BioPAX pathway converted from "Mevalonate-5-phosphate is further phosphorylated." in the Reactome database.LEFT-TO-RIGHT2.7.4.2Mevalonate-5-phosphate is further phosphorylated.Phosphomevalonate kinase (PMK) catalyzes the reversible, ATP-dependent phosphorylation of mevalonate-5-phosphate, producing mevalonate-5-pyrophosphate.Authored: Jassal, B, 2007-01-24 15:15:12Reviewed: D'Eustachio, P, 2007-01-22 01:32:07ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 113592cytosolGENE ONTOLOGYGO:0005829ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 71113592Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592ReactomeR-ALL-1135924Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.4Reactomehttp://www.reactome.orgMVA5PMevalonate-5-phosphate(R)-5-phosphomevalonic acidReactome DB_ID: 191296(R)-5-phosphomevalonic acid [ChEBI:17436](R)-5-phosphomevalonic acidChEBICHEBI:17436Reactome Database ID Release 71191296Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191296ReactomeR-ALL-1912963Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-191296.3MVA5PPMevalonate-5-pyrophosphate(R)-5-diphosphomevalonic acidReactome DB_ID: 191403(R)-5-diphosphomevalonic acid [ChEBI:15899](R)-5-diphosphomevalonic acidChEBICHEBI:15899Reactome Database ID Release 71191403Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191403ReactomeR-ALL-1914033Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-191403.3ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 29370ADP(3-) [ChEBI:456216]ADP(3-)ADP5'-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 7129370Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370ReactomeR-ALL-293704Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.4ACTIVATIONPMVKPhosphomevalonate kinaseReactome DB_ID: 191348UniProt:Q15126 PMVKPMVKPMKIPATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.SUBUNIT Monomer.TISSUE SPECIFICITY Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.INDUCTION By sterol.CAUTION Was originally thought to be located in the peroxisome (PubMed:10191291). However, was later shown to be cytosolic (PubMed:14729858, PubMed:27052676).Homo sapiensNCBI Taxonomy9606UniProtQ151262EQUAL192EQUALReactome Database ID Release 71191348Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191348ReactomeR-HSA-1913481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191348.1GENE ONTOLOGYGO:0004631gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 71191287Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191287Reactome Database ID Release 71191422Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191422ReactomeR-HSA-1914221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191422.116519518Pubmed2006Phosphomevalonate kinase: functional investigation of the recombinant human enzymeHerdendorf, TJMiziorko, HMBiochemistry 45:3235-4214729858Pubmed2004Phosphomevalonate kinase is a cytosolic protein in humansHogenboom, STuyp, JJEspeel, MKoster, JWanders, Ronald J AWaterham, HRJ Lipid Res 45:697-705