BioPAX pathway converted from "Synthesis of Leukotrienes (LT) and Eoxins (EX)" in the Reactome database. Synthesis of Leukotrienes (LT) and Eoxins (EX) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 3.3.2.6 LTA4 is hydrolyzed to LTB4 LTA4 is hydolysed to LTB4 by LTA4H This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> H2O water Reactome DB_ID: 29356 cytosol GENE ONTOLOGY GO:0005829 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 82 29356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356 Reactome R-ALL-29356 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5 Reactome http://www.reactome.org COMPOUND C00001 additional information MI MI:0361 LTA4 leukotriene A4 Reactome DB_ID: 265281 leukotriene A4 [ChEBI:15651] leukotriene A4 ChEBI CHEBI:15651 Reactome Database ID Release 82 265281 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265281 Reactome R-ALL-265281 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-265281.3 COMPOUND C00909 LTB4 Leukotriene-B(4) omega-hydroxylase leukotriene B4 Leukotriene-B(4) 20-monooxygenase Reactome DB_ID: 266056 leukotriene B4 [ChEBI:15647] leukotriene B4 ChEBI CHEBI:15647 Reactome Database ID Release 82 266056 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266056 Reactome R-ALL-266056 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266056.3 COMPOUND C02165 ACTIVATION LTA4H:Zn2+ Reactome DB_ID: 10680331 LTA4H Q9VJ39 Reactome DB_ID: 10680329 UniProt:Q9VJ39 Drosophila melanogaster NCBI Taxonomy 7227 UniProt Q9VJ39 2 EQUAL 611 EQUAL Reactome Database ID Release 82 10680329 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680329 Reactome R-DME-266022 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266022.1 1 Zn2+ Zn++ zinc(2+) Zinc ion Zn(II) Reactome DB_ID: 29426 zinc(2+) [ChEBI:29105] zinc(2+) ChEBI CHEBI:29105 Reactome Database ID Release 82 29426 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29426 Reactome R-ALL-29426 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29426.3 COMPOUND C00038 1 Reactome Database ID Release 82 10680331 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680331 Reactome R-DME-266038 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266038.1 GENE ONTOLOGY GO:0004463 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10680332 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680332 Reactome Database ID Release 82 10680334 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680334 Reactome R-DME-266072 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266072.1 Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that catalyzes the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) to the dihydroxy acid leukotriene B4 (LTB4) (Radmark et al. 1984, McGee & Fitzpatrick 1985). 2995393 Pubmed 1985 Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes McGee, J Fitzpatrick, F J Biol Chem 260:12832-7 6490615 Pubmed 1984 Leukotriene A4 hydrolase in human leukocytes. Purification and properties Rådmark, O Shimizu, T Jörnvall, H Samuelsson, B J Biol Chem 259:12339-45 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT ABCC1 mediates LTC4 export from the cell LTC4 is exported from the cytosol by ABCC1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LTC4 leukotriene C4 Reactome DB_ID: 266066 leukotriene C4 [ChEBI:16978] leukotriene C4 ChEBI CHEBI:16978 Reactome Database ID Release 82 266066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266066 Reactome R-ALL-266066 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266066.3 COMPOUND C02166 LTC4 leukotriene C4 Reactome DB_ID: 266013 extracellular region GENE ONTOLOGY GO:0005576 Reactome Database ID Release 82 266013 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266013 Reactome R-ALL-266013 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266013.3 COMPOUND C02166 ACTIVATION ABCC1 Q7KTC0 Reactome DB_ID: 10680321 plasma membrane GENE ONTOLOGY GO:0005886 UniProt:Q7KTC0 UniProt Q7KTC0 1 EQUAL 1531 EQUAL Reactome Database ID Release 82 10680321 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680321 Reactome R-DME-266068 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266068.1 GENE ONTOLOGY GO:0140359 Reactome Database ID Release 82 10680322 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680322 Reactome Database ID Release 82 10680324 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680324 Reactome R-DME-266070 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266070.1 On formation, leukotriene C4 (LTC4) is exported to the extracellular region by the ABCC1 transporter (Sjolinder et al. 1999, Lam et al. 1989) and processed further by cleavage reactions. 