome DB_ID: 10690218 1 EQUAL 1044 EQUAL Reactome Database ID Release 82 10690218 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10690218 Reactome R-DME-392274 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-392274.1 1 Reactome Database ID Release 82 10704229 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704229 Reactome R-DME-1045152 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1045152.1 1 drk GRB2-1 Q08012 Reactome DB_ID: 10704560 UniProt:Q08012 drk UniProt Q08012 1 EQUAL 217 EQUAL Reactome Database ID Release 82 10704560 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704560 Reactome R-DME-202993 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202993.1 1 Ghost homologue of p-6Y-CD19 Reactome DB_ID: 10704556 Reactome Database ID Release 82 10704556 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704556 Reactome R-DME-2076270 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2076270.1 1 Vav VAV1 Q9NHV9 Reactome DB_ID: 10704558 UniProt:Q9NHV9 Vav UniProt Q9NHV9 1 EQUAL 845 EQUAL Reactome Database ID Release 82 10704558 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704558 Reactome R-DME-1045153 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1045153.1 1 Reactome Database ID Release 82 10704562 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704562 Reactome R-DME-2076233 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2076233.1 BCAP Signalosome Reactome DB_ID: 10704231 1 Q9VFI0 phospho-stumps p-4Y-PIK3AP1 Reactome DB_ID: 10704227 UniProt:Q9VFI0 stumps UniProt Q9VFI0 263 EQUAL 419 EQUAL 444 EQUAL 459 EQUAL 1 EQUAL 805 EQUAL Reactome Database ID Release 82 10704227 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704227 Reactome R-DME-984814 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-984814.1 1 Reactome Database ID Release 82 10704231 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10704231 Reactome R-DME-2045909 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2045909.1 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10705351 1 Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10705349 Activated FGFR1:p-FRS2 Reactome DB_ID: 10705347 Q9VLL4 phospho-Dmel\CG13398 p-6Y-FRS2 Reactome DB_ID: 10669625 UniProt:Q9VLL4 Dmel\CG13398 UniProt Q9VLL4 436 EQUAL 196 EQUAL 306 EQUAL 349 EQUAL 392 EQUAL 471 EQUAL 1 EQUAL 508 EQUAL Reactome Database ID Release 82 10669625 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669625 Reactome R-DME-170959 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-170959.1 1 Converted from EntitySet in Reactome Activated FGFR1 Reactome DB_ID: 10705345 Activated FGFR1b homodimer Reactome DB_ID: 10669421 HS Heparan Sulphate heparan sulfate Reactome DB_ID: 190915 heparan sulfate [ChEBI:28815] heparan sulfate N-Acetylheparan sulfate Heparin monosulfate Heparatan sulfate Heparitin monosulfate Heparan sulphate Heparan N-sulfate Heparitin sulfate Heparin sulfate ChEBI CHEBI:28815 Reactome Database ID Release 82 190915 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=190915 Reactome R-ALL-190915 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-190915.3 1 bnl FGF1 Q9VDT9 Reactome DB_ID: 10669396 UniProt:Q9VDT9 bnl UniProt Q9VDT9 16 EQUAL 155 EQUAL Reactome Database ID Release 82 10669396 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669396 Reactome R-DME-189856 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-189856.1 2 p-8Y-FGFR1b dimer Reactome DB_ID: 10669419 Q09147 phospho-p-8Y-FGFR1b Reactome DB_ID: 10669417 UniProt:Q09147 UniProt Q09147 463 EQUAL 583 EQUAL 585 EQUAL 653 EQUAL 654 EQUAL 730 EQUAL 766 EQUAL 776 EQUAL 2 EQUAL 822 EQUAL Reactome Database ID Release 82 10669417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669417 Reactome R-DME-5656338 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5656338.1 2 Reactome Database ID Release 82 10669419 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669419 Reactome R-DME-5656340 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5656340.1 1 Reactome Database ID Release 82 10669421 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669421 Reactome R-DME-190430 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190430.1 Activated FGFR1c homodimer Reactome DB_ID: 10669436 Q09147 phospho-p-8Y-FGFR1c Reactome DB_ID: 10669434 22 EQUAL 822 EQUAL Reactome Database ID Release 82 10669434 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669434 Reactome R-DME-190434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190434.1 2 1 2 Reactome Database ID Release 82 10669436 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669436 Reactome R-DME-190425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190425.1 Activated FGFR1c bound to FGF23:Klotho Reactome DB_ID: 10669457 2 Klotho bound to FGF23 Reactome DB_ID: 10669455 bnl FGF23(25-251) Q9VDT9 Reactome DB_ID: 10669438 25 EQUAL 251 EQUAL Reactome Database ID Release 82 10669438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669438 Reactome R-DME-189891 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-189891.1 1 Klotho homodimer Reactome DB_ID: 10669453 Converted from EntitySet in Reactome Klotho Reactome DB_ID: 10669451 Membrane-bound Klotho homodimer Reactome DB_ID: 10669445 KL-1 Dmel\CG9701 Q9VV98 Reactome DB_ID: 10669443 UniProt:Q9VV98 Dmel\CG9701 UniProt Q9VV98 34 EQUAL 1012 EQUAL Reactome Database ID Release 82 10669443 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669443 Reactome R-DME-190198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190198.1 2 Reactome Database ID Release 82 10669445 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669445 Reactome R-DME-190204 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190204.1 Secreted Klotho homodimer Reactome DB_ID: 10669449 KL-2 Dmel\CG9701 Q9VV98 Reactome DB_ID: 10669447 34 EQUAL 549 EQUAL Reactome Database ID Release 82 10669447 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669447 Reactome R-DME-190201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190201.1 2 Reactome Database ID Release 82 10669449 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669449 Reactome R-DME-190203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190203.1 Reactome Database ID Release 82 10669451 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669451 Reactome R-DME-190207 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190207.1 2 Reactome Database ID Release 82 10669453 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669453 Reactome R-DME-190309 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190309.1 1 Reactome Database ID Release 82 10669455 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669455 Reactome R-DME-190208 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190208.1 2 1 Reactome Database ID Release 82 10669457 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669457 Reactome R-DME-500333 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-500333.1 Reactome Database ID Release 82 10705345 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705345 Reactome R-DME-5654170 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654170.1 1 Reactome Database ID Release 82 10705347 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705347 Reactome R-DME-5654200 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654200.1 1 GRB2:GAB1:PIK3R1 Reactome DB_ID: 10674392 1 GRB2:GAB1 Reactome DB_ID: 10674318 drk GRB2-1 Q08012 Reactome DB_ID: 10668030 1 EQUAL 217 EQUAL Reactome Database ID Release 82 10668030 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10668030 Reactome R-DME-74686 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-74686.1 1 dos GAB1 Q9VZZ9 Reactome DB_ID: 10669391 UniProt:Q9VZZ9 dos UniProt Q9VZZ9 1 EQUAL 694 EQUAL Reactome Database ID Release 82 10669391 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669391 Reactome R-DME-179795 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-179795.1 1 Reactome Database ID Release 82 10674318 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674318 Reactome R-DME-179849 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-179849.1 1 Reactome Database ID Release 82 10674392 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674392 Reactome R-DME-179864 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-179864.1 1 Reactome Database ID Release 82 10705349 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705349 Reactome R-DME-5654186 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654186.1 1 Reactome Database ID Release 82 10705351 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705351 Reactome R-DME-5654205 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654205.1 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10705359 1 Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10705357 Activated FGFR2:p-FRS2 Reactome DB_ID: 10705355 1 Converted from EntitySet in Reactome Activated FGFR2 Reactome DB_ID: 10705353 Converted from EntitySet in Reactome Activated FGFR2b homodimer bound to FGF Reactome DB_ID: 10669509 Activated FGFR2b long homodimer Reactome DB_ID: 10669486 1 2 Converted from EntitySet in Reactome Homologues of p-8Y-FGFR2-3 Reactome DB_ID: 10669484 Q07407 phospho-p-8Y-FGFR2-3 Reactome DB_ID: 10669472 UniProt:Q07407 UniProt Q07407 467 EQUAL 587 EQUAL 589 EQUAL 657 EQUAL 658 EQUAL 734 EQUAL 770 EQUAL 780 EQUAL 22 EQUAL 822 EQUAL Reactome Database ID Release 82 10669472 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669472 Reactome R-DME-190412 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190412.1 Q09147 phospho-p-8Y-FGFR2-3 Reactome DB_ID: 10669482 467 EQUAL 587 EQUAL 589 EQUAL 657 EQUAL 658 EQUAL 734 EQUAL 770 EQUAL 780 EQUAL 22 EQUAL 822 EQUAL Reactome Database ID Release 82 10669482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669482 Reactome R-DME-190412-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190412-2.1 Reactome Database ID Release 82 10669484 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669484 Reactome R-DME-190412-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190412-3.1 2 Reactome Database ID Release 82 10669486 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669486 Reactome R-DME-190411 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190411.1 Activated FGFR2b short homodimer bound to FGF Reactome DB_ID: 10669507 Converted from EntitySet in Reactome Homologues of Phosphorylated Fibroblast growth factor receptor 2b short Reactome DB_ID: 10669505 Q07407 phospho-Phosphorylated Fibroblast growth factor receptor 2b short Reactome DB_ID: 10669495 465 EQUAL 585 EQUAL 655 EQUAL 656 EQUAL 732 EQUAL 768 EQUAL 778 EQUAL 22 EQUAL 820 EQUAL Reactome Database ID Release 82 10669495 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669495 Reactome R-DME-192603 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192603.1 Q09147 phospho-Phosphorylated Fibroblast growth factor receptor 2b short Reactome DB_ID: 10669503 465 EQUAL 655 EQUAL 656 EQUAL 732 EQUAL 768 EQUAL 778 EQUAL 22 EQUAL 820 EQUAL Reactome Database ID Release 82 10669503 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669503 Reactome R-DME-192603-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192603-2.1 Reactome Database ID Release 82 10669505 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669505 Reactome R-DME-192603-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192603-3.1 2 1 2 Reactome Database ID Release 