BioPAX pathway converted from "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]" in the Reactome database.LEFT-TO-RIGHT2.6.1.1oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]Mitochondrial aspartate aminotransferase catalyzes the reversible reaction of oxaloacetate and glutamate to form aspartate and 2-oxoglutarate (alpha-ketoglutarate) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.Reviewed: Harris, RA, 2008-09-10 18:47:12GluL-GluL-glutamate(1-)L-glutamic acidL-GlutamateL-Glutaminic acidReactome DB_ID: 113552mitochondrial matrixGENE ONTOLOGYGO:0005759L-glutamate(1-) [ChEBI:29985]L-glutamate(1-)L-glutamic acid, ion(1-)[NH3+][C@@H](CCC([O-])=O)C([O-])=OWHUUTDBJXJRKMK-VKHMYHEASA-MC5H8NO4146.12136(2S)-2-ammoniopentanedioatehydrogen L-glutamateL-glutamateL-glutamic acid monoanionInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1ChEBICHEBI:29985Reactome Database ID Release 75113552Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113552ReactomeR-ALL-1135525Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113552.5Reactomehttp://www.reactome.orgCOMPOUNDC00025additional informationMIMI:0361OAAOxaloacetateoxaloacetic acidOxalacetic acid2-oxobutanedioic acidOxosuccinic acidReactome DB_ID: 113587oxaloacetic acid [ChEBI:30744]oxaloacetic acidChEBICHEBI:30744Reactome Database ID Release 75113587Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113587ReactomeR-ALL-1135874Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113587.4COMPOUNDC000362OG2-Oxoglutarate2-oxoglutaric acidOxoglutaric acid2-Ketoglutaric acidalpha-Ketoglutaric acid2-oxoglutarate(2-)Reactome DB_ID: 1135942-oxoglutarate(2-) [ChEBI:16810]2-oxoglutarate(2-)2-ketoglutaratealpha-ketoglutarate2-oxopentanedioic acid, ion(2-)2-oxoglutarateChEBICHEBI:16810Reactome Database ID Release 75113594Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113594ReactomeR-ALL-1135944Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113594.4COMPOUNDC00026L-AspL-AspartateL-aspartate(1-)L-aspartic acid2-aminosuccinic acidReactome DB_ID: 113553L-aspartate(1-) [ChEBI:29991]L-aspartate(1-)hydrogen L-aspartateC4H6NO4L-aspartate(2S)-2-ammoniobutanedioateL-aspartic acid monoanionCKLJMWTZIZZHCS-REOHCLBHSA-MInChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1132.09478(2S)-2-ammoniosuccinate[NH3+][C@@H](CC([O-])=O)C([O-])=OChEBICHEBI:29991Reactome Database ID Release 75113553Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113553ReactomeR-ALL-1135535Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113553.5COMPOUNDC00049ACTIVATIONGOT2 dimeraspartate aminotransferase, mitochondrial, holoenzymeReactome DB_ID: 70594GOT2PXLP-K279-GOT2aspartate aminotransferase, mitochondrial, apoenzyme monomerglutamate oxaloacetate transaminase-2Aspartate aminotransferase, mitochondrial precursor Transaminase AReactome DB_ID: 9608413UniProt:P00505 GOT2GOT2FUNCTION Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.SUBUNIT Homodimer.INDUCTION Up-regulated by long-time exposure to alcohol.MISCELLANEOUS In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Homo sapiensNCBI Taxonomy9606UniProtP00505279EQUALN6-pyridoxal phosphate-L-lysineMODMOD:0012830EQUAL430EQUALReactome Database ID Release 759608413Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9608413ReactomeR-HSA-96084132Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9608413.22Reactome Database ID Release 7570594Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70594ReactomeR-HSA-705942Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70594.2GENE ONTOLOGYGO:0004069gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7570595Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70595Reactome Database ID Release 7570613Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70613ReactomeR-HSA-706133Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70613.34052435Pubmed1985The primary structure of mitochondrial aspartate aminotransferase from human heartMartini, FAngelaccio, SBarra, DPascarella, SMaras, BDoonan, SBossa, FBiochim Biophys Acta 832:46-51