2753893 Pubmed 1989 The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils Lam, Bing K Owen WF, Jr Austen, KF Soberman, RJ J Biol Chem 264:12885-9 10064732 Pubmed 1999 Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1 Sjölinder, Mikael Tornhamre, S Claesson, HE Hydman, J Lindgren, J J Lipid Res 40:439-46 LEFT-TO-RIGHT 3.4.19.13 GGT1, 5 dimers hydrolyse LTC4 to LTD4 Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> H2O water Reactome DB_ID: 109276 Reactome Database ID Release 82 109276 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109276 Reactome R-ALL-109276 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109276.4 COMPOUND C00001 LTD4 leukotriene D4 Reactome DB_ID: 266074 leukotriene D4 [ChEBI:28666] leukotriene D4 ChEBI CHEBI:28666 Reactome Database ID Release 82 266074 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266074 Reactome R-ALL-266074 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266074.3 COMPOUND C05951 L-Glu L-Glutamate L-glutamate(1-) L-glutamic acid L-Glutaminic acid Reactome DB_ID: 210382 L-glutamate(1-) [ChEBI:29985] L-glutamate(1-) L-glutamic acid, ion(1-) [NH3+][C@@H](CCC([O-])=O)C([O-])=O WHUUTDBJXJRKMK-VKHMYHEASA-M C5H8NO4 146.12136 (2S)-2-ammoniopentanedioate hydrogen L-glutamate L-glutamate L-glutamic acid monoanion InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 ChEBI CHEBI:29985 Reactome Database ID Release 82 210382 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=210382 Reactome R-ALL-210382 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-210382.4 COMPOUND C00025 ACTIVATION Converted from EntitySet in Reactome GGT1, 5 dimers Reactome DB_ID: 10680313 GGT1 dimer Reactome DB_ID: 10680283 Converted from EntitySet in Reactome Homologues of GGT1(1-380) Reactome DB_ID: 10680275 M9NFP5 Dmel\CG17636 GGT1(1-380) Reactome DB_ID: 10680268 UniProt:M9NFP5 Dmel\CG17636 UniProt M9NFP5 1 EQUAL 380 EQUAL Reactome Database ID Release 82 10680268 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680268 Reactome R-DME-1247889 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1247889.1 Q7KUX2 Dmel\CG4829 GGT1(1-380) Reactome DB_ID: 10680273 UniProt:Q7KUX2 Dmel\CG4829 UniProt Q7KUX2 1 EQUAL 380 EQUAL Reactome Database ID Release 82 10680273 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680273 Reactome R-DME-1247889-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1247889-2.1 Reactome Database ID Release 82 10680275 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680275 Reactome R-DME-1247889-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1247889-3.1 1 Converted from EntitySet in Reactome Homologues of GGT1(381-569) Reactome DB_ID: 10680281 M9NFP5 Dmel\CG17636 GGT1(381-569) Reactome DB_ID: 10680277 381 EQUAL 569 EQUAL Reactome Database ID Release 82 10680277 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680277 Reactome R-DME-8943263 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8943263.1 Q7KUX2 Dmel\CG4829 GGT1(381-569) Reactome DB_ID: 10680279 381 EQUAL 569 EQUAL Reactome Database ID Release 82 10680279 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680279 Reactome R-DME-8943263-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8943263-2.1 Reactome Database ID Release 82 10680281 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680281 Reactome R-DME-8943263-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8943263-3.1 1 Reactome Database ID Release 82 10680283 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680283 Reactome R-DME-1247898 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1247898.1 GGT5 dimer Reactome DB_ID: 10680311 Converted from EntitySet in Reactome Homologues of GGT5(388-586) Reactome DB_ID: 10680309 M9NFP5 Dmel\CG17636 GGT5(388-586) Reactome DB_ID: 10680301 388 EQUAL 586 EQUAL Reactome Database ID Release 82 10680301 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680301 Reactome R-DME-265312 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265312.1 Q7KUX2 Dmel\CG4829 GGT5(388-586) Reactome DB_ID: 10680303 388 EQUAL 586 EQUAL Reactome Database ID Release 82 10680303 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680303 Reactome R-DME-265312-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265312-2.1 Ggt-1 GGT5(388-586) Q9VWT3 Reactome DB_ID: 10680305 UniProt:Q9VWT3 Ggt-1 UniProt Q9VWT3 388 EQUAL 586 EQUAL Reactome Database ID Release 82 10680305 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680305 Reactome R-DME-265312-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265312-3.1 Q9VYR2 Dmel\CG1492 GGT5(388-586) Reactome DB_ID: 10680307 UniProt:Q9VYR2 Dmel\CG1492 UniProt Q9VYR2 388 EQUAL 586 EQUAL Reactome Database ID Release 82 10680307 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680307 Reactome R-DME-265312-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265312-4.1 Reactome Database ID Release 82 10680309 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680309 Reactome R-DME-265312-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265312-5.1 1 Converted from EntitySet in Reactome Homologues of GGT5(1-387) Reactome DB_ID: 10680299 M9NFP5 Dmel\CG17636 GGT5(1-387) Reactome DB_ID: 10680285 1 EQUAL 387 EQUAL Reactome Database ID Release 82 10680285 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680285 Reactome R-DME-265313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265313.1 Q7KUX2 Dmel\CG4829 GGT5(1-387) Reactome