BioPAX pathway converted from "REG3A oligomerize to form a pore complex" in the Reactome database.LEFT-TO-RIGHTREG3A oligomerize to form a pore complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>REG3A(38-175):anionic phospholipidsReactome DB_ID: 9798739extracellular regionGENE ONTOLOGYGO:0005576Converted from EntitySet in ReactomeHomologues of REG3A(38-175)Reactome DB_ID: 9798737Reg3aREG3A(38-175)O09037Reactome DB_ID: 9798723UniProt:O09037Reg3aMus musculusNCBI Taxonomy10090UniProtO0903738EQUAL175EQUALReactome Database ID Release 759798723Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798723ReactomeR-MMU-68013521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352.1Reactomehttp://www.reactome.orgReg3gREG3A(38-175)O09049Reactome DB_ID: 9798727UniProt:O09049Reg3gUniProtO0904938EQUAL175EQUALReactome Database ID Release 759798727Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798727ReactomeR-MMU-6801352-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-2.1Reg3bREG3A(38-175)P35230Reactome DB_ID: 9798731UniProt:P35230Reg3bUniProtP3523038EQUAL175EQUALReactome Database ID Release 759798731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798731ReactomeR-MMU-6801352-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-3.1Reg3dREG3A(38-175)Q9QUS9Reactome DB_ID: 9798735UniProt:Q9QUS9Reg3dUniProtQ9QUS938EQUAL175EQUALReactome Database ID Release 759798735Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798735ReactomeR-MMU-6801352-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-4.1Reactome Database ID Release 759798737Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798737ReactomeR-MMU-6801352-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-5.11Anionic phospholipids:microbial cell surfaceReactome DB_ID: 8931784plasma membraneGENE ONTOLOGYGO:0005886anionic phospholipidAnionic phospholipidsReactome DB_ID: 1462049anionic phospholipid [ChEBI:62643]anionic phospholipidphospholipid anionanionic phospholipidsphospholipid anionsChEBICHEBI:62643Reactome Database ID Release 751462049Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1462049ReactomeR-ALL-14620494Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1462049.41Microbial cell surfaceReactome DB_ID: 8879165Reactome Database ID Release 758879165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8879165ReactomeR-ALL-88791652Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8879165.2ChEBI23367additional informationMIMI:03611Reactome Database ID Release 758931784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8931784ReactomeR-ALL-89317841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8931784.11Reactome Database ID Release 759798739Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798739ReactomeR-MMU-68018041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801804.16REG3A hexamer:anionic phospholipidReactome DB_ID: 9798743REG3A dimer:anionic phospholipidReactome DB_ID: 97987412Reactome Database ID Release 759798741Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798741ReactomeR-MMU-68017991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801799.13Reactome Database ID Release 759798743Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798743ReactomeR-MMU-68017951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801795.1Reactome Database ID Release 759798745Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798745ReactomeR-MMU-68017621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801762.1Regenerating islet-derived 3A (REG3A) is thought to recognize and kill its bacterial targets in two distinct steps (Mukherjee S et al. 2014). First, REG3A is secreted from epithelial cells as a soluble monomer that recognizes Gram-positive bacteria by binding to peptidoglycan carbohydrate via an EPN motif located in the long loop region (Lehotzky RE et al. 2010). Second, REG3A kills bacteria by oligomerizing in the bacterial membrane to form a hexameric membrane-penetrating pore that is predicted to induce uncontrolled ion efflux with subsequent osmotic lysis (Mukherjee S et al. 2014). The inhibitory N-terminus of REG3A propeptide hinders lipid binding and consequently suppresses pore formation until it is removed by trypsin after secretion into the intestinal lumen (Mukherjee S et al. 2009; 2014).24256734Pubmed2014Antibacterial membrane attack by a pore-forming intestinal C-type lectinMukherjee, SohiniZheng, HuiDerebe, Mehabaw GCallenberg, Keith MPartch, Carrie LRollins, DarcyPropheter, Daniel CRizo, JosepGrabe, MichaelJiang, Qiu-XingHooper, Lora VNature 505:103-719095652Pubmed2009Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegmentMukherjee, SohiniPartch, Carrie LLehotzky, Rebecca EWhitham, Cecilia VChu, HiutungBevins, Charles LGardner, Kevin HHooper, Lora VJ. Biol. Chem. 284:4881-820382864Pubmed2010Molecular basis for peptidoglycan recognition by a bactericidal lectinLehotzky, Rebecca EPartch, Carrie LMukherjee, SohiniCash, Heather LGoldman, William EGardner, Kevin HHooper, Lora VProc. Natl. Acad. Sci. U.S.A. 107:7722-7inferred from electronic annotationEVIDENCE CODEECO:0000203INHIBITIONReactome Database ID Release 756801800Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6801800ReactomeR-HSA-68018001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6801800.1LPSGram Negative Bacterial LipopolysaccharidelipopolysaccharideReactome DB_ID: 166005lipopolysaccharide [ChEBI:16412]lipopolysaccharidelipopolysaccharidesLPSChEBICHEBI:16412Reactome Database ID Release 75166005Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=166005ReactomeR-ALL-1660054Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-166005.4