BioPAX pathway converted from "Interaction of integrin alpha9beta1 with VCAM1" in the Reactome database. LEFT-TO-RIGHT Interaction of integrin alpha9beta1 with VCAM1 Integrin alpha9beta1 is widely expressed on smooth muscle, epithelial cells, and highly and specifically expressed on neutrophils. VCAM-1 is one of the effective ligands for the integrin alpha9beta1. This interaction mediates the neutrophile migration on VCAM-1 and extravasation of neutrophils at sites of acute inflammation. Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 Edited: Garapati, P V, 2008-03-11 10:20:45 Integrin alpha9beta1 Reactome DB_ID: 216011 plasma membrane GENE ONTOLOGY GO:0005886 ITGB1 Integrin beta-1 Fibronectin receptor beta subunit CD29 antigen Integrin VLA-4 beta subunit Reactome DB_ID: 57596 UniProt:P05556 ITGB1 ITGB1 FNRB MDF2 MSK12 FUNCTION Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity).FUNCTION (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.FUNCTION (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.FUNCTION (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.FUNCTION (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.FUNCTION (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.FUNCTION (Microbial infection) Acts as a receptor for Mammalian reovirus.FUNCTION (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.FUNCTION (Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:32487760). Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression (PubMed:32487760).FUNCTION (Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis.SUBUNIT Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 interacts with IL1B (PubMed:29030430). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (PubMed:15466886). ITGA5:ITGB1 interacts with ACE2 (PubMed:33102950). Interacts with TMEM182 and LAMB1 (By similarity).SUBUNIT (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.SUBUNIT (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.SUBUNIT (Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.SUBUNIT (Microbial infection) Interacts with mammalian reovirus capsid proteins.SUBUNIT (Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.SUBUNIT (Microbial infection) ITGA5:ITGB1 interacts with SARS coronavirus-2/SARS-CoV-2 spike protein.SUBUNIT (Microbial infection) Interacts with R.delemar CotH7 on the surface of alveolar epithelial cells.SUBUNIT (Microbial infection) Interacts with N.meningitidis serogroup B adhesin A (nadA).INDUCTION Induced in alveolar epithelial cells during exposure to the fungus R.delemar, a causative agent of mucormycosis.PTM The cysteine residues are involved in intrachain disulfide bonds.BIOTECHNOLOGY Antibodies against integrin beta-1 ITGB1 protects epithelial cells from invasion by the fungus R.delemar, a causative agent of mucormycosis, and could thus potentially be used to treat mucormycosis disease (PubMed:32487760). Antibodies against the protein also protect a neutropenic mouse model against mucormycosis (PubMed:32487760).SIMILARITY Belongs to the integrin beta chain family. Homo sapiens NCBI Taxonomy 9606 UniProt P05556 21 EQUAL 798 EQUAL Reactome Database ID Release 83 57596 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=57596 Reactome R-HSA-57596 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-57596.1 Reactome http://www.reactome.org 1 ITGA9 Integrin alpha-9 Reactome DB_ID: 215944 UniProt:Q13797 ITGA9 ITGA9 FUNCTION Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.SUBUNIT Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus).TISSUE SPECIFICITY In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.INDUCTION Up-regulated in small cell lung cancers (SCLC).SIMILARITY Belongs to the integrin alpha chain family. UniProt Q13797 30 EQUAL 1035 EQUAL Reactome Database ID Release 83 215944 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=215944 Reactome R-HSA-215944 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-215944.1 1 Reactome Database ID Release 83 216011 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=216011 Reactome R-HSA-216011 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-216011.1 ComplexPortal CPX-1816 additional information MI MI:0361 VCAM1 Vascular cell adhesion protein 1 VCA1_HUMAN Reactome DB_ID: 197834 UniProt:P19320 VCAM1 VCAM1 FUNCTION Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.TISSUE SPECIFICITY Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.INDUCTION By cytokines (e.g. IL-1, TNF-alpha).DOMAIN Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.PTM Sialoglycoprotein. UniProt P19320 25 EQUAL 739 EQUAL Reactome Database ID Release 83 197834 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197834 Reactome R-HSA-197834 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-197834.1 Integrin alpha9beta1:VCAM-1 Reactome DB_ID: 265410 1 1 Reactome Database ID Release 83 265410 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265410 Reactome R-HSA-265410 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-265410.1 Reactome Database ID Release 83 265428 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=265428 Reactome R-HSA-265428 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-265428.1 10209034 Pubmed 1999 The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1 Taooka, Y Chen, J Yednock, T Sheppard, D J Cell Biol 145:413-20