BioPAX pathway converted from "Wax biosynthesis" in the Reactome database. Wax biosynthesis This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> LEFT-TO-RIGHT 1 FAR1 reduces PalmCoA to HXOL palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1] This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> H+ proton hydron Reactome DB_ID: 70106 cytosol GENE ONTOLOGY GO:0005829 hydron [ChEBI:15378] hydron ChEBI CHEBI:15378 Reactome Database ID Release 83 70106 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106 Reactome R-ALL-70106 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.4 Reactome http://www.reactome.org COMPOUND C00080 additional information MI MI:0361 2 PALM-CoA palmitoyl-CoA Reactome DB_ID: 200993 palmitoyl-CoA(4-) [ChEBI:57379] palmitoyl-CoA(4-) 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(hexadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate) hexadecanoyl-CoA ChEBI CHEBI:57379 Reactome Database ID Release 83 200993 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=200993 Reactome R-ALL-200993 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-200993.4 COMPOUND C00154 TPNH NADPH Reactome DB_ID: 29364 NADPH(4-) [ChEBI:57783] NADPH(4-) 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADPH NADPH tetraanion ChEBI CHEBI:57783 Reactome Database ID Release 83 29364 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364 Reactome R-ALL-29364 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29364.3 COMPOUND C00005 2 TPN NADP+ NADP NADP(+) Nicotinamide adenine dinucleotide phosphate beta-Nicotinamide adenine dinucleotide phosphate Triphosphopyridine nucleotide NADP(3-) Reactome DB_ID: 29366 NADP(3-) [ChEBI:58349] NADP(3-) 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADP(+) NADP trianion ChEBI CHEBI:58349 Reactome Database ID Release 83 29366 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366 Reactome R-ALL-29366 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29366.4 COMPOUND C00006 2 CoA-SH coenzyme A coenzyme A(4-) Reactome DB_ID: 76194 coenzyme A(4-) [ChEBI:57287] coenzyme A(4-) 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] diphosphate} CoA ChEBI CHEBI:57287 Reactome Database ID Release 83 76194 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=76194 Reactome R-ALL-76194 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-76194.4 COMPOUND C00010 HXOL Hexadecanol hexadecan-1-ol Reactome DB_ID: 8848577 hexadecan-1-ol [ChEBI:16125] hexadecan-1-ol ChEBI CHEBI:16125 Reactome Database ID Release 83 8848577 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8848577 Reactome R-ALL-8848577 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8848577.3 ACTIVATION FAR1 Dmel\CG12268 Q9VCF6 Reactome DB_ID: 10691055 peroxisomal membrane GENE ONTOLOGY GO:0005778 UniProt:Q9VCF6 Dmel\CG12268 Drosophila melanogaster NCBI Taxonomy 7227 UniProt Q9VCF6 1 EQUAL 515 EQUAL Reactome Database ID Release 83 10691055 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10691055 Reactome R-DME-390412 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-390412.1 GENE ONTOLOGY GO:0016491 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 83 10691056 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10691056 Reactome Database ID Release 83 10691058 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10691058 Reactome R-DME-390425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-390425.1 Peroxisomal fatty acyl-CoA reductase 1 (FAR1) catalyzes the reaction of palmitoyl-CoA (PalmCoA) and 2 NADPH + 2 H+ to form hexadecanol (HXOL), CoASH, and 2 NADP+. As judged from mRNA levels, FAR1 is widely expressed in the body (Cheng and Russell 2004). 15220348 Pubmed 2004 Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions Cheng, Jeffrey B Russell, David W J Biol Chem 279:37789-97 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT 1 FAR2 reduces PalmCoA to HXOL palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2] This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> 2 2 2 ACTIVATION wat FAR2 Q8MS59 Reactome DB_ID: 10691066 UniProt:Q8MS59 wat UniProt Q8MS59 1 EQUAL 515 EQUAL Reactome Database ID Release 83 10691066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10691066 Reactome R-DME-390430 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-390430.1 Reactome Database ID Release 83 10691067 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10691067 Reactome Database ID Release 83 10691069 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10691069 Reactome R-DME-390438 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-390438.1 Peroxisomal fatty acyl-CoA reductase 2 (FAR2) catalyzes