82 10669507 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669507 Reactome R-DME-192597 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192597.1 Reactome Database ID Release 82 10669509 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669509 Reactome R-DME-192606 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192606.1 Converted from EntitySet in Reactome Activated FGFR2c homodimer bound to FGF Reactome DB_ID: 10669550 Activated FGFR2c long homodimer Reactome DB_ID: 10669531 Converted from EntitySet in Reactome Homologues of p-8Y-FGFR2c long Reactome DB_ID: 10669529 Q07407 phospho-p-8Y-FGFR2c long Reactome DB_ID: 10669519 466 EQUAL 586 EQUAL 588 EQUAL 733 EQUAL 769 EQUAL 779 EQUAL 22 EQUAL 821 EQUAL Reactome Database ID Release 82 10669519 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669519 Reactome R-DME-190416 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190416.1 Q09147 phospho-p-8Y-FGFR2c long Reactome DB_ID: 10669527 466 EQUAL 586 EQUAL 588 EQUAL 733 EQUAL 769 EQUAL 779 EQUAL 22 EQUAL 821 EQUAL Reactome Database ID Release 82 10669527 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669527 Reactome R-DME-190416-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190416-2.1 Reactome Database ID Release 82 10669529 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669529 Reactome R-DME-190416-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190416-3.1 2 1 2 Reactome Database ID Release 82 10669531 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669531 Reactome R-DME-190418 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190418.1 Activated FGFR2c short homodimer bound to FGF Reactome DB_ID: 10669548 Converted from EntitySet in Reactome Homologues of p-8Y-FGFR2-5 Reactome DB_ID: 10669546 Q07407 phospho-p-8Y-FGFR2-5 Reactome DB_ID: 10669538 464 EQUAL 584 EQUAL 654 EQUAL 731 EQUAL 767 EQUAL 22 EQUAL 819 EQUAL Reactome Database ID Release 82 10669538 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669538 Reactome R-DME-192600 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192600.1 Q09147 phospho-p-8Y-FGFR2-5 Reactome DB_ID: 10669544 464 EQUAL 584 EQUAL 731 EQUAL 767 EQUAL 22 EQUAL 819 EQUAL Reactome Database ID Release 82 10669544 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669544 Reactome R-DME-192600-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192600-2.1 Reactome Database ID Release 82 10669546 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669546 Reactome R-DME-192600-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192600-3.1 2 1 2 Reactome Database ID Release 82 10669548 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669548 Reactome R-DME-192592 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192592.1 Reactome Database ID Release 82 10669550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669550 Reactome R-DME-192616 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-192616.1 Reactome Database ID Release 82 10705353 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705353 Reactome R-DME-5654152 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654152.1 1 Reactome Database ID Release 82 10705355 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705355 Reactome R-DME-5654201 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654201.1 1 1 Reactome Database ID Release 82 10705357 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705357 Reactome R-DME-5654189 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654189.1 1 Reactome Database ID Release 82 10705359 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705359 Reactome R-DME-5654190 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654190.1 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10705367 Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10705365 Activated FGFR3:p-FRS2 Reactome DB_ID: 10705363 Converted from EntitySet in Reactome Activated FGFR3 Reactome DB_ID: 10705361 Activated FGFR3b homodimer Reactome DB_ID: 10669570 1 2 Converted from EntitySet in Reactome Homologues of p-6Y-FGFR3b Reactome DB_ID: 10669568 Q07407 phospho-p-6Y-FGFR3b Reactome DB_ID: 10669558 579 EQUAL 649 EQUAL 650 EQUAL 726 EQUAL 762 EQUAL 772 EQUAL 23 EQUAL 806 EQUAL Reactome Database ID Release 82 10669558 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669558 Reactome R-DME-190384 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190384.1 Q09147 phospho-p-6Y-FGFR3b Reactome DB_ID: 10669566 579 EQUAL 649 EQUAL 650 EQUAL 726 EQUAL 762 EQUAL 772 EQUAL 23 EQUAL 806 EQUAL Reactome Database ID Release 82 10669566 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669566 Reactome R-DME-190384-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190384-2.1 Reactome Database ID Release 82 10669568 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669568 Reactome R-DME-190384-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190384-3.1 2 Reactome Database ID Release 82 10669570 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669570 Reactome R-DME-190380 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190380.1 Activated FGFR3c homodimer Reactome DB_ID: 10669588 1 2 Converted from EntitySet in Reactome Homologues of p-6Y-FGFR3c Reactome DB_ID: 10669586 Q07407 phospho-p-6Y-FGFR3c Reactome DB_ID: 10669577 577 EQUAL 647 EQUAL 648 EQUAL 724 EQUAL 760 EQUAL 23 EQUAL 808 EQUAL Reactome Database ID Release 82 10669577 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669577 Reactome R-DME-190382 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190382.1 Q09147 phospho-p-6Y-FGFR3c Reactome DB_ID: 10669584 577 EQUAL 647 EQUAL 648 EQUAL 724 EQUAL 760 EQUAL 23 EQUAL 808 EQUAL Reactome Database ID Release 82 10669584 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669584 Reactome R-DME-190382-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190382-2.1 Reactome Database ID Release 82 10669586 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669586 Reactome R-DME-190382-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190382-3.1 2 Reactome Database ID Release 82 10669588 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669588 Reactome R-DME-190389 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190389.1 Reactome Database ID Release 82 10705361 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705361 Reactome R-DME-5654146 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654146.1 1 1 Reactome Database ID Release 82 10705363 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705363 Reactome R-DME-5654196 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654196.1 1 1 Reactome Database ID Release 82 10705365 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705365 Reactome R-DME-5654203 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654203.1 1 1 Reactome Database ID Release 82 10705367 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705367 Reactome R-DME-5654195 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654195.1 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K Reactome DB_ID: 10705375 1 Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10705373 Activated FGFR4:p-FRS2 Reactome DB_ID: 10705371 Converted from EntitySet in Reactome Activated FGFR4 Reactome DB_ID: 10705369 Activated FGFR4 homodimer Reactome DB_ID: 10669608 1 2 Converted from EntitySet in Reactome Homologues of p-5Y-FGFR4 Reactome DB_ID: 10669604 Q07407 phospho-p-5Y-FGFR4 Reactome DB_ID: 10669595 643 EQUAL 642 EQUAL 719 EQUAL 754 EQUAL 764 EQUAL 22 EQUAL 802 EQUAL Reactome Database ID Release 82 10669595 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669595 Reactome R-DME-190330 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190330.1 Q09147 phospho-p-5Y-FGFR4 Reactome DB_ID: 10669602 643 EQUAL 642 EQUAL 719 EQUAL 754 EQUAL 764 EQUAL 22 EQUAL 802 EQUAL Reactome Database ID Release 82 10669602 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669602 Reactome R-DME-190330-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190330-2.1 Reactome Database ID Release 82 10669604 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669604 Reactome R-DME-190330-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190330-3.1 2 Reactome Database ID Release 82 10669608 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669608 Reactome R-DME-190328 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-190328.1 Activated FGFR4 bound to FGF19:BetaKlotho Reactome DB_ID: 10669612 KLB Dmel\CG9701 Q9VV98 Reactome DB_ID: 10669610 1 EQUAL 1044 EQUAL Reactome Database ID Release 82 10669610 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669610 Reactome R-DME-1307932 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1307932.1 2 bnl FGF19 Q9VDT9 Reactome DB_ID: 10669606 25 EQUAL 216 EQUAL Reactome Database ID Release 82 10669606 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669606 Reactome R-DME-189888 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-189888.1 2 2 Reactome Database ID Release 82 10669612 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669612 Reactome R-DME-1307958 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1307958.1 Reactome Database ID Release 82 10705369 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705369 Reactome R-DME-5654158 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654158.1 1 1 Reactome Database ID Release 82 10705371 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705371 Reactome R-DME-5654193 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654193.1 1 1 Reactome Database ID Release 82 10705373 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705373 Reactome R-DME-5654191 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654191.1 1 Reactome Database ID Release 82 10705375 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705375 Reactome R-DME-5654187 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654187.1 Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10705381 1 Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10705379 Activated FGFR1:p-FRS2:p-PTPN11 Reactome DB_ID: 10705377 Ghost homologue of p-Y546,Y584-PTPN11 Reactome DB_ID: 10669629 Reactome Database ID Release 82 10669629 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669629 Reactome R-DME-162573 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-162573.1 1 1 Reactome Database ID Release 82 10705377 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705377 Reactome R-DME-5654204 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654204.1 1 1 Reactome Database ID Release 82 10705379 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705379 Reactome R-DME-5654185 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654185.1 1 Reactome Database ID Release 82 10705381 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705381 Reactome R-DME-5654188 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654188.1 Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10705387 1 Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10705385 Activated FGFR2:p-FRS2:p-PTPN11 Reactome DB_ID: 10705383 1 1 Reactome Database ID Release 82 10705383 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705383 Reactome R-DME-5654184 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654184.1 1 1 Reactome Database ID Release 82 10705385 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705385 Reactome R-DME-5654194 