BioPAX pathway converted from "TORC2 (mTOR) phosphorylates AKT at S473" in the Reactome database.
LEFT-TO-RIGHT
2.7.11.1
TORC2 (mTOR) phosphorylates AKT at S473
This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>
ATP
Adenosine 5'-triphosphate
ATP(4-)
Reactome DB_ID: 113592
cytosol
GENE ONTOLOGY
GO:0005829
ATP(4-) [ChEBI:30616]
ATP(4-)
ATP
atp
Adenosine 5'-triphosphate
ChEBI
CHEBI:30616
Reactome Database ID Release 83
113592
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592
Reactome
R-ALL-113592
5
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5
Reactome
http://www.reactome.org
COMPOUND
C00002
additional information
MI
MI:0361
AKT:PIP3
Reactome DB_ID: 10764500
plasma membrane
GENE ONTOLOGY
GO:0005886
Converted from EntitySet in Reactome
AKT
Reactome DB_ID: 10764498
Converted from EntitySet in Reactome
Homologues of AKT1
Reactome DB_ID: 10764488
AKT1
Q17941
Reactome DB_ID: 10764484
UniProt:Q17941
Caenorhabditis elegans
NCBI Taxonomy
6239
UniProt
Q17941
1
EQUAL
480
EQUAL
Reactome Database ID Release 83
10764484
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764484
Reactome
R-CEL-199416
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-199416.1
AKT1
Q9XTG7
Reactome DB_ID: 10764486
UniProt:Q9XTG7
UniProt
Q9XTG7
1
EQUAL
480
EQUAL
Reactome Database ID Release 83
10764486
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764486
Reactome
R-CEL-199416-2
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-199416-2.1
Reactome Database ID Release 83
10764488
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764488
Reactome
R-CEL-199416-3
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-199416-3.1
Converted from EntitySet in Reactome
Homologues of AKT2
Reactome DB_ID: 10764494
AKT2
Q17941
Reactome DB_ID: 10764490
1
EQUAL
481
EQUAL
Reactome Database ID Release 83
10764490
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764490
Reactome
R-CEL-202053
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-202053.1
AKT2
Q9XTG7
Reactome DB_ID: 10764492
1
EQUAL
481
EQUAL
Reactome Database ID Release 83
10764492
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764492
Reactome
R-CEL-202053-2
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-202053-2.1
Reactome Database ID Release 83
10764494
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764494
Reactome
R-CEL-202053-3
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-202053-3.1
AKT3
Q17941
Reactome DB_ID: 10764496
1
EQUAL
479
EQUAL
Reactome Database ID Release 83
10764496
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764496
Reactome
R-CEL-2976006
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2976006.1
Reactome Database ID Release 83
10764498
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764498
Reactome
R-CEL-202052
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-202052.1
1
PIP3
PI(3,4,5)P3
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Phosphatidylinositol-3,4,5-trisphosphate
Reactome DB_ID: 179838
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836]
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)
ChEBI
CHEBI:57836
Reactome Database ID Release 83
179838
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179838
Reactome
R-ALL-179838
4
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179838.4
COMPOUND
C05981
1
Reactome Database ID Release 83
10764500
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764500
Reactome
R-CEL-2317329
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317329.1
ADP
Adenosine 5'-diphosphate
ADP(3-)
Reactome DB_ID: 29370
ADP(3-) [ChEBI:456216]
ADP(3-)
ADP
5'-O-[(phosphonatooxy)phosphinato]adenosine
ADP trianion
ChEBI
CHEBI:456216
Reactome Database ID Release 83
29370
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370
Reactome
R-ALL-29370
5
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5
COMPOUND
C00008
p-S-AKT:PIP3
Reactome DB_ID: 10764518
Converted from EntitySet in Reactome
p-S-AKT
Reactome DB_ID: 10764516
Converted from EntitySet in Reactome
Homologues of p-S473-AKT1
Reactome DB_ID: 10764506
Q17941
phospho-p-S473-AKT1
Reactome DB_ID: 10764502
473
EQUAL
O-phospho-L-serine
MOD
MOD:00046
1
EQUAL
480
EQUAL
Reactome Database ID Release 83
10764502
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764502
Reactome
R-CEL-377265
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-377265.1
Q9XTG7
phospho-p-S473-AKT1
Reactome DB_ID: 10764504
473
EQUAL
1
EQUAL
480
EQUAL
Reactome Database ID Release 83
10764504
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764504
Reactome
R-CEL-377265-2
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-377265-2.1
Reactome Database ID Release 83
10764506
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764506
Reactome
R-CEL-377265-3
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-377265-3.1
Converted from EntitySet in Reactome
Homologues of p-S474-AKT2
Reactome DB_ID: 10764512
Q17941
phospho-p-S474-AKT2
Reactome DB_ID: 10764508
474
EQUAL
1
EQUAL
481
EQUAL
Reactome Database ID Release 83
10764508
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764508
Reactome
R-CEL-2317312
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317312.1
Q9XTG7
phospho-p-S474-AKT2
Reactome DB_ID: 10764510
474
EQUAL
1
EQUAL
481
EQUAL
Reactome Database ID Release 83
10764510
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764510
Reactome
R-CEL-2317312-2
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317312-2.1
Reactome Database ID Release 83
10764512
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764512
Reactome
R-CEL-2317312-3
