BioPAX pathway converted from "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" in the Reactome database.LEFT-TO-RIGHT2.7.11p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kBThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>IkB(alpha):NF-kB complexReactome DB_ID: 9724452cytosolGENE ONTOLOGYGO:0005829NfkbiaNFKBIAQ9Z1E3Reactome DB_ID: 9720081UniProt:Q9Z1E3NfkbiaMus musculusNCBI Taxonomy10090UniProtQ9Z1E31EQUAL317EQUALReactome Database ID Release 759720081Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720081ReactomeR-MMU-1681511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-168151.1Reactomehttp://www.reactome.org1NFKB1(1-433):RELAReactome DB_ID: 9724393Nfkb1NFKB1(1-433)P25799Reactome DB_ID: 9720069UniProt:P25799Nfkb1UniProtP257991EQUAL433EQUALReactome Database ID Release 759720069Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720069ReactomeR-MMU-1681681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-168168.11RelaRELAQ04207Reactome DB_ID: 9720065UniProt:Q04207RelaUniProtQ042071EQUAL551EQUALReactome Database ID Release 759720065Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720065ReactomeR-MMU-1681721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-168172.11Reactome Database ID Release 759724393Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9724393ReactomeR-MMU-1940431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-194043.11Reactome Database ID Release 759724452Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9724452ReactomeR-MMU-1939381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-193938.1ATPAdenosine 5'-triphosphateATP(4-)Reactome DB_ID: 113592ATP(4-) [ChEBI:30616]ATP(4-)ATPatpAdenosine 5'-triphosphateChEBICHEBI:30616Reactome Database ID Release 75113592Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113592ReactomeR-ALL-1135924Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.4COMPOUNDC00002additional informationMIMI:03612p-S32,36-IkB-alpha:NF-kB complexReactome DB_ID: 9728125Q9Z1E3phospho-Nfkbiap-S32,S36-NFKBIAReactome DB_ID: 972009332EQUALO-phospho-L-serineMODMOD:0004636EQUAL1EQUAL317EQUALReactome Database ID Release 759720093Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720093ReactomeR-MMU-1776771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-177677.111Reactome Database ID Release 759728125Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9728125ReactomeR-MMU-56076711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607671.1ADPAdenosine 5'-diphosphateADP(3-)Reactome DB_ID: 29370ADP(3-) [ChEBI:456216]ADP(3-)ADP5&apos;-O-[(phosphonatooxy)phosphinato]adenosineADP trianionChEBICHEBI:456216Reactome Database ID Release 7529370Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29370ReactomeR-ALL-293704Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.4COMPOUNDC000082ACTIVATIONactiveUnit: #Protein7p-S177,S181-IKKB:IKKA:pUb-NEMOReactome DB_ID: 9728120IkbkgK63polyUb-NEMOO88522Reactome DB_ID: 9728118UniProt:O88522IkbkgUniProtO88522321EQUALubiquitinylated lysineMODMOD:01148325EQUAL326EQUAL1EQUAL419EQUALReactome Database ID Release 759728118Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9728118ReactomeR-MMU-2025301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-202530.11ChukCHUKQ60680Reactome DB_ID: 9720200UniProt:Q60680ChukUniProtQ606801EQUAL745EQUALReactome Database ID Release 759720200Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720200ReactomeR-MMU-1681041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-168104.11O88351phospho-Ikbkbp-S177,S181-IKBKBReactome DB_ID: 9720115UniProt:O88351IkbkbUniProtO88351177EQUAL181EQUAL1EQUAL756EQUALReactome Database ID Release 759720115Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720115ReactomeR-MMU-2025061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-202506.11Reactome Database ID Release 759728120Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9728120ReactomeR-MMU-2025621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-202562.1GENE ONTOLOGYGO:0004674gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 759728126Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9728126Reactome Database ID Release 759728128Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9728128ReactomeR-MMU-2025411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-202541.1NF-kB is sequestered in the cytosol of unstimulated cells through the interactions with a class of inhibitor proteins, called IkBs, which mask the nuclear localization signal (NLS) of NF-kB and prevent its nuclear translocation. A key event in NF-kB activation involves phosphorylation of IkB (at sites equivalent to Ser32 and Ser36 of IkB-alpha or Ser19 and Ser22 of IkB-beta) by IKK. The phosphorylated IkB-alpha is recognized by the E3 ligase complex and targeted for ubiquitin-mediated proteasomal degradation, releasing the NF-kB dimer p50/p65 into the nucleus to turn on target genes. (Karin & Ben-Neriah 2000)9252186Pubmed1997A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaBDiDonato, JAHayakawa, MRothwarf, DMZandi, EKarin, MNature 388:548-5415145317Pubmed2004The two NF-kappaB activation pathways and their role in innate and adaptive immunityBonizzi, GKarin, MTrends Immunol 25:280-815371334Pubmed2004Signaling to NF-kappaBHayden, MSGhosh, SGenes Dev 18:2195-22410837071Pubmed2000Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityKarin, MBen-Neriah, YAnnu. Rev. Immunol. 18:621-638601309Pubmed1996Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activityChen, Z JParent, LManiatis, TCell 84:853-6217363905Pubmed2007Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathwaysShambharkar, PBBlonska, MPappu, BPLi, HYou, YSakurai, HDarnay, BGHara, HPenninger, JLin, XEMBO J 26:1794-805inferred from electronic annotationEVIDENCE CODEECO:0000203