BioPAX pathway converted from "Activation of Rap1 by membrane-associated GEFs" in the Reactome database. LEFT-TO-RIGHT Activation of Rap1 by membrane-associated GEFs This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> GTP Guanosine 5'-triphosphate GTP)(4-) Reactome DB_ID: 29438 cytosol GENE ONTOLOGY GO:0005829 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) ChEBI CHEBI:37565 Reactome Database ID Release 82 29438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438 Reactome R-ALL-29438 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.4 Reactome http://www.reactome.org COMPOUND C00044 additional information MI MI:0361 RAP1:GDP Reactome DB_ID: 10760565 plasma membrane GENE ONTOLOGY GO:0005886 RAP1A Q18246 Reactome DB_ID: 10760488 UniProt:Q18246 Caenorhabditis elegans NCBI Taxonomy 6239 UniProt Q18246 1 EQUAL 181 EQUAL Reactome Database ID Release 82 10760488 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760488 Reactome R-CEL-354118 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-354118.1 1 GDP Guanosine 5'-diphosphate Guanosine diphosphate GDP(3-) Reactome DB_ID: 29420 GDP(3-) [ChEBI:58189] GDP(3-) 5'-O-[(phosphonatooxy)phosphinato]guanosine guanosine 5'-diphosphate(3-) GDP guanosine 5'-diphosphate trianion guanosine 5'-diphosphate GDP trianion ChEBI CHEBI:58189 Reactome Database ID Release 82 29420 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29420 Reactome R-ALL-29420 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29420.3 COMPOUND C00035 1 Reactome Database ID Release 82 10760565 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760565 Reactome R-CEL-354074 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-354074.1 RAP1:GTP Reactome DB_ID: 10760490 1 1 Reactome Database ID Release 82 10760490 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760490 Reactome R-CEL-354126 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-354126.1 ACTIVATION Converted from EntitySet in Reactome Rap1 cAMP-GEFs Reactome DB_ID: 10764089 P34578 RAPGEF3 Reactome DB_ID: 10762909 UniProt:P34578 UniProt P34578 1 EQUAL 923 EQUAL Reactome Database ID Release 82 10762909 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10762909 Reactome R-CEL-3008670 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-3008670.1 P34578 RAPGEF4 Reactome DB_ID: 10762878 1 EQUAL 1011 EQUAL Reactome Database ID Release 82 10762878 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10762878 Reactome R-CEL-3008666 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-3008666.1 Reactome Database ID Release 82 10764089 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764089 Reactome R-CEL-392485 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-392485.1 GENE ONTOLOGY GO:0005085 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 10772646 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10772646 Reactome Database ID Release 82 10772648 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10772648 Reactome R-CEL-939265 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-939265.1 Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP. 15334074 Pubmed 2004 CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation Crittenden, JR Bergmeier, W Zhang, Y Piffath, CL Liang, Y Wagner, DD Housman, DE Graybiel, AM Nat Med 10:982-6 15469846 Pubmed 2004 RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion Lafuente, EM van Puijenbroek, AA Krause, M Carman, CV Freeman, GJ Berezovskaya, A Constantine, E Springer, TA Gertler, FB Boussiotis, VA Dev Cell 7:585-95 12585966 Pubmed 2003 Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C Giuliano, S Nesbitt, WS Rooney, M Jackson, SP Biochem J 372:163-72 16757337 Pubmed 2006 Rap1 regulation of RIAM and cell adhesion Lafuente, E Boussiotis, VA Methods Enzymol 407:345-58 16076873 Pubmed 2005 Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions Stork, PJ Dillon, TJ Blood 106:2952-61 inferred from electronic annotation EVIDENCE CODE ECO:0000203