the reaction of palmitoyl-CoA (PalmCoA) and 2 NADPH + 2 H+ to form hexadecanol (HXOL), CoASH, and 2 NADP+. As judged from mRNA levels, FAR2 is not widely expressed in the body but is abundant in brain (Cheng and Russell 2004). LEFT-TO-RIGHT 2.3.1.75 AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Acyl-CoA Acyl_minus_CoA Reactome DB_ID: 192172 endoplasmic reticulum lumen GENE ONTOLOGY GO:0005788 acyl-CoA [ChEBI:17984] acyl-CoA ChEBI CHEBI:17984 Reactome Database ID Release 83 192172 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=192172 Reactome R-ALL-192172 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-192172.2 ARACOH arachidyl alcohol icosan-1-ol Reactome DB_ID: 5696426 icosan-1-ol [ChEBI:75627] icosan-1-ol arachidyl alcohol 1-eicosanol arachidic alcohol eicosan-1-ol eicosyl alcohol ChEBI CHEBI:75627 Reactome Database ID Release 83 5696426 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5696426 Reactome R-ALL-5696426 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5696426.3 CoA-SH coenzyme A Reactome DB_ID: 162743 Reactome Database ID Release 83 162743 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=162743 Reactome R-ALL-162743 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-162743.5 COMPOUND C00010 wax ester arachidyl ester Reactome DB_ID: 5696412 wax ester [ChEBI:10036] wax ester Wax esters ChEBI CHEBI:10036 Reactome Database ID Release 83 5696412 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5696412 Reactome R-ALL-5696412 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5696412.3 ACTIVATION Converted from EntitySet in Reactome Homologues of AWAT1 Reactome DB_ID: 10726467 AWAT1 Dmel\CG1946 A1Z739 Reactome DB_ID: 10726461 endoplasmic reticulum membrane GENE ONTOLOGY GO:0005789 UniProt:A1Z739 Dmel\CG1946 UniProt A1Z739 1 EQUAL 328 EQUAL Reactome Database ID Release 83 10726461 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10726461 Reactome R-DME-5696425 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696425.1 AWAT1 Dmel\CG1941 Q7JYK2 Reactome DB_ID: 10726463 UniProt:Q7JYK2 Dmel\CG1941 UniProt Q7JYK2 1 EQUAL 328 EQUAL Reactome Database ID Release 83 10726463 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10726463 Reactome R-DME-5696425-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696425-2.1 Dgat2 AWAT1 Q7K1C2 Reactome DB_ID: 10726465 UniProt:Q7K1C2 Dgat2 UniProt Q7K1C2 1 EQUAL 328 EQUAL Reactome Database ID Release 83 10726465 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10726465 Reactome R-DME-5696425-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696425-3.1 Reactome Database ID Release 83 10726467 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10726467 Reactome R-DME-5696425-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696425-4.1 GENE ONTOLOGY GO:0047196 Reactome Database ID Release 83 10726468 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10726468 Reactome Database ID Release 83 10726470 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10726470 Reactome R-DME-5696424 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696424.1 Arachidyl alcohol (ARACOH) is straight-chain fatty alcohol of C20 length used as an emollient in cosmetics. Esterification of alcohols with fatty acids represents the formation of both storage and cytoprotective molecules in the body. Overproduction of these esters is associated with several disease pathologies, including atherosclerosis and obesity. The ER membrane-associated acyl-CoA wax alcohol acyltransferase 1 (AWAT1) mediates the esterification of its preferred substrate ARACOH (Turkish et al. 2005). 15671038 Pubmed 2005 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily Turkish, Aaron R Henneberry, Annette L Cromley, Debra Padamsee, Mahajabeen Oelkers, P Bazzi, Hisham Christiano, Angela M Billheimer, JT Sturley, Stephen L J. Biol. Chem. 280:14755-64 LEFT-TO-RIGHT 2.3.1.75 AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PALM-PALM palmityl palmitate Reactome DB_ID: 8848499 palmityl palmitate [ChEBI:75584] palmityl palmitate hexadecanyl hexadecanoate cetyl palmitate n-hexadecanyl palmitate WE(16:0/16:0) hexadecyl hexadecanoate n-hexadecyl hexadecanoate palmitic acid, cetyl ester palmitic acid palmityl ester hexadecanoic acid, hexadecyl ester ChEBI CHEBI:75584 Reactome Database ID Release 83 8848499 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8848499 Reactome R-ALL-8848499 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8848499.3 ACTIVATION Converted from EntitySet in Reactome Homologues of AWAT2 Reactome DB_ID: 10713766 AWAT2 Dmel\CG1946 A1Z739 Reactome DB_ID: 10713760 1 EQUAL 333 EQUAL Reactome