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654194.1 1 Reactome Database ID Release 82 10705387 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705387 Reactome R-DME-5654192 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654192.1 Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K Reactome DB_ID: 10705393 1 Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 Reactome DB_ID: 10705391 1 Activated FGFR3:p-FRS2:p-PTPN11 Reactome DB_ID: 10705389 1 1 Reactome Database ID Release 82 10705389 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705389 Reactome R-DME-5654198 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654198.1 1 Reactome Database ID Release 82 10705391 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705391 Reactome R-DME-5654199 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654199.1 1 Reactome Database ID Release 82 10705393 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705393 Reactome R-DME-5654197 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5654197.1 ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha Reactome DB_ID: 10705408 1 ESRs:STRN:ESTG:MyrG-pY419-SRC Reactome DB_ID: 10705406 ESRs:STRN:ESTG Reactome DB_ID: 10705404 ERR ESR1 Q8WS79 Reactome DB_ID: 10705395 UniProt:Q8WS79 ERR UniProt Q8WS79 1 EQUAL 595 EQUAL Reactome Database ID Release 82 10705395 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705395 Reactome R-DME-9020968 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-9020968.1 2 ESTG estrogen Reactome DB_ID: 9027649 estrogen [ChEBI:50114] estrogen ChEBI CHEBI:50114 Reactome Database ID Release 82 9027649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9027649 Reactome R-ALL-9027649 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9027649.3 2 Cka STRN D3DML3 Reactome DB_ID: 10705402 UniProt:D3DML3 Cka UniProt D3DML3 1 EQUAL 780 EQUAL Reactome Database ID Release 82 10705402 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705402 Reactome R-DME-9037081 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-9037081.1 2 Reactome Database ID Release 82 10705404 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705404 Reactome R-DME-9027648 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-9027648.1 1 P00528 phospho-MyrG-p-Y419-SRC Reactome DB_ID: 10680863 UniProt:P00528 UniProt P00528 2 EQUAL N-myristoylglycine MOD MOD:00068 419 EQUAL 2 EQUAL 536 EQUAL Reactome Database ID Release 82 10680863 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680863 Reactome R-DME-1810408 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1810408.1 1 Reactome Database ID Release 82 10705406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705406 Reactome R-DME-9021593 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-9021593.1 1 Reactome Database ID Release 82 10705408 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705408 Reactome R-DME-9021654 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-9021654.1 Reactome Database ID Release 82 10705410 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705410 Reactome R-DME-2316432 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2316432.1 GENE ONTOLOGY GO:0046934 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10705411 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705411 Reactome Database ID Release 82 10705413 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705413 Reactome R-DME-2316434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2316434.1 GENE ONTOLOGY GO:0051897 gene ontology term for cellular process MI MI:0359 A number of different extracellular signals converge on PI3K activation. PI3K can be activated downstream of receptor tyrosine kinases (RTKs) such as FGFR (Ong et al. 2001, Eswarakumar et al. 2005), KIT (Chian et al. 2001, Ronnstrand 2004, Reber et al. 2006), PDGF (Coughlin et al. 1989, Fantl et al. 1992, Heldin et al. 1998), insulin receptor IGF1R (Hadari et al. 1992, Kooijman et al. 1995), and EGFR and its family members (Rodrigues et al. 2000, Jackson et al. 2004, Kainulainen et al. 2000, Junttila et al. 2009). Other proteins, such as CD28 (Pages et al. 1996, Koyasu 2003, Kane and Weiss, 2003) and TRAT1 (Bruyns et al. 1998, Koyasu 2003, Kolsch et al. 2006), can also trigger PI3K activity.<br><br>In unstimulated cells, PI3K class IA exists as an inactive heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). Binding of the iSH2 domain of the p85 regulatory subunit to the ABD and C2 domains of the p110 catalytic subunit both stabilizes p110 and inhibits its catalytic activity. This inhibition is relieved when the SH2 domains of p85 bind phosphorylated tyrosines on activated RTKs or their adaptor proteins. Binding to membrane-associated receptors brings activated PI3K in proximity to its membrane-localized substrate, PIP2 (Mandelker et al. 2009, Burke et al. 2011). 16612002 Pubmed 2006 Normal T-cell development and immune functions in TRIM-deficient mice Kolsch, U Arndt, B Reinhold, D Lindquist, JA Juling, N Kliche, S Pfeffer, K Bruyns, E Schraven, B Simeoni, L Mol Cell Biol 26:3639-48 10722704 Pubmed 2000 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis Kainulainen, V Sundvall, M Määttä, JA Santiestevan, E Klagsbrun, Michael Elenius, K J Biol Chem 275:8641-9 21827948 Pubmed 2011 Dynamics of the phosphoinositide 3-kinase p110? interaction with p85? and membranes reveals aspects of regulation distinct from p110? Burke, John E Vadas, Oscar Berndt, Alex Finegan, Tara Perisic, O Williams, RL Structure 19:1127-37 11353842 Pubmed 2001 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH Hadari, YR Gotoh, N Guy, GR Schlessinger, J Lax, I Proc Natl Acad Sci U S A 98:6074-9 2466336 Pubmed 1989 Role of phosphatidylinositol kinase in PDGF receptor signal transduction Coughlin, SR Escobedo, JA Williams, LT Science 243:1191-4 16483568 Pubmed 2006 Stem cell factor and its receptor c-Kit as targets for inflammatory diseases Reber, L Da Silva, CA Frossard, N Eur J Pharmacol 533:327-40 10648629 Pubmed 2000 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Rodrigues, GA Falasca, M Zhang, Z Ong, SH Schlessinger, J Mol Cell Biol 20:1448-59 15526160 Pubmed 2004 Signal transduction via the stem cell factor receptor/c-Kit Rönnstrand, Lars Cell Mol Life Sci 61:2535-48 15059917 Pubmed 2004 Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects Jackson, JG St Clair, P Sliwkowski, MX Brattain, Michael G Cancer Res 64:2601-9 12660731 Pubmed 2003 The role of PI3K in immune cells Koyasu, S Nat Immunol 4:313-9 15863030 Pubmed 2005 Cellular signaling by fibroblast growth factor receptors Eswarakumar, VP Lax, I Schlessinger, J Cytokine Growth Factor Rev 16:139-49 8621607 Pubmed 1996 Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association Pagès, F Ragueneau, M Klasen, S Battifora, M Couez, D Sweet, R Truneh, A Ward, SG Olive, D J Biol Chem 271:9403-9 19411071 Pubmed 2009 Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941 Junttila, TT Akita, Robert W Parsons, K Fields, C Lewis Phillips, GD Friedman, LS Sampath, D Sliwkowski, MX Cancer Cell 15:429-40 1381348 Pubmed 1992 Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers Hadari, Yaron Tzahar, E Nadiv, Orna Rothenberg, Paul Roberts, Charles LeRoith, Derek Yarden, Y Zick, Yehiel J. Biol. Chem. 267:17483-6 11520784 Pubmed 2001 Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant Chian, R Young, S Danilkovitch-Miagkova, A Rönnstrand, Lars Leonard, E Ferrao, P Ashman, L Linnekin, D Blood 98:1365-73 9687533 Pubmed 1998 T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane Bruyns, E Marie-Cardine, A Kirchgessner, H Sagolla, K Shevchenko, A Mann, M Autschbach, F Bensussan, A Meuer, S Schraven, B J Exp Med 188:561-75 9739761 Pubmed 1998 Signal transduction via platelet-derived growth factor receptors Heldin, Carl-Henrik Ostman, A Rönnstrand, Lars Biochim Biophys Acta 1378:F79-113 19805105 Pubmed 2009 A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane Mandelker, Diana Gabelli, Sandra B Schmidt-Kittler, Oleg Zhu, Jiuxiang Cheong, Ian Huang, Chuan-Hsiang Kinzler, KW Vogelstein, B Amzel, L Mario Proc. Natl. Acad. Sci. U.S.A. 106:16996-7001 7543144 Pubmed 1995 Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes Kooijman, Ron Lauf, Jeroen Kappers, Astrid Rijkers, Ger J. Exp. Med. 182:593-7 1374684 Pubmed 1992 Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways Fantl, WJ Escobedo, JA Martin, GA Turck, CW del Rosario, M McCormick, F Williams, LT Cell 69:413-23 12670391 Pubmed 2003 The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 Kane, LP Weiss, A Immunol Rev 192:7-20 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT PIP3 recruits AKT to the membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome AKT Reactome DB_ID: 10683045 AKT1 Q8INB9 Reactome DB_ID: 10683041 UniProt:Q8INB9 Akt1 Akt1 CG4006 FUNCTION Serine/threonine kinase involved in various developmental processes (PubMed:9601646, PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:12172554, PubMed:11872800, PubMed:14525946, PubMed:12893776, PubMed:15466161, PubMed:15712201). During early embryogenesis, acts as a survival protein (PubMed:9601646, PubMed:10962553). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:25329475, PubMed:29025897, PubMed:24603715). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553).SUBUNIT Interacts with trbl.TISSUE SPECIFICITY Ubiquitously expressed. Present in ovary, where it is concentrated at the basal side of follicle cells.DEVELOPMENTAL STAGE Expressed both maternally and zygotically. Strongly expressed in embryo and pupa. Weakly expressed in larva. Mildly expressed in adult.DOMAIN Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.PTM Phosphorylated and activated by Pk61C/PDK1 (PubMed:11344272). Phosphorylated on Ser-586 by the TORC2 complex (PubMed:10962553, PubMed:15718470, PubMed:22493059).DISRUPTION PHENOTYPE Death at the first instar larval stage (PubMed:9601646). Conditional RNAi-mediated knockdown in the female germline reduces ovary size (PubMed:24786828). RNAi-mediated knockdown in both larval salivary glands and fat body, results in small salivary glands displaying ectopic lipid storage and reduced expression of CdsA (PubMed:24603715).SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. UniProt Q8INB9 1 EQUAL 480 EQUAL Reactome Database ID Release 82 10683041 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683041 Reactome R-DME-58252 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-58252.1 AKT3 Q8INB9 Reactome DB_ID: 10683043 1 EQUAL 479 EQUAL Reactome Database ID Release 82 10683043 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683043 Reactome R-DME-2976007 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2976007.1 AKT2 Q8INB9 Reactome DB_ID: 10669710 1 EQUAL 481 EQUAL Reactome Database ID Release 82 10669710 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669710 Reactome R-DME-49859 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-49859.1 Reactome Database ID Release 82 10683045 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10683045 Reactome R-DME-202088 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202088.1 AKT:PIP3 Reactome DB_ID: 10676696 1 Converted from EntitySet in Reactome AKT Reactome DB_ID: 10676694 AKT1 Q8INB9 Reactome DB_ID: 10676688 1 EQUAL 480 EQUAL Reactome Database ID Release 82 10676688 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676688 Reactome R-DME-199416 