BioPAX pathway converted from "Carbonic anhydrase dehydrates bicarbonate (mitochondria)" in the Reactome database.LEFT-TO-RIGHT4.2.1.1Carbonic anhydrase dehydrates bicarbonate (mitochondria)Carbonic anhydrase VA (CA5A, Nagao et al. 1993, Franchi et al. 2003, Nishimori et al. 2007) and carbonic anhydrase VB (CA5B, Fujikawa-Adachi et al. 1999, Nishimori et al. 2005, Nishimori et al. 2007) dehydrate bicarbonate in mitochondria to yield water and carbon dioxide (reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.Authored: May, B, 2011-08-06Reviewed: Jassal, B, 2012-05-16Reviewed: Silverman, DN, 2012-05-16Edited: May, B, 2011-08-06HCO3-BicarbonatehydrogencarbonateAcid carbonateReactome DB_ID: 29896mitochondrial matrixGENE ONTOLOGYGO:0005759hydrogencarbonate [ChEBI:17544]hydrogencarbonateChEBICHEBI:17544Reactome Database ID Release 7529896Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29896ReactomeR-ALL-298963Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29896.3Reactomehttp://www.reactome.orgCOMPOUNDC00288additional informationMIMI:0361H+hydronReactome DB_ID: 113529hydron [ChEBI:15378]hydronChEBICHEBI:15378Reactome Database ID Release 75113529Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529ReactomeR-ALL-1135294Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113529.4COMPOUNDC00080H2OwaterReactome DB_ID: 113521water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 75113521Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113521ReactomeR-ALL-1135213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113521.3COMPOUNDC00001CO2carbon dioxideReactome DB_ID: 29376carbon dioxide [ChEBI:16526]carbon dioxideChEBICHEBI:16526Reactome Database ID Release 7529376Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29376ReactomeR-ALL-293763Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29376.3COMPOUNDC00011ACTIVATIONConverted from EntitySet in ReactomeCA5A,B:ZincMitochondrial Carbonic AnhydraseReactome DB_ID: 1475016CA5A:ZincCarbonic Anhydrase VA:ZincReactome DB_ID: 1237314Zn2+Zn++zinc(2+)Zinc ionZn(II)Reactome DB_ID: 880067zinc(2+) [ChEBI:29105]zinc(2+)ChEBICHEBI:29105Reactome Database ID Release 75880067Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=880067ReactomeR-ALL-8800673Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-880067.3COMPOUNDC000381CA5ACarbonic anhydrase 5A, mitochondrialCAH5A_HUMANReactome DB_ID: 1237028UniProt:P35218 CA5ACA5ACA5FUNCTION Reversible hydration of carbon dioxide. Low activity.ACTIVITY REGULATION Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt).SIMILARITY Belongs to the alpha-carbonic anhydrase family.Homo sapiensNCBI Taxonomy9606UniProtP3521839EQUAL305EQUALReactome Database ID Release 751237028Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1237028ReactomeR-HSA-12370281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1237028.11Reactome Database ID Release 751237314Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1237314ReactomeR-HSA-12373141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1237314.1CA5B:ZincCarbonic Anhydrase VB:ZincReactome DB_ID: 1237319CA5BCarbonic anhydrase 5B, mitochondrialCAH5B_HUMANReactome DB_ID: 1237023UniProt:Q9Y2D0 CA5BCA5BFUNCTION Reversible hydration of carbon dioxide.ACTIVITY REGULATION Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).TISSUE SPECIFICITY Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver.SIMILARITY Belongs to the alpha-carbonic anhydrase family.UniProtQ9Y2D034EQUAL317EQUALReactome Database ID Release 751237023Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1237023ReactomeR-HSA-12370231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1237023.111Reactome Database ID Release 751237319Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1237319ReactomeR-HSA-12373191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1237319.1Reactome Database ID Release 751475016Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1475016ReactomeR-HSA-14750161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1475016.1GENE ONTOLOGYGO:0004089gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 751475031Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1475031Reactome Database ID Release 751475028Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1475028ReactomeR-HSA-14750281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1475028.116302824Pubmed2005Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitorsNishimori, IVullo, DInnocenti, AScozzafava, AMastrolorenzo, ASupuran, CTJ Med Chem 48:7860-69336012Pubmed1997Structure and mechanism of carbonic anhydraseLindskog, SPharmacol Ther 74:1-2014611844Pubmed2003Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anionsFranchi, MVullo, DGallori, EAntel, JWurl, MScozzafava, ASupuran, CTBioorg Med Chem Lett 13:2857-618356065Pubmed1993Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16Nagao, YPlatero, JSWaheed, ASly, William SProc Natl Acad Sci U S A 90:7623-710409679Pubmed1999Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome xFujikawa-Adachi, KNishimori, ITaguchi, TOnishi, SJ Biol Chem 274:21228-3317761422Pubmed2007Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very differentNishimori, IInnocenti, AVullo, DScozzafava, ASupuran, CTBioorg Med Chem 15:6742-7