BioPAX pathway converted from "GSSeSG is reduced to GSSeH and GSH by Gsr" in the Reactome database. LEFT-TO-RIGHT GSSeSG is reduced to GSSeH and GSH by Gsr In the rat cytosol, glutathione reductase (Gsr) homodimer is involved in the reduction of selenodiglutathione (GSSeSG) into gluthathioselenol (GSSeH) and reduced glutathione (GSH) (Bjornstedt et al. 1992). Authored: Williams, MG, 2014-05-06 Reviewed: Rush, MG, 2015-08-30 Edited: D'Eustachio, Peter, 2015-08-29 TPNH NADPH Reactome DB_ID: 29364 cytosol GENE ONTOLOGY GO:0005829 NADPH(4-) [ChEBI:57783] NADPH(4-) 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADPH NADPH tetraanion ChEBI CHEBI:57783 Reactome Database ID Release 82 29364 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364 Reactome R-ALL-29364 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29364.3 Reactome http://www.reactome.org COMPOUND C00005 additional information MI MI:0361 H+ proton hydron Reactome DB_ID: 70106 hydron [ChEBI:15378] hydron ChEBI CHEBI:15378 Reactome Database ID Release 82 70106 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106 Reactome R-ALL-70106 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.4 COMPOUND C00080 GSSeSG selenodiglutathione Reactome DB_ID: 5357667 selenodiglutathione(2-) [ChEBI:71259] selenodiglutathione(2-) GSSeSG(2-) selenodiglutathione ChEBI CHEBI:71259 Reactome Database ID Release 82 5357667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357667 Reactome R-ALL-5357667 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357667.4 GSH Reduced glutathione glutathione 5-L-Glutamyl-L-cysteinylglycine N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine gamma-L-Glutamyl-L-cysteinyl-glycine glutathionate(1-) Reactome DB_ID: 29450 glutathionate(1-) [ChEBI:57925] glutathionate(1-) glutathionate ion glutathionate anion glutathionate glutathione ChEBI CHEBI:57925 Reactome Database ID Release 82 29450 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450 Reactome R-ALL-29450 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29450.4 COMPOUND C00051 GSSeH glutathioselenol Reactome DB_ID: 5357664 glutathioselenol [ChEBI:64729] glutathioselenol GSSeH ChEBI CHEBI:64729 Reactome Database ID Release 82 5357664 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357664 Reactome R-ALL-5357664 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357664.3 TPN NADP+ NADP NADP(+) Nicotinamide adenine dinucleotide phosphate beta-Nicotinamide adenine dinucleotide phosphate Triphosphopyridine nucleotide NADP(3-) Reactome DB_ID: 29366 NADP(3-) [ChEBI:58349] NADP(3-) 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADP(+) NADP trianion ChEBI CHEBI:58349 Reactome Database ID Release 82 29366 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366 Reactome R-ALL-29366 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29366.4 COMPOUND C00006 ACTIVATION 2xGsr-2:2xFAD glutathione reductase holoenzyme Reactome DB_ID: 5357643 FAD FAD(3-) Flavin adenine dinucleotide Reactome DB_ID: 29386 FAD(3-) [ChEBI:57692] FAD(3-) FAD trianion FAD ChEBI CHEBI:57692 Reactome Database ID Release 82 29386 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29386 Reactome R-ALL-29386 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29386.3 COMPOUND C00016 2 Gsr Glutathione reductase GSHR_RAT Reactome DB_ID: 5357649 UniProt:P70619 Gsr Gsr FUNCTION Maintains high levels of reduced glutathione in the cytosol.SUBUNIT Homodimer; disulfide-linked.SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Rattus norvegicus NCBI Taxonomy 10116 UniProt P70619 1 EQUAL 424 EQUAL Reactome Database ID Release 82 5357649 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357649 Reactome R-RNO-5357649 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-5357649.1 2 Reactome Database ID Release 82 5357643 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357643 Reactome R-RNO-5357643 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-5357643.1 GENE ONTOLOGY GO:0098622 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 5359072 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359072 Reactome Database ID Release 82 2408514 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2408514 Reactome R-RNO-2408514 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2408514.1 1569062 Pubmed 1992 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase Björnstedt, M Kumar, S Holmgren, Arne J. Biol. Chem. 267:8030-4