BioPAX pathway converted from "REG3A binds bacterial phospholipids" in the Reactome database.LEFT-TO-RIGHTREG3A binds bacterial phospholipidsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeHomologues of REG3A(38-175)Reactome DB_ID: 9798737Reg3aREG3A(38-175)O09037Reactome DB_ID: 9798723extracellular regionGENE ONTOLOGYGO:0005576UniProt:O09037Reg3aMus musculusNCBI Taxonomy10090UniProtO0903738EQUAL175EQUALReactome Database ID Release 759798723Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798723ReactomeR-MMU-68013521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352.1Reactomehttp://www.reactome.orgReg3gREG3A(38-175)O09049Reactome DB_ID: 9798727UniProt:O09049Reg3gUniProtO0904938EQUAL175EQUALReactome Database ID Release 759798727Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798727ReactomeR-MMU-6801352-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-2.1Reg3bREG3A(38-175)P35230Reactome DB_ID: 9798731UniProt:P35230Reg3bUniProtP3523038EQUAL175EQUALReactome Database ID Release 759798731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798731ReactomeR-MMU-6801352-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-3.1Reg3dREG3A(38-175)Q9QUS9Reactome DB_ID: 9798735UniProt:Q9QUS9Reg3dUniProtQ9QUS938EQUAL175EQUALReactome Database ID Release 759798735Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798735ReactomeR-MMU-6801352-41Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-4.1Reactome Database ID Release 759798737Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798737ReactomeR-MMU-6801352-51Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801352-5.1Anionic phospholipids:microbial cell surfaceReactome DB_ID: 8931784plasma membraneGENE ONTOLOGYGO:0005886anionic phospholipidAnionic phospholipidsReactome DB_ID: 1462049anionic phospholipid [ChEBI:62643]anionic phospholipidphospholipid anionanionic phospholipidsphospholipid anionsChEBICHEBI:62643Reactome Database ID Release 751462049Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1462049ReactomeR-ALL-14620494Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1462049.41Microbial cell surfaceReactome DB_ID: 8879165Reactome Database ID Release 758879165Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8879165ReactomeR-ALL-88791652Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8879165.2ChEBI23367additional informationMIMI:03611Reactome Database ID Release 758931784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8931784ReactomeR-ALL-89317841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8931784.1REG3A(38-175):anionic phospholipidsReactome DB_ID: 979873911Reactome Database ID Release 759798739Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798739ReactomeR-MMU-68018041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801804.1Reactome Database ID Release 759798775Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798775ReactomeR-MMU-68017761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801776.1Structural studies of human REG3A by X-ray diffraction with electron microscopy suggest that REG3A binds to bacterial membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing pore (Mukherjee S et al. 2014).24256734Pubmed2014Antibacterial membrane attack by a pore-forming intestinal C-type lectinMukherjee, SohiniZheng, HuiDerebe, Mehabaw GCallenberg, Keith MPartch, Carrie LRollins, DarcyPropheter, Daniel CRizo, JosepGrabe, MichaelJiang, Qiu-XingHooper, Lora VNature 505:103-7inferred from electronic annotationEVIDENCE CODEECO:0000203