BioPAX pathway converted from "AKT binds PDPK1" in the Reactome database. LEFT-TO-RIGHT AKT binds PDPK1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> PDPK1:PIP3 Reactome DB_ID: 10757975 plasma membrane GENE ONTOLOGY GO:0005886 PIP3 PI(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate Phosphatidylinositol-3,4,5-trisphosphate Reactome DB_ID: 179838 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836] 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) 2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) ChEBI CHEBI:57836 Reactome Database ID Release 83 179838 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=179838 Reactome R-ALL-179838 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-179838.4 Reactome http://www.reactome.org COMPOUND C05981 additional information MI MI:0361 1 PDPK1 Q9UA62 Reactome DB_ID: 10757973 UniProt:Q9UA62 Caenorhabditis elegans NCBI Taxonomy 6239 UniProt Q9UA62 1 EQUAL 556 EQUAL Reactome Database ID Release 83 10757973 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10757973 Reactome R-CEL-61459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-61459.1 1 Reactome Database ID Release 83 10757975 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10757975 Reactome R-CEL-109697 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-109697.1 p-S-AKT:PIP3 Reactome DB_ID: 10764518 Converted from EntitySet in Reactome p-S-AKT Reactome DB_ID: 10764516 Converted from EntitySet in Reactome Homologues of p-S473-AKT1 Reactome DB_ID: 10764506 Q17941 phospho-p-S473-AKT1 Reactome DB_ID: 10764502 UniProt:Q17941 UniProt Q17941 473 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 480 EQUAL Reactome Database ID Release 83 10764502 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764502 Reactome R-CEL-377265 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-377265.1 Q9XTG7 phospho-p-S473-AKT1 Reactome DB_ID: 10764504 UniProt:Q9XTG7 UniProt Q9XTG7 473 EQUAL 1 EQUAL 480 EQUAL Reactome Database ID Release 83 10764504 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764504 Reactome R-CEL-377265-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-377265-2.1 Reactome Database ID Release 83 10764506 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764506 Reactome R-CEL-377265-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-377265-3.1 Converted from EntitySet in Reactome Homologues of p-S474-AKT2 Reactome DB_ID: 10764512 Q17941 phospho-p-S474-AKT2 Reactome DB_ID: 10764508 474 EQUAL 1 EQUAL 481 EQUAL Reactome Database ID Release 83 10764508 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764508 Reactome R-CEL-2317312 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317312.1 Q9XTG7 phospho-p-S474-AKT2 Reactome DB_ID: 10764510 474 EQUAL 1 EQUAL 481 EQUAL Reactome Database ID Release 83 10764510 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764510 Reactome R-CEL-2317312-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317312-2.1 Reactome Database ID Release 83 10764512 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764512 Reactome R-CEL-2317312-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317312-3.1 Q17941 phospho-p-S472-AKT3 Reactome DB_ID: 10764514 472 EQUAL 1 EQUAL 479 EQUAL Reactome Database ID Release 83 10764514 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764514 Reactome R-CEL-3009363 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-3009363.1 Reactome Database ID Release 83 10764516 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764516 Reactome R-CEL-2317317 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317317.1 1 1 Reactome Database ID Release 83 10764518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764518 Reactome R-CEL-2317310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317310.1 p-S-AKT:PDPK1:PIP3 Reactome DB_ID: 10792324 1 1 Reactome Database ID Release 83 10792324 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10792324 Reactome R-CEL-2317313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317313.1 Reactome Database ID Release 83 10792326 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10792326 Reactome R-CEL-2317314 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317314.1 GENE ONTOLOGY GO:0032148 gene ontology term for cellular process MI MI:0359 Once phosphorylated on serine residue S473, AKT bound to PIP3 forms a complex with PIP3-bound PDPK1 i.e. PDK1 (Scheid et al. 2002, Sarabassov et al. 2005) 12167717 Pubmed 2002 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B Scheid, MP Marignani, PA Woodgett, JR Mol Cell Biol 22:6247-60 15718470 Pubmed 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Sarbassov, DD Guertin, DA Ali, SM Sabatini, DM Science 307:1098-101 inferred from electronic annotation EVIDENCE CODE ECO:0000203