BioPAX pathway converted from "IL13RA1 binds TYK2" in the Reactome database.LEFT-TO-RIGHTIL13RA1 binds TYK2Interleukin-13 receptor subunit alpha-1 (IL13RA1) constitutively associates with Non-receptor tyrosine-protein kinase 2 (TYK2) (Umeshita-Suyama et al. 2000, Roy et al. 2002, LaPorte et al. 2008, Bhattacharjee et al. 2013).Authored: Jupe, Steve, 2015-07-01Reviewed: Leibovich, Samuel, 2016-09-02Edited: Jupe, Steve, 2016-09-02IL13RA1Interleukin-13 receptor alpha-1I13R1_HUMANReactome DB_ID: 449671plasma membraneGENE ONTOLOGYGO:0005886UniProt:P78552 IL13RA1IL13RA1IL13RIL13RAFUNCTION Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.SUBUNIT Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.TISSUE SPECIFICITY Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.SIMILARITY Belongs to the type I cytokine receptor family. Type 5 subfamily.Homo sapiensNCBI Taxonomy9606UniProtP7855222EQUAL427EQUALReactome Database ID Release 76449671Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=449671ReactomeR-HSA-4496711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-449671.1Reactomehttp://www.reactome.orgTYK2Non-receptor tyrosine-protein kinase TYK2TYK2_HUMANReactome DB_ID: 877348cytosolGENE ONTOLOGYGO:0005829UniProt:P29597 TYK2TYK2FUNCTION Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.SUBUNIT Interacts with JAKMIP1.TISSUE SPECIFICITY Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.DOMAIN The FERM domain mediates interaction with JAKMIP1.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.UniProtP295971EQUAL1187EQUALReactome Database ID Release 76877348Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=877348ReactomeR-HSA-8773481Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-877348.1IL13RA1:TYK2Reactome DB_ID: 678582911Reactome Database ID Release 766785829Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6785829ReactomeR-HSA-67858291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6785829.1Reactome Database ID Release 766785762Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6785762ReactomeR-HSA-67857622Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6785762.212223527Pubmed2002IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of StatsRoy, BiswajitBhattacharjee, AshishXu, BFord, DwayneMaizel, Abby LCathcart, Martha KJ. Leukoc. Biol. 72:580-923124025Pubmed2013IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophagesBhattacharjee, AshishShukla, MeenakshiYakubenko, Valentin PMulya, AnnyKundu, SumanCathcart, Martha KFree Radic. Biol. Med. 54:1-1618243101Pubmed2008Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 systemLaporte, SLJuo, ZSVaclavikova, JColf, LAQi, XHeller, NMKeegan, ADGarcia, KCCell 132:259-7211058569Pubmed2000Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activationUmeshita-Suyama, RSugimoto, RAkaiwa, MArima, KYu, BWada, MKuwano, MNakajima, KHamasaki, NIzuhara, KInt. Immunol. 12:1499-509