BioPAX pathway converted from "Thiosulfate can transfer its sulfur atom to glutathione" in the Reactome database.LEFT-TO-RIGHT2.8.1.3Thiosulfate can transfer its sulfur atom to glutathioneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>S2O3(2-)thiosulfate(2-)Reactome DB_ID: 1614595mitochondrial matrixGENE ONTOLOGYGO:0005759thiosulfate(2-) [ChEBI:16094]thiosulfate(2-)Hyposulfitethiosulphatethiosulfate ion(2-)trioxido-1kappa(3)O-disulfate(S--S)(2-)ThiosulfateTETRATHIONATES2O3(2-)[SO3S](2-)ChEBICHEBI:16094Reactome Database ID Release 751614595Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614595ReactomeR-ALL-16145953Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1614595.3Reactomehttp://www.reactome.orgH+hydronReactome DB_ID: 113529hydron [ChEBI:15378]hydronChEBICHEBI:15378Reactome Database ID Release 75113529Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113529ReactomeR-ALL-1135294Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113529.4COMPOUNDC00080additional informationMIMI:0361GSHReduced glutathioneglutathione5-L-Glutamyl-L-cysteinylglycineN-(N-gamma-L-Glutamyl-L-cysteinyl)glycinegamma-L-Glutamyl-L-cysteinyl-glycineReactome DB_ID: 1655887glutathione [ChEBI:16856]glutathioneChEBICHEBI:16856Reactome Database ID Release 751655887Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655887ReactomeR-ALL-16558873Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1655887.3COMPOUNDC000512sulfitesulfite(2-)Reactome DB_ID: 1614538sulfite [ChEBI:17359]sulfiteChEBICHEBI:17359Reactome Database ID Release 751614538Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1614538ReactomeR-ALL-16145383Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1614538.3GSSGoxidized glutathioneglutathione disulfideReactome DB_ID: 1655882glutathione disulfide [ChEBI:17858]glutathione disulfideChEBICHEBI:17858Reactome Database ID Release 751655882Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655882ReactomeR-ALL-16558823Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1655882.3COMPOUNDC00127H2Shydrogen sulfideReactome DB_ID: 1655881hydrogen sulfide [ChEBI:16136]hydrogen sulfideChEBICHEBI:16136Reactome Database ID Release 751655881Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1655881ReactomeR-ALL-16558813Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1655881.3ACTIVATIONTstd1TSTD1E9PY03Reactome DB_ID: 9762414cytosolGENE ONTOLOGYGO:0005829UniProt:E9PY03Tstd1Mus musculusNCBI Taxonomy10090UniProtE9PY031EQUAL115EQUALReactome Database ID Release 759762414Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9762414ReactomeR-MMU-90145291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9014529.1GENE ONTOLOGYGO:0050337gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 759762415Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9762415Reactome Database ID Release 759762417Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9762417ReactomeR-MMU-16558791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1655879.1Thiosulfate is able to transfer its sulfur atom to glutathione, a reaction investigated in yeast (Chauncey & Westley 1983). Recombinant human thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1 aka KAT1) (and its yeast equivalent RDL1) catalyse a predicted thiosulfate-dependent conversion of glutathione (GSH) to glutathione disulfide (GSSG) (Melideo et al. 2014).24981631Pubmed2014Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast orthologMelideo, Scott LJackson, Michael RJorns, Marilyn SchumanBiochemistry 53:4739-536361026Pubmed1983The catalytic mechanism of yeast thiosulfate reductaseChauncey, TRWestley, JJ Biol Chem 258:15037-45inferred from electronic annotationEVIDENCE CODEECO:0000203