BioPAX pathway converted from "REG3A binds bacterial phospholipids" in the Reactome database.LEFT-TO-RIGHTREG3A binds bacterial phospholipidsStructural studies of human REG3A by X-ray diffraction with electron microscopy suggest that REG3A binds to bacterial membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing pore (Mukherjee S et al. 2014).Authored: Shamovsky, Veronica, 2015-10-05Reviewed: Hains, David S, 2016-08-02Reviewed: Jupe, Steve, 2016-04-15Edited: Shamovsky, Veronica, 2016-08-15Anionic phospholipids:microbial cell surfaceReactome DB_ID: 8931784plasma membraneGENE ONTOLOGYGO:0005886anionic phospholipidAnionic phospholipidsReactome DB_ID: 1462049anionic phospholipid [ChEBI:62643]anionic phospholipidphospholipid anionanionic phospholipidsphospholipid anionsChEBICHEBI:62643Reactome Database ID Release 751462049Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1462049ReactomeR-ALL-14620494Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1462049.4Reactomehttp://www.reactome.org1Microbial cell surfaceReactome DB_ID: 8879165Reactome Database ID Release 758879165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8879165ReactomeR-ALL-88791652Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8879165.2ChEBI23367additional informationMIMI:03611Reactome Database ID Release 758931784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8931784ReactomeR-ALL-89317841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8931784.1HIPREG3A(38-175)Regenerating islet-derived protein 3-alphaHepatointestinal pancreatic proteinPancreatitis-associated protein 1PAPReactome DB_ID: 6801352extracellular regionGENE ONTOLOGYGO:0005576UniProt:Q06141 REG3AREG3AHIPPAPPAP1FUNCTION Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.SUBUNIT Interacts with EXTL3.TISSUE SPECIFICITY Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.INDUCTION Appears in pancreatic juice after induction of pancreatic inflammation.DOMAIN The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.PTM Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.Homo sapiensNCBI Taxonomy9606UniProtQ0614138EQUAL175EQUALReactome Database ID Release 756801352Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6801352ReactomeR-HSA-68013521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6801352.1REG3A(38-175):anionic phospholipidsReactome DB_ID: 680180411Reactome Database ID Release 756801804Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6801804ReactomeR-HSA-68018046Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6801804.6Reactome Database ID Release 756801776Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6801776ReactomeR-HSA-68017761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6801776.124256734Pubmed2014Antibacterial membrane attack by a pore-forming intestinal C-type lectinMukherjee, SohiniZheng, HuiDerebe, Mehabaw GCallenberg, Keith MPartch, Carrie LRollins, DarcyPropheter, Daniel CRizo, JosepGrabe, MichaelJiang, Qiu-XingHooper, Lora VNature 505:103-7