BioPAX pathway converted from "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol" in the Reactome database.LEFT-TO-RIGHTNa+, K+/2Cl- cotransportSLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosolTwo genes (SLC12A1 and SLC12A2) encode Na+,K+/2Cl- cotransporters (NKCC2 and NKCC1 respectively). SLC12A1 (Simon DB et al, 1996) is kidney-specific whilst SLC12A2 (Payne JA et al, 1995) is ubiquitously expressed. Two Cl- ions are electroneutrally transported into cells with a Na+ ion and a K+ ion.Authored: Jassal, Bijay, 2009-06-12Reviewed: He, L, 2009-08-24Edited: Jassal, Bijay, 2009-06-12K+Potassiumpotassium(1+)Reactome DB_ID: 74126extracellular regionGENE ONTOLOGYGO:0005576potassium(1+) [ChEBI:29103]potassium(1+)PotassiumK+ChEBICHEBI:29103Reactome Database ID Release 7574126Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74126ReactomeR-ALL-741263Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74126.3Reactomehttp://www.reactome.orgCOMPOUNDC00238additional informationMIMI:0361Na+sodium ionsodium(1+)SodiumReactome DB_ID: 74113sodium(1+) [ChEBI:29101]sodium(1+)ChEBICHEBI:29101Reactome Database ID Release 7574113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=74113ReactomeR-ALL-741133Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74113.3COMPOUNDC01330Cl-chlorideReactome DB_ID: 188972chloride [ChEBI:17996]chlorideChEBICHEBI:17996Reactome Database ID Release 75188972Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188972ReactomeR-ALL-1889723Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188972.3COMPOUNDC001152Na+sodium ionsodium(1+)SodiumReactome DB_ID: 83910cytosolGENE ONTOLOGYGO:0005829Reactome Database ID Release 7583910Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=83910ReactomeR-ALL-839103Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83910.3COMPOUNDC01330Cl-chlorideReactome DB_ID: 352022Reactome Database ID Release 75352022Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352022ReactomeR-ALL-3520223Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-352022.3COMPOUNDC001152K+Potassiumpotassium(1+)Reactome DB_ID: 29804Reactome Database ID Release 7529804Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29804ReactomeR-ALL-298043Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29804.3COMPOUNDC00238ACTIVATIONConverted from EntitySet in ReactomeSLC12A1,2NKCC cotransportersReactome DB_ID: 426153SLC12A1Solute carrier family 12 member 1S12A1_HUMANReactome DB_ID: 426139plasma membraneGENE ONTOLOGYGO:0005886UniProt:Q13621 SLC12A1SLC12A1NKCC2FUNCTION Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system.ACTIVITY REGULATION Activated by WNK3.SUBUNIT When phosphorylated, interacts with PPP3CB.TISSUE SPECIFICITY Kidney specific.SIMILARITY Belongs to the SLC12A transporter family.Homo sapiensNCBI Taxonomy9606UniProtQ136211EQUAL1099EQUALReactome Database ID Release 75426139Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426139ReactomeR-HSA-4261391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426139.1SLC12A2Solute carrier family 12 member 2S12A2_HUMANReactome DB_ID: 426146UniProt:P55011 SLC12A2SLC12A2NKCC1FUNCTION Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.ACTIVITY REGULATION Activated by WNK3.TISSUE SPECIFICITY Expressed in many tissues.SIMILARITY Belongs to the SLC12A transporter family.UniProtP550111EQUAL1212EQUALReactome Database ID Release 75426146Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426146ReactomeR-HSA-4261461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426146.1Reactome Database ID Release 75426153Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426153ReactomeR-HSA-4261531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426153.1GENE ONTOLOGYGO:0008511gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 75426140Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426140Reactome Database ID Release 75426086Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=426086ReactomeR-HSA-4260861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-426086.17629105Pubmed1995Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colonPayne, JAXu, JCHaas, MLytle, CYWard, DForbush B, 3rdJ Biol Chem 270:17977-858640224Pubmed1996Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2Simon, DBKaret, FEHamdan, JMDiPietro, ASanjad, SALifton, RPNat Genet 13:183-8