BioPAX pathway converted from "SUMOylation of XPC" in the Reactome database.LEFT-TO-RIGHTSUMOylation of XPCThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeSUMO1,2,3:UBE2IReactome DB_ID: 9794284SUMO1:C93-UBE2IReactome DB_ID: 9774115nucleoplasmGENE ONTOLOGYGO:0005654Ube2iSUMO1-C93-UBE2IP63280Reactome DB_ID: 9774110UniProt:P63280 Ube2iUbe2iUbc9Ubce2iUbce9FUNCTION Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (By similarity).PATHWAY Protein modification; protein sumoylation.SUBUNIT Forms a complex with SENP6 and UBE2I in response to UV irradiation (By similarity). Forms a tight complex with RANGAP1 and RANBP2 (By similarity). Identified in a complex with SUMO2 and UBE2I, where one ZNF451 interacts with one UBE2I and two SUMO2 chains, one bound to the UBE2I active site and the other to another region of the same UBE2I molecule (By similarity). Interacts with SETX (By similarity). Interacts with HIPK1 and HIPK2 (PubMed:10535925). Interacts with PPM1J (PubMed:12633878). Interacts with RASD2 (By similarity). Interacts with TCF3 (PubMed:9409784). Interacts with NR2C1; the interaction promotes its sumoylation (PubMed:17187077). Interacts with SIAH1 (By similarity). Interacts with PARP (By similarity). Interacts with various transcription factors such as TFAP2A, TFAP2B, and TFAP2C (By similarity). Interacts with AR (By similarity). Interacts with ETS1 (By similarity). Interacts with SOX4 (By similarity). Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B (By similarity). Interacts with FOXL2 (By similarity). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain (By similarity). Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains (By similarity). Interacts with FHIT (By similarity). Interacts with PRKRA and p53/TP53 (PubMed:22214662). Interacts with UHRF2 (By similarity). Interacts with NR3C1 and this interaction is enhanced in the presence of RWDD3 (By similarity). Interacts with MTA1 (By similarity). Interacts with ZNF451 (By similarity). Interacts with CPEB3 (PubMed:26074071). Interacts with SUMO1, SUMO2, and SUMO3 (By similarity). Interacts with IPO13 (By similarity). Interacts with DNMT1 (By similarity).TISSUE SPECIFICITY Present in spleen, kidney, lung, brain, heart and testis (at protein level).PTM Phosphorylation at Ser-71 significantly enhances SUMOylation activity.DISRUPTION PHENOTYPE Death prior to E7.5 due to major defects in nuclear organization.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family.Mus musculusNCBI Taxonomy10090UniProtP6328093EQUALS-(glycyl)-L-cysteine (Cys-Gly)MODMOD:002111EQUAL158EQUALReactome Database ID Release 759774110Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774110ReactomeR-MMU-37306171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3730617.1Reactomehttp://www.reactome.org1Sumo1UBE2I-G97-SUMO1P63166Reactome DB_ID: 9774113UniProt:P63166 Sumo1Sumo1Smt3cSmt3h3Ubl1FUNCTION Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (By similarity).SUBUNIT Interacts with USP25 (via ts SIM domain) the interaction weakly sumoylates USP25. Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (By similarity). Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PRKN. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with BHLHE40/DEC1. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1 (By similarity).TISSUE SPECIFICITY Ubiquitous.DEVELOPMENTAL STAGE Expressed at 13.5 dpc strongly in the upper lip, primary palate and medial edge epithelia of the secondary palate. At 14.5 dpc expression could be seen in the medial edge epithelial seam.INDUCTION By hypoxia.PTM Cleavage of precursor form by SENP1 or SENP2 is necessary for function.PTM Polymeric SUMO1 chains undergo polyubiquitination by RNF4.SIMILARITY Belongs to the ubiquitin family. SUMO subfamily.UniProtP6316697EQUAL2EQUAL97EQUALReactome Database ID Release 759774113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774113ReactomeR-MMU-37306221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3730622.11Reactome Database ID Release 759774115Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774115ReactomeR-MMU-29937831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2993783.1SUMO2:UBE2IReactome DB_ID: 9774276Ube2iSUMO2-C93-UBE2IP63280Reactome DB_ID: 977427193EQUAL1EQUAL158EQUALReactome Database ID