BioPAX pathway converted from "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex" in the Reactome database. LEFT-TO-RIGHT 2.7.11.1 IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.<p>Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2. Authored: Shamovsky, V, 2010-11-30 Reviewed: D'Eustachio, P, 2010-12-06 Edited: Shamovsky, V, 2011-02-24 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 cytosol GENE ONTOLOGY GO:0005829 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 82 113592 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 Reactome http://www.reactome.org COMPOUND C00002 additional information MI MI:0361 2 IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex Reactome DB_ID: 571321 endosome membrane GENE ONTOLOGY GO:0010008 IRAK2 Reactome DB_ID: 993993 UniProt:Q5F382 RCJMB04_29d24 RCJMB04_29d24 <submittedName> <fullName>Putative uncharacterized protein</fullName> </submittedName> Gallus gallus NCBI Taxonomy 9031 UniProt Q5F382 1 EQUAL 691 EQUAL Reactome Database ID Release 82 993993 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=993993 Reactome R-GGA-993993 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-993993.1 2 activated TLR7/or TLR21 : MyD88 : IRAK4 complex Reactome DB_ID: 451434 IRAK4 Reactome DB_ID: 993981 UniProt:Q5ZJM6 RCJMB04_17b10 RCJMB04_17b10 <submittedName> <fullName>Putative uncharacterized protein</fullName> </submittedName> UniProt Q5ZJM6 1 EQUAL 373 EQUAL Reactome Database ID Release 82 993981 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=993981 Reactome R-GGA-993981 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-993981.1 2 activated TLR7/ or TLR21 : MyD88 complex Reactome DB_ID: 451459 MyD88 Reactome DB_ID: 573258 UniProt:A5HNF6 MYD88 MYD88 RCJMB04_14h3 FUNCTION Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.TISSUE SPECIFICITY Expressed in spleen, liver, kidney, bursa of Fabricius, lung and brain (at protein level). Expressed in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus, bursa of Fabricius, muscle and lung.DOMAIN The intermediate domain (ID) is required for the phosphorylation and activation of IRAK. UniProt A5HNF6 1 EQUAL 299 EQUAL Reactome Database ID Release 82 573258 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=573258 Reactome R-GGA-573258 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-573258.1 2 Converted from EntitySet in Reactome activated TLR7 or 21 bound to ligand Reactome DB_ID: 573279 TLR21 bound to unmethylated CpG DNA Reactome DB_ID: 451483 TLR21 homodimer Reactome DB_ID: 451503 TLR21 Reactome DB_ID: 451525 UniProt:Q5ZJ34 RCJMB04_21a21 RCJMB04_21a21 UniProt Q5ZJ34 1 EQUAL 972 EQUAL Reactome Database ID Release 82 451525 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451525 Reactome R-GGA-451525 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451525.1 2 Reactome Database ID Release 82 451503 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451503 Reactome R-GGA-451503 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451503.1 1 Unmethylated CpG DNA Reactome DB_ID: 167913 Reactome Database ID Release 82 167913 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167913 Reactome R-ALL-167913 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-167913.3 ChEBI 61120 1 Reactome Database ID Release 82 451483 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451483 Reactome R-GGA-451483 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451483.1 chicken TLR7 homodimer bound to recognized ligands Reactome DB_ID: 451537 Converted from EntitySet in Reactome Ligands recognized by chicken TLR7 Reactome DB_ID: 188130 Converted from EntitySet in Reactome Imidazoquinoline compounds Reactome DB_ID: 188128 R-848 resiquimod Reactome DB_ID: 188126 endosome lumen GENE ONTOLOGY GO:0031904 resiquimod [ChEBI:36706] resiquimod ChEBI CHEBI:36706 Reactome Database ID Release 82 188126 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188126 Reactome R-ALL-188126 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188126.4 IMIQ imiquimod Reactome DB_ID: 188127 imiquimod [ChEBI:36704] imiquimod ChEBI CHEBI:36704 Reactome Database ID Release 82 188127 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188127 Reactome R-ALL-188127 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188127.4 Reactome Database ID Release 82 188128 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188128 Reactome R-ALL-188128 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188128.2 ssRNA Reactome DB_ID: 167963 Reactome Database ID Release 82 167963 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167963 Reactome R-ALL-167963 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-167963.3 ChEBI 33697 Reactome Database ID Release 82 188130 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=188130 Reactome R-ALL-188130 8 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-188130.8 1 TLR7 homodimer Reactome DB_ID: 451536 chicken TLR7 Reactome DB_ID: 451496 UniProt:Q5ZJD0 TLR7 TLR7 RCJMB04_19d10 UniProt Q5ZJD0 1 EQUAL 1059 EQUAL Reactome Database ID Release 82 451496 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451496 Reactome R-GGA-451496 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451496.1 2 Reactome Database ID Release 82 451536 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451536 Reactome R-GGA-451536 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451536.1 1 Reactome Database ID Release 82 451537 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451537 Reactome R-GGA-451537 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451537.1 Reactome Database ID Release 82 573279 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=573279 Reactome R-GGA-573279 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-573279.1 1 Reactome Database ID Release 82 451459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451459 Reactome R-GGA-451459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451459.1 1 Reactome Database ID Release 82 451434 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451434 Reactome R-GGA-451434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451434.1 1 Reactome Database ID Release 82 571321 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571321 Reactome R-GGA-571321 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-571321.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 82 29370 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 2 p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 Reactome DB_ID: 994003 activated TLR7/or TLR21: MyD88 : p-IRAK4 complex Reactome DB_ID: 571317 1 activated IRAK4 Reactome DB_ID: 993980 O-phospho-L-serine MOD MOD:00046 O-phospho-L-threonine MOD MOD:00047 1 EQUAL 373 EQUAL Reactome Database ID Release 82 993980 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=993980 Reactome R-GGA-993980 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-993980.1 2 Reactome Database ID Release 82 571317 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571317 Reactome R-GGA-571317 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-571317.1 1 phosphorylated IRAK2 Reactome DB_ID: 994002 phosphorylated residue MOD MOD:00696 1 EQUAL 691 EQUAL Reactome Database ID Release 82 994002 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=994002 Reactome R-GGA-994002 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-994002.1 2 Reactome Database ID Release 82 994003 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=994003 Reactome R-GGA-994003 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-994003.1 ACTIVATION activeUnit: #Protein6 GENE ONTOLOGY GO:0004674 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 82 571329 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571329 Reactome Database ID Release 82 571327 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571327 Reactome R-GGA-571327 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-571327.1 19224918 Pubmed 2009 Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control Wan, Y Xiao, H Affolter, J Kim, TW Bulek, K Chaudhuri, S Carlson, D Hamilton, T Mazumder, B Stark, GR Thomas, J Li, X J Biol Chem 284:10367-75 18438411 Pubmed 2008 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Kawagoe, T Sato, S Matsushita, K Kato, H Matsui, Kuniko Kumagai, Y Saitoh, T Kawai, T Takeuchi, O Akira, Shizuo Nat Immunol 9:684-91 19539094 Pubmed 2009 The avian Toll-Like receptor pathway--subtle differences amidst general conformity Cormican, P Lloyd, AT Downing, T Connell, SJ Bradley, D O'Farrelly, C Dev Comp Immunol 33:967-73