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317312-3.1
Q17941
phospho-p-S472-AKT3
Reactome DB_ID: 10764514
472
EQUAL
1
EQUAL
479
EQUAL
Reactome Database ID Release 83
10764514
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764514
Reactome
R-CEL-3009363
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-3009363.1
Reactome Database ID Release 83
10764516
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764516
Reactome
R-CEL-2317317
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317317.1
1
1
Reactome Database ID Release 83
10764518
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764518
Reactome
R-CEL-2317310
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317310.1
ACTIVATION
activeUnit: #Protein18
TORC2 complex
Reactome DB_ID: 10764532
MLST8
mlst-8
P91040
Reactome DB_ID: 10760182
UniProt:P91040
mlst-8
UniProt
P91040
1
EQUAL
326
EQUAL
Reactome Database ID Release 83
10760182
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760182
Reactome
R-CEL-165676
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-165676.1
1
Ghost homologue of PRR5
Reactome DB_ID: 10764530
Reactome Database ID Release 83
10764530
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764530
Reactome
R-CEL-6795323
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6795323.1
1
rict-1
RICTOR
G5EFN2
Reactome DB_ID: 10764523
UniProt:G5EFN2
rict-1
UniProt
G5EFN2
1
EQUAL
1708
EQUAL
Reactome Database ID Release 83
10764523
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764523
Reactome
R-CEL-198632
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-198632.1
1
sinh-1
MAPKAP1
Q9NA80
Reactome DB_ID: 10764528
UniProt:Q9NA80
sinh-1
UniProt
Q9NA80
2
EQUAL
522
EQUAL
Reactome Database ID Release 83
10764528
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764528
Reactome
R-CEL-3006620
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-3006620.1
1
MTOR
let-363
Q95Q95
Reactome DB_ID: 10760187
UniProt:Q95Q95
let-363
UniProt
Q95Q95
1
EQUAL
2549
EQUAL
Reactome Database ID Release 83
10760187
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760187
Reactome
R-CEL-165662
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-165662.1
1
Reactome Database ID Release 83
10764532
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764532
Reactome
R-CEL-198626
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-198626.1
GENE ONTOLOGY
GO:0004674
gene ontology term for cellular function
MI
MI:0355
Same Catalyst Activity
Reactome Database ID Release 83
10764533
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764533
Reactome Database ID Release 83
10764539
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764539
Reactome
R-CEL-198640
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-198640.1
GENE ONTOLOGY
GO:0032148
gene ontology term for cellular process
MI
MI:0359
Under conditions of growth and mitogen stimulation S473 phosphorylation of AKT is carried out by mTOR (mammalian Target of Rapamycin). This kinase is found in two structurally and functionally distinct protein complexes, named TOR complex 1 (TORC1) and TOR complex 2 (TORC2). It is TORC2 complex, which is composed of mTOR, RICTOR, SIN1 (also named MAPKAP1) and LST8, that phosphorylates AKT at S473 (Sarbassov et al., 2005). This complex also regulates actin cytoskeletal reorganization (Jacinto et al., 2004; Sarbassov et al., 2004). TORC1, on the other hand, is a major regulator of ribosomal biogenesis and protein synthesis (Hay and Sonenberg, 2004). TORC1 regulates these processes largely by the phosphorylation/inactivation of the repressors of mRNA translation 4E binding proteins (4E BPs) and by the phosphorylation/activation of ribosomal S6 kinase (S6K1). TORC1 is also the principal regulator of autophagy. In other physiological conditions, other kinases may be responsible for AKT S473 phosphorylation.<br>
Phosphorylation of AKT on S473 by TORC2 complex is a prerequisite for AKT phosphorylation on T308 by PDPK1 (Scheid et al. 2002, Sarabassov et al. 2005).
15314020
Pubmed
2004
Upstream and downstream of mTOR
Hay, N
Sonenberg, Nahum
Genes Dev 18:1926-45
19303758
Pubmed
2009
PIKKing on PKB: regulation of PKB activity by phosphorylation
Bozulic, L
Hemmings, BA
Curr Opin Cell Biol 21:256-61
12167717
Pubmed
2002
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
Scheid, MP
Marignani, PA
Woodgett, JR
Mol Cell Biol 22:6247-60
15718470
Pubmed
2005
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, DD
Guertin, DA
Ali, SM
Sabatini, DM
Science 307:1098-101
15268862
Pubmed
2004
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
Sarbassov, DD
Ali, SM
Kim, DH
Guertin, DA
Latek, RR
Erdjument-Bromage, H
Tempst, P
Sabatini, DM
Curr Biol 14:1296-302
15467718
Pubmed
2004
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Jacinto, E
Loewith, R
Schmidt, A
Lin, S
Ruegg, MA
Hall, A
Hall, MN
Nat Cell Biol 6:1122-8
inferred from electronic annotation
EVIDENCE CODE
ECO:0000203
INHIBITION
Reactome Database ID Release 83
10764540
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764540
AKT:PIP3:THEM4/TRIB3
Reactome DB_ID: 10764537
TRIB3
G5EED4
Reactome DB_ID: 10764535
UniProt:G5EED4
UniProt
G5EED4
1
EQUAL
358
EQUAL
Reactome Database ID Release 83
10764535
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764535
Reactome
R-CEL-199447
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-199447.1
1
1
Reactome Database ID Release 83
10764537
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764537
Reactome
R-CEL-199453
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-199453.1