Release 759774271Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774271ReactomeR-MMU-37306191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3730619.11G3UZ60Gm49325UBE2I-G93-SUMO2Reactome DB_ID: 9774274UniProt:G3UZ60Gm49325UniProtG3UZ6093EQUAL1EQUAL93EQUALReactome Database ID Release 759774274Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774274ReactomeR-MMU-37306251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3730625.11Reactome Database ID Release 759774276Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774276ReactomeR-MMU-29937781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2993778.1SUMO3:UBE2IReactome DB_ID: 9774284Sumo3UBE2I-G92-SUMO3Q9Z172Reactome DB_ID: 9774282UniProt:Q9Z172 Sumo3Sumo3Smt3aSmt3h1FUNCTION Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).SUBUNIT Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity (By similarity). Interacts with ARNTL/BMAL1.PTM Polymeric chains can be formed through Lys-11 cross-linking.PTM Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.SIMILARITY Belongs to the ubiquitin family. SUMO subfamily.UniProtQ9Z17292EQUAL1EQUAL92EQUALReactome Database ID Release 759774282Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774282ReactomeR-MMU-37306111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3730611.11Ube2iSUMO3-C93-UBE2IP63280Reactome DB_ID: 977427993EQUAL1EQUAL158EQUALReactome Database ID Release 759774279Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774279ReactomeR-MMU-37306291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3730629.11Reactome Database ID Release 759774284Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774284ReactomeR-MMU-29937821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2993782.1Reactome Database ID Release 759794284Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794284ReactomeR-MMU-67904711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6790471.1Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1LReactome DB_ID: 9790836XpaXPAQ64267Reactome DB_ID: 9789914UniProt:Q64267XpaUniProtQ642672EQUAL273EQUALReactome Database ID Release 759789914Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789914ReactomeR-MMU-674371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-67437.11Chd1lCHD1LQ9CXF7Reactome DB_ID: 9789920UniProt:Q9CXF7Chd1lUniProtQ9CXF71EQUAL897EQUALReactome Database ID Release 759789920Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789920ReactomeR-MMU-56889161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5688916.11PAR-PARP1,PAR-PARP2 dimersReactome DB_ID: 9785744Converted from EntitySet in ReactomePAR-PARP1,PAR-PARP2Reactome DB_ID: 9785742Parp1PAR-PARP1P11103Reactome DB_ID: 9785737UniProt:P11103Parp1UniProtP11103L-glutamyl-5-poly(ADP-ribose)MODMOD:003002EQUAL1014EQUALReactome Database ID Release 759785737Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785737ReactomeR-MMU-56517131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5651713.1Parp2PAR-PARP2O88554Reactome DB_ID: 9785740UniProt:O88554Parp2UniProtO885541EQUAL583EQUALReactome Database ID Release 759785740Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785740ReactomeR-MMU-56517151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5651715.1Reactome Database ID Release 759785742Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785742ReactomeR-MMU-56517121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5651712.12Reactome Database ID Release 759785744Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785744ReactomeR-MMU-56517091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5651709.11TFIIH CoreReactome DB_ID: 9789916Gtf2h1GTF2H1Q9DBA9Reactome DB_ID: 9711585UniProt:Q9DBA9Gtf2h1UniProtQ9DBA91EQUAL548EQUALReactome Database ID Release 759711585Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9711585ReactomeR-MMU-659121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-65912.11Gtf2h3GTF2H3Q8VD76Reactome DB_ID: 9711573UniProt:Q8VD76Gtf2h3UniProtQ8VD761EQUAL308EQUALReactome Database ID Release 759711573Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9711573ReactomeR-MMU-659161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-65916.11Ercc2ERCC2O08811Reactome DB_ID: 9711565UniProt:O08811Ercc2UniProtO088111EQUAL760EQUALReactome Database ID Release 