BioPAX pathway converted from "Activation and dimerization of c-JUN in the nucleus" in the Reactome database. LEFT-TO-RIGHT 2.7.11 Activation and dimerization of c-JUN in the nucleus Shortly after phosphorylation JNKs are translocated to nucleus where they associate and activate their target transcription factors. Authored: Shamovsky, V, 2009-09-22 Reviewed: D'Eustachio, P, 2010-05-23 Edited: Shamovsky, V, 2010-05-04 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 29358 nucleoplasm GENE ONTOLOGY GO:0005654 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 29358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29358 Reactome R-ALL-29358 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3 Reactome http://www.reactome.org COMPOUND C00002 additional information MI MI:0361 4 c-JUN Transcription factor AP-1 Reactome DB_ID: 438016 UniProt:P18870 JUN JUN FUNCTION Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.SUBUNIT Interacts with FOS to form a dimer. Interacts with Gallid herpesvirus 2 MEQ protein.SIMILARITY Belongs to the bZIP family. Jun subfamily. Gallus gallus NCBI Taxonomy 9031 UniProt P18870 1 EQUAL 314 EQUAL Reactome Database ID Release 82 438016 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438016 Reactome R-GGA-438016 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-438016.1 2 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 113582 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 113582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113582 Reactome R-ALL-113582 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3 COMPOUND C00008 4 activated c-JUN dimer Reactome DB_ID: 437991 phosphorylated c-JUN Transcription factor AP-1 Reactome DB_ID: 438013 63 EQUAL O-phospho-L-serine MOD MOD:00046 73 EQUAL 1 EQUAL 314 EQUAL Reactome Database ID Release 82 438013 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438013 Reactome R-GGA-438013 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-438013.1 2 Reactome Database ID Release 82 437991 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437991 Reactome R-GGA-437991 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-437991.1 ACTIVATION activeUnit: #Protein7 activeUnit: #Protein8 activeUnit: #Protein9 Converted from EntitySet in Reactome phosphorylated JNK homologs Reactome DB_ID: 438012 phosphorylated MAPK9_(JNK2) mitogen-activated protein kinase 9 Reactome DB_ID: 437993 UniProt:P79996 MAPK9 MAPK9 JNK2 FUNCTION Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity).ACTIVITY REGULATION Activated by threonine and tyrosine phosphorylation.TISSUE SPECIFICITY Expressed in the neuroepithelium of developing brain at stages 16 to 26.DOMAIN The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. UniProt P79996 183 EQUAL O-phospho-L-threonine MOD MOD:00047 185 EQUAL O4'-phospho-L-tyrosine MOD MOD:00048 1 EQUAL 382 EQUAL Reactome Database ID Release 82 437993 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437993 Reactome R-GGA-437993 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-437993.1 phosphorylated MAPK10 Reactome DB_ID: 437960 ENSEMBL:ENSGALP00000018075 MAPK10 MAPK10 ENSEMBL ENSGALP00000018075 Reactome Database ID Release 82 437960 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437960 Reactome R-GGA-437960 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-437960.1 phosphorylated MAPK8 Reactome DB_ID: 437983 ENSEMBL:ENSGALP00000009848 MAPK8 MAPK8 ENSEMBL ENSGALP00000009848 1 EQUAL 427 EQUAL Reactome Database ID Release 82 437983 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437983 Reactome R-GGA-437983 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-437983.1 Reactome Database ID Release 82 438012 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438012 Reactome R-GGA-438012 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-438012.1 GENE ONTOLOGY GO:0004705 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 438001 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438001 phosphorylated MAPK10 Reactome DB_ID: 437973 cytosol GENE ONTOLOGY GO:0005829 Reactome Database ID Release 82 437973 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437973 Reactome R-GGA-437973 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-437973.1 phosphorylated MAPK8 Reactome DB_ID: 437976 1 EQUAL 427 EQUAL Reactome Database ID Release 82 437976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437976 Reactome R-GGA-437976 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-437976.1 phosphorylated MAPK9_(JNK2) mitogen-activated protein kinase 9 Reactome DB_ID: 438015 1 EQUAL 382 EQUAL Reactome Database ID Release 82 438015 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438015 Reactome R-GGA-438015 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-438015.1 Reactome Database ID Release 82 438026 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438026 Reactome R-GGA-438026 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-438026.2 18793328 Pubmed 2008 c-Jun expression, activation and function in neural cell death, inflammation and repair Raivich, G J Neurochem 107:898-906 INHIBITION Reactome Database ID Release 82 442857 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442857 Reactome R-GGA-442857 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442857.1 Converted from EntitySet in Reactome MAPK phosphatases dual specificity phosphatases Reactome DB_ID: 442886 MKP1 Dual specificity protein phosphatase 1 Reactome DB_ID: 442888 UniProt:O42253 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 1 MKP1 UniProt O42253 1 EQUAL 353 EQUAL Reactome Database ID Release 82 442888 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442888 Reactome R-GGA-442888 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442888.1 MKP2 DUSP4 Reactome DB_ID: 442850 UniProt:Q9PW71 DUSP4 DUSP4 MKP2 FUNCTION Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. UniProt Q9PW71 1 EQUAL 375 EQUAL Reactome Database ID Release 82 442850 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442850 Reactome R-GGA-442850 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442850.1 MKP3 DUSP6 Reactome DB_ID: 442887 UniProt:Q7T2L9 MKP3 MKP3 dual specificity phosphatase 6 UniProt Q7T2L9 1 EQUAL 382 EQUAL Reactome Database ID Release 82 442887 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442887 Reactome R-GGA-442887 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442887.1 MKP5 DUSP10 Reactome DB_ID: 442877 UniProt:Q5ZJF8 Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 10 RCJMB04_18i8 UniProt Q5ZJF8 1 EQUAL 478 EQUAL Reactome Database ID Release 82 442877 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442877 Reactome R-GGA-442877 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442877.1 DUSP16 Reactome DB_ID: 442935 ENSEMBL:ENSGALP00000001453 DUSP16 DUSP16 ENSEMBL ENSGALP00000001453 Reactome Database ID Release 82 442935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442935 Reactome R-GGA-442935 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442935.1 DUSP3 dual specificity phosphatase 3 Reactome DB_ID: 442882 ENSEMBL:ENSGALP00000016127 DUSP3 DUSP3 ENSEMBL ENSGALP00000016127 Reactome Database ID Release 82 442882 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442882 Reactome R-GGA-442882 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442882.1 DUSP5 Reactome DB_ID: 442941 ENSEMBL:ENSGALP00000013956 dual specificity phosphatase 5 dual specificity phosphatase 5 DUSP5 ENSEMBL ENSGALP00000013956 Reactome Database ID Release 82 442941 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442941 Reactome R-GGA-442941 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442941.1 DUSP8 Reactome DB_ID: 442917 ENSEMBL:ENSGALP00000010737 DUSP8 DUSP8 ENSEMBL ENSGALP00000010737 Reactome Database ID Release 82 442917 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442917 Reactome R-GGA-442917 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442917.1 MKP6 DUSP14 Reactome DB_ID: 442874 ENSEMBL:ENSGALP00000008741 DUSP14 DUSP14 dual specificity phosphatase 14 ENSEMBL ENSGALP00000008741 Reactome Database ID Release 82 442874 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442874 Reactome R-GGA-442874 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442874.1 Reactome Database ID Release 82 442886 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442886 Reactome R-GGA-442886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442886.1