BioPAX pathway converted from "Activated chicken TAK1 dissociates from the activated TLR3 complex" in the Reactome database. LEFT-TO-RIGHT Activated chicken TAK1 dissociates from the activated TLR3 complex Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leaves the activated TLR4 complex and translocates to the cytosol Authored: Shamovsky, V, 2010-08-04 Reviewed: D'Eustachio, P, 2010-10-15 Edited: Shamovsky, V, 2010-11-05 viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2:TAB3 :phospho TAK1 : TAB1 : free pUb chain Reactome DB_ID: 434152 endosome membrane GENE ONTOLOGY GO:0010008 phosphorylated TAK1 Reactome DB_ID: 433952 ENSEMBL:ENSGALP00000025101 TGF-beta- activated kinase 1 TGF-beta- activated kinase 1 MAP3K7 Gallus gallus NCBI Taxonomy 9031 ENSEMBL ENSGALP00000025101 O-phospho-L-threonine MOD MOD:00047 1 EQUAL 617 EQUAL Reactome Database ID Release 82 433952 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433952 Reactome R-GGA-433952 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433952.1 Reactome http://www.reactome.org 2 free K63_polyubiquitin chain Reactome DB_ID: 451962 cytosol GENE ONTOLOGY GO:0005829 Reactome Database ID Release 82 451962 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451962 Reactome R-GGA-451962 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451962.1 2 TAB2 Reactome DB_ID: 433923 ENSEMBL:ENSGALP00000020155 TAB2 TAB2 MAP3K7IP2 (TAB2) ENSEMBL ENSGALP00000020155 1 EQUAL 697 EQUAL Reactome Database ID Release 82 433923 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433923 Reactome R-GGA-433923 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433923.1 2 viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 Reactome DB_ID: 434102 viral dsRNA : TLR3 : TICAM1 Reactome DB_ID: 433947 viral dsRNA:TLR3 Reactome DB_ID: 433883 TLR3 Reactome DB_ID: 433892 UniProt:Q0PQ88 Toll-like receptor 3 Toll-like receptor 3 TLR3 SIMILARITY Contains 1 TIR domain. UniProt Q0PQ88 1 EQUAL 1011 EQUAL Reactome Database ID Release 82 433892 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433892 Reactome R-GGA-433892 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433892.1 2 IBV dsRNA intermediate form Reactome DB_ID: 9014378 endosome lumen GENE ONTOLOGY GO:0031904 Reactome Database ID Release 82 9014378 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9014378 Reactome R-IBR-9014378 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-IBR-9014378.1 1 Reactome Database ID Release 82 433883 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433883 Reactome R-GGA-433883 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433883.3 1 TRIF TICAM1 TLR_adaptor_molecule1 Reactome DB_ID: 433979 UniProt:A0FKC7 Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta TLR adaptor molecule 1(TRIF) <submittedName> <fullName>Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta</fullName> </submittedName> UniProt A0FKC7 1 EQUAL 735 EQUAL Reactome Database ID Release 82 433979 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433979 Reactome R-GGA-433979 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433979.1 2 Reactome Database ID Release 82 433947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433947 Reactome R-GGA-433947 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433947.2 1 pUb_TRAF6 Reactome DB_ID: 434011 K63_polyubiquitin chain Reactome DB_ID: 433989 Reactome Database ID Release 82 433989 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433989 Reactome R-GGA-433989 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433989.1 1 TRAF6 Reactome DB_ID: 433792 UniProt:E1C626 TRAF6 TRAF6 SIMILARITY: Contains 1 MATH domain. UniProt E1C626 Reactome Database ID Release 82 433792 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433792 Reactome R-GGA-433792 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433792.1 1 Reactome Database ID Release 82 434011 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434011 Reactome R-GGA-434011 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434011.1 2 Reactome Database ID Release 82 434102 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434102 Reactome R-GGA-434102 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434102.2 1 TAB3 Reactome DB_ID: 442975 ENSEMBL:ENSGALP00000026205 TAB3 TAB3 MAP3K7IP3 ENSEMBL ENSGALP00000026205 Reactome Database ID Release 82 442975 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442975 Reactome R-GGA-442975 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442975.1 2 TAB1 Reactome DB_ID: 434141 UniProt:Q5ZJW3 RCJMB04_15c17 RCJMB04_15c17 <submittedName> <fullName>Putative uncharacterized protein</fullName> </submittedName> UniProt Q5ZJW3 1 EQUAL 438 EQUAL Reactome Database ID Release 82 434141 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434141 Reactome R-GGA-434141 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434141.1 2 Reactome Database ID Release 82 434152 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434152 Reactome R-GGA-434152 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434152.2 pUB-TRAF6:TAB2:TAB3:TAB1:free K63-pUb chain:phospho TAK1 Reactome DB_ID: 921146 pUb_TRAF6 Reactome DB_ID: 451455 K63_polyubiquitin chain Reactome DB_ID: 434061 Reactome Database ID Release 82 434061 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434061 Reactome R-GGA-434061 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434061.1 1 TRAF6 Reactome DB_ID: 433886 Reactome Database ID Release 82 433886 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433886 Reactome R-GGA-433886 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433886.1 1 Reactome Database ID Release 82 451455 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451455 Reactome R-GGA-451455 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451455.1 2 TAB2 Reactome DB_ID: 434032 1 EQUAL 697 EQUAL Reactome Database ID Release 82 434032 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434032 Reactome R-GGA-434032 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434032.1 2 2 TAB1 Reactome DB_ID: 433882 1 EQUAL 438 EQUAL Reactome Database ID Release 82 433882 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433882 Reactome R-GGA-433882 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433882.1 2 phosphorylated TAK1 Reactome DB_ID: 451473 1 EQUAL 617 EQUAL Reactome Database ID Release 82 451473 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451473 Reactome R-GGA-451473 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451473.1 2 TAB3 Reactome DB_ID: 442867 Reactome Database ID Release 82 442867 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442867 Reactome R-GGA-442867 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442867.1 2 Reactome Database ID Release 82 921146 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=921146 Reactome R-GGA-921146 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-921146.1 Reactome Database ID Release 82 921145 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=921145 Reactome R-GGA-921145 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-921145.3 12609980 Pubmed 2003 Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR Jiang, Z Zamanian-Daryoush, M Nie, H Silva, AM Williams, BR Li, X J Biol Chem 278:16713-9