759711565Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9711565ReactomeR-MMU-674431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-67443.11Gtf2h2GTF2H2Q9JIB4Reactome DB_ID: 9711577UniProt:Q9JIB4Gtf2h2UniProtQ9JIB41EQUAL395EQUALReactome Database ID Release 759711577Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9711577ReactomeR-MMU-659141Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-65914.11Gtf2h5GTF2H5Q8K2X8Reactome DB_ID: 9711589UniProt:Q8K2X8Gtf2h5UniProtQ8K2X81EQUAL71EQUALReactome Database ID Release 759711589Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9711589ReactomeR-MMU-56884461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5688446.11Ercc3ERCC3P49135Reactome DB_ID: 9711569UniProt:P49135Ercc3UniProtP491351EQUAL782EQUALReactome Database ID Release 759711569Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9711569ReactomeR-MMU-674391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-67439.11Gtf2h4GTF2H4O70422Reactome DB_ID: 9711581UniProt:O70422Gtf2h4UniProtO704221EQUAL462EQUALReactome Database ID Release 759711581Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9711581ReactomeR-MMU-659181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-65918.11Reactome Database ID Release 759789916Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789916ReactomeR-MMU-56896241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5689624.11Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDBReactome DB_ID: 9790834Ub:XPC:RAD23:CETN2Reactome DB_ID: 9790029Cetn2CETN2Q9R1K9Reactome DB_ID: 9778964UniProt:Q9R1K9Cetn2UniProtQ9R1K91EQUAL172EQUALReactome Database ID Release 759778964Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9778964ReactomeR-MMU-45704901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4570490.11Converted from EntitySet in ReactomeRAD23Reactome DB_ID: 9790022Rad23bRAD23BP54728Reactome DB_ID: 9789621UniProt:P54728Rad23bUniProtP547281EQUAL409EQUALReactome Database ID Release 759789621Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789621ReactomeR-MMU-625901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-62590.1Rad23aRAD23AP54726Reactome DB_ID: 9789617UniProt:P54726Rad23aUniProtP547261EQUAL363EQUALReactome Database ID Release 759789617Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789617ReactomeR-MMU-56880761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5688076.1Reactome Database ID Release 759790022Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790022ReactomeR-MMU-56881301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5688130.11Ub:XPCReactome DB_ID: 9790027Converted from EntitySet in ReactomeUbUbiquitinUBIQ_HUMANReactome DB_ID: 9707835Ubiquitin (Pps27a)Reactome DB_ID: 940369UniProt:P62983 Rps27aRps27aUba80Ubcep1SUBUNIT Ribosomal protein S27a is part of the 40S ribosomal subunit.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.UniProtP629831EQUAL76EQUALReactome Database ID Release 75940369Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940369ReactomeR-MMU-9403691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940369.1Ubiquitin (Uba52)Reactome DB_ID: 940378UniProt:P62984 Uba52Uba52Ubcep2SUBUNIT Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).MISCELLANEOUS Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.UniProtP629841EQUAL76EQUALReactome Database ID Release 75940378Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940378ReactomeR-MMU-9403781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940378.1Ubiquitin (Ubc 1)Reactome DB_ID: 940376UniProt:P0CG50 UbcUbcMISCELLANEOUS Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family.UniProtP0CG501EQUAL76EQUALReactome Database ID Release 75940376Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940376ReactomeR-MMU-9403761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940376.1Ubiquitin (Ubc 2)Reactome DB_ID: 94037477EQUAL152EQUALReactome Database ID Release 75940374Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940374ReactomeR-MMU-9403741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940374.1Ubiquitin (Ubc 3)Reactome DB_ID: 940381153EQUAL228EQUALReactome Database ID Release 75940381Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940381ReactomeR-MMU-9403811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940381.1Ubiquitin (Ubb 1)Reactome DB_ID: 940367UniProt:P0CG49 UbbUbbSUBUNIT Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family.UniProtP0CG491EQUAL76EQUALReactome Database ID Release 75940367Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940367ReactomeR-MMU-9403671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940367.1Ubiquitin (Ubb 2)Reactome DB_ID: 94036677EQUAL152EQUALReactome Database ID Release 75940366Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940366ReactomeR-MMU-9403661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940366.1Ubiquitin (Ubb 3)Reactome DB_ID: 940380153EQUAL228EQUALReactome Database ID Release 75940380Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940380ReactomeR-MMU-9403801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940380.1Ubiquitin (Ubb 4)Reactome DB_ID: 940385229EQUAL304EQUALReactome Database ID Release 75940385Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=940385ReactomeR-MMU-9403851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-940385.1UbbUBC(305-380)P0CG49Reactome DB_ID: 9707825305EQUAL380EQUALReactome Database ID Release 759707825Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9707825ReactomeR-MMU-9398631Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-939863.1Reactome Database ID Release 759707835Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9707835ReactomeR-MMU-685241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-68524.11XpcUb-XPCP51612Reactome DB_ID: 9790025UniProt:P51612XpcUniProtP51612ubiquitinylated lysineMODMOD:011482EQUAL940EQUALReactome Database ID Release 759790025Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790025ReactomeR-MMU-67829441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6782944.11Reactome Database ID Release 759790027Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790027ReactomeR-MMU-67829511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6782951.11Reactome Database ID Release 759790029Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790029ReactomeR-MMU-67829471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6782947.11PAR-UV-DDBReactome DB_ID: 9789929Rbx1E3 ubiquitin-protein ligase RBX1 ecNumber6.3.2.-/ecNumberRBX1_MOUSERbx1Reactome DB_ID: 3247499UniProt:P62878 Rbx1Rbx1FUNCTION E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B (PubMed:22118460). Interacts with CAND1 (PubMed:22118460). Interacts with UBE2M (By similarity). Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (ELOB and ELOC), CUL2 or CUL5 and VHL. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II (By similarity). Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (ELOB and ELOC), CUL2 and MED8; elongin BC complex (ELOB and ELOC), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (ELOB and ELOC), elongin A/ELOA or SOCS1 or WSB1 and CUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Interacts with CDC34. Interacts with GLMN. GLMN competes for the binding site of the E2 ubiquitin-conjugating enzyme CDC34 and disrupts CDC34 binding. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and CDC34 (By similarity). Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein. Part of the BCR(ENC1) complex containing ENC1. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KLHL41) complex containing KLHL41. Part of the BCR(KEAP1) complex containing KEAP1 (By similarity). Interacts with DCUN1D3 (By similarity). Interacts with SESN1 and SESN2 (By similarity). Interacts with NOTCH2 (By similarity). Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1 (By similarity).TISSUE SPECIFICITY Widely expressed.DOMAIN The RING-type zinc finger domain is essential for ubiquitin ligase activity (By similarity). It coordinates an additional third zinc ion (PubMed:22118460).SIMILARITY Belongs to the RING-box family.UniProtP628782EQUAL108EQUALReactome Database ID Release 753247499Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3247499ReactomeR-MMU-32474991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3247499.11Converted from EntitySet in ReactomeCUL4Reactome DB_ID: 9785796Cul4aCUL4AQ3TCH7Reactome DB_ID: 9785790UniProt:Q3TCH7Cul4aUniProtQ3TCH71EQUAL759EQUALReactome Database ID Release 759785790Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785790ReactomeR-MMU-9760061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-976006.1Cul4bCUL4BA2A432Reactome