BioPAX pathway converted from "p52:RELB translocates from cytosol to nucleus" in the Reactome database.LEFT-TO-RIGHTp52:RELB translocates from cytosol to nucleusThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>p52:RELBReactome DB_ID: 9783556cytosolGENE ONTOLOGYGO:0005829Nfkb2NFKB2(1-454)Q9WTK5Reactome DB_ID: 9720073UniProt:Q9WTK5Nfkb2Mus musculusNCBI Taxonomy10090UniProtQ9WTK51EQUAL454EQUALReactome Database ID Release 759720073Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720073ReactomeR-MMU-1681441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-168144.1Reactomehttp://www.reactome.org1RelbRELBQ04863Reactome DB_ID: 9783500UniProt:Q04863RelbUniProtQ048631EQUAL579EQUALReactome Database ID Release 759783500Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9783500ReactomeR-MMU-56076521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607652.11Reactome Database ID Release 759783556Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9783556ReactomeR-MMU-56076991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607699.1p52:RELBReactome DB_ID: 9783621nucleoplasmGENE ONTOLOGYGO:0005654Nfkb2NFKB2(1-454)Q9WTK5Reactome DB_ID: 97201651EQUAL454EQUALReactome Database ID Release 759720165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9720165ReactomeR-MMU-1776741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-177674.11RelbRELBQ04863Reactome DB_ID: 97836191EQUAL579EQUALReactome Database ID Release 759783619Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9783619ReactomeR-MMU-56076561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607656.11Reactome Database ID Release 759783621Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9783621ReactomeR-MMU-56076791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607679.1Reactome Database ID Release 759783623Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9783623ReactomeR-MMU-56077411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5607741.1Following 26S-proteasomal processing, NFKB2 p52:RELB dimer is translocated from cytosol into the nucleus where it stimulates expression of target genes (Lin & Karin 2003). Dectin-1 induced RELB-p52 triggers the transcription of chemokines C-C motif chemokine 17 (CCL17) and CCL22 and repression of interleukin 12B (IL12B) transcription (Gringhuis et al. 2009). 12654254Pubmed2003NF-kappaB in cancer: a marked targetLin, AnningKarin, MSemin. Cancer Biol. 13:107-148921937Pubmed1996Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situFeuillard, JKörner, MIsraël, AVassy, JRaphael, MEur. J. Immunol. 26:2547-5119122653Pubmed2009Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and SykGringhuis, Sonja Iden Dunnen, JeroenLitjens, Manjavan der Vlist, MichielWevers, BrigitteBruijns, Sven C MGeijtenbeek, Teunis B HNat. Immunol. 10:203-13inferred from electronic annotationEVIDENCE CODEECO:0000203