Database ID Release 83 10713760 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10713760 Reactome R-DME-8848506 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8848506.1 AWAT2 Dmel\CG1941 Q7JYK2 Reactome DB_ID: 10713762 1 EQUAL 333 EQUAL Reactome Database ID Release 83 10713762 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10713762 Reactome R-DME-8848506-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8848506-2.1 Dgat2 AWAT2 Q7K1C2 Reactome DB_ID: 10713764 1 EQUAL 333 EQUAL Reactome Database ID Release 83 10713764 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10713764 Reactome R-DME-8848506-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8848506-3.1 Reactome Database ID Release 83 10713766 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10713766 Reactome R-DME-8848506-4 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8848506-4.1 Reactome Database ID Release 83 10736121 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10736121 Reactome Database ID Release 83 10736123 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10736123 Reactome R-DME-8848582 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8848582.1 AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of HXOL (hexadecanol) and PALM-CoA (palmitoyl-CoA) to form the wax monoester palmityl palmitate. The enzyme also acts efficiently on other long-chain fatty alcohols and fatty acyl CoAs. It is abundant in skin and is thought to play a central role in the synthesis of wax molecules that protect the skin from drying (Cheng & Russell 2004; Turkish et al. 2005; Yen et al. 2005). 15220349 Pubmed 2004 Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family Cheng, Jeffrey B Russell, David W J. Biol. Chem. 279:37798-807 16106050 Pubmed 2005 A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters Yen, Chi-Liang Eric Brown, Charles H Monetti, Mara Farese, RV J. Lipid Res. 46:2388-97 LEFT-TO-RIGHT 2.3.1.76 AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> atROL Retinol all-trans-retinol Vitamin A Vitamin A1 Reactome DB_ID: 30209 all-trans-retinol [ChEBI:17336] all-trans-retinol ChEBI CHEBI:17336 Reactome Database ID Release 83 30209 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=30209 Reactome R-ALL-30209 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-30209.3 COMPOUND C00473 atR-PALM all-trans-retinyl palmitate Reactome DB_ID: 2534407 all-trans-retinyl palmitate [ChEBI:17616] all-trans-retinyl palmitate ChEBI CHEBI:17616 Reactome Database ID Release 83 2534407 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2534407 Reactome R-ALL-2534407 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2534407.3 ACTIVATION GENE ONTOLOGY GO:0050252 Reactome Database ID Release 83 10713767 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10713767 Reactome Database ID Release 83 10736125 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10736125 Reactome R-DME-8848585 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8848585.1 AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of atROL (all-trans retinol) and PALM-CoA (palmitoyl-CoA) to form the ester retinyl palmitate. This ester is thought to provide an inactive storage form of retinol and might play a role in protecting skin, where AWAT2 is most abundant from the effects of UV light (Arne et al. 2017; Yen et al. 2005). 28096191 Pubmed 2017 Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2 (AWAT2) Arne, Jason M Widjaja-Adhi, Made Airanthi K Hughes, Taylor Huynh, Kevin W Silvaroli, Josie A Chelstowska, Sylwia Moiseenkova-Bell, Vera Y Golczak, Marcin J. Lipid Res. Reactome Database ID Release 83 10750305 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10750305 Reactome R-DME-9640463 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-9640463.1 GENE ONTOLOGY GO:0010025 gene ontology term for cellular process MI MI:0359 Waxes are esters of long chain fatty acids and long chain fatty alcohols that play an important role in protecting the skin surface from drying and abrasion. Enzymes that catalyze two reactions of wax biosynthesis have been characterized in humans. FAR1 and FAR2 catalyze the reduction of fatty acids to fatty alcohols in the peroxisome and AWAT1 and AWAT2 catalyze the reaction of fatty alcohols and acyl-CoA in the cytosol to form wax esters. The existence of a transport process, otherwise uncharacterized, to move fatty alcohols from the peroxisome to the cytosol is inferred from the observation that cultured cells that do not normally synthesize waxes can be induced to do so by co-transfection with DNA constructs encoding FAR and AWAT enzymes (Cheng & Russell 2004a,b).