BioPAX pathway converted from "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11" in the Reactome database.LEFT-TO-RIGHTPEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11The RING-type E3 ubiquitin ligase sub-complex PEX2:PEX10:PEX12 catalyzes the transfer of ubiquitin from an E2-ubiquitin conjugate (one of Ub:UBE2D1, Ub:UBE2D2, or Ub:UBE2D3) to the cysteine-11 residue of the substrate PEX5L, the peroxisomal matrix protein shuttling receptor (Carvalho et al. 2007; Grou et al. 2008, Okumoto et al. 2011, Sargent et al. 2016, inferred from yeast in Dodt and Gould 1996). In contrast to PEX5, PEX7 transiently associated with the docking and translocation module (which comprises PEX14, PEX13, PEX2, PEX10, and PEX12) is not ubiquitinated. The thiol ester bond between ubiquitin and the cysteine residue of PEX5 is unusual among ubiquitin substrates, which usually have isopeptide bonds between ubiquitin and a lysine residue. Monoubiquitination of PEX5 at cysteine-11 is an integral and mandatory step in the PEX5-mediated peroxisomal protein transport pathway; in its absence, PEX5 and PEX7 cannot be extracted from the peroxisomal membrane docking-translocation machinery (the peroxisomal protein translocon), and thus transport of newly synthesized peroxisomal matrix proteins to the organelle matrix stops (Grou et al. 2009). In addition to monoubiquitinating PEX5 during peroxisomal protein import, the PEX2:PEX10:PEX12 sub-complex has also been implicated in pexophagy, a type of selective autophagy targeting peroxisomes. Pexophagy seems to be triggered mainly by ubiquitination of PEX5, which, in this case, can occur either at its cysteine-11 or lysine-209 residues, but ubiquitination of ABCD3 (also known as PMP70) and other peroxisomal membrane proteins may also be involved (Zhang et al. 2015, inferred from mouse in Nordgren et al. 2015, Sargent et al. 2016).Authored: May, Bruce, 2017-01-01Reviewed: Fransen, Marc, 2018-02-13Reviewed: Van Veldhoven, Paul P, 2018-02-13Reviewed: Azevedo, Jorge E, 2018-03-12Edited: May, Bruce, 2017-01-01PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14Reactome DB_ID: 9033521peroxisomal membraneGENE ONTOLOGYGO:0005778PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12Reactome DB_ID: 9033513PEX13:PEX14Peroxisomal Docking ComplexReactome DB_ID: 9033095PEX13Peroxisomal membrane protein PEX13PEX13_HUMANReactome DB_ID: 452790UniProt:Q92968 PEX13PEX13FUNCTION Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins.SUBUNIT Interacts with PEX19.SIMILARITY Belongs to the peroxin-13 family.CAUTION It is uncertain whether Met-1 or Met-40 is the initiator.Homo sapiensNCBI Taxonomy9606UniProtQ929681EQUAL403EQUALReactome Database ID Release 74452790Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=452790ReactomeR-HSA-4527901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-452790.1Reactomehttp://www.reactome.org1PEX14Peroxisomal membrane protein PEX14PEX14_HUMANReactome DB_ID: 9033101UniProt:O75381 PEX14PEX14FUNCTION Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.SUBUNIT Interacts with PEX5, PEX13 and PEX19. Interacts with tubulin.SIMILARITY Belongs to the peroxin-14 family.UniProtO753812EQUAL377EQUALReactome Database ID Release 749033101Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033101ReactomeR-HSA-90331011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033101.11Reactome Database ID Release 749033095Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033095ReactomeR-HSA-90330951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033095.11PEX7Peroxisomal targeting signal 2 receptorPEX7_HUMANReactome DB_ID: 9033493UniProt:O00628 PEX7PEX7PTS2RFUNCTION Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.SUBUNIT Interacts with PEX5 (By similarity). Interacts with VWA8 (PubMed:30204880).TISSUE SPECIFICITY Ubiquitous. Highest expression in pancreas, skeletal muscle and heart.SIMILARITY Belongs to the WD repeat peroxin-7 family.UniProtO006281EQUAL323EQUALReactome Database ID Release 749033493Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033493ReactomeR-HSA-90334931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033493.11PEX2:PEX10:PEX12Peroxisomal RING finger complexReactome DB_ID: 8953904PEX10Peroxisome biogenesis factor 10PEX10_HUMANReactome DB_ID: 8953928UniProt:O60683 PEX10PEX10RNF69FUNCTION Somewhat implicated in the biogenesis of peroxisomes.SUBUNIT Interacts with PEX19.SIMILARITY Belongs to the pex2/pex10/pex12 family.UniProtO606831EQUAL326EQUALReactome Database ID Release 