BioPAX pathway converted from "PIPOX oxidises PPCA to P6C" in the Reactome database.LEFT-TO-RIGHT1.5.3.7PIPOX oxidises PPCA to P6CThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>O2OxygendioxygenReactome DB_ID: 113535peroxisomal matrixGENE ONTOLOGYGO:0005782dioxygen [ChEBI:15379]dioxygenChEBICHEBI:15379Reactome Database ID Release 75113535Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113535ReactomeR-ALL-1135353Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113535.3Reactomehttp://www.reactome.orgCOMPOUNDC00007additional informationMIMI:0361PPCAL-pipecolic acidReactome DB_ID: 5693325L-pipecolic acid [ChEBI:30913]L-pipecolic acidChEBICHEBI:30913Reactome Database ID Release 755693325Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5693325ReactomeR-ALL-56933253Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5693325.3H2O2hydrogen peroxideReactome DB_ID: 113575hydrogen peroxide [ChEBI:16240]hydrogen peroxideChEBICHEBI:16240Reactome Database ID Release 75113575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113575ReactomeR-ALL-1135753Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113575.3COMPOUNDC00027P6C(2S)-2,3,4,5-tetrahydropyridine-2-carboxylate(S)-1-piperideine-6-carboxylateReactome DB_ID: 6783877(S)-1-piperideine-6-carboxylate [ChEBI:58769](S)-1-piperideine-6-carboxylateL-1-piperideine-6-carboxylate(S)-2,3,4,5-tetrahydropyridine-2-carboxylateDelta(1)-piperideine-6-L-carboxylateChEBICHEBI:58769Reactome Database ID Release 756783877Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6783877ReactomeR-ALL-67838773Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6783877.3ACTIVATIONPipoxPIPOXQ9D826Reactome DB_ID: 9793349UniProt:Q9D826PipoxMus musculusNCBI Taxonomy10090UniProtQ9D8261EQUAL390EQUALReactome Database ID Release 759793349Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9793349ReactomeR-MMU-4529111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-452911.1GENE ONTOLOGYGO:0050031gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 759793350Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9793350Reactome Database ID Release 759793352Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9793352ReactomeR-MMU-67838801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6783880.1Peroxisomal sarcosine oxidase (PIPOX aka L-pipecolate oxidase) is an important enzyme in the pipecolate pathway of lysine degradation. The saccharopine pathway is the predominant lysine degradative pathway in extracerebral tissues, whereas the pipecolate pathway predominates in adult brain. PIPOX can mediate the oxidation of L-pipecolate (PPCA) to (S)-1-piperideine-6-carboxylate (P6C), an intermediate in equilibrium with alpha-aminoadipate delta-semialdehyde (AAS), which connects the two degradative pathways. Patients lacking PIPOX accumulate PPCA which can lead to psychiatric and neurological disorders (Dodt et al. 2000, Hallen et al. 2013).10642506Pubmed2000L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidasesDodt, GKim, DGReimann, SAReuber, BEMcCabe, KGould, Stephen JMihalik, SJBiochem J 345:487-9424043460Pubmed2013Lysine metabolism in mammalian brain: an update on the importance of recent discoveriesHallen, AndréJamie, Joanne FCooper, Arthur J LAmino Acids 45:1249-72inferred from electronic annotationEVIDENCE CODEECO:0000203