BioPAX pathway converted from "Activated TLR7 or 21 recruits MyD88" in the Reactome database. LEFT-TO-RIGHT Activated TLR7 or 21 recruits MyD88 Cloning and analysis of full length chicken MyD88 revealed an open reading frame which encodes a predicted protein sequence of 368 amino acids (aa). Two more chicken MyD88 isoforms with 299 and 376 residues are described in the literature [Qiu Y et al 2008, Lynn et al 2003]. The amino acid sequences of the chMyD88 368 and 376 residue isoforms are 99% identical, 97% identical to the 299 aa chMyD88 predicted peptide and 68% identical to human MyD88 (296 aa).<p>Chicken MyD88 is recruited to the activated hetero or homodimer of chTLR that is located either on plasma membrane (TLR4, TLR2/1, TLR5 and TLR15) or endosome membrane (TLR7 and TLR21). Authored: Shamovsky, V, 2010-11-30 Reviewed: D'Eustachio, P, 2010-12-06 Edited: Shamovsky, V, 2011-02-24 MyD88 Reactome DB_ID: 433987 cytosol GENE ONTOLOGY GO:0005829 UniProt:A5HNF6 MYD88 MYD88 RCJMB04_14h3 FUNCTION Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.TISSUE SPECIFICITY Expressed in spleen, liver, kidney, bursa of Fabricius, lung and brain (at protein level). Expressed in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus, bursa of Fabricius, muscle and lung.DOMAIN The intermediate domain (ID) is required for the phosphorylation and activation of IRAK. Gallus gallus NCBI Taxonomy 9031 UniProt A5HNF6 1 EQUAL 299 EQUAL Reactome Database ID Release 81 433987 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433987 Reactome R-GGA-433987 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433987.1 Reactome http://www.reactome.org 2 Converted from EntitySet in Reactome activated TLR7 or 21 bound to ligand Reactome DB_ID: 573279 TLR21 bound to unmethylated CpG DNA Reactome DB_ID: 451483 endosome membrane GENE ONTOLOGY GO:0010008 Unmethylated CpG DNA Reactome DB_ID: 167913 Reactome Database ID Release 81 167913 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167913 Reactome R-ALL-167913 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-167913.3 ChEBI 61120 additional information MI MI:0361 1 TLR21 homodimer Reactome DB_ID: 451503 TLR21 Reactome DB_ID: 451525 UniProt:Q5ZJ34 RCJMB04_21a21 RCJMB04_21a21 UniProt Q5ZJ34 1 EQUAL 972 EQUAL Reactome Database ID Release 81 451525 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451525 Reactome R-GGA-451525 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451525.1 2 Reactome Database ID Release 81 451503 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451503 Reactome R-GGA-451503 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451503.1 1 Reactome Database ID Release 81 451483 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451483 Reactome R-GGA-451483 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451483.1 chicken TLR7 homodimer bound to recognized ligands Reactome DB_ID: 451537 TLR7 homodimer Reactome DB_ID: 451536 chicken TLR7 Reactome DB_ID: 451496 UniProt:Q5ZJD0 TLR7 TLR7 RCJMB04_19d10 UniProt Q5ZJD0 1 EQUAL 1059 EQUAL Reactome Database ID Release 81 451496 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451496 Reactome R-GGA-451496 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451496.1 2 Reactome Database ID Release 81 451536 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451536 Reactome R-GGA-451536 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451536.1 1 Converted from EntitySet in Reactome Ligands recognized by chicken TLR7 Reactome DB_ID: 188130 Converted from EntitySet in Reactome Imidazoquinoline compounds Reactome DB_ID: 188128 R-848 resiquimod Reactome DB_ID: 188126 endosome lumen GENE ONTOLOGY GO:0031904 resiquimod [ChEBI:36706] resiquimod ChEBI CHEBI:36706 Reactome Database ID Release 81 188126 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188126 Reactome R-ALL-188126 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188126.4 IMIQ imiquimod Reactome DB_ID: 188127 imiquimod [ChEBI:36704] imiquimod ChEBI CHEBI:36704 Reactome Database ID Release 81 188127 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188127 Reactome R-ALL-188127 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188127.4 Reactome Database ID Release 81 188128 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188128 Reactome R-ALL-188128 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188128.2 ssRNA Reactome DB_ID: 167963 Reactome Database ID Release 81 167963 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167963 Reactome R-ALL-167963 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-167963.3 ChEBI 33697 Reactome Database ID Release 81 188130 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188130 Reactome R-ALL-188130 8 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188130.8 1 Reactome Database ID Release 81 451537 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451537 Reactome R-GGA-451537 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451537.1 Reactome Database ID Release 81 573279 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=573279 Reactome R-GGA-573279 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-573279.1 activated TLR7/ or TLR21 : MyD88 complex Reactome DB_ID: 451459 MyD88 Reactome DB_ID: 573258 1 EQUAL 299 EQUAL Reactome Database ID Release 81 573258 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=573258 Reactome R-GGA-573258 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-573258.1 2 1 Reactome Database ID Release 81 451459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451459 Reactome R-GGA-451459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451459.1 Reactome Database ID Release 81 451439 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451439 Reactome R-GGA-451439 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451439.1 17676477 Pubmed 2007 Molecular cloning and expression analysis of chicken MyD88 and TRIF genes Wheaton, S Lambourne, MD Sarson, AJ Brisbin, JT Mayameei, A Sharif, S DNA Seq 18:480-6 18582498 Pubmed 2008 Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88) Qiu, Y Shen, Y Li, X Ding, C Ma, Z Dev Comp Immunol 32:1522-30 19002681 Pubmed 2009 Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickens Nerren, JR Swaggerty, CL MacKinnon, KM Genovese, KJ He, H Pevzner, I Kogut, MH Immunogenetics 61:71-7