DB_ID: 10680287 1 EQUAL 387 EQUAL Reactome Database ID Release 82 10680287 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680287 Reactome R-DME-265313-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265313-2.1 Ggt-1 GGT5(1-387) Q9VWT3 Reactome DB_ID: 10680292 1 EQUAL 387 EQUAL Reactome Database ID Release 82 10680292 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680292 Reactome R-DME-265313-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265313-3.1 Q9VYR2 Dmel\CG1492 GGT5(1-387) Reactome DB_ID: 10680297 1 EQUAL 387 EQUAL Reactome Database ID Release 82 10680297 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680297 Reactome R-DME-265313-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265313-4.1 Reactome Database ID Release 82 10680299 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680299 Reactome R-DME-265313-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265313-5.1 1 Reactome Database ID Release 82 10680311 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680311 Reactome R-DME-265314 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-265314.1 Reactome Database ID Release 82 10680313 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680313 Reactome R-DME-2162130 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2162130.1 GENE ONTOLOGY GO:0036374 Reactome Database ID Release 82 10680314 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680314 Reactome Database ID Release 82 10680316 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680316 Reactome R-DME-266046 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266046.1 The reversible conversion of leukotriene C4 (LTC4) to leukotriene D4 (LTD4) is catalysed by gamma-glutamyl transferases 1 (GGT1) and 5 (GGT5). GGTs are present on the outer surface of plasma membranes and are a heterodimer of a heavy and a light chain. Its action involves the hydrolysis of the gamma-glutamyl peptide bond of glutathione and glutathione conjugates, releasing glutamate. In this example, LTC4 is a glutathione conjugate that is hydrolysed to LTD4 (Anderson et al. 1982, Wickham et al. 2011). 21447318 Pubmed 2011 Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes Wickham, S West, MB Cook, PF Hanigan, MH Anal Biochem 414:208-14 6122208 Pubmed 1982 Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids Anderson, ME Allison, RD Meister, Alton Proc Natl Acad Sci U S A 79:1088-91 LEFT-TO-RIGHT 3.4.13.21 3.4.13.18 Further cleavage of LTD4 forms LTE4 LTD4 is converted to LTE4 by DPEP1/2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Gly Aminoacetic acid glycine zwitterion glycine Reactome DB_ID: 266029 glycine zwitterion [ChEBI:57305] glycine zwitterion glycine DHMQDGOQFOQNFH-UHFFFAOYSA-N 2-azaniumylacetate C2H5NO2 InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) [NH3+]CC([O-])=O 75.06660 ChEBI CHEBI:57305 Reactome Database ID Release 82 266029 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266029 Reactome R-ALL-266029 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266029.4 COMPOUND C00037 LTE4 leukotriene E4 Reactome DB_ID: 266033 leukotriene E4 [ChEBI:15650] leukotriene E4 ChEBI CHEBI:15650 Reactome Database ID Release 82 266033 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266033 Reactome R-ALL-266033 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266033.3 COMPOUND C05952 ACTIVATION Converted from EntitySet in Reactome DPEP1,2,3 dimers Reactome DB_ID: 10680260 DPEP1 dimer Reactome DB_ID: 10680225 DPEP1 CG7198 Q9VJ94 Reactome DB_ID: 10680223 UniProt:Q9VJ94 CG7198 UniProt Q9VJ94 17 EQUAL 385 EQUAL Reactome Database ID Release 82 10680223 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680223 Reactome R-DME-2142820 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2142820.1 2 1 Reactome Database ID Release 82 10680225 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680225 Reactome R-DME-2142831 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2142831.1 DPEP2 dimer Reactome DB_ID: 10680246 Converted from EntitySet in Reactome Homologues of DPEP2 Reactome DB_ID: 10680244 DPEP2 Dmel\CG6154 Q9VBG1 Reactome DB_ID: 10680230 UniProt:Q9VBG1 Dmel\CG6154 UniProt Q9VBG1 33 EQUAL 463 EQUAL Reactome Database ID Release 82 10680230 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680230 Reactome R-DME-266067 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266067.1 DPEP2 CG7198 Q9VJ94 Reactome DB_ID: 10680232 33 EQUAL 463 EQUAL Reactome Database ID Release 82 10680232 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680232 Reactome R-DME-266067-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266067-2.1 DPEP2 Dmel\CG5282 Q9VPG0 Reactome DB_ID: 10680237 UniProt:Q9VPG0 Dmel\CG5282 UniProt Q9VPG0 33 EQUAL 463 EQUAL Reactome Database ID Release 82 10680237 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680237 Reactome R-DME-266067-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266067-3.1 DPEP2 CG5917 X2JCU8 Reactome DB_ID: 10680242 UniProt:X2JCU8 CG5917 UniProt X2JCU8 33 EQUAL 463 