748953928Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953928ReactomeR-HSA-89539281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8953928.11PEX2Peroxisome biogenesis factor 2PEX2_HUMANReactome DB_ID: 8953913UniProt:P28328 PEX2PEX2PAF1PMP3PMP35PXMP3RNF72FUNCTION Somewhat implicated in the biogenesis of peroxisomes.SIMILARITY Belongs to the pex2/pex10/pex12 family.UniProtP283281EQUAL305EQUALReactome Database ID Release 748953913Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953913ReactomeR-HSA-89539131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8953913.11PEX12Peroxisome assembly protein 12PEX12_HUMANReactome DB_ID: 8953911UniProt:O00623 PEX12PEX12PAF3FUNCTION Required for protein import into peroxisomes.SUBUNIT Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain.SIMILARITY Belongs to the pex2/pex10/pex12 family.UniProtO006231EQUAL359EQUALReactome Database ID Release 748953911Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953911ReactomeR-HSA-89539111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8953911.11Reactome Database ID Release 748953904Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953904ReactomeR-HSA-89539042Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8953904.21PEX5_HUMANPEX5 isoform LPeroxisomal targeting signal 1 receptorReactome DB_ID: 9033489UniProt:P50542-1 PEX5PEX5PXR1FUNCTION Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.SUBUNIT Interacts with PEX7 and PEX13 (By similarity). Interacts with PEX12 and PEX14. Interacts (Cys-linked ubiquitinated) with ZFAND6. Interacts with VWA8 in a PEX7-dependent manner (By similarity).TISSUE SPECIFICITY Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.PTM Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.SIMILARITY Belongs to the peroxisomal targeting signal receptor family.UniProt IsoformP50542-11EQUAL639EQUALReactome Database ID Release 749033489Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033489ReactomeR-HSA-90334891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033489.11Reactome Database ID Release 749033513Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033513ReactomeR-HSA-90335131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033513.11Ub:UBE2D1,2,3Reactome DB_ID: 8953915cytosolGENE ONTOLOGYGO:0005829Converted from EntitySet in ReactomeUb-C85-UBE2D1,2,3Reactome DB_ID: 8963780UbcH5/Ubc4Ub-C85-UBE2D1Reactome DB_ID: 8864160UniProt:P51668 UBE2D1UBE2D1SFTUBC5AUBCH5UBCH5AFUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.TISSUE SPECIFICITY Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.PTM Autoubiquitinated in vitro.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family.CAUTION PubMed:9362508 cloned and sequenced SFT which consisted of UBE2D1 last coding exon along with intronic sequences on the 5'-end of this exon. A function in iron transport has been described.UniProtP5166885EQUALS-(glycyl)-L-cysteine (Cys-Gly)MODMOD:002111EQUAL147EQUALReactome Database ID Release 748864160Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8864160ReactomeR-HSA-88641601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8864160.1UbcH5bUb-C85-UBE2D2Ubiquitin-conjugating enzyme E2 D2UB2D2_HUMANReactome DB_ID: 8864214UniProt:P62837 UBE2D2UBE2D2PUBC1UBC4UBC5BUBCH4UBCH5BFUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3. Interacts with PPP1R11 (By similarity).SIMILARITY Belongs to the ubiquitin-conjugating enzyme family.UniProtP6283785EQUAL1EQUAL147EQUALReactome Database ID Release 748864214Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8864214ReactomeR-HSA-88642141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8864214.1UbcH5cUb-C85-UBE2D3Ubiquitin-conjugating enzyme E2 D3UB2D3_HUMANReactome DB_ID: 8864191UniProt:P61077 UBE2D3UBE2D3UBC5CUBCH5CFUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (PubMed:24211586). Interacts with DDX58 and RNF135; involved in DDX58 ubiquitination and activation (PubMed:28469175).PTM Phosphorylated by AURKB.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family.UniProtP6107785EQUAL1EQUAL147EQUALReactome Database ID Release 748864191Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8864191ReactomeR-HSA-88641911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8864191.1Reactome Database ID Release 748963780Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8963780ReactomeR-HSA-89637801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8963780.11Converted from EntitySet in ReactomeUbubiquitinReactome DB_ID: 113595RPS27ARPS27A(1-76)ubiquitin (RPS27A)Reactome DB_ID: 939205UniProt:P62979 RPS27ARPS27AUBA80UBCEP1SUBUNIT Ribosomal protein S27a is part of the 40S ribosomal subunit.