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199416.1 AKT2 Q8INB9 Reactome DB_ID: 10676690 1 EQUAL 481 EQUAL Reactome Database ID Release 82 10676690 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676690 Reactome R-DME-202053 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202053.1 AKT3 Q8INB9 Reactome DB_ID: 10676692 1 EQUAL 479 EQUAL Reactome Database ID Release 82 10676692 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676692 Reactome R-DME-2976006 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2976006.1 Reactome Database ID Release 82 10676694 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676694 Reactome R-DME-202052 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202052.1 1 Reactome Database ID Release 82 10676696 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676696 Reactome R-DME-2317329 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2317329.1 Reactome Database ID Release 82 10705419 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705419 Reactome R-DME-2317332 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2317332.1 GENE ONTOLOGY GO:0032148 PIP3 generated by PI3K recruits AKT (also known as protein kinase B) to the membrane, through its PH (pleckstrin-homology) domains. The binding of PIP3 to the PH domain of AKT is the rate-limiting step in AKT activation (Scheid et al. 2002). In mammals there are three AKT isoforms (AKT1-3) encoded by three separate genes. The three isoforms share a high degree of amino acid identity and have indistinguishable substrate specificity in vitro. However, isoform-preferred substrates in vivo cannot be ruled out. The relative expression of the three isoforms differs in different mammalian tissues: AKT1 is the predominant isoform in the majority of tissues, AKT2 is the predominant isoform in insulin-responsive tissues, and AKT3 is the predominant isoform in brain and testes. All 3 isoforms are expressed in human and mouse platelets (Yin et al. 2008; O'Brien et al. 2008). Note: all data in the pathway refer to AKT1, which is the most studied. 17914025 Pubmed 2008 The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation Yin, H Stojanovic, A Hay, N Du, X Blood 111:658-65 12167717 Pubmed 2002 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B Scheid, MP Marignani, PA Woodgett, JR Mol Cell Biol 22:6247-60 2008 The role of Akt3 in Platelet Activation O'Brien, K Stojanovic, A Hay, N Du, X Arteriosclerosis, Thrombosis, and Vascular Biology 28:e162 LEFT-TO-RIGHT PIP3 recruits PDPK1 to the membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PDPK1 Q9W0V1 Reactome DB_ID: 10677776 UniProt:Q9W0V1 Pdk1 Pdk1 Pk61C CG1210 FUNCTION Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.DEVELOPMENTAL STAGE Highly expressed in Malpighian tubule primordia from stage late 11 to 13. Expressed in hindgut at stage 13. After stage 14, ubiquitously expressed at low levels.DOMAIN The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.DISRUPTION PHENOTYPE Death during the second instar stage.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. UniProt Q9W0V1 1 EQUAL 556 EQUAL Reactome Database ID Release 82 10677776 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677776 Reactome R-DME-202210 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202210.1 PDPK1:PIP3 Reactome DB_ID: 10669722 PDPK1 Q9W0V1 Reactome DB_ID: 10669720 1 EQUAL 556 EQUAL Reactome Database ID Release 82 10669720 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669720 Reactome R-DME-61459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-61459.1 1 1 Reactome Database ID Release 82 10669722 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669722 Reactome R-DME-109697 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-109697.1 Reactome Database ID Release 82 10705343 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705343 Reactome R-DME-2316429 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2316429.1 PIP3 generated by PI3K recruits phosphatidylinositide-dependent protein kinase 1 (PDPK1 i.e. PDK1) to the membrane, through its PH (pleckstrin-homology) domain. PDPK1 binds PIP3 with high affinity, and also shows low affinity for PIP2 (Currie et al. 1999). 9895304 Pubmed 1999 Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Currie, RA Walker, KS Gray, A Deak, M Casamayor, A Downes, CP Cohen, P Alessi, DR Lucocq, J Biochem J 337:575-83 LEFT-TO-RIGHT 2.7.11.1 TORC2 (mTOR) phosphorylates AKT at S473 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p-S-AKT:PIP3 Reactome DB_ID: 10676706 Converted from EntitySet in Reactome p-S-AKT Reactome DB_ID: 10676704 Q8INB9 phospho-p-S473-AKT1 Reactome DB_ID: 10676698 473 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 480 EQUAL Reactome Database ID Release 82 10676698 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676698 Reactome R-DME-377265 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-377265.1 Q8INB9 phospho-p-S474-AKT2 Reactome DB_ID: 10676700 474 EQUAL 1 EQUAL 481 EQUAL Reactome Database ID Release 82 10676700 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676700 Reactome R-DME-2317312 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2317312.1 Q8INB9 phospho-p-S472-AKT3 Reactome DB_ID: 10676702 472 EQUAL 1 EQUAL 479 EQUAL Reactome Database ID Release 82 10676702 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676702 Reactome R-DME-3009363 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3009363.1 Reactome Database ID Release 82 10676704 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676704 Reactome R-DME-2317317 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2317317.1 1 1 Reactome Database ID Release 82 10676706 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676706 Reactome R-DME-2317310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2317310.1 ACTIVATION activeUnit: #Protein84 TORC2 complex Reactome DB_ID: 10676720 Ghost homologue of PRR5 Reactome DB_ID: 10676718 Reactome Database ID Release 82 10676718 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676718 Reactome R-DME-6795323 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6795323.1 1 Sin1 MAPKAP1 Q9V719 Reactome DB_ID: 10676716 UniProt:Q9V719 Sin1 UniProt Q9V719 2 EQUAL 522 EQUAL Reactome Database ID Release 82 10676716 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676716 Reactome R-DME-3006620 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3006620.1 1 rictor RICTOR Q9VWJ6 Reactome DB_ID: 10676711 UniProt:Q9VWJ6 rictor UniProt Q9VWJ6 1 EQUAL 1708 EQUAL Reactome Database ID Release 82 10676711 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676711 Reactome R-DME-198632 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198632.1 1 Lst8 MLST8 Q9W328 Reactome DB_ID: 10672529 UniProt:Q9W328 Lst8 UniProt Q9W328 1 EQUAL 326 EQUAL Reactome Database ID Release 82 10672529 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10672529 Reactome R-DME-165676 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-165676.1 1 Tor MTOR Q9VK45 Reactome DB_ID: 10672534 UniProt:Q9VK45 Tor UniProt Q9VK45 1 EQUAL 2549 EQUAL Reactome Database ID Release 82 10672534 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10672534 Reactome R-DME-165662 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-165662.1 1 Reactome Database ID Release 82 10676720 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676720 Reactome R-DME-198626 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198626.1 GENE ONTOLOGY GO:0004674 Reactome Database ID Release 82 10676721 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676721 Reactome Database ID Release 82 10676727 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676727 Reactome R-DME-198640 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198640.1 Under conditions of growth and mitogen stimulation S473 phosphorylation of AKT is carried out by mTOR (mammalian Target of Rapamycin). This kinase is found in two structurally and functionally distinct protein complexes, named TOR complex 1 (TORC1) and TOR complex 2 (TORC2). It is TORC2 complex, which is composed of mTOR, RICTOR, SIN1 (also named MAPKAP1) and LST8, that phosphorylates AKT at S473 (Sarbassov et al., 2005). This complex also regulates actin cytoskeletal reorganization (Jacinto et al., 2004; Sarbassov et al., 2004). TORC1, on the other hand, is a major regulator of ribosomal biogenesis and protein synthesis (Hay and Sonenberg, 2004). TORC1 regulates these processes largely by the phosphorylation/inactivation of the repressors of mRNA translation 4E binding proteins (4E BPs) and by the phosphorylation/activation of ribosomal S6 kinase (S6K1). TORC1 is also the principal regulator of autophagy. In other physiological conditions, other kinases may be responsible for AKT S473 phosphorylation.<br> Phosphorylation of AKT on S473 by TORC2 complex is a prerequisite for AKT phosphorylation on T308 by PDPK1 (Scheid et al. 2002, Sarabassov et al. 2005). 19303758 Pubmed 2009 PIKKing on PKB: regulation of PKB activity by phosphorylation Bozulic, L Hemmings, BA Curr Opin Cell Biol 21:256-61 15268862 Pubmed 2004 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Sarbassov, DD Ali, SM Kim, DH Guertin, DA Latek, RR Erdjument-Bromage, H Tempst, P Sabatini, DM Curr Biol 14:1296-302 15467718 Pubmed 2004 Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Jacinto, E Loewith, R Schmidt, A Lin, S Ruegg, MA Hall, A Hall, MN Nat Cell Biol 6:1122-8 15314020 Pubmed 2004 Upstream and downstream of mTOR Hay, N Sonenberg, Nahum Genes Dev 18:1926-45 15718470 Pubmed 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Sarbassov, DD Guertin, DA Ali, SM Sabatini, DM Science 307:1098-101 INHIBITION Reactome Database ID Release 82 10676728 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676728 AKT:PIP3:THEM4/TRIB3 Reactome DB_ID: 10676725 trbl TRIB3 Q9V3Z1 Reactome DB_ID: 10676723 UniProt:Q9V3Z1 trbl UniProt Q9V3Z1 1 EQUAL 358 EQUAL Reactome Database ID Release 82 10676723 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676723 Reactome R-DME-199447 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199447.1 1 1 Reactome Database ID Release 82 10676725 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676725 Reactome R-DME-199453 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199453.1 LEFT-TO-RIGHT AKT binds PDPK1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> p-S-AKT:PDPK1:PIP3 Reactome DB_ID: 10705415 1 1 Reactome Database ID Release 82 10705415 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705415 Reactome R-DME-2317313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2317313.1 Reactome Database ID Release 82 10705417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705417 Reactome R-DME-2317314 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2317314.1 Once phosphorylated on serine residue S473, AKT bound to PIP3 forms a complex with PIP3-bound PDPK1 i.e. PDK1 (Scheid et al. 2002, Sarabassov et al. 2005) AKT phosphorylates targets in the cytosol This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.11.1 AKT phosphorylates IKKalpha This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CHUK Q9VEZ5 Reactome DB_ID: 10676676 UniProt:Q9VEZ5 IKKbeta IKKbeta DIK ird5 CG4201 FUNCTION Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel (PubMed:10636911, PubMed:11018014, PubMed:11156609, PubMed:30119996). Phosphorylates inhibitors of NF-kappa-B (cact) thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor (PubMed:10636911, PubMed:11018014, PubMed:11156609). Essential for antibacterial immune response (PubMed:11018014). Also required for antiviral immune response (PubMed:30119996).SUBUNIT Interacts with key to form the I-kappa-B kinase complex. In vitro, interacts with cact.DEVELOPMENTAL STAGE Expressed both maternally and zygotically throughout development. Highest expression is in early embryos and third larval instar.PTM Autophosphorylated; upon LPS stimulation it is transiently activated, and can be autophosphorylated.