EQUAL Reactome Database ID Release 82 10680242 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680242 Reactome R-DME-266067-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266067-4.1 Reactome Database ID Release 82 10680244 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680244 Reactome R-DME-266067-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266067-5.1 2 1 Reactome Database ID Release 82 10680246 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680246 Reactome R-DME-266059 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266059.1 DPEP3 dimer Reactome DB_ID: 10680258 Converted from EntitySet in Reactome Homologues of DPEP3 Reactome DB_ID: 10680256 DPEP3 Dmel\CG6154 Q9VBG1 Reactome DB_ID: 10680248 36 EQUAL 463 EQUAL Reactome Database ID Release 82 10680248 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680248 Reactome R-DME-5490265 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5490265.1 DPEP3 CG7198 Q9VJ94 Reactome DB_ID: 10680250 36 EQUAL 463 EQUAL Reactome Database ID Release 82 10680250 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680250 Reactome R-DME-5490265-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5490265-2.1 DPEP3 Dmel\CG5282 Q9VPG0 Reactome DB_ID: 10680252 36 EQUAL 463 EQUAL Reactome Database ID Release 82 10680252 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680252 Reactome R-DME-5490265-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5490265-3.1 DPEP3 CG5917 X2JCU8 Reactome DB_ID: 10680254 36 EQUAL 463 EQUAL Reactome Database ID Release 82 10680254 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680254 Reactome R-DME-5490265-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5490265-4.1 Reactome Database ID Release 82 10680256 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680256 Reactome R-DME-5490265-5 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5490265-5.1 2 1 Reactome Database ID Release 82 10680258 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680258 Reactome R-DME-5490228 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5490228.1 Reactome Database ID Release 82 10680260 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680260 Reactome R-DME-2162149 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2162149.1 GENE ONTOLOGY GO:0016805 Reactome Database ID Release 82 10680261 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680261 Reactome Database ID Release 82 10680263 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10680263 Reactome R-DME-266012 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-266012.1 Another outer surface membrane-bound, homodimeric enzyme, dipeptidase, existing in two forms DPEP1 (Adachi et al. 1989) and DPEP2 (Lee et al. 1983, Raulf et al. 1987), further hydrolyses leukotriene D4 (LTD4) to leukotriene E4 (LTE4), cleaving a glycine residue in the process. 3563417 Pubmed 1987 Release and functional characterization of the leukotriene D4-metabolizing enzyme (dipeptidase) from human polymorphonuclear leucocytes Raulf, M König, W Köller, M Stüning, M Scand J Immunol 25:305-13 6293969 Pubmed 1983 Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes Lee, CW Lewis, RA Corey, EJ Austen, KF Immunology 48:27-35 2768222 Pubmed 1989 Purification and characterization of human microsomal dipeptidase Adachi, Hideki Kubota, I Okamura, N Iwata, H Tsujimoto, M Nakazato, H Nishihara, T Noguchi, T J Biochem 105:957-61 Reactome Database ID Release 82 10741379 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10741379 Reactome R-DME-2142691 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-2142691.1 GENE ONTOLOGY GO:0006691 gene ontology term for cellular process MI MI:0359 Leukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and activation of leukocytes. LTs were discovered in 1938 and were termed the "slow release substance" (SRS) until their structures were determined in 1979 and they were then renamed to leukotrienes. LTs are derived from arachidonic acid through action by arachidonate 5-lipoxygenase (ALOX5). Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are generated as products derived from leukotriene A4 (LTA4). Eoxins are generated from leukotrienes (LTs) and resemble cysteinyl leukotrienes but have a different three-dimensional structure (Murphy & Gijon 2007, Hammarstrom 1983, MA.Claesson 2009, Vance & Vance 2008, Buczynski et al. 2009). 19130894 Pubmed 2009 On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma Claesson, HE Prostaglandins Other Lipid Mediat 89:120-5 19244215 Pubmed 2009 Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology Buczynski, MW Dumlao, DS Dennis, EA J Lipid Res 50:1015-38 17623009 Pubmed 2007 Biosynthesis and metabolism of leukotrienes Murphy, RC Gijon, MA Biochem J 405:379-95 978-0-444-53219-0 ISBN 2008 The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways Smith, William L Murphy, RC Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition (Book): 331-362 6311078 Pubmed 1983 Leukotrienes Hammarström, Sven Annu Rev Biochem 52:355-77