BioPAX pathway converted from "ABC7, mABC1 and mABC2 mediate heme transport" in the Reactome database.LEFT-TO-RIGHTABC7, mABC1 and mABC2 mediate heme transportThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 113593mitochondrial matrixGENE ONTOLOGYGO:0005759ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 70113593Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113593ReactomeR-ALL-1135934Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113593.4Reactomehttp://www.reactome.orghemeprotohemeferroheme bReactome DB_ID: 189444ferroheme b [ChEBI:17627]ferroheme bChEBICHEBI:17627Reactome Database ID Release 70189444Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189444ReactomeR-ALL-1894443Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-189444.3H2OwaterReactome DB_ID: 113521water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 70113521Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113521ReactomeR-ALL-1135213Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113521.3hemehemeferroheme bheme (ferrous)Reactome DB_ID: 71185cytosolGENE ONTOLOGYGO:0005829Reactome Database ID Release 7071185Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71185ReactomeR-ALL-711853Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-71185.3ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 113581ADP(3-) [ChEBI:456216]ADP(3-)ADP5&apos;-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 70113581Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113581ReactomeR-ALL-1135814Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113581.4PiOrthophosphatephosphate(3-)PhosphateReactome DB_ID: 113548phosphate(3-) [ChEBI:18367]phosphate(3-)ChEBICHEBI:18367Reactome Database ID Release 70113548Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113548ReactomeR-ALL-1135483Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113548.3ACTIVATIONConverted from EntitySet in ReactomeHeme transportersReactome DB_ID: 9688990ABC7 dimerReactome DB_ID: 9688976mitochondrial inner membraneGENE ONTOLOGYGO:0005743Q61102ABCB7(23-752)Reactome DB_ID: 9688974UniProt:Q61102Mus musculusNCBI Taxonomy10090UniProtQ6110223EQUAL752EQUALReactome Database ID Release 709688974Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688974ReactomeR-MMU-13689931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1368993.12Reactome Database ID Release 709688976Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688976ReactomeR-MMU-13690411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1369041.1mABC2 dimerReactome DB_ID: 9688982ABCB10Q9JI39Reactome DB_ID: 9688980UniProt:Q9JI39UniProtQ9JI39106EQUAL738EQUALReactome Database ID Release 709688980Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688980ReactomeR-MMU-13690151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1369015.12Reactome Database ID Release 709688982Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688982ReactomeR-MMU-13689891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1368989.1mABC1 dimerReactome DB_ID: 9688988ABCB8Q9CXJ4Reactome DB_ID: 9688986UniProt:Q9CXJ4UniProtQ9CXJ456EQUAL735EQUALReactome Database ID Release 709688986Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688986ReactomeR-MMU-13690041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1369004.12Reactome Database ID Release 709688988Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688988ReactomeR-MMU-13690731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1369073.1Reactome Database ID Release 709688990Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688990ReactomeR-MMU-13690301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1369030.1GENE ONTOLOGYGO:0015232gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 709688991Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688991Reactome Database ID Release 709688993Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9688993ReactomeR-MMU-3825601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-382560.1Mitochondrial ABC transporters are thought to play a key role in iron metabolism and heme biosynthesis. All mitochondrial ABC transporters described to date are of the half-transporter type and would probably function as dimers (Ramjeesingh et al. 2003) but their dimerization partners have not yet been identified. ABC7 is the functional human orthologue of yeast Atm1p (Csere et al. 1998), is predicted to dimerize in the same way as Atm1p (Chloupková et al. 2004) and is probably involved in iron homeostasis. Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310] (Allikmets et al. 1999). Human genes ABCB8 and ABCB10 encode mABC1 and mABC2 respectively (Hogue et al. 1999, Zhang et al 2000 respectively). They would be expected to dimerize, as demonstrated for mABC2 (Graf et al. 2004). Both are believed to have similar functionality to ABC7 although this has not been demonstrated yet.9883897Pubmed1998Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1pCsere, PLill, RKispal, GFEBS Lett 441:266-7010196363Pubmed1999Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)Allikmets, RRaskind, WHHutchinson, ASchueck, NDDean, MKoeller, DMHum Mol Genet 8:743-915215243Pubmed2004Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me)Graf, SAHaigh, SECorson, EDShirihai, OSJ Biol Chem 279:42954-6315225610Pubmed2004The mitochondrial ABC transporter Atm1p functions as a homodimerChloupková, MReaves, SKLeBard, LMKoeller, DMFEBS Lett 569:65-912892562Pubmed2003Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective poreRamjeesingh, MUgwu, FLi, CDhani, SHuan, LJWang, YBear, CEBiochem J 375:633-419878413Pubmed1999Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane proteinHogue, DLLiu, LLing, VJ Mol Biol 285:379-8910922475Pubmed2000M-ABC2, a new human mitochondrial ATP-binding cassette membrane proteinZhang, FHogue, DLLiu, LFisher, CLHui, DChilds, SLing, VFEBS Lett 478:89-94inferred from electronic annotationEVIDENCE CODEECO:0000203