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. UniProt Q9VEZ5 1 EQUAL 745 EQUAL Reactome Database ID Release 82 10676676 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676676 Reactome R-DME-168104 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-168104.1 Q9VEZ5 phospho-p-T23-CHUK Reactome DB_ID: 10676679 23 EQUAL O-phospho-L-threonine MOD MOD:00047 1 EQUAL 745 EQUAL Reactome Database ID Release 82 10676679 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676679 Reactome R-DME-198615 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198615.1 ACTIVATION activeUnit: #Protein88 Converted from EntitySet in Reactome Active AKT p-T,p-S-AKT Reactome DB_ID: 10676671 Q8INB9 phospho-p-T308,S473-AKT1 Reactome DB_ID: 10676665 308 EQUAL 1 EQUAL 480 EQUAL Reactome Database ID Release 82 10676665 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676665 Reactome R-DME-198356 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198356.1 Q8INB9 phospho-p-T309,S474-AKT2 Reactome DB_ID: 10669728 309 EQUAL 1 EQUAL 481 EQUAL Reactome Database ID Release 82 10669728 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10669728 Reactome R-DME-202062 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202062.1 Q8INB9 phospho-p-T305,S472-AKT3 Reactome DB_ID: 10676669 305 EQUAL 1 EQUAL 479 EQUAL Reactome Database ID Release 82 10676669 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676669 Reactome R-DME-3009367 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3009367.1 Reactome Database ID Release 82 10676671 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676671 Reactome R-DME-202074 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202074.1 Reactome Database ID Release 82 10676672 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676672 Reactome Database ID Release 82 10676681 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676681 Reactome R-DME-198611 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198611.1 GENE ONTOLOGY GO:0043491 AKT mediates IKKalpha (Inhibitor of nuclear factor kappa B kinase subunit alpha) phosphorylation at threonine 23, which is required for NF-kB activation. NF-kB promoted gene transcription enhances neuronal survival. 10485710 Pubmed 1999 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase Ozes, ON Mayo, LD Gustin, JA Pfeffer, SR Pfeffer, LM Donner, DB Nature 401:82-5 LEFT-TO-RIGHT 2.7.11.1 AKT phosphorylates p21Cip1 and p27Kip1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> dap CDKN1B Q7JNL9 Reactome DB_ID: 10674843 UniProt:Q7JNL9 dap UniProt Q7JNL9 1 EQUAL 198 EQUAL Reactome Database ID Release 82 10674843 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10674843 Reactome R-DME-198622 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198622.1 Q7JNL9 phospho-dap p-T157-CDKN1B Reactome DB_ID: 10676684 157 EQUAL 1 EQUAL 198 EQUAL Reactome Database ID Release 82 10676684 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676684 Reactome R-DME-198629 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198629.1 ACTIVATION activeUnit: #Protein88 Reactome Database ID Release 82 10676686 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676686 Reactome R-DME-198613 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198613.1 Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by AKT leads to their retention in the cytoplasm, segregating these cyclin-dependent kinase (CDK) inhibitors from cyclin-CDK complexes. 12244303 Pubmed 2002 Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer Viglietto, G Motti, ML Bruni, P Melillo, RM D'Alessio, A Califano, D Vinci, F Chiappetta, G Tsichlis, P Bellacosa, A Fusco, A Santoro, M Nat Med 8:1136-44 11231573 Pubmed 2001 Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells Zhou, B P Liao, Y Xia, W Spohn, B Lee, M H Hung, M C Nat. Cell Biol. 3:245-52 LEFT-TO-RIGHT 2.7.11.1 AKT phosphorylates TSC2, inhibiting it This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> gig TSC2 Q9VW83 Reactome DB_ID: 10672491 UniProt:Q9VW83 gig UniProt Q9VW83 1 EQUAL 1807 EQUAL Reactome Database ID Release 82 10672491 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10672491 Reactome R-DME-2980548 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2980548.1 2 Q9VW83 phospho-gig p-S939,T1462-TSC2 Reactome DB_ID: 10676663 939 EQUAL 1462 EQUAL 1 EQUAL 1807 EQUAL Reactome Database ID Release 82 10676663 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676663 Reactome R-DME-199484 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199484.1 2 ACTIVATION activeUnit: #Protein88 Reactome Database ID Release 82 10676674 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676674 Reactome R-DME-198609 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198609.1 AKT phosphorylates and inhibits TSC2 (tuberin), a suppressor of the TOR kinase pathway, which senses nutrient levels in the environment. TSC2 forms a protein complex with TSC1 and this complex acts as a GAP (GTPase activating protein) for the RHEB G-protein. RHEB, in turn, activates the TOR kinase. Thus, an active AKT1 activates the TOR kinase, both of which are positive signals for cell growth (an increase in cell mass) and division.<br>The TOR kinase regulates two major processes: translation of selected mRNAs in the cell and autophagy. In the presence of high nutrient levels TOR is active and phosphorylates the 4EBP protein releasing the eukaryotic initiation factor 4E (eIF4E), which is essential for cap-dependent initiation of translation and promoting growth of the cell (PMID: 15314020). TOR also phosphorylates the S6 kinase, which is implicated in ribosome biogenesis as well as in the modification of the S6 ribosomal protein. AKT can also activate mTOR by another mechanism, involving phosphorylation of PRAS40, an inhibitor of mTOR activity. 12150915 Pubmed 2002 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway Manning, BD Tee, AR Logsdon, MN Blenis, J Cantley, Lewis C Mol Cell 10:151-62 12172553 Pubmed 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Inoki, K Li, Yun Zhu, T Wu, J Guan, KL Nat Cell Biol 4:648-57 LEFT-TO-RIGHT 2.7.11.1 AKT phosphorylates AKT1S1 (PRAS40) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 PRAS40 AKT1S1 Q7JXA2 Reactome DB_ID: 10672627 UniProt:Q7JXA2 PRAS40 UniProt Q7JXA2 1 EQUAL 256 EQUAL Reactome Database ID Release 82 10672627 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10672627 Reactome R-DME-200155 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-200155.1 Q7JXA2 phospho-PRAS40 p-S183,T246-AKT1S1 Reactome DB_ID: 10677122 183 EQUAL 246 EQUAL 1 EQUAL 256 EQUAL Reactome Database ID Release 82 10677122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677122 Reactome R-DME-200163 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-200163.1 2 ACTIVATION activeUnit: #Protein88 Reactome Database ID Release 82 10677124 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677124 Reactome R-DME-200143 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-200143.1 PRAS40 (proline-rich Akt/PKB substrate 40 kDa) is a substrate of AKT, the phosphorylation of which leads to the binding of this protein to 14-3-3. PRAS40 binds to mTOR complexes, mediating AKT signals to mTOR. Interaction of PRAS40 with the mTOR kinase domain is induced under conditions that inhibit mTOR signalling, such as growth factor deprivation. Binding of PRAS40 inhibits mTOR. PRAS40 phosphorylation by AKT and association with the cytosolic anchor protein 14-3-3, lead to mTOR stimulation (Vander Haar E, et al, 2007). Although it was originally identified in the context of insulin signalling, it was later shown that PRAS40 may also play a role in nerve growth factor-mediated neuroprotection (Saito A, et al, 2004). 12524439 Pubmed 2003 Identification of a proline-rich Akt substrate as a 14-3-3 binding partner Kovacina, KS Park, GY Bae, SS Guzzetta, AW Schaefer, E Birnbaum, MJ Roth, RA J Biol Chem 278:10189-94 17277771 Pubmed 2007 Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 Vander Haar, E Lee, SI Bandhakavi, S Griffin, TJ Kim, DH Nat Cell Biol 9:316-23 14973226 Pubmed 2004 Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor Saito, A Narasimhan, P Hayashi, T Okuno, S Ferrand-Drake, M Chan, PH J Neurosci 24:1584-93 LEFT-TO-RIGHT 2.7.11.1 AKT phosphorylates MKRN1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Mkrn1 MKRN1 Q9VP20 Reactome DB_ID: 10696124 UniProt:Q9VP20 Mkrn1 UniProt Q9VP20 1 EQUAL 482 EQUAL Reactome Database ID Release 82 10696124 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10696124 Reactome R-DME-976042 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-976042.1 Q9VP20 phospho-Mkrn1 p-S109-MKRN1 Reactome DB_ID: 10733690 109 EQUAL 1 EQUAL 482 EQUAL Reactome Database ID Release 82 10733690 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10733690 Reactome R-DME-8948758 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8948758.1 ACTIVATION activeUnit: #Protein88 Reactome Database ID Release 82 10733692 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10733692 Reactome R-DME-8948757 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8948757.1 AKT1 (and possibly AKT2 and AKT3), activated in response to EGF treatment, phosphorylates MKRN1, an E3 ubiquitin ligase, on serine residue S109. AKT-mediated phosphorylation results in stabilization of MKRN1, protecting it from ubiquitination and proteasome-mediated degradation (Lee et al. 2015). 