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.UniProtP629791EQUAL76EQUALReactome Database ID Release 74939205Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939205ReactomeR-HSA-9392051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939205.1UBA52UBA52(1-76)ubiquitin (UBA52)Reactome DB_ID: 939203UniProt:P62987 UBA52UBA52UBCEP2SUBUNIT Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.UniProtP629871EQUAL76EQUALReactome Database ID Release 74939203Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939203ReactomeR-HSA-9392031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939203.1UBBUBB(1-76)ubiquitin (UBB 1)Reactome DB_ID: 939214UniProt:P0CG47 UBBUBBSUBUNIT Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS The mRNA encoding variant UBB(+1) is produced by an unknown mechanism involving the deletion of a GT dinucleotide in the close proximity of a GAGAG motif (PubMed:9422699). This variant mRNA is found in normal brain, but the encoded protein accumulates only in brain neurofibrillary tangles and neuritic plaques in Alzheimer disease and other tauopathies, as well as polyglutaminopathies (PubMed:14597671). UBB(+1) variant cannot be used for polyubiquitination, is not effectively degraded by the proteasome when ubiquitinated and ubiquitinated UBB(+1) is refractory to disassembly by deubiquitinating enzymes (DUBs). In healthy brain, UBB(+1) C-terminus can be cleaved by UCHL3 (PubMed:21762696).MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY Belongs to the ubiquitin family.UniProtP0CG471EQUAL76EQUALReactome Database ID Release 74939214Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939214ReactomeR-HSA-9392141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939214.1UBB(77-152)ubiquitin (UBB 2)Reactome DB_ID: 93921377EQUAL152EQUALReactome Database ID Release 74939213Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939213ReactomeR-HSA-9392131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939213.1UBB(153-228)ubiquitin (UBB 3)Reactome DB_ID: 939230153EQUAL228EQUALReactome Database ID Release 74939230Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939230ReactomeR-HSA-9392301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939230.1UBCUBC(1-76)ubiquitin (UBC 1)Reactome DB_ID: 939188UniProt:P0CG48 UBCUBCMISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family.UniProtP0CG481EQUAL76EQUALReactome Database ID Release 74939188Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939188ReactomeR-HSA-9391881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939188.1UBC(77-152)ubiquitin (UBC 2)Reactome DB_ID: 93916477EQUAL152EQUALReactome Database ID Release 74939164Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939164ReactomeR-HSA-9391641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939164.1UBC(153-228)ubiquitin (UBC 3)Reactome DB_ID: 939258153EQUAL228EQUALReactome Database ID Release 74939258Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939258ReactomeR-HSA-9392581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939258.1UBC(229-304)ubiquitin (UBC 4)Reactome DB_ID: 939192229EQUAL304EQUALReactome Database ID Release 74939192Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939192ReactomeR-HSA-9391921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939192.1UBC(305-380)ubiquitin (UBC 5)Reactome DB_ID: 939232305EQUAL380EQUALReactome Database ID Release 74939232Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939232ReactomeR-HSA-9392321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939232.1UBC(381-456)ubiquitin (UBC 6)Reactome DB_ID: 939191381EQUAL456EQUALReactome Database ID Release 74939191Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939191ReactomeR-HSA-9391911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939191.1UBC(457-532)ubiquitin (UBC 7)Reactome DB_ID: 939184457EQUAL532EQUALReactome Database ID Release 74939184Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939184ReactomeR-HSA-9391841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939184.1UBC(533-608)ubiquitin (UBC 8)Reactome DB_ID: 939239533EQUAL608EQUALReactome Database ID Release 74939239Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939239ReactomeR-HSA-9392391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939239.1UBC(609-684)ubiquitin (UBC 9)Reactome DB_ID: 939165609EQUAL684EQUALReactome Database ID Release 