BioPAX pathway converted from "Release of mouse platelet cytosolic components" in the Reactome database. LEFT-TO-RIGHT Release of mouse platelet cytosolic components Platelet releasate contains a range of proteins that do not originate in specialized storage granules. In some cases platelet lysis may contribute to the presence of these proteins in the platelet relesate. Authored: de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 Converted from EntitySet in Reactome Platelet releasate mouse cytosolic proteins Reactome DB_ID: 482773 Cap1 Adenylyl cyclase-associated protein 1 CAP1_MOUSE Reactome DB_ID: 350732 cytosol GENE ONTOLOGY GO:0005829 UniProt:P40124 Cap1 Cap1 Cap FUNCTION Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.SUBUNIT Homodimer. Binds actin monomers (By similarity).TISSUE SPECIFICITY Ubiquitous.SIMILARITY Belongs to the CAP family. Mus musculus NCBI Taxonomy 10090 UniProt P40124 2 EQUAL 474 EQUAL Reactome Database ID Release 82 350732 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=350732 Reactome R-MMU-350732 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350732.1 Reactome http://www.reactome.org Cfl1 Cofilin-1 Reactome DB_ID: 350722 UniProt:P18760 Cfl1 Cfl1 FUNCTION Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11809832). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:25208553). Required for the centralization of the mitotic spindle and symmetric division of zygotes (PubMed:25208553). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (PubMed:15649475).SUBUNIT Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (PubMed:11809832). It is a major component of intranuclear and cytoplasmic actin rods (By similarity). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (PubMed:25208553). Interacts with C9orf72 (PubMed:27723745).TISSUE SPECIFICITY Widely distributed in various tissues. Not found in skeletal muscle.DEVELOPMENTAL STAGE In 10.5 dpc embryo somites is expressed in a ventral cell layer (myotome).PTM Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (PubMed:25107909). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).SIMILARITY Belongs to the actin-binding proteins ADF family. UniProt P18760 2 EQUAL 166 EQUAL Reactome Database ID Release 82 350722 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=350722 Reactome R-MMU-350722 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350722.1 Pfn1 Profilin-1 Reactome DB_ID: 350757 UniProt:P62962 Pfn1 Pfn1 FUNCTION Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).SUBUNIT Interacts with VASP. Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1 (By similarity). Interacts with HTT (By similarity).PTM Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.SIMILARITY Belongs to the profilin family. UniProt P62962 2 EQUAL 140 EQUAL Reactome Database ID Release 82 350757 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=350757 Reactome R-MMU-350757 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350757.1 Reactome Database ID Release 82 482773 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482773 Reactome R-MMU-482773 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-482773.1 Converted from EntitySet in Reactome Platelet releasate mouse cytosolic proteins Reactome DB_ID: 482778 Cap1 Adenylyl cyclase-associated protein 1 CAP1_MOUSE Reactome DB_ID: 350692 extracellular region GENE ONTOLOGY GO:0005576 2 EQUAL 474 EQUAL Reactome Database ID Release 82 350692 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=350692 Reactome R-MMU-350692 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350692.1 Cfl1 Cofilin-1 Reactome DB_ID: 350721 2 EQUAL 166 EQUAL Reactome Database ID Release 82 350721 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=350721 Reactome R-MMU-350721 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350721.1 Pfn1 Profilin-1 Reactome DB_ID: 350698 2 EQUAL 140 EQUAL Reactome Database ID Release 82 350698 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=350698 Reactome R-MMU-350698 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-350698.1 Reactome Database ID Release 82 482778 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482778 Reactome R-MMU-482778 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-482778.1 Reactome Database ID Release 82 482767 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=482767 Reactome R-MMU-482767 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-482767.1 14630798 Pubmed 2004 Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions Coppinger, JA Cagney, G Toomey, S Kislinger, T Belton, O McRedmond, JP Cahill, DJ Emili, A Fitzgerald, DJ Maguire, PB Blood 103:2096-104