26183061 Pubmed 2015 PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis Lee, Min-Sik Jeong, Man-Hyung Lee, Hyun-Woo Han, Hyun-Ji Ko, Aram Hewitt, SM Kim, Jae-Hoon Chun, Kyung-Hee Chung, Joon-Yong Lee, Cheolju Cho, Hanbyoul Song, Jaewhan Nat Commun 6:7769 Reactome Database ID Release 82 10741197 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10741197 Reactome R-DME-198323 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198323.1 Following activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kinase, which, in turn, contributes to AKT activation (positive feedback loop). AKT phosphorylates targets in the nucleus This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.11.1 AKT phosphorylates CREB1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> CrebB CREB1 Q9VWW0 Reactome DB_ID: 10676926 nucleoplasm GENE ONTOLOGY GO:0005654 UniProt:Q9VWW0 CrebB UniProt Q9VWW0 1 EQUAL 341 EQUAL Reactome Database ID Release 82 10676926 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676926 Reactome R-DME-52777 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-52777.1 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 29358 Reactome Database ID Release 82 29358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358 Reactome R-ALL-29358 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3 COMPOUND C00002 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 113582 Reactome Database ID Release 82 113582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582 Reactome R-ALL-113582 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3 COMPOUND C00008 Q9VWW0 phospho-CrebB p-S133-CREB1 Reactome DB_ID: 10676929 133 EQUAL 1 EQUAL 341 EQUAL Reactome Database ID Release 82 10676929 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676929 Reactome R-DME-111910 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-111910.1 ACTIVATION Converted from EntitySet in Reactome Active AKT p-T,p-S-AKT p-T308,S473-AKT1,(p-T309,S474-AKT2,p-T305,S472-AKT3) Reactome DB_ID: 10676937 Q8INB9 phospho-p-T308,S473-AKT1 Reactome DB_ID: 10676931 1 EQUAL 480 EQUAL Reactome Database ID Release 82 10676931 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676931 Reactome R-DME-198357 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198357.1 Q8INB9 phospho-p-T309,S474-AKT2 Reactome DB_ID: 10676933 1 EQUAL 481 EQUAL Reactome Database ID Release 82 10676933 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676933 Reactome R-DME-202087 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202087.1 Q8INB9 phospho-p-T305,S472-AKT3 Reactome DB_ID: 10676935 1 EQUAL 479 EQUAL Reactome Database ID Release 82 10676935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676935 Reactome R-DME-3009365 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3009365.1 Reactome Database ID Release 82 10676937 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676937 Reactome R-DME-202072 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202072.1 Reactome Database ID Release 82 10676938 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676938 Reactome Database ID Release 82 10676940 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676940 Reactome R-DME-199298 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199298.1 AKT phosphorylates CREB (cAMP response element-binding protein) at serine 133 and activates gene expression via a CREB-dependent mechanism, thus promoting cell survival. 9829964 Pubmed 1998 CREB is a regulatory target for the protein kinase Akt/PKB Du, K Montminy, M J Biol Chem 273:32377-9 LEFT-TO-RIGHT 2.7.11.1 AKT phosphorylates FOXO transcription factors This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 3 foxo FOXO1 Q95V55 Reactome DB_ID: 10676944 UniProt:Q95V55 foxo foxo Afx CG3143 FUNCTION Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.SUBUNIT Interacts with melt.DISRUPTION PHENOTYPE Mutant foxo lacking Akt1 phosphorylation sites no longer responds to insulin inhibition, remains in the nucleus, and is constitutively active, inducing cell arrest. UniProt Q95V55 1 EQUAL 655 EQUAL Reactome Database ID Release 82 10676944 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676944 Reactome R-DME-199300 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199300.1 Q95V55 phospho-foxo p-T24,S256,S319-FOXO1 Reactome DB_ID: 10676955 24 EQUAL 256 EQUAL 319 EQUAL 1 EQUAL 655 EQUAL Reactome Database ID Release 82 10676955 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676955 Reactome R-DME-199306 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199306.1 3 ACTIVATION Reactome Database ID Release 82 10676970 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676970 Reactome R-DME-199299 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199299.1 AKT-mediated phosphorylation of Forkhead box (FOX) transcription factors of the FOXO family, FOXO1 (FKHR), FOXO3 (FoxO3a, also known as FKHRL1) and FOXO4 (AFX) contributes to PI3K/AKT signaling-stimulated cell survival and growth. Activated AKT1 phosphorylates FOXO1 on threonine residue T24 and serine residues S256 and S319 (Rena et al. 1999), FOXO3 on threonine residue T32 and serine residues S253 and S315 (Brunet et al. 1999), and FOXO4 on threonine residue T32 and serine residues S197 and S262 (Kops et al. 1999).<br>Based on studies with recombinant mouse Foxo6 expressed in the human embryonic kidney cell line HEK293, FOXO6 has two conserved AKT phosphorylation sites: T26 and S184. Mouse Foxo6 has a third predicted Akt phosphorylation site at the C-terminus, T338, which is not present in other Foxo family members and is not conserved in human FOXO6. T26 and S184 are phosphorylated in response to growth factors known to activate PI3K/AKT signaling, but AKT has not been explicitly identified as the responsible kinase. In contrast to other FOXO family members, FOXO6 remains predominantly nuclear irrespective of growth factor-induced signaling, and only a small portion of phosphorylated FOXO6 may shuttle to the cytosol. Phosphorylation of FOXO6 on putative AKT sites, however, may inhibit binding of FOXO6 to target DNA sites (Jacobs et al. 2003, van der Heide et al. 2005).<br>Protein phosphatase DUSP6 (MKP3) may act to dephosphorylate FOXO1 after AKT-mediated phosphorylation (Rodrigues et al. 2017). 10358075 Pubmed 1999 Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B Rena, G Guo, S Cichy, SC Unterman, TG Cohen, P J Biol Chem 274:17179-83 12857750 Pubmed 2003 FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics Jacobs, Frank M J van der Heide, Lars P Wijchers, Patrick J E C Burbach, J Peter H Hoekman, Marco F M Smidt, Marten P J. Biol. Chem. 278:35959-67 10102273 Pubmed 1999 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Brunet, A Bonni, A Zigmond, MJ Lin, MZ Juo, P Hu, LS Anderson, MJ Arden, KC Blenis, J Greenberg, ME Cell 96:857-68 15987244 Pubmed 2005 FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling van der Heide, Lars P Jacobs, Frank M J Burbach, J Peter H Hoekman, Marco F M Smidt, Marten P Biochem. J. 391:623-9 28866049 Pubmed 2017 Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus Rodrigues, Bárbara de Almeida Kuga, Gabriel Keine Muñoz, Vitor Rosetto Gaspar, Rafael Calais Tavares, Mariana Rosolen Botezelli, José Diego da Silva, Adelino Sanchez Ramos Cintra, Dennys Esper de Moura, Leandro Pereira Simabuco, Fernando Moreira Ropelle, Eduardo Rochete Pauli, José Rodrigo Neurosci. Lett. 659:14-17 LEFT-TO-RIGHT 2.7.11.1 AKT can phosphorylate RSK This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 Converted from EntitySet in Reactome Homologues of RPS6KB2 Reactome DB_ID: 10677068 Q94533 RPS6KB2 Reactome DB_ID: 10677061 UniProt:Q94533 UniProt Q94533 1 EQUAL 482 EQUAL Reactome Database ID Release 82 10677061 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677061 Reactome R-DME-199877 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199877.1 Q9VWQ2 RPS6KB2 Reactome DB_ID: 10677066 UniProt:Q9VWQ2 UniProt Q9VWQ2 1 EQUAL 482 EQUAL Reactome Database ID Release 82 10677066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677066 Reactome R-DME-199877-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199877-2.1 Reactome Database ID Release 82 10677068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677068 Reactome R-DME-199877-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199877-3.1 2 Converted from EntitySet in Reactome Homologues of p-S15,S356-RPS6KB2 Reactome DB_ID: 10677078 Q94533 phospho-p-S15,S356-RPS6KB2 Reactome DB_ID: 10677072 15 EQUAL 356 EQUAL 1 EQUAL 482 EQUAL Reactome Database ID Release 82 10677072 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677072 Reactome R-DME-199844 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199844.1 Q9VWQ2 phospho-p-S15,S356-RPS6KB2 Reactome DB_ID: 10677076 15 EQUAL 356 EQUAL 1 EQUAL 482 EQUAL Reactome Database ID Release 82 10677076 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677076 Reactome R-DME-199844-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199844-2.1 Reactome Database ID Release 82 10677078 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677078 Reactome R-DME-199844-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199844-3.1 ACTIVATION Reactome Database ID Release 82 10677080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677080 Reactome R-DME-199839 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199839.1 Ribosomal protein S6 kinase beta-2 (RSK) activation is a highly conserved mitogenic response, and the activities of RSK are stimulated by multiple serine/threonine phosphorylations by different upstream kinases, one of which is AKT. 10490848 Pubmed 1999 Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt Koh, H Jee, K Lee, B Kim, J Kim, D Yun, YH Kim, JW Choi, HS Chung, J Oncogene 18:5115-9 LEFT-TO-RIGHT 2.7.11.1 AKT can phosphorylate NR4A1 (NUR77) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Hr38 NR4A1 P49869 Reactome DB_ID: 10677085 UniProt:P49869 Hr38 UniProt P49869 1 EQUAL 598 EQUAL Reactome Database ID Release 82 10677085 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677085 Reactome R-DME-199831 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199831.1 P49869 phospho-Hr38 p-S351-NR4A1 Reactome DB_ID: 10677088 351 EQUAL 1 EQUAL 598 EQUAL Reactome Database ID Release 82 10677088 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677088 Reactome R-DME-199846 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199846.1 ACTIVATION Reactome Database ID Release 82 10677090 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677090 Reactome R-DME-199863 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199863.1 AKT inhibits DNA binding of NUR77 and inhibits its pro-apoptotic function (PMID 11438550). However, the relevance of AKT for NUR77 phosphorylation has recently been questioned: according to recent work, NUR77 is phosphorylated by RSK (and MSK) rather than by AKT (PMID 16223362). 11274386 Pubmed 2001 Akt phosphorylates and regulates the orphan nuclear receptor Nur77 Pekarsky, Y Hallas, C Palamarchuk, A Koval, A Bullrich, F Hirata, Y Bichi, R Letofsky, J Croce, CM Proc Natl Acad Sci U S A 98:3690-4 Reactome Database ID Release 82 10741223 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10741223 Reactome R-DME-198693 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198693.1 After translocation into the nucleus, AKT can phosphorylate a number of targets there such as CREB, forkhead transcription factors, SRK and NUR77. Negative regulation of the PI3K/AKT network This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 3.1.3.67 PTEN dephosphorylates PIP3 PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> H2O water Reactome DB_ID: 29356 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 82 29356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356 Reactome R-ALL-29356 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5 COMPOUND C00001 Pi Orthophosphate hydrogenphosphate Phosphate Inorganic Phosphate Reactome DB_ID: 29372 hydrogenphosphate [ChEBI:43474] hydrogenphosphate hydrogen phosphate phosphate [PO3(OH)](2-) INORGANIC PHOSPHATE GROUP HYDROGENPHOSPHATE ION HPO4(2-) [P(OH)O3](2-) ChEBI CHEBI:43474 Reactome Database ID Release 82 29372 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29372 Reactome R-ALL-29372 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4 COMPOUND C00009 ACTIVATION Pten PTEN Q7KMQ6 Reactome DB_ID: 10677016 UniProt:Q7KMQ6 Pten Pten CG5671 Dmel_CG5671 <submittedName ref="1 2 3 4"> <fullName>Pten, isoform B</fullName> </submittedName> <submittedName> <fullName>IP16020p</fullName> </submittedName> <submittedName> <fullName>Phosphatase PTEN</fullName> </submittedName> UniProt Q7KMQ6 2 EQUAL 403 EQUAL Reactome Database ID Release 82 10677016 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677016 Reactome R-DME-199420 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199420.1 GENE ONTOLOGY GO:0016314 Reactome Database ID Release 82 10677017 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677017 Reactome Database ID Release 82 10677019 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677019 Reactome R-DME-199456 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199456.1 GENE ONTOLOGY GO:0051898 At the plasma membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) (Maehama & Dixon 1998, Myers et al. 1998, Das et al. 2003). The PI3K network is negatively regulated by phospholipid phosphatases that dephosphorylate PIP3, thus hampering AKT activation (Myers et al. 1998). The tumour suppressor PTEN is the primary phospholipid phosphatase.