BioPAX pathway converted from "Csnk1a1 phosphorylates Smo dimer" in the Reactome database.LEFT-TO-RIGHT2.7.11Csnk1a1 phosphorylates Smo dimerNumerous residues in the C-terminal tail of Smo are phosphorylated by Csnk1a1 as assessed by an in vitro kinase assay. Of these, residues S592, S594, T597 and S599 in the S0 region appear to play the most important role in Smo activation in response to Shh. Initial phosphorylation by Csnk1a promotes further phosphorylation by both Csnk1a1 and by Ardbk1/Grk2, and phosphorylation is required to promote a conformational change in the C-terminal Smo tail that is required to propagate the Hh signal to downstream effectors (Chen et al, 2011; Chen et al, 2010; Zhao et al, 2007).Authored: Rothfels, Karen, 2014-10-24Reviewed: Liu, Yulu Cherry, 2014-11-09Edited: Gillespie, Marc E, 2014-10-30Smo dimer:Csnk1a1Reactome DB_ID: 5632611ciliary membraneGENE ONTOLOGYGO:0060170Smo dimerReactome DB_ID: 5632605SmoReactome DB_ID: 5632510UniProt:P56726 SmoSmoSmohFUNCTION G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).SUBUNIT Homodimer (By similarity). Interacts with ARRB2 (PubMed:15618519). Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (PubMed:22072986). Interacts with KIF7, DLG5 and SDCBP (PubMed:25644602). Interacts with GAS8/DRC4 (PubMed:21659505).SIMILARITY Belongs to the G-protein coupled receptor Fz/Smo family.Mus musculusNCBI Taxonomy10090UniProtP5672633EQUAL793EQUALReactome Database ID Release 755632510Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632510ReactomeR-MMU-56325101Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632510.1Reactomehttp://www.reactome.org2Reactome Database ID Release 755632605Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632605ReactomeR-MMU-56326051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632605.11Ck1Csnk1a1casein kinase 1 alphaReactome DB_ID: 5632506ciliumGENE ONTOLOGYGO:0005929UniProt:Q8BK63 Csnk1a1Csnk1a1FUNCTION Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity).SUBUNIT Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. Interacts with FAM83H; recruits CSNK1A1 to keratin filaments.SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.UniProtQ8BK632EQUAL337EQUALReactome Database ID Release 755632506Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632506ReactomeR-MMU-56325062Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632506.21Reactome Database ID Release 755632611Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632611ReactomeR-MMU-56326111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632611.1ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 5632460ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 755632460Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632460ReactomeR-ALL-56324604Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5632460.4COMPOUNDC00002additional informationMIMI:03618pS592, S594, T597, S599-Smo dimer:Csnk1a1Reactome DB_ID: 5632627pS592, S594, T597, S599-Smo dimerReactome DB_ID: 5632626pS592, S594, T597, S599-SmoReactome DB_ID: 5632523592EQUALO-phospho-L-serineMODMOD:00046594EQUAL597EQUALO-phospho-L-threonineMODMOD:00047599EQUAL33EQUAL793EQUALReactome Database ID Release 755632523Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632523ReactomeR-MMU-56325231Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632523.12Reactome Database ID Release 755632626Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632626ReactomeR-MMU-56326261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632626.111Reactome Database ID Release 755632627Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632627ReactomeR-MMU-56326271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632627.1ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 5632457ADP(3-) [ChEBI:456216]ADP(3-)ADP5'-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 755632457Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632457ReactomeR-ALL-56324574Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5632457.4COMPOUNDC000088ACTIVATIONactiveUnit: #Protein2GENE ONTOLOGYGO:0004674gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 755632633Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632633Reactome Database ID Release 755632661Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5632661ReactomeR-MMU-56326611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5632661.121695114Pubmed2011Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothenedChen, YongbinSasai, NoriakiMa, GuoqiangYue, TaoJia, JianhangBriscoe, JamesJiang, JinPLoS Biol. 9:e100108320844016Pubmed2010G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in DrosophilaChen, YongbinLi, ShuangTong, ChaoZhao, YunWang, BingLiu, YajuanJia, JianhangJiang, JinGenes Dev. 24:2054-6717960137Pubmed2007Hedgehog regulates smoothened activity by inducing a conformational switchZhao, YTong, CJiang, JNature 450:252-8