BioPAX pathway converted from "SeO3(2-) combines with GSH to form GSSeSG and GSSG" in the Reactome database. LEFT-TO-RIGHT SeO3(2-) combines with GSH to form GSSeSG and GSSG In the rat cytosol, selenite (SeO3(2-)) and reduced glutathione (GSH) spontaneously react to form selenodiglutathione (GSSeSG) and glutathione disulfide (GSSG). This has been proposed to be the major form of entry of selenium compounds into metabolism (Bjornstedt et al. 1992). Authored: Williams, MG, 2014-05-06 Reviewed: Rush, MG, 2015-08-30 Edited: D'Eustachio, Peter, 2015-08-29 H+ proton hydron Reactome DB_ID: 70106 cytosol GENE ONTOLOGY GO:0005829 hydron [ChEBI:15378] hydron ChEBI CHEBI:15378 Reactome Database ID Release 82 70106 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106 Reactome R-ALL-70106 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.4 Reactome http://www.reactome.org COMPOUND C00080 additional information MI MI:0361 3 SeO3(2-) selenite(2-) Reactome DB_ID: 5357720 selenite(2-) [ChEBI:18212] selenite(2-) ChEBI CHEBI:18212 Reactome Database ID Release 82 5357720 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357720 Reactome R-ALL-5357720 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357720.3 GSH Reduced glutathione glutathione 5-L-Glutamyl-L-cysteinylglycine N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine gamma-L-Glutamyl-L-cysteinyl-glycine glutathionate(1-) Reactome DB_ID: 29450 glutathionate(1-) [ChEBI:57925] glutathionate(1-) glutathionate ion glutathionate anion glutathionate glutathione ChEBI CHEBI:57925 Reactome Database ID Release 82 29450 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29450 Reactome R-ALL-29450 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29450.4 COMPOUND C00051 4 GSSG oxidized glutathione glutathione disulfide glutathione disulfide(2-) Reactome DB_ID: 111745 glutathione disulfide(2-) [ChEBI:58297] glutathione disulfide(2-) (2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxylatomethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-azaniumyl-5-oxopentanoate) glutathione disulfide glutathione disulfide dianion ChEBI CHEBI:58297 Reactome Database ID Release 82 111745 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111745 Reactome R-ALL-111745 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111745.4 COMPOUND C00127 H2O water Reactome DB_ID: 29356 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 82 29356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356 Reactome R-ALL-29356 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5 COMPOUND C00001 3 GSSeSG selenodiglutathione Reactome DB_ID: 5357667 selenodiglutathione(2-) [ChEBI:71259] selenodiglutathione(2-) GSSeSG(2-) selenodiglutathione ChEBI CHEBI:71259 Reactome Database ID Release 82 5357667 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357667 Reactome R-ALL-5357667 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5357667.4 Reactome Database ID Release 82 2408553 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2408553 Reactome R-RNO-2408553 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2408553.1 1569062 Pubmed 1992 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase Björnstedt, M Kumar, S Holmgren, Arne J. Biol. Chem. 267:8030-4