<br>Early studies indicated that magnesium ion, Mg2+, was needed for the catalytic activity of PTEN isolated from bovine thymus (Kabuyama et al. 1996). Subsequent studies have shown that PTEN was catalytically active in buffers free of magnesium and magnesium was not detected as part of the PTEN crystal (Lee et al. 1999). 12808147 Pubmed 2003 Membrane-binding and activation mechanism of PTEN Das, S Dixon, JE Cho, W Proc Natl Acad Sci U S A 100:7491-6 9811831 Pubmed 1998 The lipid phosphatase activity of PTEN is critical for its tumor supressor function Myers, MP Pass, I Batty, IH van der Kaay, J Stolarov, JP Hemmings, BA Downes, CP Tonks, NK Wigler, Michael H Proc Natl Acad Sci U S A 95:13513-8 10555148 Pubmed 1999 Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Lee, Jie-Oh Yang, Haijuan Georgescu, Maria-Magdalena Di Cristofano, Antonio Maehama, Tomohiko Shi, Y Dixon, Jack Pandolfi, Pier Pavletich, Nikola Cell 99:323-34 8681945 Pubmed 1996 Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus Kabuyama, Y Nakatsu, N Homma, Y Fukui, Y Eur. J. Biochem. 238:350-6 9593664 Pubmed 1998 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate Maehama, T Dixon, JE J Biol Chem 273:13375-8 LEFT-TO-RIGHT THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome Database ID Release 82 10677012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677012 Reactome R-DME-199443 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199443.1 The phosphorylation of membrane-recruited AKT at threonine and serine can be inhibited by direct binding of two different proteins, C-terminal modulator protein (THEM4 i.e. CTMP), which binds to the carboxy-terminal tail of AKT (Maira et al. 2001), or Tribbles homolog 3 (TRIB3), which binds to the catalytic domain of AKT (Du et al. 2003). 11598301 Pubmed 2001 Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane Maira, SM Galetic, I Brazil, DP Kaech, S Ingley, E Thelen, M Hemmings, BA Science 294:374-80 12791994 Pubmed 2003 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Du, K Herzig, S Kulkarni, RN Montminy, M Science 300:1574-7 LEFT-TO-RIGHT 3.1.3.16 PHLPP dephosphorylates S473 in AKT This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome P-AKT p-T-AKT Phospho-AKT Reactome DB_ID: 10676978 Q8INB9 phospho-p-T308-AKT1 Reactome DB_ID: 10676972 1 EQUAL 480 EQUAL Reactome Database ID Release 82 10676972 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676972 Reactome R-DME-198634 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-198634.1 Q8INB9 phospho-p-T309-AKT2 Reactome DB_ID: 10676974 1 EQUAL 481 EQUAL Reactome Database ID Release 82 10676974 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676974 Reactome R-DME-202066 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202066.1 Q8INB9 phospho-p-T305-AKT3 Reactome DB_ID: 10676976 1 EQUAL 479 EQUAL Reactome Database ID Release 82 10676976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676976 Reactome R-DME-3009370 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3009370.1 Reactome Database ID Release 82 10676978 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676978 Reactome R-DME-202084 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-202084.1 ACTIVATION PHLPP (Mn2+ cofactor) Reactome DB_ID: 10677007 Mn2+ Manganese manganese(2+) Mn(II) Reactome DB_ID: 29418 manganese(2+) [ChEBI:29035] manganese(2+) Mn(2+) MANGANESE (II) ION manganese, ion (Mn2+) manganese(II) manganous ion ChEBI CHEBI:29035 Reactome Database ID Release 82 29418 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29418 Reactome R-ALL-29418 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29418.3 COMPOUND C00034 2 Converted from EntitySet in Reactome PHLPP Reactome DB_ID: 10677005 Converted from EntitySet in Reactome Homologues of PHLPP1 Reactome DB_ID: 10676995 PHLPP1 CT11751 Q0E8W8 Reactome DB_ID: 10676983 UniProt:Q0E8W8 CT11751 UniProt Q0E8W8 1 EQUAL 1717 EQUAL Reactome Database ID Release 82 10676983 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676983 Reactome R-DME-199421 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199421.1 Phlpp PHLPP1 Q9VJ07 Reactome DB_ID: 10676988 UniProt:Q9VJ07 Phlpp UniProt Q9VJ07 1 EQUAL 1717 EQUAL Reactome Database ID Release 82 10676988 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676988 Reactome R-DME-199421-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199421-2.1 Lrr47 PHLPP1 Q9VKU0 Reactome DB_ID: 10676993 UniProt:Q9VKU0 Lrr47 UniProt Q9VKU0 1 EQUAL 1717 EQUAL Reactome Database ID Release 82 10676993 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676993 Reactome R-DME-199421-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199421-3.1 Reactome Database ID Release 82 10676995 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676995 Reactome R-DME-199421-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199421-4.1 Converted from EntitySet in Reactome Homologues of PHLPP2 Reactome DB_ID: 10677003 PHLPP2 CT11751 Q0E8W8 Reactome DB_ID: 10676997 1 EQUAL 1323 EQUAL Reactome Database ID Release 82 10676997 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676997 Reactome R-DME-2327837 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2327837.1 Phlpp PHLPP2 Q9VJ07 Reactome DB_ID: 10676999 1 EQUAL 1323 EQUAL Reactome Database ID Release 82 10676999 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676999 Reactome R-DME-2327837-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2327837-2.1 Lrr47 PHLPP2 Q9VKU0 Reactome DB_ID: 10677001 1 EQUAL 1323 EQUAL Reactome Database ID Release 82 10677001 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677001 Reactome R-DME-2327837-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2327837-3.1 Reactome Database ID Release 82 10677003 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677003 Reactome R-DME-2327837-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2327837-4.1 Reactome Database ID Release 82 10677005 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677005 Reactome R-DME-2327836 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2327836.1 1 Reactome Database ID Release 82 10677007 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677007 Reactome R-DME-199450 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199450.1 GENE ONTOLOGY GO:0004722 Reactome Database ID Release 82 10677008 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677008 Reactome Database ID Release 82 10677010 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10677010 Reactome R-DME-199425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-199425.1 The PH domain leucine-rich repeat-containing protein phosphatases, PHLPP1 (Gao et al. 2005) and PHLPP2 (Brognard et al. 2007) can specifically dephosphorylate the serine residue and inactivate AKT. 17386267 Pubmed 2007 PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms Brognard, John Sierecki, Emma Gao, Tianyan Newton, Alexandra C Mol. Cell 25:917-31 15808505 Pubmed 2005 PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth Gao, T Furnari, F Newton, AC Mol Cell 18:13-24 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 2.7.1.68 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI4P Phosphatidylinositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4-phosphates Reactome DB_ID: 392417 1-phosphatidyl-1D-myo-inositol 4-phosphate [ChEBI:17526] 1-phosphatidyl-1D-myo-inositol 4-phosphate ChEBI CHEBI:17526 Reactome Database ID Release 82 392417 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=392417 Reactome R-ALL-392417 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-392417.3 COMPOUND C01277 PubChem Substance 4496 ACTIVATION Converted from EntitySet in Reactome PIP5K1A-C Reactome DB_ID: 10700660 PIP5K1A PIP5K59B A0A6M3Q9L5 Reactome DB_ID: 10700649 UniProt:A0A6M3Q9L5 PIP5K59B UniProt A0A6M3Q9L5 1 EQUAL 562 EQUAL Reactome Database ID Release 82 10700649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700649 Reactome R-DME-1806260 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806260.1 Converted from EntitySet in Reactome Homologues of PIP5K1B Reactome DB_ID: 10700658 PIP5K1B PIP5K59B A0A6M3Q9L5 Reactome DB_ID: 10700651 1 EQUAL 540 EQUAL Reactome Database ID Release 82 10700651 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700651 Reactome R-DME-1806216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806216.1 sktl PIP5K1B Q9W2R3 Reactome DB_ID: 10700656 UniProt:Q9W2R3 sktl UniProt Q9W2R3 1 EQUAL 540 EQUAL Reactome Database ID Release 82 10700656 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700656 Reactome R-DME-1806216-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806216-2.1 Reactome Database ID Release 82 10700658 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700658 Reactome R-DME-1806216-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806216-3.1 Reactome Database ID Release 82 10700660 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700660 Reactome R-DME-1806157 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806157.1 GENE ONTOLOGY GO:0016308 Reactome Database ID Release 82 10700850 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700850 Reactome Database ID Release 82 10700852 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700852 Reactome R-DME-1676082 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1676082.1 At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP5K1A (Halstead et al. 2006, Zhang et al. 1997), PIP5K1B (Zhang et al. 1997), and PIP5K1C (Di Paolo et al. 2002).<br><br>This reaction is of particular interest because its regulation by small GTPases of the RHO and ARF families, not yet annotated here, ties the process of phosphatidylinositol phosphate biosynthesis to regulation of the actin cytoskeleton and vesicular trafficking, and hence to diverse aspects of cell motility and signalling (Oude Weernink et al. 2004, 2007). 