BioPAX pathway converted from "LTC4 is exported from the cytosol by ABCC1" in the Reactome database. LEFT-TO-RIGHT ABCC1 mediates LTC4 export from the cell LTC4 is exported from the cytosol by ABCC1 On formation, leukotriene C4 (LTC4) is exported to the extracellular region by the ABCC1 transporter (Sjolinder et al. 1999, Lam et al. 1989) and processed further by cleavage reactions. Authored: Jassal, Bijay, 2008-10-01 Reviewed: Rush, MG, 2012-11-10 Edited: Jassal, B, 2008-04-21 14:30:22 LTC4 leukotriene C4 Reactome DB_ID: 266066 cytosol GENE ONTOLOGY GO:0005829 leukotriene C4 [ChEBI:16978] leukotriene C4 ChEBI CHEBI:16978 Reactome Database ID Release 82 266066 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266066 Reactome R-ALL-266066 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266066.3 Reactome http://www.reactome.org COMPOUND C02166 additional information MI MI:0361 LTC4 leukotriene C4 Reactome DB_ID: 266013 extracellular region GENE ONTOLOGY GO:0005576 Reactome Database ID Release 82 266013 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266013 Reactome R-ALL-266013 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-266013.3 COMPOUND C02166 ACTIVATION MRP1 ABCC1 Multidrug resistance-associated protein 1 Reactome DB_ID: 266068 plasma membrane GENE ONTOLOGY GO:0005886 UniProt:P33527 ABCC1 ABCC1 MRP MRP1 FUNCTION Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).ACTIVITY REGULATION MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export.TISSUE SPECIFICITY Lung, testis and peripheral blood mononuclear cells.SIMILARITY Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Homo sapiens NCBI Taxonomy 9606 UniProt P33527 1 EQUAL 1531 EQUAL Reactome Database ID Release 82 266068 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266068 Reactome R-HSA-266068 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-266068.2 GENE ONTOLOGY GO:0140359 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 266058 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266058 Reactome Database ID Release 82 266070 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=266070 Reactome R-HSA-266070 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-266070.1 2753893 Pubmed 1989 The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils Lam, Bing K Owen WF, Jr Austen, KF Soberman, RJ J Biol Chem 264:12885-9 10064732 Pubmed 1999 Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1 Sjölinder, Mikael Tornhamre, S Claesson, HE Hydman, J Lindgren, J J Lipid Res 40:439-46