BioPAX pathway converted from "PIN1 binds phosphorylated PIP4K2B" in the Reactome database. LEFT-TO-RIGHT PIN1 binds phosphorylated PIP4K2B This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> ESS1 PIN1 P22696 Reactome DB_ID: 10903658 nucleoplasm GENE ONTOLOGY GO:0005654 UniProt:P22696 ESS1 Saccharomyces cerevisiae NCBI Taxonomy 4932 UniProt P22696 1 EQUAL 163 EQUAL Reactome Database ID Release 82 10903658 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10903658 Reactome R-SCE-936016 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-936016.1 Reactome http://www.reactome.org Converted from EntitySet in Reactome p-S326-PIP4K2B dimers Reactome DB_ID: 10915989 PIP4K2A:p-S326-PIP4K2B Reactome DB_ID: 10915983 P38994 phospho-MSS4 p-S326-PIP4K2B Reactome DB_ID: 10915981 UniProt:P38994 MSS4 UniProt P38994 326 EQUAL O-phospho-L-serine MOD MOD:00046 1 EQUAL 416 EQUAL Reactome Database ID Release 82 10915981 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10915981 Reactome R-SCE-8877679 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-8877679.1 1 MSS4 PIP4K2A P38994 Reactome DB_ID: 10914453 2 EQUAL 406 EQUAL Reactome Database ID Release 82 10914453 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10914453 Reactome R-SCE-6811484 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-6811484.1 1 Reactome Database ID Release 82 10915983 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10915983 Reactome R-SCE-8877681 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-8877681.1 p-S326-PIP4K2B:p-S326-PIP4K2B Reactome DB_ID: 10915985 2 Reactome Database ID Release 82 10915985 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10915985 Reactome R-SCE-8877687 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-8877687.1 p-S326-PIP4K2B:PIP4K2C Reactome DB_ID: 10915987 1 MSS4 PIP4K2C P38994 Reactome DB_ID: 10914459 2 EQUAL 421 EQUAL Reactome Database ID Release 82 10914459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10914459 Reactome R-SCE-6811499 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-6811499.1 1 Reactome Database ID Release 82 10915987 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10915987 Reactome R-SCE-8877686 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-8877686.1 Reactome Database ID Release 82 10915989 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10915989 Reactome R-SCE-8877680 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-8877680.1 p-S326-PIP4K2B dimers:PIN1 Reactome DB_ID: 10915994 1 1 Reactome Database ID Release 82 10915994 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10915994 Reactome R-SCE-8877690 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-8877690.1 Reactome Database ID Release 82 10915996 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10915996 Reactome R-SCE-8877692 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SCE-8877692.1 Peptidyl-prolyl cis-trans isomerase PIN1 binds to PIP4K2B phosphorylated at serine residue S326. PIP4K2B is phosphorylated at S326 under conditions of cellular stress, such as increased level of reactive oxygen species (ROS). Phosphorylation of PIP4K2B at threonine residue T322 may also contribute to PIN1 binding. PIN1 induces conformational change of PIP4K2B, resulting in inactivation of PIP4K2B dimers. This enables increase of the nuclear PI5P levels. PI5P positively regulates expression of genes involved in neutralization of ROS (Keune et al. 2012). 23193159 Pubmed 2012 Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress Keune, Willem-Jan Jones, David R Bultsma, Yvette Sommer, Lilly Zhou, Xiao Zhen Lu, Kun Ping Divecha, Nullin Sci Signal 5:ra86 inferred from electronic annotation EVIDENCE CODE ECO:0000203