17245604 Pubmed 2007 Phospholipase D signaling: orchestration by PIP2 and small GTPases Oude Weernink, PA López de Jesús, M Schmidt, M Naunyn Schmiedebergs Arch Pharmacol 374:399-411 9211928 Pubmed 1997 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules Zhang, Xiaoxuan Loijens, JC Boronenkov, IV Parker, GJ Norris, FA Chen, J Thum, O Prestwich, GD Majerus, PW Anderson, RA J Biol Chem 272:17756-61 16979564 Pubmed 2006 A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis Halstead, JR van Rheenen, J Snel, MH Meeuws, S Mohammed, S D'Santos, CS Heck, AJ Jalink, K Divecha, Nullin Curr Biol 16:1850-6 12422219 Pubmed 2002 Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Di Paolo, G Pellegrini, L Letinic, K Cestra, G Zoncu, R Voronov, S Chang, S Guo, J Wenk, MR De Camilli, Pietro Nature 420:85-9 15464023 Pubmed 2004 Regulation and cellular roles of phosphoinositide 5-kinases Oude Weernink, PA Schmidt, M Jakobs, KH Eur J Pharmacol 500:87-99 LEFT-TO-RIGHT 2.7.1.149 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PI5P 1-phosphatidyl-1D-myo-inositol 5-phosphate Reactome DB_ID: 1806240 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) [ChEBI:57795] 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-) 1-phosphatidyl-1D-myo-inositol 5-phosphate trianions a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) 2,3-bis(alkanoyloxy)propyl (1R,2R,3R,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-(phosphonatooxy)cyclohexyl phosphate 1-phosphatidyl-1D-myo-inositol 5-phosphate trianion ChEBI CHEBI:57795 Reactome Database ID Release 82 1806240 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806240 Reactome R-ALL-1806240 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1806240.4 ACTIVATION Converted from EntitySet in Reactome PIP4K2 dimers Reactome DB_ID: 10700686 PIP4K2A:PIP4K2A Reactome DB_ID: 10700670 PIP4K PIP4K2A Q8SXX1 Reactome DB_ID: 10700668 UniProt:Q8SXX1 PIP4K UniProt Q8SXX1 2 EQUAL 406 EQUAL Reactome Database ID Release 82 10700668 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700668 Reactome R-DME-1604641 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1604641.1 2 Reactome Database ID Release 82 10700670 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700670 Reactome R-DME-1806252 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806252.1 PIP4K2A:PIP4K2B Reactome DB_ID: 10700674 PIP4K PIP4K2B Q8SXX1 Reactome DB_ID: 10700672 1 EQUAL 416 EQUAL Reactome Database ID Release 82 10700672 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700672 Reactome R-DME-1806208 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806208.1 1 1 Reactome Database ID Release 82 10700674 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700674 Reactome R-DME-1806183 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806183.1 PIP4K2B:PIP4K2B Reactome DB_ID: 10700676 2 Reactome Database ID Release 82 10700676 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700676 Reactome R-DME-1806168 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806168.1 PIP4K2A:PIP4K2C Reactome DB_ID: 10700680 PIP4K PIP4K2C Q8SXX1 Reactome DB_ID: 10700678 2 EQUAL 421 EQUAL Reactome Database ID Release 82 10700678 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700678 Reactome R-DME-1604638 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1604638.1 1 1 Reactome Database ID Release 82 10700680 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700680 Reactome R-DME-6808605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6808605.1 PIP4K2C:PIP4K2C Reactome DB_ID: 10700682 2 Reactome Database ID Release 82 10700682 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700682 Reactome R-DME-6808604 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6808604.1 PIP4K2B:PIP4K2C Reactome DB_ID: 10700684 1 1 Reactome Database ID Release 82 10700684 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700684 Reactome R-DME-6808599 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6808599.1 Reactome Database ID Release 82 10700686 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700686 Reactome R-DME-1806229 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1806229.1 GENE ONTOLOGY GO:0016309 Reactome Database ID Release 82 10700687 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700687 Reactome Database ID Release 82 10700689 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700689 Reactome R-DME-1675776 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1675776.1 At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).<br><br>The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015). 18753295 Pubmed 2008 Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron Clarke, JH Emson, PC Irvine, RF Am J Physiol Renal Physiol 295:F1422-30 19896968 Pubmed 2010 Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Clarke, JH Wang, M Irvine, RF Adv Enzyme Regul 50:12-8 23758345 Pubmed 2013 Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization Clarke, Jonathan H Irvine, Robin F Biochem. J. 454:49-57 9367159 Pubmed 1997 A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Rameh, Lucia Tolias, KF Duckworth, BC Cantley, Lewis C Nature 390:192-6 25495341 Pubmed 2015 The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site Clarke, Jonathan H Giudici, Maria-Luisa Burke, John E Williams, RL Maloney, David J Marugan, Juan Irvine, Robin F Biochem. J. 466:359-67 LEFT-TO-RIGHT 3.1.3.16 AKT1 dephosphorylation by PP2A-B56-beta,gamma This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 2 ACTIVATION PP2A-B56-beta,gamma Reactome DB_ID: 10727218 Converted from EntitySet in Reactome PP2A-catalytic subunit C Reactome DB_ID: 10676388 PPP2CA P23696 Reactome DB_ID: 10676386 UniProt:P23696 mts mts PP2A Pp2A-28D CG7109 PTM Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).SIMILARITY Belongs to the PPP phosphatase family. PP-2A subfamily. UniProt P23696 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10676386 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676386 Reactome R-DME-165971 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-165971.1 Reactome Database ID Release 82 10676388 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676388 Reactome R-DME-165977 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-165977.1 1 Converted from EntitySet in Reactome PPP2R5B,PPP2R5C B56beta,B56gamma Reactome DB_ID: 10727216 wdb PPP2R5B A0A6F7R657 Reactome DB_ID: 10676360 UniProt:A0A6F7R657 wdb UniProt A0A6F7R657 1 EQUAL 497 EQUAL Reactome Database ID Release 82 10676360 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676360 Reactome R-DME-535469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-535469.1 Converted from EntitySet in Reactome Homologues of PPP2R5C Reactome DB_ID: 10676374 wrd PPP2R5C Q8IN89 Reactome DB_ID: 10676367 UniProt:Q8IN89 wrd UniProt Q8IN89 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10676367 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676367 Reactome R-DME-3008954 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3008954.1 Q9VXB7 Dmel\CG32568 PPP2R5C Reactome DB_ID: 10676372 UniProt:Q9VXB7 Dmel\CG32568 UniProt Q9VXB7 1 EQUAL 524 EQUAL Reactome Database ID Release 82 10676372 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676372 Reactome R-DME-3008954-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3008954-2.1 Reactome Database ID Release 82 10676374 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676374 Reactome R-DME-3008954-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3008954-3.1 Reactome Database ID Release 82 10727216 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10727216 Reactome R-DME-6811516 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6811516.1 1 Converted from EntitySet in Reactome PP2A-subunit A Reactome DB_ID: 10676384 P36179 Pp2A-29B PPP2R1A Reactome DB_ID: 10676380 UniProt:P36179 Pp2A-29B Pp2A-29B CG17291 FUNCTION The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.SUBUNIT PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit (PR65) (subunit A). The core complex associates with a third, variable subunit (subunit B), which confers distinct properties to the holoenzyme.TISSUE SPECIFICITY Expression varies in tissues throughout development. Highly distributed expression in early embryos. In late embryonal development, found at high levels in nervous system and gonads. In third instar larvae, found in brain, imaginal disks and salivary glands.DEVELOPMENTAL STAGE Expressed both maternally and zygotically. Expressed at lower levels in larvae and adult.DOMAIN Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.SIMILARITY Belongs to the phosphatase 2A regulatory subunit A family. UniProt P36179 2 EQUAL 589 EQUAL Reactome Database ID Release 82 10676380 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676380 Reactome R-DME-165982 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-165982.1 Reactome Database ID Release 82 10676384 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676384 Reactome R-DME-165990 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-165990.1 1 Reactome Database ID Release 82 10727218 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10727218 Reactome R-DME-6811526 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6811526.1 Reactome Database ID Release 82 10727225 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10727225 Reactome Database ID Release 82 10727227 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10727227 Reactome R-DME-6811504 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6811504.1 The protein phosphatase 2A (PP2A) complex containing a regulatory subunit B56 beta (PPP2R5B) or B56 gamma (PPP2R5C) dephosphorylates activated AKT1 on threonine residue T308 and serine residue S473, thus halting PI3K/AKT signaling (Rocher et al. 2007). Phosphatidylinositol-5-phosphate (PI5P) negatively regulates PP2A-mediated dephosphorylation of AKT1 by promoting, through an unknown mechanism, an inhibitory phosphorylation on tyrosine residue Y307 (Chen et al. 1992) of the catalytic subunit of PP2A (Ramel et al. 2009). 19576174 Pubmed 2009 PtdIns5P protects Akt from dephosphorylation through PP2A inhibition Ramel, Damien Lagarrigue, Frédéric Dupuis-Coronas, Sophie Chicanne, Gaëtan Leslie, Nicholas Gaits-Iacovoni, Frédérique Payrastre, Bernard Tronchère, Hélène Biochem. Biophys. Res. Commun. 387:127-31 1325671 Pubmed 1992 Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation Chen, J Martin, B L Brautigan, D L Science 257:1261-4 17200115 Pubmed 2007 Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity Rocher, Géraldine Letourneux, Claire Lenormand, Philippe Porteu, Françoise J. Biol. Chem. 282:5468-77 INHIBITION Reactome Database ID Release 82 9906825 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9906825 LEFT-TO-RIGHT 2.7.10.2 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PP2A Reactome DB_ID: 10676390 1 1 Converted from EntitySet in Reactome PP2A regulatory subunit B56 Reactome DB_ID: 10676378 wdb PPP2R5A A0A6F7R657 Reactome DB_ID: 10676358 1 EQUAL 486 EQUAL Reactome Database ID Release 82 10676358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676358 Reactome R-DME-196235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-196235.1 wrd PPP2R5D Q8IN89 Reactome DB_ID: 10676365 1 EQUAL 602 EQUAL Reactome Database ID Release 82 10676365 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676365 Reactome R-DME-3008950 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3008950.1 Reactome Database ID Release 82 10676378 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676378 Reactome R-DME-196216 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-196216.1 1 Reactome Database ID Release 82 10676390 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10676390 Reactome R-DME-196206 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-196206.1 p-Y307-PP2A Reactome DB_ID: 10729339 1 Converted from EntitySet in Reactome p-Y307-PP2A-catalytic subunit C Reactome DB_ID: 10729337 P23696 phospho-p-Y307-PPP2CA Reactome DB_ID: 10729335 307 EQUAL 1 EQUAL 309 EQUAL Reactome Database ID Release 82 10729335 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10729335 Reactome R-DME-8857939