DB_ID: 9785794UniProt:A2A432Cul4bUniProtA2A4321EQUAL913EQUALReactome Database ID Release 759785794Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785794ReactomeR-MMU-9759731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-975973.1Reactome Database ID Release 759785796Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785796ReactomeR-MMU-9760811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-976081.11DDB1:PAR-DDB2Reactome DB_ID: 9789927Ddb2PAR-DDB2Q99J79Reactome DB_ID: 9789925UniProt:Q99J79Ddb2UniProtQ99J791EQUAL427EQUALReactome Database ID Release 759789925Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789925ReactomeR-MMU-56966541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696654.11Ddb1DDB1Q3U1J4Reactome DB_ID: 9785800UniProt:Q3U1J4Ddb1UniProtQ3U1J41EQUAL1140EQUALReactome Database ID Release 759785800Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785800ReactomeR-MMU-534891Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-53489.11Reactome Database ID Release 759789927Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789927ReactomeR-MMU-56966801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696680.11Reactome Database ID Release 759789929Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789929ReactomeR-MMU-56966491Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696649.11damaged DNA with open bubble structureReactome DB_ID: 109944Reactome Database ID Release 75109944Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109944ReactomeR-ALL-1099442Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109944.2ChEBI61120additional informationMIMI:03611Reactome Database ID Release 759790834Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790834ReactomeR-MMU-56892971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5689297.11Reactome Database ID Release 759790836Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790836ReactomeR-MMU-56910181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5691018.1Ube2iSUMO-conjugating enzyme UBC9UBC9_MOUSEUbe2iReactome DB_ID: 9124831EQUAL158EQUALReactome Database ID Release 75912483Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=912483ReactomeR-MMU-9124831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-912483.1Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1LReactome DB_ID: 97942951Ub,SUMO:XPC:RAD23:CETN2Reactome DB_ID: 9794293Ub,SUMO:XPCReactome DB_ID: 9794291XpcUb,SUMO-XPCP51612Reactome DB_ID: 9794287sumoylated lysineMODMOD:011492EQUAL940EQUALReactome Database ID Release 759794287Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794287ReactomeR-MMU-67904601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6790460.111Converted from EntitySet in ReactomeSUMO1,2,3Reactome DB_ID: 9794289Sumo1SUMO1P63166Reactome DB_ID: 97462142EQUAL97EQUALReactome Database ID Release 759746214Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9746214ReactomeR-MMU-8773041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-877304.1SUMO2Gm49325G3UZ60Reactome DB_ID: 97740461EQUAL93EQUALReactome Database ID Release 759774046Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9774046ReactomeR-MMU-29842811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2984281.1Sumo3Small ubiquitin-related modifier 3SUMO3_MOUSEReactome DB_ID: 37306571EQUAL92EQUALReactome Database ID Release 753730657Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3730657ReactomeR-MMU-37306571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3730657.1Reactome Database ID Release 759794289Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794289ReactomeR-MMU-29908381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2990838.11Reactome Database ID Release 759794291Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794291ReactomeR-MMU-67904621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6790462.1111Reactome Database ID Release 759794293Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794293ReactomeR-MMU-67904611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6790461.1111111Reactome Database ID Release 759794295Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794295ReactomeR-MMU-67904681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6790468.1ACTIVATIONConverted from EntitySet in ReactomePIAS1,3Reactome DB_ID: 9794297Pias1E3 SUMO-protein ligase PIAS1 ecNumber6.3.2.