74939165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=939165ReactomeR-HSA-9391651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-939165.1Reactome Database ID Release 74113595Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113595ReactomeR-HSA-1135951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-113595.11Reactome Database ID Release 748953915Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8953915ReactomeR-HSA-89539151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8953915.11Reactome Database ID Release 749033521Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033521ReactomeR-HSA-90335211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033521.1PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14Reactome DB_ID: 90334971Ub:PEX5LReactome DB_ID: 90334981PEX5_HUMANUb-C11-PEX5LPeroxisomal targeting signal 1 receptorReactome DB_ID: 903350111EQUAL1EQUAL639EQUALReactome Database ID Release 749033501Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033501ReactomeR-HSA-90335011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033501.11Reactome Database ID Release 749033498Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033498ReactomeR-HSA-90334981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033498.1111Reactome Database ID Release 749033497Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033497ReactomeR-HSA-90334971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033497.1Converted from EntitySet in ReactomeUBE2D1,2,3UbcH5a,b,cReactome DB_ID: 1234120UBE2D1UbcH5/Ubc4Reactome DB_ID: 1742361EQUAL147EQUALReactome Database ID Release 74174236Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=174236ReactomeR-HSA-1742361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-174236.1UBE2D2UbcH5bUbiquitin-conjugating enzyme E2 D2UB2D2_HUMANReactome DB_ID: 9346281EQUAL147EQUALReactome Database ID Release 74934628Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=934628ReactomeR-HSA-9346281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-934628.1UBE2D3UbcH5cUbiquitin-conjugating enzyme E2 D3UB2D3_HUMANReactome DB_ID: 9346301EQUAL147EQUALReactome Database ID Release 74934630Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=934630ReactomeR-HSA-9346301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-934630.1Reactome Database ID Release 741234120Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1234120ReactomeR-HSA-12341201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1234120.1ACTIVATIONGENE ONTOLOGYGO:0061630gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 749034385Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9034385Reactome Database ID Release 749033485Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9033485ReactomeR-HSA-90334853Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9033485.326086376Pubmed2015Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblastsNordgren, MarcusFrancisco, TâniaLismont, CelienHennebel, LoreBrees, ChantalWang, BoVan Veldhoven, Paul PAzevedo, Jorge EFransen, MarcAutophagy 11:1326-4027597759Pubmed2016PEX2 is the E3 ubiquitin ligase required for pexophagy during starvationSargent, Graemevan Zutphen, TimShatseva, TatianaZhang, LingDi Giovanni, ValeriaBandsma, RobertKim, Peter KijunJ. Cell Biol. 214:677-9021554508Pubmed2011Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recyclingOkumoto, KanjiMisono, SachiMiyata, NonMatsumoto, YuiMukai, SatoruFujiki, YukioTraffic 12:1067-8319208625Pubmed2009Properties of the ubiquitin-pex5p thiol ester conjugateGrou, Cláudia PCarvalho, Andreia FPinto, Manuel PHuybrechts, Sofie JSá-Miranda, ClaraFransen, MAzevedo, Jorge EJ. Biol. Chem. 284:10504-1326344566Pubmed2015ATM functions at the peroxisome to induce pexophagy in response to ROSZhang, JiangweiTripathi, Durga NandJing, JiAlexander, AngelaKim, JinheePowell, Reid TDere, RuheeTait-Mulder, JacquelineLee, Ji-HoonPaull, Tanya TPandita, Raj KCharaka, Vijaya KPandita, Tej KKastan, Michael BWalker, Cheryl LynNat. Cell Biol. 17:1259-6918359941Pubmed2008Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptorGrou, Cláudia PCarvalho, Andreia FPinto, Manuel PWiese, SebastianPiechura, HeikeMeyer, Helmut EWarscheid, BettinaSá-Miranda, ClaraAzevedo, Jorge EJ. Biol. Chem. 283:14190-724865970Pubmed2014A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathwayRodrigues, Tony AAlencastre, Inês SFrancisco, TâniaBrites, PedroFransen, MarcGrou, Cláudia PAzevedo, Jorge EMol. Cell. Biol. 34:2917-288991089Pubmed1996Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptorDodt, GGould, S JJ. Cell Biol. 135:1763-74