-/ecNumberPIAS1_MOUSEPias1Reactome DB_ID: 3261170UniProt:O88907 Pias1Pias1Ddxbp1FUNCTION Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474).PATHWAY Protein modification; protein sumoylation.SUBUNIT Interacts with NR2C1; the interaction promotes its sumoylation. Interacts with DDX21, CSRP2, AXIN1, JUN, SATB2, PLAG1, TP53 and STAT1 (dimer), following IFNA1-stimulation. Interacts with SP3 (preferentially when SUMO-modified). Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase (By similarity). Interacts with CHUK/IKKA; this interaction induces PIAS1 phosphorylation. Interacts with PTK2/FAK1; the interaction promotes its sumoylation (By similarity). Interacts with SUMO1, UBE2I, NCOA2 and AR. Interacts with NR2C1; the interaction promotes its sumoylation. Interacts with DDX5. Interacts with MTA1 (By similarity). Interacts with PML (isoform PML-12). Interacts with PRDM1 (By similarity).TISSUE SPECIFICITY Expressed in kidney, heart, spleen, brain and cerebellum; weak expression, if any, in liver and lung.DEVELOPMENTAL STAGE Expressed as early as 7.6 dpc. Expression remains high through 15.5 dpc (PubMed:10854042). In 3T3-L1 cells, expression is transiently induced during late adipocyte differentiation (PubMed:24061474).DOMAIN The LXXLL motif is a transcriptional coregulator signature.DOMAIN The SP-RING-type domain is required for promoting EKLF sumoylation.PTM Sumoylated.SIMILARITY Belongs to the PIAS family.UniProtO889071EQUAL651EQUALReactome Database ID Release 753261170Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3261170ReactomeR-MMU-32611701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-3261170.1Pias3PIAS3O54714Reactome DB_ID: 9775179UniProt:O54714Pias3UniProtO547141EQUAL628EQUALReactome Database ID Release 759775179Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9775179ReactomeR-MMU-29937641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2993764.1Reactome Database ID Release 759794297Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794297ReactomeR-MMU-67904551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6790455.1GENE ONTOLOGYGO:0019789gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 759794298Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794298Reactome Database ID Release 759794300Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9794300ReactomeR-MMU-67904541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6790454.1XPC undergoes SUMOylation following UV irradiation on several consensus SUMOylation sites (van Cuijk et al. 2015). SUMOylation of XPC probably succeeds the UV-DDB mediated ubiquitination of XPC, as the presence of both DDB2 and XPA is required for SUMOylation (Wang et al. 2005), but it has also been reported that SUMOylation of XPC was DDB2-independent (Akita et al. 2015). It is unclear whether XPC is modified by SUMO1 (Wang et al. 2005, Akita et al. 2015) or poly-SUMO2/3 (Poulsen et al. 2013). SUMO conjugases PIAS1 and PIAS3 both interact with XPC and may catalyze XPC SUMOylation (Akita et al. 2015).26042670Pubmed2015SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repairAkita, MasakiTak, Yon-SooShimura, TsutomuMatsumoto, SyotaOkuda-Shimizu, YukiShimizu, YuichiroNishi, RyotaroSaitoh, HisatoIwai, ShigenoriMori, ToshioIkura, TsuyoshiSakai, WataruHanaoka, FumioSugasawa, KaoruSci Rep 5:1098423751493Pubmed2013RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage responsePoulsen, Sara LHansen, Rebecca KWagner, Sebastian Avan Cuijk, Loesvan Belle, Gijsbert JStreicher, WernerWikström, MatsChoudhary, ChunaramHoutsmuller, Adriaan BMarteijn, Jurgen ABekker-Jensen, SimonMailand, NielsJ. Cell Biol. 201:797-80726151477Pubmed2015SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repairvan Cuijk, Loesvan Belle, Gijsbert JTurkyilmaz, YaseminPoulsen, Sara LJanssens, Roel CTheil, Arjan FSabatella, MariangelaLans, HannesMailand, NielsHoutsmuller, Adriaan BVermeulen, WimMarteijn, Jurgen ANat Commun 6:749916030353Pubmed2005DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiationWang, Qi-EnZhu, QianzhengWani, GulzarEl-Mahdy, Mohamed ALi, JinyouWani, Altaf ANucleic Acids Res. 33:4023-34inferred from electronic annotationEVIDENCE CODEECO:0000203